IJERPH, Vol. 17, Pages 1020: Estimation of Occupational Exposure to Asbestos in Italy by the Linkage of Mesothelioma Registry (ReNaM) and National Insurance Archives. Methodology and Results International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031020 Authors: Chiara Airoldi Daniela Ferrante Lucia Miligi Sara Piro Giorgia Stoppa Enrica Migliore Elisabetta Chellini Antonio Romanelli Carlo Sciacchitano Carolina Mensi Domenica Cavone...
Thu Feb 06, 2020 02:00
IJERPH, Vol. 17, Pages 1019: Emissions Control of Hydrochloric and Fluorhydric Acid in cement Factories from Romania International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031019 Authors: Voicu Ciobanu Istrate Tudor From the available statistical data, cement factories co-process a range of over 100 types of waste (sorted both industrial and household) being authorized for their use as combustion components in clinker ovens. Therefore, the...
Thu Feb 06, 2020 02:00
IJERPH, Vol. 17, Pages 1018: Sexting, Online Sexual Victimization, and Psychopathology Correlates by Sex: Depression, Anxiety, and Global Psychopathology International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031018 Authors: Gassó Mueller-Johnson Montiel Recent research on sexting highlighted a relationship between this new technology-mediated behavior and psychopathology correlates, although up to date results are mixed, and so far, studies have...
Thu Feb 06, 2020 02:00
IJERPH, Vol. 17, Pages 1017: The Epidemiology of Skin Cancer and Public Health Strategies for Its Prevention in Southern Africa International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17031017 Authors: Caradee Y. Wright D. Jean du Preez Danielle A. Millar Mary Norval Skin cancer is a non-communicable disease that has been underexplored in Africa, including Southern Africa. Exposure to solar ultraviolet radiation (UVR) is an important, potentially...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1092: Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation International Journal of Molecular Sciences doi: 10.3390/ijms21031092 Authors: Daou Hassani Matos De Castro Costa Seelaender Moresi Rocchi Adamo Li Agbulut Coletti An idiopathic myopathy characterized by central nuclei in muscle fibers, a hallmark of muscle regeneration, has been observed in cancer patients. In cancer cachexia skeletal muscle is incapable...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1093: Sustained Release of Levobupivacaine, Lidocaine, and Acemetacin from Electrosprayed Microparticles: In Vitro and In Vivo Studies International Journal of Molecular Sciences doi: 10.3390/ijms21031093 Authors: Chen Liu Yeh Chen Liu In this study, we explored the release characteristics of analgesics, namely levobupivacaine, lidocaine, and acemetacin, from electrosprayed poly(D,L-lactide-co-glycolide) (PLGA) microparticles. The drug-loaded particles...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1088: Genome-Wide Characterization and Expression Profiling of GASA Genes during Different Stages of Seed Development in Grapevine (Vitis vinifera L.) Predict Their Involvement in Seed Development International Journal of Molecular Sciences doi: 10.3390/ijms21031088 Authors: Bilal Ahmad Jin Yao Songlin Zhang Xingmei Li Xiuming Zhang Vivek Yadav Xiping Wang Members of the plant-specific GASA (gibberellic acid-stimulated Arabidopsis) gene family have...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1089: The Three-Dimensional Ultrastructure of the Human Alveolar Epithelium Revealed by Focused Ion Beam Electron Microscopy International Journal of Molecular Sciences doi: 10.3390/ijms21031089 Authors: Schneider Wrede Mühlfeld Thin type 1 alveolar epithelial (AE1) and surfactant producing type 2 alveolar epithelial(AE2) cells line the alveoli in the lung and are essential for normal lung function. Function is intimatelyinterrelated to structure, so...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1090: Effect of S-Allyl –L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis International Journal of Molecular Sciences doi: 10.3390/ijms21031090 Authors: Bronowicka-Adamska Bentke Lasota Wróbel The S-Allyl-L-cysteine (SAC) component of aged garlic extract (AGE) is proven to have anticancer, antihepatotoxic, neuroprotective and neurotrophic properties. -Cystathionase (CTH), cystathionine...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1091: Effect of Cholesterol on the Organic Cation Transporter OCTN1 (SLC22A4) International Journal of Molecular Sciences doi: 10.3390/ijms21031091 Authors: Lorena Pochini Gilda Pappacoda Michele Galluccio Francesco Pastore Mariafrancesca Scalise Cesare Indiveri The effect of cholesterol was investigated on the OCTN1 transport activity measured as [14C]-tetraethylamonium or [3H]-acetylcholine uptake in proteoliposomes reconstituted with native transporter...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1082: Different Frequency of Cyclic Tensile Strain Relates to Anabolic/Catabolic Conditions Consistent with Immunohistochemical Staining Intensity in Tenocytes International Journal of Molecular Sciences doi: 10.3390/ijms21031082 Authors: Kubo Hoffmann Goltz Schnakenberg Jahr Merkel Schulze-Tanzil Pufe Tohidnezhad Tenocytes are mechanosensitive cells intimately adapting their expression profile and hence, their phenotype to their...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1083: Pre- and Neonatal Exposure to Lead (Pb) Induces Neuroinflammation in the Forebrain Cortex, Hippocampus and Cerebellum of Rat Pups International Journal of Molecular Sciences doi: 10.3390/ijms21031083 Authors: Chibowska Korbecki Gutowska Metryka Tarnowski Goschorska Barczak Chlubek Baranowska-Bosiacka Lead (Pb) is a heavy metal with a proven neurotoxic effect. Exposure is particularly dangerous to the developing brain in the...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1084: Celastrol Alleviates Gamma Irradiation-Induced Damage by Modulating Diverse Inflammatory Mediators International Journal of Molecular Sciences doi: 10.3390/ijms21031084 Authors: Wang Ahn Alharbi Shair Arfuso Sethi Chinnathambi Tang The present study aimed to explore the possible radioprotective effects of celastrol and relevant molecular mechanisms in an in vitro cell and in vivo mouse models exposed to gamma radiation. Human keratinocytes...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1085: Dbp5/DDX19 between Translational Readthrough and Nonsense Mediated Decay International Journal of Molecular Sciences doi: 10.3390/ijms21031085 Authors: Beißel Grosse Krebber The DEAD-box protein Dbp5 (human DDX19) remodels RNA-protein complexes. Dbp5 functions in ribonucleoprotein export and translation termination. Termination occurs, when the ribosome has reached a stop codon through the Dbp5 mediated delivery of the eukaryotic termination factor...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1086: Differences in the Inflammatory Response of White Adipose Tissue and Adipose-Derived Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21031086 Authors: Taha Volkmer Haas Alberton Straub David-Rus Aszodi Giunta Saller The application of liposuctioned white adipose tissue (L-WAT) and adipose-derived stem cells (ADSCs) as a novel immunomodulatory treatment option is the currently subject of various clinical...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1087: EjFRI, FRIGIDA (FRI) Ortholog from Eriobotrya japonica, Delays Flowering in Arabidopsis International Journal of Molecular Sciences doi: 10.3390/ijms21031087 Authors: Weiwei Chen Peng Wang Dan Wang Min Shi Yan Xia Qiao He Jiangbo Dang Qigao Guo Danlong Jing Guolu Liang In the model species Arabidopsis thaliana, FRIGIDA (FRI) is a key regulator of flowering time and can inhibit flowering without vernalization. However, little information...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1081: Acute Myeloid Leukemia in Patients Living with HIV Infection: Several Questions, Fewer Answers International Journal of Molecular Sciences doi: 10.3390/ijms21031081 Authors: Fabio Forghieri Vincenzo Nasillo Francesca Bettelli Valeria Pioli Davide Giusti Andrea Gilioli Cristina Mussini Enrico Tagliafico Tommaso Trenti Andrea Cossarizza Rossana Maffei Patrizia Barozzi Leonardo Potenza Roberto Marasca Franco Narni Mario Luppi...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1078: Gene Expression Signature Predictive of Neuroendocrine Transformation in Prostate Adenocarcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21031078 Authors: Ostano Mello-Grand Sesia Gregnanin Peraldo-Neia Guana Jachetti Farsetti Chiorino Neuroendocrine prostate cancer (NEPC) can arise de novo, but much more commonly occurs as a consequence of a selective pressure from androgen deprivation therapy or androgen...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1080: Differential Expression of Genes at Panicle Initiation and Grain Filling Stages Implied in Heterosis of Rice Hybrids International Journal of Molecular Sciences doi: 10.3390/ijms21031080 Authors: Jawahar Lal Katara Ram Lakhan Verma Madhuchhanda Parida Umakanta Ngangkham Kutubuddin Ali Molla Kalyani Makarand Barbadikar Mitadru Mukherjee Parameswaran C Sanghamitra Samantaray Nageswara Rao Ravi Onkar Nath Singh Trilochan Mohapatra ...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1073: Dystonia: Sparse Synapses for D2 Receptors in Striatum of a DYT1 Knock-out Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21031073 Authors: D’Angelo Paldino Cardarelli Sorge Fusco Biagioni Mercuri Giorgi Sancesario Dystonia pathophysiology has been partly linked to downregulation and dysfunction ofdopamine D2 receptors in striatum. We aimed to investigate the possible morpho‐structuralcorrelates of...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1074: An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients International Journal of Molecular Sciences doi: 10.3390/ijms21031074 Authors: Daniel Missailidis Sarah J. Annesley Claire Y. Allan Oana Sanislav Brett A. Lidbury Donald P. Lewis Paul R. Fisher Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an enigmatic condition characterized by exacerbation of symptoms...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1075: RasGRP2 Structure, Function and Genetic Variants in Platelet Pathophysiology International Journal of Molecular Sciences doi: 10.3390/ijms21031075 Authors: Canault Alessi RasGRP2 is calcium and diacylglycerol-regulated guanine nucleotide exchange factor I that activates Rap1, which is an essential signaling-knot in “inside-out” αIIbβ3 integrin activation in platelets. Inherited platelet function disorder caused by...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1076: Root Proteomic Analysis of Two Grapevine Rootstock Genotypes Showing Different Susceptibility to Salt Stress International Journal of Molecular Sciences doi: 10.3390/ijms21031076 Authors: Prinsi Failla Scienza Espen Keywords: NaCl; Vitis; LC-ESI-MS/MS; carbon and energy metabolism; oxidative stress
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1077: Liver Iron Retention Estimated from Utilization of Oral and Intravenous Radioiron in Various Anemias and Hemochromatosis in Humans International Journal of Molecular Sciences doi: 10.3390/ijms21031077 Authors: van Vuren van Wijk van Beers Marx Patients with hereditary hemochromatosis and non-transfusion-dependent hereditary anemia develop predominantly liver iron-overload. We present a unique method allowing quantification of liver iron retention...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1079: Bisphenol A (BPA)-Induced Changes in the Number of Serotonin-Positive Cells in the Mucosal Layer of Porcine Small Intestine—the Preliminary Studies International Journal of Molecular Sciences doi: 10.3390/ijms21031079 Authors: Slawomir Gonkowski Bisphenol A (BPA) is a substance used in the production of plastics which has a negative impact on many internal organs. Because BPA is normally toxic for the gastrointestinal (GI) tract, the intestine is especially...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1072: CB1 Activity Drives the Selection of Navigational Strategies: A Behavioral and c-Fos Immunoreactivity Study International Journal of Molecular Sciences doi: 10.3390/ijms21031072 Authors: Daniela Laricchiuta Francesca Balsamo Carlo Fabrizio Anna Panuccio Andrea Termine Laura Petrosini To promote efficient explorative behaviors, subjects adaptively select spatial navigational strategies based on landmarks or a cognitive map. The hippocampus works...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1054: Minimal Residual Disease Detection in Acute Lymphoblastic Leukemia International Journal of Molecular Sciences doi: 10.3390/ijms21031054 Authors: Kruse Abdel-Azim Kim Ruan Phan Ogana Wang Lee Gang Khazal Kim Minimal residual disease (MRD) refers to a chemotherapy/radiotherapy-surviving leukemia cell population that gives rise to relapse of the disease. The detection of MRD is critical for predicting the outcome and for...
Wed Feb 05, 2020 02:00
IJMS, Vol. 21, Pages 1071: Dual Role of Chondrocytes in Rheumatoid Arthritis: The Chicken and the Egg International Journal of Molecular Sciences doi: 10.3390/ijms21031071 Authors: Chia-Chun Tseng Yi-Jen Chen Wei-An Chang Wen-Chan Tsai Tsan-Teng Ou Cheng-Chin Wu Wan-Yu Sung Jeng-Hsien Yen Po-Lin Kuo Rheumatoid arthritis (RA) is one of the inflammatory joint diseases that display features of articular cartilage destruction. The underlying disturbance results from...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1069: Current Biomedical Use of Copper Chelation Therapy International Journal of Molecular Sciences doi: 10.3390/ijms21031069 Authors: Baldari Di Rocco Toietta Copper is an essential microelement that plays an important role in a wide variety of biological processes. Copper concentration has to be finely regulated, as any imbalance in its homeostasis can induce abnormalities. In particular, excess copper plays an important role in the etiopathogenesis of...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1068: StABI5 Involved in the Regulation of Chloroplast Development and Photosynthesis in Potato International Journal of Molecular Sciences doi: 10.3390/ijms21031068 Authors: Zhu Li Feng Ren Abscisic acid (ABA) insensitive 5 (ABI5)—a core transcription factor of the ABA signaling pathway—is a basic leucine zipper transcription factor that plays a key role in the regulation of seed germination and early seedling growth. ABI5 interacts...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1070: Local and Systemic Humoral Response to Autologous Lineage-Negative Cells Intrathecal Administration in ALS Patients International Journal of Molecular Sciences doi: 10.3390/ijms21031070 Authors: Baumert Sobuś Gołąb-Janowska Ulańczyk Paczkowska Łuczkowska Zawiślak Milczarek Osękowska Meller Machowska-Sempruch Wełnicka Safranow Nowacki Machaliński Amyotrophic lateral sclerosis (ALS) remains a fatal disease...
Thu Feb 06, 2020 02:00
IJMS, Vol. 21, Pages 1067: Full-Length Transcriptome Assembly of Italian Ryegrass Root Integrated with RNA-Seq to Identify Genes in Response to Plant Cadmium Stress International Journal of Molecular Sciences doi: 10.3390/ijms21031067 Authors: Hu Zhang He Cao Zhang Lou Cai Cadmium (Cd) is a toxic heavy metal element. It is relatively easily absorbed by plants and enters the food chain, resulting in human exposure to Cd. Italian ryegrass (Lolium multiflorum Lam.),...
Thu Feb 06, 2020 02:00
JCDD, Vol. 7, Pages 7: Acknowledgement to Reviewers of Journal of Cardiovascular Development and Disease in 2019 Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd7010007 Authors: JCDD Editorial Office Peer review is an essential part in the publication process, ensuring that Journal of Cardiovascular Development and Disease maintains high quality standards for its published papers [...]
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 455: Inpatient Burden and Mortality of Goodpasture’s Syndrome in the United States: Nationwide Inpatient Sample 2003–2014 Journal of Clinical Medicine doi: 10.3390/jcm9020455 Authors: Kaewput Thongprayoon Boonpheng Ungprasert Bathini Chewcharat Srivali Vallabhajosyula Cheungpasitporn Background: Goodpasture’s syndrome is a rare, life-threatening, small vessel vasculitis. Given its rarity, data on its inpatient burden and resource...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 453: Extracorporeal Shockwave Therapy Treatment in Upper Limb Diseases: A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9020453 Authors: Testa Vescio Perez Consoli Costarella Sessa Pavone Background: Rotator cuff tendinopathy (RCT), subacromial impingement (SAIS), and medial (MEP) and lateral (LEP) epicondylitis are the most common causes of upper limb pain caused by microtrauma and degeneration. There are several therapeutic...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 452: Pain Predictors in a Population of Temporomandibular Disorders Patients Journal of Clinical Medicine doi: 10.3390/jcm9020452 Authors: Osiewicz Lobbezoo Ciapała Pytko-Polończyk Manfredini The aim of the present study was to assess the potential role of some biological, psychological, and social factors to predict the presence of painful temporomandibular disorders (TMDs) in a TMD-patient population. The study sample consisted of 109 consecutive...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 454: Circulating Irisin and esRAGE as Early Biomarkers of Decline of Metabolic Health Journal of Clinical Medicine doi: 10.3390/jcm9020454 Authors: Dozio Vianello Sitzia Ambrogi Benedini Gorini Rampoldi Rigolini Tacchini Romanelli A decline in metabolic health may take place before observing any alteration in the levels of the traditional metabolic markers. New indicators of metabolic derangement are therefore compelling. Irisin...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 444: Outcomes of Vitrectomy for Long-Duration Macular Hole Journal of Clinical Medicine doi: 10.3390/jcm9020444 Authors: Lumi Mahnic Petrovski Petrovski : The present study investigated the functional and anatomical outcomes of idiopathic chronic macular hole (MH) surgery with different surgical approaches related to the chronicity and diameter of the MH. A comparative retrospective study between three groups of patients who underwent vitrectomy for long-duration...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 450: Towards Understanding Therapeutic Failures in Masquelet Surgery: First Evidence that Defective Induced Membrane Properties are Associated with Clinical Failures Journal of Clinical Medicine doi: 10.3390/jcm9020450 Authors: Durand Barbier Mathieu Poyot Demoures Souraud Masquelet Collombet The two-stage Masquelet induced-membrane technique (IMT) consists of cement spacer-driven membrane induction followed by an autologous cancellous...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 449: Consensus-Based Recommendations for Advance Directives of People with Parkinson’s Disease in Regard to Typical Complications by German Movement Disorder Specialists Journal of Clinical Medicine doi: 10.3390/jcm9020449 Authors: Klietz Berndt Wegner Schneider Höglinger Eggers Stiel A huge proportion of people with Parkinson’s disease (PwP) in Germany have written an advance directive (AD). However, the content of these forms in...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 448: Total, Bioavailable, and Free Vitamin D Levels and Their Prognostic Value in Pulmonary Arterial Hypertension Journal of Clinical Medicine doi: 10.3390/jcm9020448 Authors: Callejo Mondejar-Parreño Esquivel-Ruiz Olivencia Moreno Blanco Escribano-Subias Cogolludo Barbera Perez-Vizcaino Introduction: Epidemiological studies suggest a relationship between vitamin D deficiency and cardiovascular and respiratory diseases. However,...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 445: Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use Journal of Clinical Medicine doi: 10.3390/jcm9020445 Authors: Gonzalo José Jimenez-Puerta Juan Antonio Marchal Elena López-Ruiz Patricia Gálvez-Martín Due to the great therapeutic interest that involves the translation of mesenchymal stromal cells (MSCs) into clinical practice, they have been widely studied as innovative drugs,...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 447: Combined Brain-Heart Magnetic Resonance Imaging in Autoimmune Rheumatic Disease Patients with Cardiac Symptoms: Hypothesis Generating Insights from a Cross-sectional Study Journal of Clinical Medicine doi: 10.3390/jcm9020447 Authors: Markousis-Mavrogenis Mitsikostas Koutsogeorgopoulou Dimitroulas Katsifis Argyriou Apostolou Velitsista Vartela Manolopoulou Tektonidou Kolovou Kitas Sfikakis Mavrogeni Background:...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 446: Postpartum Diet Quality: A Cross-Sectional Analysis from the Australian Longitudinal Study on Women’s Health Journal of Clinical Medicine doi: 10.3390/jcm9020446 Authors: Martin Joham Mishra Hodge Moran Harrison Reproductive-aged women are at high risk of developing obesity, and diet quality is a potential modifiable risk factor. There is limited research exploring diet quality and its association with time since childbirth. Using data from...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 451: Effects of Immobilization and Re-Mobilization on Knee Joint Arthrokinematic Motion Quality Journal of Clinical Medicine doi: 10.3390/jcm9020451 Authors: Dawid Bączkowicz Grzegorz Skiba Krzysztof Falkowski Przemysław Domaszewski Noelle Selkow Background: Knee immobilization is a common intervention for patients with traumatic injuries. However, it usually leads to biomechanical/morphological disturbances of articular tissues. These changes may contribute...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 440: Torquetenovirus Serum Load and Long-Term Outcomes in Renal Transplant Recipients Journal of Clinical Medicine doi: 10.3390/jcm9020440 Authors: Gore Gomes-Neto Wang Bakker Niesters de Joode Verschuuren Westra Leer-Buter Following transplantation, patients must take immunosuppressive medication for life. Torquetenovirus (TTV) is thought to be marker for immunosuppression, and TTV–DNA levels after organ transplantation have...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 443: Inhibition of Anaplerosis Attenuated Vascular Proliferation in Pulmonary Arterial Hypertension Journal of Clinical Medicine doi: 10.3390/jcm9020443 Authors: Mathews Valuparampil Varghese Joel James Cody A Eccles Maki Niihori Olga Rafikova Ruslan Rafikov Vascular remodeling is considered a key event in the pathogenesis of pulmonary arterial hypertension (PAH). However, mechanisms of gaining the proliferative phenotype by pulmonary vascular cells...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 441: Correlations between the Quality of Life Domains and Clinical Variables in Sarcopenic Osteoporotic Postmenopausal Women Journal of Clinical Medicine doi: 10.3390/jcm9020441 Authors: Cevei Onofrei Cioara Stoicanescu (1) Background: both sarcopenia and osteoporosis are major health problems in postmenopausal women. The aim of the study was to evaluate the quality of life (QoL) and the associated factors for sarcopenia in osteoporotic postmenopausal...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 439: Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients for the Treatment of Severe Aortic Stenosis Journal of Clinical Medicine doi: 10.3390/jcm9020439 Authors: Polimeni Sorrentino De Rosa Spaccarotella Mongiardo Sabatino Indolfi Recently, two randomized trials, the PARTNER 3 and the Evolut Low Risk Trial, independently demonstrated that transcatheter aortic valve replacement (TAVR) is non-inferior to surgical aortic...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 442: Socioeconomic Inequities in Adherence to Positive Airway Pressure Therapy in Population-Level Analysis Journal of Clinical Medicine doi: 10.3390/jcm9020442 Authors: Abhishek Pandey Suresh Mereddy Daniel Combs Safal Shetty Salma I. Patel Saif Mashaq Azizi Seixas Kerry Littlewood Girardin Jean-Luis Sairam Parthasarathy (a) Background: In patients with sleep apnea, poor adherence to positive airway pressure (PAP) therapy has been associated...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 438: Analysis of Running-Related Injuries: The Vienna Study Journal of Clinical Medicine doi: 10.3390/jcm9020438 Authors: Emir Benca Stephan Listabarth Florian K.J. Flock Eleonore Pablik Claudia Fischer Sonja M. Walzer Ronald Dorotka Reinhard Windhager Pejman Ziai Background: This study aimed to provide an extensive and up-to-date analysis of running-related injuries (RRI) and analyze a broad range of contributing factors for a large heterogeneous...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 437: Urinary Excretion of N1-methyl-2-pyridone-5-carboxamide and N1-methylnicotinamide in Renal Transplant Recipients and Donors Journal of Clinical Medicine doi: 10.3390/jcm9020437 Authors: Carolien P. J. Deen Anna van der Veen António W. Gomes-Neto Johanna M. Geleijnse Karin J. Borgonjen-van den Berg M. Rebecca Heiner-Fokkema Ido P. Kema Stephan J. L. Bakker N1-methylnicotinamide (N1-MN) and N1-methyl-2-pyridone-5-carboxamide (2Py) are successive...
Thu Feb 06, 2020 02:00
JCM, Vol. 9, Pages 436: Inclusion Biogenesis, Methods of Isolation and Clinical Application of Human Cellular Exosomes Journal of Clinical Medicine doi: 10.3390/jcm9020436 Authors: Max Tschuschke Ievgeniia Kocherova Artur Bryja Paul Mozdziak Ana Angelova Volponi Krzysztof Janowicz Rafał Sibiak Hanna Piotrowska-Kempisty Dariusz Iżycki Dorota Bukowska Paweł Antosik Jamil A. Shibli Marta Dyszkiewicz-Konwińska Bartosz Kempisty Exosomes are a heterogenous...
Thu Feb 06, 2020 02:00
Life, Vol. 10, Pages 13: Endolithic Fungal Species Markers for Harshest Conditions in the McMurdo Dry Valleys, Antarctica Life doi: 10.3390/life10020013 Authors: Coleine Pombubpa Zucconi Onofri Stajich Selbmann The microbial communities that inhabit lithic niches inside sandstone in the Antarctic McMurdo Dry Valleys of life’s limits on Earth. The cryptoendolithic communities survive in these ice-free areas that have the lowest temperatures on Earth coupled...
Thu Feb 06, 2020 02:00
Membranes, Vol. 10, Pages 25: The Application of Submerged Modules for Membrane Distillation Membranes doi: 10.3390/membranes10020025 Authors: Gryta This paper deals with the efficiency of capillary modules without an external housing, which were used as submerged modules in the membrane distillation process. The commercial hydrophobic capillary membranes fabricated for the microfiltration process were applied. Several constructional variants of submerged modules were discussed. The...
Thu Feb 06, 2020 02:00
Metabolites, Vol. 10, Pages 57: Background Diet Influences TMAO Concentrations Associated with Red Meat Intake without Influencing Apparent Hepatic TMAO-Related Activity in a Porcine Model Metabolites doi: 10.3390/metabo10020057 Authors: Thøgersen Rasmussen Sundekilde Goethals Van Hecke Vossen De Smet Bertram Red meat has been associated with an increased cardiovascular disease (CVD) risk, possibly through gut microbial-derived trimethylamine-N-oxide (TMAO)....
Thu Feb 06, 2020 02:00
Metabolites, Vol. 10, Pages 58: Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle Metabolites doi: 10.3390/metabo10020058 Authors: Cônsolo Silva Buarque Higuera-Padilla Barbosa Zawadzki Colnago Netto Gerrard Silva To clarify the relationship between beef genetic selection for growth and precocity with muscle metabolism and metabolites, we performed metabolomic analysis using Longissimus lumborum (LL) muscle from Nellore...
Thu Feb 06, 2020 02:00
Microorganisms, Vol. 8, Pages 221: Proteolytic Activity of Bacillus subtilis upon κ-Casein Undermines Its “Caries-Safe” Effect Microorganisms doi: 10.3390/microorganisms8020221 Authors: Duanis-Assaf Kenan Sionov Steinberg Shemesh Milk is believed to be a relatively “caries-safe” food. This belief relies on the fact that caseins, which constitute around 80% of milk’s protein content, were found to inhibit the adhesion of Streptococcus mutans...
Thu Feb 06, 2020 02:00
Microorganisms, Vol. 8, Pages 217: Isolation of an Obligate Mixotrophic Methanogen That Represents the Major Population in Thermophilic Fixed-Bed Anaerobic Digesters Microorganisms doi: 10.3390/microorganisms8020217 Authors: Nagoya Kouzuma Ueno Watanabe Methanothermobacter Met2 is a metagenome-assembled genome (MAG) that encodes a putative mixotrophic methanogen constituting the major populations in thermophilic fixed-bed anaerobic digesters. In order to characterize its...
Thu Feb 06, 2020 02:00
Microorganisms, Vol. 8, Pages 219: Removal of Soil Microbes Alters Interspecific Competitiveness of Epichloë Endophyte-Infected over Endophyte-Free Leymus chinensis Microorganisms doi: 10.3390/microorganisms8020219 Authors: Liu Chen Qin Shi Gao Ren Epichloë endophytes may not only affect the growth and resistances of host grasses, but may also affect soil environment including soil microbes. Can Epichloë endophyte-mediated modification of soil microbes...
Thu Feb 06, 2020 02:00
Microorganisms, Vol. 8, Pages 218: Analysis of the Bacterial Diversity of Paipa Cheese (a Traditional Raw Cow’s Milk Cheese from Colombia) by High-Throughput Sequencing Microorganisms doi: 10.3390/microorganisms8020218 Authors: Castellanos-Rozo Pérez Pulido Grande Lucas Gálvez Background: Paipa cheese is a traditional, semi-ripened cheese made from raw cow’s milk in Colombia. The aim of this work was to gain insights on the microbiota of Paipa cheese by using...
Thu Feb 06, 2020 02:00
Microorganisms, Vol. 8, Pages 220: Effect of Dose and Timing of Burdock (Arctium lappa) Root Intake on Intestinal Microbiota of Mice Microorganisms doi: 10.3390/microorganisms8020220 Authors: Watanabe Sasaki Miyakawa Nakayama Lyu Shibata Water-soluble dietary fiber such as inulin improves the beta diversity of the intestinal microbiota of mice fed with a high-fat diet (HFD). The circadian clock is the system that regulates the internal daily rhythm, and it affects...
Thu Feb 06, 2020 02:00
Microorganisms, Vol. 8, Pages 216: Recombinant of the Staphylococcal Bacteriophage Lysin CHAPk and Its Elimination against Streptococcus agalactiae Biofilms Microorganisms doi: 10.3390/microorganisms8020216 Authors: Shan Yang Teng Wang Mao Hao Ma Fan Wang Bovine mastitis is the most important infectious disease, causing significant losses in the dairy industry, in which Streptococcus agalactiae is a major pathogen. In this study, lysin CHAPk, derived...
Thu Feb 06, 2020 02:00
Microorganisms, Vol. 8, Pages 215: Methylcellulose Hydrogel with Melissa officinalis Essential Oil as a Potential Treatment for Oral Candidiasis Microorganisms doi: 10.3390/microorganisms8020215 Authors: Elisa Serra Fabien Saubade Cosimo Ligorio Kathryn Whitehead Alastair Sloan David W. Williams Araida Hidalgo-Bastida Joanna Verran Sladjana Malic Candida spp. are the most prevalent fungi of the human microbiota and are opportunistic pathogens that can cause oral...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 709: Assessment of Biodegradation Efficiency of Polychlorinated Biphenyls (PCBs) and Petroleum Hydrocarbons (TPH) in Soil Using Three Individual Bacterial Strains and Their Mixed Culture Molecules doi: 10.3390/molecules25030709 Authors: Steliga Wojtowicz Kapusta Brzeszcz Biodegradation is one of the most effective and profitable methods for the elimination of toxic polychlorinated biphenyls (PCBs) and total petroleum hydrocarbons (TPH) from the...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 708: Ion-Trap Mass Spectrometric Analysis of Bisphenol A Interactions With Titanium Dioxide Nanoparticles and Milk Proteins Molecules doi: 10.3390/molecules25030708 Authors: Edward P.C. Lai Hendrik Kersten Thorsten Benter Quantitative analysis of endocrine-disrupting molecules such as bisphenol A (BPA) in freshwater to determine their widespread occurrence in environmental resources has been challenged by various adsorption and desorption processes. In...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 710: Extraction Optimization, Structural Characterization, and Anticoagulant Activity of Acidic Polysaccharides from Auricularia auricula-judae Molecules doi: 10.3390/molecules25030710 Authors: Bian Wang Shi To explore Auricularia auricula-judae polysaccharides (AAP) as natural anticoagulants for application in the functional food industry, ultrasound assisted extraction (UAE) was optimized for the extraction of AAP by using a response surface methodology...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 706: Digital PCR as an Emerging Tool for Monitoring of Microbial Biodegradation Molecules doi: 10.3390/molecules25030706 Authors: Cao Yu Dong Chen Zhang Biodegradation of contaminants is extremely complicated due to unpredictable microbial behaviors. Monitoring of microbial biodegradation drives us to determine (1) the amounts of specific degrading microbes, (2) the abundance, and (3) expression level of relevant functional genes. To this endeavor,...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 703: Z-Ajoene Inhibits Growth of Colon Cancer by Promotion of CK1α Dependent β-Catenin Phosphorylation Molecules doi: 10.3390/molecules25030703 Authors: Hua Li Ji Hye Jeong Sung Won Kwon Sang Kook Lee Hwa Jin Lee Jae-Ha Ryu Aberrant activation of a Wnt/β-catenin pathway results in nuclear accumulation of β-catenin in colon cancer. Inhibiting β-catenin is one strategy for treating colon cancer. Here, we identified Z-ajoene,...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 707: Trityl-Containing Alcohols—An Efficient Chirality Transmission Process from Inductor to the Stereodynamic Propeller and their Solid-State Structural Diversity Molecules doi: 10.3390/molecules25030707 Authors: Sylwia Górczyńska Aleksandra Brzdonkiewicz Maciej Jelecki Agnieszka Czapik Bartosz Stasiak Marcin Kwit The cascade process of a dynamic chirality transmission from the permanent chirality center to the stereodynamic triphenylmethyl group...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 705: New Modified Deoxythymine with Dibranched Tetraethylene Glycol Stabilizes G-Quadruplex Structures Molecules doi: 10.3390/molecules25030705 Authors: Hisae Tateishi-Karimata Tatsuya Ohyama Takahiro Muraoka Shigenori Tanaka Kazushi Kinbara Naoki Sugimoto Methods for stabilizing G-quadruplex formation is a promising therapeutic approach for cancer treatment and other biomedical applications because stable G-quadruplexes efficiently inhibit biological...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 700: The Tomato Metallocarboxypeptidase Inhibitor I, which Interacts with a Heavy Metal-Associated Isoprenylated Protein, Is Implicated in Plant Response to Cadmium Molecules doi: 10.3390/molecules25030700 Authors: Anna Manara Elisa Fasani Barbara Molesini Giovanni DalCorso Federica Pennisi Tiziana Pandolfini Antonella Furini Metallocarboxypeptidases are metal-dependent enzymes, whose biological activity is regulated by inhibitors directed...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 702: New Advanced Materials and Sorbent-Based Microextraction Techniques as Strategies in Sample Preparation to Improve the Determination of Natural Toxins in Food Samples Molecules doi: 10.3390/molecules25030702 Authors: Casado Gañán Morante-Zarcero Sierra Natural toxins are chemical substances that are not toxic to the organisms that produce them, but which can be a potential risk to human health when ingested through food. Thus, it is of high...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 701: Synthesis of New Series of 2-C-(β-D-glucopyranosyl)-Pyrimidines and Their Evaluation as Inhibitors of Some Glycoenzymes Molecules doi: 10.3390/molecules25030701 Authors: Szennyes Gyémánt Somsák Bokor Despite the substantial interest in C-glycosyl heterocycles as mimetics of biologically active native glycans, the appearance of C-glycopyranosyl derivatives of six-membered heterocycles, both in synthetic and biological contexts, is rather scarce....
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 704: Radiosynthesis of [18F]-Labelled Pro-Nucleotides (ProTides) Molecules doi: 10.3390/molecules25030704 Authors: Cavaliere Probst Paisey Marshall Dheere Aigbirhio McGuigan Westwell Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success. Despite the translation...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 699: Thermodynamic Driving Forces and Chemical Reaction Fluxes; Reflections on the Steady State Molecules doi: 10.3390/molecules25030699 Authors: Pekař Molar balances of continuous and batch reacting systems with a simple reaction are analyzed from the point of view of finding relationships between the thermodynamic driving force and the chemical reaction rate. Special attention is focused on the steady state, which has been the core subject of previous similar...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 697: Hydrogen-Bonding Linkers Yield a Large-Pore, Non-Catenated, Metal-Organic Framework with pcu Topology Molecules doi: 10.3390/molecules25030697 Authors: Mohammad S. Yazdanparast Victor W. Day Tendai Gadzikwa Pillared paddle-wheel-based metal-organic framework (MOF) materials are an attractive target as they offer a reliable method for constructing well-defined, multifunctional materials. A drawback of these materials, which has limited their application,...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 698: A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L Molecules doi: 10.3390/molecules25030698 Authors: Dana Pathak Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an endopeptidase activity. Although its primary functions were originally thought to be only of a housekeeping enzyme that degraded intracellular and endocytosed proteins in lysosome, numerous recent studies suggest that...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 695: Synergetic Improvement of Stability and Conductivity of Hybrid Composites formed by PEDOT:PSS and SnO Nanoparticles Molecules doi: 10.3390/molecules25030695 Authors: Antonio Vázquez-López Anisa Yaseen David Maestre Julio Ramírez-Castellanos Erik S. Marstein Smagul Zh. Karazhanov Ana Cremades In this work, layered hybrid composites formed by tin oxide (SnO) nanoparticles synthesized by hydrolysis and poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 694: Design, Synthesis and Characterization of a Novel Type of Thermo-Responsible Phospholipid Microcapsule–Alginate Composite Hydrogel for Drug Delivery Molecules doi: 10.3390/molecules25030694 Authors: Liang Ding Xinxia Cui Rui Jiang Keya Zhou Yalei Wen Chenfeng Wang Zhilian Yue Shigang Shen Xuefeng Pan Liposomes are extensively used in drug delivery, while alginates are widely used in tissue engineering. However, liposomes are usually...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 696: The Antioxidant Activity of Prenylflavonoids Molecules doi: 10.3390/molecules25030696 Authors: Clementina M. M. Santos Artur M. S. Silva Prenylated flavonoids combine the flavonoid moiety and the lipophilic prenyl side-chain. A great number of derivatives belonging to the class of chalcones, flavones, flavanones, isoflavones and other complex structures possessing different prenylation patterns have been studied in the past two decades for their potential...
Thu Feb 06, 2020 02:00
Molecules, Vol. 25, Pages 692: Formal [3+2] Cycloaddition Reactions of Electron-Rich Aryl Epoxides with Alkenes under Lewis Acid Catalysis Affording Tetrasubstituted Tetrahydrofurans Molecules doi: 10.3390/molecules25030692 Authors: Víctor E. Macías-Villamizar Luís Cuca-Suárez Santiago Rodríguez Florenci V. González We report on the regio- and stereoselective synthesis of tetrahydrofurans by reaction between epoxides and alkenes in the presence of a Lewis acid. This is an unprecedented...
Thu Feb 06, 2020 02:00
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