Caring for the Critically Ill Patient ,  Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial Pierre-Francois Laterre, MD; Scott M. Berry, PhD; Allan Blemings, MS; et al. Caring for the Critically Ill Patient Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure: A Randomized Clinical Trial Arnaud W. Thille, MD, PhD; Grégoire Muller, MD; Arnaud Gacouin, MD; et al. Editorial: Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients ; Irene Telias, MD; Niall D. Ferguson, MD, MSc Caring for the Critically Ill Patient Changes in End-of-Life Practices in European Intensive Care Units From 1999 to 2016 Charles L. Sprung, MD; Bara Ricou, MD; Christiane S. Hartog, MD; et al. Editorial: A Measured Dose of Optimism for the Evolution of ICU-Based Palliative Care ; Christopher E. Cox, MD, MPH; May Hua, MD, MS; David Casarett, MD, MA EDITORIAL A Measured Dose of Optimism for the Evolution of ICU-Based Palliative Care Christopher E. Cox, MD, MPH; May Hua, MD, MS; David Casarett, MD, MA Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients Irene Telias, MD; Niall D. Ferguson, MD, MSc

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CLINICAL CHALLENGE Multiple Lung Masses in a Young Woman Observe only Perform cardiac echocardiography to rule out right-sided endocarditis Refer the patient to oncology for chemotherapy Start treatment with sirolimus What would you do next?