Current and Future Treatments of Rhinitis and Sinusitis.

Current and Future Treatments of Rhinitis and Sinusitis.:

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Current and Future Treatments of Rhinitis and Sinusitis.

J Allergy Clin Immunol Pract. 2020 Jan 28;:

Authors: Patel GB, Kern RC, Bernstein JA, Hae-Sim P, Peters AT

Abstract

Advances in understanding the pathogenic mechanisms of both rhinitis and chronic rhinosinusitis have resulted in new treatment options, especially for chronic rhinosinusitis. A review of relevant medical and surgical clinical studies shows that intranasal corticosteroids, antihistamines, and allergen immunotherapy continue to be the best treatments for chronic rhinitis. Dupilumab is the first biologic approved for chronic rhinosinusitis with polyps. Omalizumab, mepolizumab and benralizumab may have a future role in the treatment of chronic rhinosinusitis. Novel corticosteroid delivery devices such as exhalation delivery system for fluticasone and bioabsorbable sinus implants provide enhanced and localized distribution of corticosteroids. Surgical management tailored to the underlying disease process improves clinical outcomes in chronic rhinosinusitis with or without nasal polyposis. Advances in the understanding of the heterogenous nature of rhinitis and rhinosinusitis has resulted in more precise treatments. Improving the understanding of different endotypes should provide better knowledge to determine appropriate current and new therapies to treat these diseases.

PMID: 32004747 [PubMed - as supplied by publisher]