Genome-wide localisation of histone H3S57ph in proliferating and hydroxyurea pre-treated cells

GSE119742 Genome-wide localisation of histone H3S57ph in proliferating and hydroxyurea pre-treated cells: Contributors : Daniel Fisher ; Nikolaos Parisis

Series Type : Genome binding/occupancy profiling by high throughput sequencing

Organism : Homo sapiens

We identified a species of histone H3 phosphorylated on serine 57 and showed that it is involved in responses to DNA replication stress. Here we asked whether it is specifically localised in the human genome by ChIP-seq from human osteosarcoma cells (U2OS) growing exponentially or treated with 2mM hydroxyurea for 2 hours to stall DNA replication forks