Long-Term Effects of Botulinum Toxin in Large-Angle Infantile Esotropia

Long-Term Effects of Botulinum Toxin in Large-Angle Infantile Esotropia:



Authors Gallo FG, Plaitano C, Esposito Veneruso P, Magli A



Received 8 July 2020



Accepted for publication 18 August 2020



Published 19 October 2020 Volume 2020:14 Pages 3399—3402



DOI https://doi.org/10.2147/OPTH.S266652



Checked for plagiarism Yes



Review by Single anonymous peer review



Peer reviewer comments 2



Editor who approved publication: Dr Scott Fraser





Flavio Gioele Gallo,1 Carmen Plaitano,2 Paolo Esposito Veneruso,3 Adriano Magli1



1Department of Medicine and Surgery, University of Salerno, Salerno, Italy; 2Department of Ophthalmology, A.O.U. San Giovanni Di Dio e Ruggi d’Aragona-Scuola Medica Salernitana, Salerno, Italy; 3Division of Ophthalmology, University Hospital “Federico II”, Naples, Italy



Correspondence: Flavio Gioele Gallo

Department of Medicine and Surgery, University of Salerno, Via Salvador Allende, 43, Baronissi, Salerno 84081, Italy

Tel +39 3898535899

Email gallo.flavio.gioele@gmail.com



Purpose: The purpose of this study is the motor outcome analysis of early Botulinum toxin (BT) treatment in patients affected by large-angle infantile esotropia (IE).

Patients and Methods: Retrospective analysis of 130 medical charts of IE patients who underwent BT injections between 2004 and 2019 was performed. All patients underwent BT injections within 13 months of age.

Results: Thirty patients, matching the inclusion criteria, were included in the study. Twenty-eight patients showing residual ET ≥ 25 PD (34.3± 6.6 PD ranged from 25 to 50) underwent surgery.

Conclusion: Our result after 1 Botulinum toxin injection showed a very low success rate (6.7%) at last follow-up (28.3± 7.2 months). Our data would suggest one Botulinum toxin injection in children affected by large-angle infantile esotropia allows a significant reduction of deviation but does not avoid the need for surgical treatment.



Keywords: strabismus, pediatric, congenital