ScienceDirect Publication: Talanta
- Vacuum-assisted sorbent extraction: An analytical methodology for the determination of ultraviolet filters in environmental samples
Publication date: Available online 25 September 2019Source: TalantaAuthor(s): María J. Trujillo-Rodríguez, Jared L. Anderson, Sage J.B. Dunham, Victoria L. Noad, Daniel B. CardinAbstractVacuum-assisted sorbent extraction (VASE) has been applied for the first time in the determination of UV filters in water samples in combination with gas chromatography-mass spectrometry. VASE is a variant of headspace extraction which was developed in conjunction Science: Current Issue
- Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pat - Unraveling the origin of chirality from plasmonic nanoparticle-protein complexes
Plasmon-coupled circular dichroism has emerged as a promising approach for ultrasensitive detection of biomolecular conformations through coupling between molecular chirality and surface plasmons. Chiral nanoparticle assemblies without chiral molecules present also have large optical activities. We apply single-particle circular differential scattering spectroscopy coupled with electron imaging and simulations to identify both structural chiralit - A giant exoplanet orbiting a very-low-mass star challenges planet formation models
Surveys have shown that super-Earth and Neptune-mass exoplanets are more frequent than gas giants around low-mass stars, as predicted by the core accretion theory of planet formation. We report the discovery of a giant planet around the very-low-mass star GJ 3512, as determined by optical and near-infrared radial-velocity observations. The planet has a minimum mass of 0.46 Jupiter masses, very high for such a small host star, and an eccentric 204 - High thermoelectric performance in low-cost SnS0.91Se0.09 crystals
Thermoelectric technology allows conversion between heat and electricity. Many good thermoelectric materials contain rare or toxic elements, so developing low-cost and high-performance thermoelectric materials is warranted. Here, we report the temperature-dependent interplay of three separate electronic bands in hole-doped tin sulfide (SnS) crystals. This behavior leads to synergistic optimization between effective mass (m*) and carrier mobility - Maleness-on-the-Y (MoY) orchestrates male sex determination in major agricultural fruit fly pests
In insects, rapidly evolving primary sex-determining signals are transduced by a conserved regulatory module controlling sexual differentiation. In the agricultural pest Ceratitis capitata (Mediterranean fruit fly, or Medfly), we identified a Y-linked gene, Maleness-on-the-Y (MoY), encoding a small protein that is necessary and sufficient for male development. Silencing or disruption of MoY in XY embryos causes feminization, whereas overexpressio - The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3
Circadian rhythmicity is a defining feature of mammalian metabolism that synchronizes metabolic processes to day-night light cycles. Here, we show that the intestinal microbiota programs diurnal metabolic rhythms in the mouse small intestine through histone deacetylase 3 (HDAC3). The microbiota induced expression of intestinal epithelial HDAC3, which was recruited rhythmically to chromatin, and produced synchronized diurnal oscillations in histon - Three-dimensional crystals of adaptive knots
Starting with Gauss and Kelvin, knots in fields were postulated to behave like particles, but experimentally they were found only as transient features or required complex boundary conditions to exist and could not self-assemble into three-dimensional crystals. We introduce energetically stable, micrometer-sized knots in helical fields of chiral liquid crystals. While spatially localized and freely diffusing in all directions, they resemble collo - Chromosome errors in human eggs shape natural fertility over reproductive life span
Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are prefe - Deconstructing the sources of genotype-phenotype associations in humans
Efforts to link variation in the human genome to phenotypes have progressed at a tremendous pace in recent decades. Most human traits have been shown to be affected by a large number of genetic variants across the genome. To interpret these associations and to use them reliably—in particular for phenotypic prediction—a better understanding of the many sources of genotype-phenotype associations is necessary. We summarize the progress that has been - Mapping human cell phenotypes to genotypes with single-cell genomics
The cumulative activity of all of the body’s cells, with their myriad interactions, life histories, and environmental experiences, gives rise to a condition that is distinctly human and specific to each individual. It is an enduring goal to catalog our human cell types, to understand how they develop, how they vary between individuals, and how they fail in disease. Single-cell genomics has revolutionized this endeavor because sequencing-based met
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