| Related Articles |
J Clin Endocrinol Metab. 2020 Feb 04;:
Authors: Casagrande SS, Cowie CC, Sosenko JM, Mizokami-Stout K, Boulton AJM, Pop-Busui R
Abstract
CONTEXT: Evidence suggests that heart rate (HR) is a prognostic factor for cardiovascular disease, for which persons with diabetes are at increased risk.
OBJECTIVE: To determine the association between heart rate and glycemic status in a nationally representative sample of U.S. adults, and, among adults with diagnosed diabetes, the association between heart rate and A1c level.
DESIGN: Cross-sectional study.
SETTING: National Health and Nutrition Examination Surveys, 2011-2016.
PARTICIPANTS: U.S. general adult (age ≥20 years) population who had information on glycemic status based on self-report, A1c, and fasting plasma glucose (N=8,562).
INTERVENTION: None.
MAIN OUTCOME MEASURE: Mean heart rate (beat per minute).
RESULTS: After adjustment for examination time, age, other demographic characteristics, health insurance, health behaviors, body mass index, cardiovascular and kidney disease, and taking antihypertensive medications, mean HR was significantly higher for those with diagnosed (75 bpm), undiagnosed diabetes (75 bpm), and prediabetes (73 bpm) compared to those with normoglycemia (71 bpm, p<0.05 for all); this association was robust for both men and women. Mean HR increased with increasing A1c level among persons with diagnosed diabetes independent of other risk factors [A1c<7.0% (<53mmol/mol), 73 bpm vs. A1c≥11.0% (≥97mmol/mol), 79 bpm, p<0.001); this association was most pronounced for women.
CONCLUSIONS: Adjusted mean HR was higher among persons with diabetes and increased glycemia, which may reflect underlying autonomic and/or myocardial dysfunction among those with diabetes.
PMID: 32016389 [PubMed - as supplied by publisher]
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου