Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy [Cell Biology]

Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy [Cell Biology]:

Asbestos causes malignant transformation of primary human mesothelial cells (HM), leading to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as exposure to asbestos induces HM death. However, some asbestos-exposed HM escape cell death, accumulate DNA damage, and may become transformed. We previously demonstrated that, upon asbestos exposure, HM and...