R-dihydroetorphine Analgesia and Respiratory Depression,Post Hoc Analysis of ADRENAL

	FREE Post Hoc Analysis of ADRENAL   In a post hoc analysis of the Adjunctive Glucocorticoid Therapy in Patients with Septic Shock (ADRENAL) trial, in participants who fulfilled either the Sepsis-3 or -2 inclusion criteria or those with severe septic shock, a continuous infusion of hydrocortisone did not result in a lower 90-day mortality than placebo.
	FREE R-dihydroetorphine Analgesia and Respiratory Depression The effects of four R-dihydroetorphine doses (12.5, 75, 125, and 150 ng/kg) on isohypercapnic ventilation and antinociception were studied in 40 male volunteers. Over the dose range tested, an apparent maximum in respiratory depression to 33% of baseline ventilation was identified, but a maximum in antinociception was not reached. At an R-dihydroetorphine effect-site concentration of 20 pg/ml, the probability of analgesia was 60%, while the probability of analgesia without respiratory depression was 45%. The probability of analgesia increased to 95% at 100 pg/ml, but the probability of analgesia without respiratory depression was reduced to 20%.