Parkin inhibits necroptosis to prevent cancer    pp915 - 916  Kai Cao & Stephen W. G. Tait  doi:10.1038/s41556-019-0350-1  HER2 joins AKT to inhibit STING immunity    pp917 - 918  Ian D. Odell & Richard A. Flavell  doi:10.1038/s41556-019-0368-4  Migrasomes take center stage    pp918 - 920  Stefania Tavano & Carl-Philipp Heisenberg  doi:10.1038/s41556-019-0369-3  Equal opportunities in stemness    pp921 - 923  Qing Nie & Maksim V. Plikus  doi:10.1038/s41556-019-0366-6
LETTERS
Tracing the cellular dynamics of sebaceous gland development in normal and perturbed states    pp924 - 932  Marianne Stemann Andersen, Edouard Hannezo, Svetlana Ulyanchenko, Soline Estrach, Yasuko Antoku et al.  doi:10.1038/s41556-019-0362-x  Andersen, Hannezo, Ulyanchenko et al. map cell behaviour and spatiotemporal dynamics of the sebaceous gland during homeostasis and oncogene-induced gland expansion, and show that all basal cells contribute to long-term gland maintenance.
Dynamic polyhedral actomyosin lattices remodel micron-scale curved membranes during exocytosis in live mice    pp933 - 939  Seham Ebrahim, Desu Chen, Max Weiss, Lenka Malec, Yeap Ng et al.  doi:10.1038/s41556-019-0365-7  Using intravital imaging, Ebrahim et al. show that actin and non-muscle myosin II assemble into polyhedral lattices around the vesicle membrane to mediate exocytic secretion in live tissues.
Advertisement
Nature Outline: Biosimilars Some of the most effective new pharmaceutical drugs are highly complex biological molecules. To make such therapies less expensive and more broadly available, drug developers seek to fashion biosimilars — good-enough copies that can be produced at large scale. Access free online Produced with support from Henlius
ARTICLES
The AMPK–Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome    pp940 - 951  Seung Baek Lee, Jung Jin Kim, Sang-Ah Han, Yingfang Fan, Li-Sha Guo et al.  doi:10.1038/s41556-019-0356-8  AMPK and Parkin keep the necrosome in check. Lee et al. show that AMPK activates Parkin and prevents RIPK1−RIPK3 complex formation by promoting RIPK3 ubiquitination, thereby negatively regulating necroptosis, inflammation and tumour initiation.
Asymmetric inheritance of spindle microtubule-organizing centres preserves replicative lifespan    pp952 - 965  Javier Manzano-López, Laura Matellán, Alejandra Álvarez-Llamas, José Carlos Blanco-Mira & Fernando doi:10.1038/s41556-019-0364-8  Yeast cells segregate the old spindle pole body into the bud. Manzano-López et al. report that inverted segregation accelerates ageing due to aberrant partition of protein aggregates and damaged mitochondria.
Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation    pp966 - 977  Dong Jiang, Zheng Jiang, Di Lu, Xuan Wang, Haisha Liang et al.  doi:10.1038/s41556-019-0358-6  Yu and colleagues report the formation of migrasomes during zebrafish gastrulation. Migrasomes provide signalling molecules to guide the migration of dorsal forerunner cells, thus controlling organ morphogenesis.
5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs    pp978 - 990  Xin Chen, Ang Li, Bao-Fa Sun, Ying Yang, Ya-Nan Han et al.  doi:10.1038/s41556-019-0361-y  Chen et al. provide an m5C landscape in bladder cancer and show m5C enrichment at oncogene mRNAs that promotes tumour progression. They identify YBX1 as the m5C ‘reader’ that recruits ELAVL1 to stabilize mRNAs.
Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains    pp991 - 1002  Yuwei Huang, Ben Zucker, Shaojin Zhang, Sharon Elias, Yun Zhu et al.  doi:10.1038/s41556-019-0367-5  Yu and colleagues report that migrasome formation depends on tetraspanin and cholesterol. Macrodomains formed by clustering of tetraspanin- and cholesterol-enriched membrane domains swell to generate migrasomes.
IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma    pp1003 - 1014  Satoshi Kofuji, Akiyoshi Hirayama, Alexander Otto Eberhardt, Risa Kawaguchi, Yuki Sugiura et al.  doi:10.1038/s41556-019-0363-9  Kofuji et al. demonstrate that upregulation of IMPDH2 promotes nucleostemin stabilization and nucleoli malformation, and its inactivation induces growth arrest in glioblastoma.
Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes    pp1015 - 1026  Lulu Sun, Yuqing Wang, Jin Cen, Xiaolong Ma, Lei Cui et al.  doi:10.1038/s41556-019-0359-5  Sun et al. demonstrate that the development of bona fide liver cancer can be modelled at structural and molecular levels by introducing c-Myc into directly reprogrammed human hepatocytes with inactivated p53 and RB.
HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity    pp1027 - 1040  Shiying Wu, Qian Zhang, Fei Zhang, Fansen Meng, Shengduo Liu et al.  doi:10.1038/s41556-019-0352-z  Wu et al. demonstrate that HER2 recruits AKT1 to disrupt the STING signalosome, thereby suppressing damage-induced cellular senescence and STING-mediated antiviral and antitumour responses in vivo.
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening    pp1041 - 1051  Matteo Boretto, Nina Maenhoudt, Xinlong Luo, Aurélie Hennes, Bram Boeckx et al.  doi:10.1038/s41556-019-0360-z  Boretto et al. demonstrate that organoids derived from patients with various types of endometrial pathologies can model disease traits and diversity, and can be used as a drug-screening tool.