Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats: Objective. Propofol is a classical anesthetic and induces consciousness loss, and gamma-aminobutyric-acid-type-A (GABA-A) receptor is its target. Righting reflex is associated with conscious response. The nucleus basalis (NB) acts as a major relay between the reticular activating system and the frontal cortex (FC). Propofol may mediate righting reflex by affecting GABA-A receptor in NB. Methods. Fifty male SD rats (250-350 g) were divided into parts I and II. In part I, 20 male SD rats were randomly divided into control group (CG) and NB-lesion group (NG, ibotenic acid-induced NB lesion). In part II, 30 male SD rats were treated with saline (0.9% NaCl, SG group), muscimol (a GABA-A receptor agonist, MG group), and gabazine (a GABA-A receptor antagonist, GG group) in NB, respectively. Two weeks later, the activity of the rats was measured between CG and NG groups. The rats were intravenously injected with propofol (50 mg/kg/h) to test the time of loss of righting reflex (LORR) in all rats. When LORR occurred, the rats received single administration of propofol (12 mg/kg) to measure the time of return of righting reflex (RORR). Electroencephalogram (EEG) activity of the frontal cortex (FC) was recorded. Results. The numbers of NB neurons were reduced by 44% in the NG group compared to the CG group () whereas the activity of rats was reduced a little in the NG group when compared with the CG group, but the statistical difference was insignificant (). The dose-response curve of propofol shifted to the left in the NG group, and the statistical difference for the time of LORR was insignificant between the two groups (). However, the time of RORR and FC delta power increased in the NG group compared with the CG group (). In part II, the time of RORR and FC powder increased in the MG group when compared to the SG group while reverse results were observed in the GG group (). There was no significant influence on the time of LORR and ED50 among the three groups ().Conclusions. The unilateral NB lesion increased the recovery time and FC delta power, and the NB region might be involved in the emergence after propofol administration. Propofol plays a crucial role for causing conscious loss by affecting GABA-A receptor in NB.
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Πληροφορίες
Ετικέτες
Πέμπτη 20 Φεβρουαρίου 2020
Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats
Αναρτήθηκε από
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
στις
10:27 μ.μ.
Ετικέτες
00302841026182,
00306932607174,
alsfakia@gmail.com,
Anapafseos 5 Agios Nikolaos 72100 Crete Greece,
Medicine by Alexandros G. Sfakianakis,
Telephone consultation 11855 int 1193
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Αρχειοθήκη ιστολογίου
-
►
2023
(276)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (143)
-
►
2022
(1976)
- ► Δεκεμβρίου (116)
- ► Σεπτεμβρίου (158)
- ► Φεβρουαρίου (165)
- ► Ιανουαρίου (161)
-
►
2021
(3661)
- ► Δεκεμβρίου (161)
- ► Σεπτεμβρίου (274)
- ► Φεβρουαρίου (64)
- ► Ιανουαρίου (368)
-
▼
2020
(4554)
- ► Δεκεμβρίου (400)
- ► Σεπτεμβρίου (381)
-
▼
Φεβρουαρίου
(638)
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Metastatic renal cell carcinoma to the pancreas an...
- Cardiovascular Volume Reserve in Patients with Hea...
- Extracorporeal membrane oxygenation support for po...
- Design of an end-effector for robot-assisted ultra...
- An automatic approach to establish clinically desi...
- Validation of radiological reduction criteria with...
- Lunge exercises with blood-flow restriction induce...
- Effect of seat tube angle and crank arm length on ...
- Characterizing Vocal Tract Dimensions in the Vocal...
- Prevalence of chronic fatigue syndrome/myalgic enc...
- CD4+CD38+ central memory T cells contribute to HIV...
- The relation of hearing-specific patient-reported ...
- Managing Hyperprogressive Disease in the Era of Pr...
- Multi-view Spatial Aggregation Framework for Joint...
- Proteasomal inhibition triggers viral oncoprotein ...
- Submental island flap vs free tissue transfer in o...
- Induced tumor heterogeneity reveals factors inform...
- Cancers, Vol. 12, Pages 527: Animal Models in Micr...
- Cancers, Vol. 12, Pages 529: Highly Expressed miR-...
- Atypical chemokine receptors in tumor cell growth ...
- Structure and function of β-arrestins, their emerg...
- Targeting G protein-coupled receptors in cancer th...
- Human genetics of HCV infection phenotypes in the ...
- A Recurrent Pathogenic Variant in TPM2 Reveals Fur...
- Predictors of malignancy in high-risk indeterminat...
- Evaluation of an optimal cutoff of parathyroid ven...
- GLP-1 receptor agonists and pancreatic safety conc...
- Update of Genetic and Molecular Causes of Adrenoco...
- Lifestyle intervention with longitudinal follow up...
- Phonak Marvel Now Available on Custom and BTE Hear...
- Audiological Results with the SAMBA Audio Processo...
- Submental island flap vs free tissue transfer in o...
- Current applications and challenges of circulating...
- A rare intramuscular osteolipoma: A case report.
- Resection of Second, Third, and Fourth Branchial C...
- Surgical Techniques to Improve the Soft Tissue Tri...
- Morphing as a Selection Tool in the Rhinoplasty Co...
- Dexmedetomidine Pharmacokinetics in Neonates with ...
- Diagnosis of Patent Foramen Ovale: The Combination...
- Gastroprotective Activity of the Total Flavones fr...
- Green Tea Polyphenols Modulated Cerebral SOD Expre...
- Transfer of Organochlorine Pesticide Residues duri...
- Character and child factors contribute to characte...
- Adherence to Azathioprine/6-Mercaptopurine in Chil...
- Effects of Nutritional Strategies on Glucose Homeo...
- Objective Clinical and Radiological Response under...
- Tissue Engineering Approaches for Enamel, Dentin, ...
- Oral Mesenchymal Stem/Progenitor Cells: The Immuno...
- Risk Factors for Pharyngocutaneous Fistula After T...
- Multi-dimensional models for functional testing of...
- Cutaneous myopericytoma on the forehead: A rare lo...
- Intractable chronic granulomatous perioral dermati...
- Tumor necrosis factor-alpha polymorphisms in the p...
- Follicular Becker's nevus: A new clinical variant
- Cutaneous metastasis of signet cell gastric carcinoma
- Lymphoma on the nasal dorsum: Report of a rare case
- Food hypersensitivity reactions to seafish in atop...
- Urticaria due to acitretin in a patient with liche...
- Fine Particulate matter (PM2.5) is a risk factor f...
- Hidradenoma papilliferum: Everyone else's diagnosis
- Neurotheology—The Triad of Religion, Spirituality,...
- Development of Muffin Using Palmyra (Borassus flab...
- Elements of Treatment Adherence in Children with C...
- Nutritional Composition of Bovine Colostrum: Palat...
- Metoclopramide-Induced Extrapyramidal Side Effects...
- A Multi-Centered Case Series Highlighting the Clin...
- Pediatric Drug Poisoning Is on the Rise
- Top Five Tips to Avoid Dangerous Chemicals
- Prostaglandin E 2 in a TLR3- and 7/8-agonist-based...
- Identification and validation of tumour microenvir...
- Anti-inflammatory microenvironment of esophageal a...
- Clinical relevance of the comparative expression o...
- Myeloid-derived suppressor cells impede T cell fun...
- Precision medicine and surgery for multiple endocr...
- Primary Paraganglioma of the Facial Canal: An Evid...
- Effect of Scala Tympani Height on Insertion Depth ...
- Demographic and Tumor Characteristic Impact on Lar...
- Effects of Pregnancy on Otosclerosis
- High-Frequency Conductive Hearing following Total ...
- Clinical Efficacy of Stent in Patients with Cervic...
- Chronic Opioid Use after Laryngeal Cancer Treatmen...
- Complete versus Limited Endoscopic Sinus Surgery f...
- Tracheostomy in the Extremely Premature Neonate: A...
- Impact of Time to Diagnosis and Treatment in Head ...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Medicine by Alexandros G. Sfakianakis,Anapafseos 5...
- Treatment of basilar artery stenosis with an Apoll...
- Elevated Prevalence of Azole-Resistant Aspergillus...
- Music Training, Working Memory, and Neural Oscilla...
- Clinical outcomes following proton therapy for adu...
- Long-term outcomes of multimodality management for...
- Brain Sciences, Vol. 10, Pages 126: Streptococcus ...
- Brain Sciences, Vol. 10, Pages 128: Leg Dominance ...
- Bone Marrow Mesenchymal Stem Cell-Derived Hepatocy...
- Safety of Human Adipose Stromal Vascular Fraction ...
- miR-29a Promotes the Neurite Outgrowth of Rat Neur...
- ► Ιανουαρίου (691)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου