Three‐dimensional neuroanatomy of the intra‐epidermal nervous system

Three‐dimensional neuroanatomy of the intra‐epidermal nervous system:

Abstract

Intra‐epidermal nerve fibers (IENFs) are presumed to comprise mainly of itch‐transmitting nerve fibers, and variations in their density have been studied in itch disorders; epidermal nerve fiber density is also a criterion in diagnosing small fiber neuropathy in clinical neurological practice. IENFs are typically identified with 2‐dimensional (2D) histological slides, but 2D sections do not accurately represent nerves, which branch out in three‐dimensions (3D).