Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity [Cell Biology]

Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity [Cell Biology]:

Deregulated global mRNA translation is an emerging feature of cancer cells. Oncogenic transformation in colorectal cancer (CRC) is driven by mutations in APC, KRAS, SMAD4, and TP53, known as the adenoma-carcinoma sequence (ACS). Here we introduce each of these driver mutations into intestinal organoids to show that they are modulators...