Τρίτη 20 Οκτωβρίου 2020

 

The Cancer Nurse as Primary Palliative Care Agent During COVID-19
No abstract available
Cancer Nursing - Published Ahead-of-Print
1w
The Impact of Delays in Low-Income Women’s Breast Cancer Experiences
Background Low-income, underinsured and uninsured women are less likely to be diagnosed via mammogram and more often diagnosed at later stages, with a resultant negative impact on survival. The New Jersey Cancer Education and Early Detection Program provides access to cancer screening services for low-income, underinsured and uninsured individuals. This program was recently evaluated, and it was found that enrollees were more likely to be diagnosed at later stages than nonenrollees, which may...
Cancer Nursing - Published Ahead-of-Print
1w
From Probands to Relatives: Communication of Genetic Risk for Hereditary Breast-Ovarian Cancer and Its Influence on Subsequent Testing
Background The genetic risk communication from proband to relatives varies from family to family, and patients often need support with the communication of genetic test results and making decisions to manage hereditary cancer risks. Objective The aim of this study was to characterize the communication of BRCA1 or BRCA2 (BRCA1/2) genetic risk from proband to first-degree relatives (FDRs) using a social network framework. Methods We characterized network and nonnetwork factors to explore...
Cancer Nursing - Published Ahead-of-Print
1w
Sexuality After Treatment of Diffuse Large B-cell Lymphoma: Patients' Experiences and Psychometric Testing of the Sexual Adjustment Questionnaire-Swedish Version II
Background Sexuality is an important part of health-related quality of life. To ensure adequate supportive interventions, valid and reliable instruments specific to sexual changes and adjustments after cancer treatment are needed. Objectives The aims of this study were to test the psychometric properties of the Sexual Adjustment Questionnaire-Swedish version II (SAQ-SII) in patients treated for diffuse large B-cell lymphoma and to describe and explore patients' experiences of sexuality after...
Cancer Nursing - Published Ahead-of-Print
1w
Hispanic Children Hospitalized With Acute Lymphoblastic Leukemia Are at Increased Risk of Pancreatitis
Background There have been remarkable advances in overall survival following the diagnosis of acute lymphoblastic leukemia in childhood, but toxicities, including pancreatitis, remain a concern. Pancreatitis occurs early in therapy, before extensive exposure to the chemotherapy agents associated with its development, indicating there are underlying risk factors for some children. The role of race/ethnicity in treatment-related pancreatitis has not been well established. Objective The aim...
Cancer Nursing - Published Ahead-of-Print
1w
The Effects of Preoperative Education for Patients With Cancer: A Systematic Review and Meta-analysis
Background The results of previous experimental studies have been inconsistent in the effect of preoperative education on postoperative outcomes, and there have been no meta-analyses focusing solely on preoperative education for patients with cancer. Objectives To identify the magnitude and direction of the effects of preoperative education and to investigate the influence of moderators on postoperative outcomes for patients undergoing cancer-related surgery. Methods A systematic review...
Cancer Nursing - Published Ahead-of-Print
1w
Developing a Next-of-Kin Involvement Guide in Cancer Care—Results From a Consensus Process
Background In hospital cancer care, there is no set standard for next-of-kin involvement in improving the quality of care and patient safety. There is therefore a growing need for tools and methods that can guide this complex area. Objective The aim of this study was to present the results from a consensus-based participatory process of designing a guide for next-of-kin involvement in hospital cancer care. Method A consensus process based on a modified Nominal group technique was applied...
Cancer Nursing - Published Ahead-of-Print
1w
Complete Blood Count Collected Via Venipuncture Versus Peripherally Inserted Central Catheter in Hematological Patients: A Comparison of 2 Methods
Background The use of peripherally inserted central catheters (PICCs) in cancer care is increasing over traditional central venous catheters. Nurses frequently collect blood by venipuncture when a PICC is inserted, as there is no available evidence to confirm the reliability of blood tests collected through PICCs in adults. Objective The aim of this study was to assess the reliability of blood samples for complete blood count (CBC) obtained through PICCs as an alternative to venipuncture. ...
Cancer Nursing - Published Ahead-of-Print
1w
Coping Strategies of Adolescent and Young Adult Survivors of Childhood Cancer: A Qualitative Study
Background Many adolescent and young adult (AYA) survivors of childhood cancer are dealing with late effects of the cancer and its treatment. Objective The aim of this study was to explore how AYA survivors cope with their childhood cancer experience and its long-term consequences. Methods This is a descriptive qualitative study in which 21 semistructured interviews with AYA survivors of childhood cancer were conducted. A thematic analysis was conducted by a multidisciplinary research...
Cancer Nursing - Published Ahead-of-Print
1w
Perceptions of Older Adult Care Among Ambulatory Oncology Nurses
Background Most cancer treatment is provided in the ambulatory setting; thus, it is important to know what issues ambulatory oncology nurses identify in their practice with older cancer patients as well as resources that are helpful or are needed. Objective The aim of this study was to capture ambulatory oncology nurses’ perceptions of the unique aspects of caring for older patients and to present the development process, content validity testing, and psychometric evaluation of a survey designed...
Cancer Nursing - Published Ahead-of-Print
1w
Effects of a Mind Map–Based Life Review Program on Anxiety and Depressive Symptoms on Cancer Patients Undergoing Chemotherapy: A Randomized Controlled Trial
Background Cancer patients undergoing chemotherapy often experience psychological distress. The mind map–based life review program (MBLRP) offers the potential to reduce patients’ negative emotions. However, its effects remain unknown. Objective The objective of this study is to determine the effects of the MBLRP on anxiety and depressive symptoms in cancer patients undergoing chemotherapy. Methods A randomized controlled trial with repeated measures was adopted. Eighty-four cancer patients...
Cancer Nursing - Published Ahead-of-Print
1w
Effectiveness of Self-administered Acupressure for Family Caregivers of Advanced Cancer Patients With Insomnia: A Randomized Controlled Trail
Background Sleep disturbances are common among family caregivers (FCs) of patients with advanced cancer. Self-administered acupressure can combat insomnia, but no study has been conducted to evaluate its efficacy in caregivers of patients with advanced cancer. Objective The aim of this study is to investigate whether self-administered acupressure improves sleep quality for FCs of patients with advanced cancer. Methods Family caregivers of patients with advanced cancer who reported sleep...
Cancer Nursing - Published Ahead-of-Print
1w
“I’m Not From Another Planet”: The Alienating Cancer Care Experiences of Trans and Gender-Diverse People
Background There is little research that addresses the needs of trans and gender diverse people with cancer. Emerging evidence shows unique concerns, particularly in relation to gendered cancers such as breast and gynecological. Objective The aim of this study was to explore the intersubjective experiences in cancer care of trans and gender-diverse people to inform a microethical approach to improving care for this community. Methods Qualitative interviews (n = 12) were conducted with...
Cancer Nursing - Published Ahead-of-Print
1w
Identification of Distinct Profiles of Cancer-Related Fatigue and Associated Risk Factors for Breast Cancer Patients Undergoing Chemotherapy: A Latent Class Analysis
Background Cancer-related fatigue is a complex, multidimensional, subjective experience that affects patients physically, emotionally, and mentally. The interindividual variability in symptoms of cancer-related fatigue merits further exploration. Objective Our objective was to identify distinct profiles of cancer-related fatigue experienced by breast cancer patients undergoing chemotherapy and to evaluate how subgroups vary demographically in clinical characteristics and in modifiable factors...
Cancer Nursing - Published Ahead-of-Print
1w
The Symptom Experience and Self-management Strategies of Women Undergoing Cervical Cancer Treatment: A Qualitative Study
Background Cervical cancer treatment modalities, such as surgery, chemotherapy, radiation, and brachytherapy, often result in short- and long-term adverse effects such as nausea, fatigue, and sexual dysfunction. Chemotherapy and radiation are typically provided on an outpatient basis, requiring women to be more active in self-managing their symptoms at home. Objective The aim of this study was to explore how women with cervical cancer experience symptoms and manage daily life during treatment. ...
Cancer Nursing - Published Ahead-of-Print
1w
An Integrative Review on Factors Contributing to Fear of Cancer Recurrence Among Young Adult Breast Cancer Survivors
Background Fear of cancer recurrence (FCR) is the most prevalent need among breast cancer survivors. Age is the most consistent predictor of higher FCR, with prevalence rates as high as 70% among young adults. Although the association between age and higher FCR is well established, a more comprehensive understanding of the factors contributing to higher FCR among young adult breast cancer survivors is needed. Objective The purpose of this integrative review was to explore the factors associated...
Cancer Nursing - Published Ahead-of-Print
1w
Symptom Disclosure Process Among Iranian Women With Self-discovered Breast Cancer
Background Breast cancer is the most common malignancy among Iranian women. Symptom disclosure plays an important role in help-seeking behavior among women with self-discovered breast cancer. Objective The aim of this study was to explain how symptoms are disclosed by Iranian women. Methods This study was conducted based on the grounded theory qualitative approach. Twenty-two Iranian women with breast cancer, who discovered the symptoms themselves and were referred to 2 teaching hospitals...
Cancer Nursing - Published Ahead-of-Print
1w
Patients' Experience of Communication During Their Course of Treatment in an Oncology Outpatient Clinic: Qualitative Study
Background Communication between patients and healthcare professionals becomes increasingly important as patients with cancer are primarily treated in outpatient settings, where the time to communicate is brief. There is a need to understand patients' experiences of communication to ensure person-centered communication during treatment. Objective The aim of this study was to explore how patients experience communication with healthcare professionals during their course of treatment in an...
Cancer Nursing - Published Ahead-of-Print
1w
Patient Engagement in Breast Cancer Survivorship Care
Background Patient engagement (PE) is a key factor for early-stage breast cancer survivors during survivorship, yet little is known about what factors may contribute to PE. Objectives The aims of this study were to describe the relationship between sociodemographic factors, survivorship variables, and PE and explore how variations in these variables might contribute to PE in breast cancer survivors. Methods A cross-sectional, web-based self-report national survey was conducted to assess...
Cancer Nursing - Published Ahead-of-Print
1w
Pain Management Experiences Among Hospitalized Postcraniotomy Brain Tumor Patients
Background Brain tumors account for the majority of central nervous system tumors, and most are removed by craniotomies. Many postcraniotomy patients experience moderate or severe pain after surgery, but patient perspectives on their experiences with pain management in the hospital have not been well described. Objective The aim of this study was to describe how patients who have undergone a craniotomy for brain tumor removal experience pain management while hospitalized. Methods Qualitative...
Cancer Nursing - Published Ahead-of-Print
1w
Effects of a Roy’s Adaptation Model–Guided Support Group Intervention on Sexual Adjustment, Body Image, and Perceived Social Support in Women With Breast Cancer
Background The side effects of local and systemic treatments for breast cancer negatively impact the body image, sexual functioning, and social life of women on treatment for breast cancer. One of the ways to help these women adapt to their disease and cope with the effects of the disease and the side effects of its treatment is through support groups. Objective The aim of this study was to investigate the effect of a support group intervention, guided by Roy’s Adaptation Model, on sexual...
Cancer Nursing - Published Ahead-of-Print
1w
A Systematic Mixed-Studies Review of Hope Experiences in Parents of Children With Cancer
Background Hope is negatively associated with parental psychosocial distress and psychological maladjustment as well as an important aspect of emotional well-being and coping for adults with cancer and their caregivers. Yet, little is known about hope experiences of parents of children with cancer. Objective The aim of this study was to comprehensively describe hope experiences in parents of children with cancer using a systematic mixed-studies review. Intervention/Methods Psych INFO,...
Cancer Nursing - Published Ahead-of-Print
1w
Exploring the Positive Thinking of Patients With Prostate Cancer: Self-efficacy as a Mediator
Background Research has explored the effectiveness of positive thinking on individuals, but only a few studies have investigated the factors that influence individual positive thinking, particularly among patients with prostate cancer. Objectives The aim of this study was to understand the factors that affect positive thinking among patients with prostate cancer and the mediating role of self-efficacy. Methods A cross-sectional design and a convenience sampling method were used to recruit...
Cancer Nursing - Published Ahead-of-Print
1w
What Variables Contribute to the Achievement of a Preferred Home Death for Cancer Patients in Receipt of Home-Based Palliative Care in Canada?
Background Home is often deemed to be the preferred place of death for most patients. Knowing the factors related to the actualization of a preferred home death may yield evidence to enhance the organization and delivery of healthcare services. Objective The objectives of this study were to measure the congruence between a preferred and actualized home death among cancer patients in receipt of home-based palliative care in Canada and explore predictors of actualizing a preferred home death. ...
Cancer Nursing - Published Ahead-of-Print
1w
Gender Differences in Cancer Patients’ Preferences for Truth-Telling in Taiwan
Background There is a lack of studies investigating gender differences in cancer truth-telling, especially from the Asia Pacific countries. Objective The aim of this study was to compare preferences for cancer truth-telling between male and female cancer patients in Taiwan. Methods We used a quantitative cross-sectional design. Cancer patients (aged ≥18 years) were enrolled from 6 hospitals across Taiwan. A Taiwanese version of the Japanese truth-telling questionnaire was used to collect...
Cancer Nursing - Published Ahead-of-Print
1w
The Understanding of Dignity Among In-Hospital Patients Living With Incurable Esophageal Cancer
Background Dignity is an inherent value in palliative care, but understanding dignity among people living with and hospitalized for incurable esophageal cancer has not been explored. Objective The aim of this study was to empirically explore the meaning of dignity in people hospitalized with incurable esophageal cancer. Methods A qualitative hermeneutic approach, inspired by Gadamer, guided the research process and interpretation of the transcribed interviews. Eighteen patients participated...
Cancer Nursing - Published Ahead-of-Print
1w
What Can Social Media Tell Us About Patient Symptoms: A Text-Mining Approach to Online Ovarian Cancer Forum
Background Ovarian cancer (OvCa) patients suffer from symptoms that severely affect quality of life. To optimally manage these symptoms, their symptom experiences must be better understood. Social media have emerged as a data source to understand these experiences. Objective The objective of this study was to use topic modeling (ie, latent Dirichlet allocation [LDA]) to understand the symptom experience of OvCa patients through analysis of online forum posts from OvCa patients and their caregivers. ...
Cancer Nursing - Published Ahead-of-Print
1w
Documentation of Symptoms in Children Newly Diagnosed With Cancer Highlights the Need for Routine Assessment Using Self-report
Background Symptom management is a cornerstone of quality care and has the potential to vastly influence patient experiences. The supportive care needs of children, however, are not well described. Objective The aims of this study were to describe documentation about assessment and occurrence of symptoms in medical records of children with cancer and to compare the profile of documented symptoms with child self-report. Methods Twelve weeks of medical records of children (8–18 years)...
Cancer Nursing - Published Ahead-of-Print
1w
Experience of Ambulatory Cancer Care: Understanding Patients' Perspectives of Quality Using Sentiment Analysis
Background The move of cancer treatment into the outpatient setting can impact patient experience. Understanding how service delivery change impacts different people requires service feedback to inform future delivery development. The use of patient experience questionnaires often generates large amount of free-text data that are difficult to analyze. Objective The aim of this study was to describe a proof-of-concept study exploring the experiences and perceptions of people undergoing cancer...
Cancer Nursing - Published Ahead-of-Print
1w
Concomitant Benefits of an Auricular Acupressure Intervention for Women With Cancer on Family Caregiver Sleep Quality
Background Sleep disturbance is a frequent and significant problem challenge for family caregivers of patients with cancer. A previously tested 6-week auricular acupressure intervention was found to reduce symptom burden in women with cancer. It is possible that such an intervention has a concomitant benefit for family caregivers. Objectives The aim of this study was to explore if the effects of an auricular acupressure intervention on major symptoms experienced by women with ovarian cancer...
Cancer Nursing - Published Ahead-of-Print
1w
Resilience in Patients With Lung Cancer: Structural Equation Modeling
Background Resilience is important for patients with cancer. However, the relationships among factors affecting the resilience of patients with lung cancer have not been studied sufficiently. Objective The aim of this study was to clarify the relationships among social support, resilience, self-efficacy, and symptom distress among patients with lung cancer. Methods Through simple random sampling, 303 patients with lung cancer from 4 tertiary hospitals in Changsha, China, were recruited...
Cancer Nursing - Published Ahead-of-Print
1w
Stories of Lymphoma Survivors in Early Aftercare: A Narrative Inquiry
Background Survivors of lymphoma experience multiple challenges after treatment. However, a lack of knowledge of in-depth experiences of lymphoma survivors in early aftercare persists. Objective To gain an in-depth understanding of the experiences of lymphoma survivors in early aftercare who have received an aftercare consultation based on evidence-based guideline recommendations, with an advanced practice nurse. Methods This study used a narrative design. We recruited lymphoma survivors...
Cancer Nursing - Published Ahead-of-Print
1w
Smartphone Dongle for Cancer Biomarker Measurement
Researchers at McMaster and Brock universities in Canada have developed a hand-held device that can provide rapid measurements of cancer biomarkers in blood samples. Termed an electrochemical bio‐barcode assay, the device could be used to measure a variety of health markers at home, and is similar to the devices used by patients with diabetes to measure blood glucose levels. Monitoring and detecting disease using blood-based biomarkers typically requires a blood sample to be sent to a laboratory...
MedWorm Cancer & Oncology Blogs
7h
Dear Newly Diagnosed: What We Wish We Knew
In today’s show, Gabe discusses what he could have done differently as a newly diagnosed bipolar patient that may have made his life a little easier. He and Lisa also discuss some common pitfalls a new patient may run into. For example, what’s the problem when patients are told they need to be med-compliant at all costs? Should you be open at work about your illness? Join us to hear Gabe’s experiences and learn from his rookie mistakes (which actually ended up working out in the end anyway). (Transcript...
MedWorm Cancer & Oncology Blogs
7h
Sales and Excise Taxes on the Ballot
Chris EdwardsThere have been 20 questions to increase, cut, or limit income taxes on statewide ballots over the past decade, as compiled byBallotpedia. I examined those ballotshere and found that voters favored the small ‐​government side 60 percent of the time.What about sales and excise taxes? In November,Oregon voters will decide on Measure 108, which would increase taxes on cigarettes by $2 per pack. Governor Kate Brown —who received an “F” on this year’sCato fiscal report—has pushed for the...
MedWorm Cancer & Oncology Blogs
9h
Fight Aging! Newsletter, October 19th 2020
In conclusion, we found that regardless of the presence of multimorbidity, engaging in a healthier lifestyle was associated with up to 6.3 years longer life for men and 7.6 years for women; however, not all lifestyle risk factors equally correlated with life expectancy, with smoking being significantly worse than others. A Hydrogel Scaffold to Encourage Peripheral Nerve Regeneration https://www.fightaging.org/archives/2020/10/a-hydrogel-scaffold-to-encourage-peripheral-nerve-regeneration/...
MedWorm Cancer & Oncology Blogs
1d
Using CRISPR to Remove Mutated Sequences of Nuclear DNA Required by Cancerous Cells
Fusion genes feature in many cancers, a form of mutation in which two genes are joined together, such as through deletion of the DNA sequences that normally separate the two genes. The resulting mutant fusion gene sequence encodes a fusion protein that can have novel effects, or in which both portions remain functional, but are now produced in at inappropriate times and in inappropriate amounts. This change in cell biochemistry can be important in driving cancerous behavior, and this appears to be...
MedWorm Cancer & Oncology Blogs
2d
Investigating Zebrafish Biochemistry in Search of Mechanisms of Neural Regeneration
Zebrafish are highly regenerative, capable of regrowing organs, and even nervous system tissue such as the retina. Research groups investigate these species in search of specific mechanisms of proficient regeneration, with the hope that they can be ported over to human biochemistry. In the best case scenario, mechanisms of this nature could still exist in mammals, retained in order to conduct embryonic development, but actively suppressed in some way in adults, possibly because such suppression reduces...
MedWorm Cancer & Oncology Blogs
2d
COVID-19 as a Disease of Aging
Researchers are writing a great many papers these days to point out the obvious regarding COVID-19, that the vast majority of SARS-CoV-2 coronavirus mortality occurs in olders individuals, particularly those who already suffer age-related disease and thus a high burden of tissue and immune system dysfunction. This process of repeating the obvious seems necessary, given that the public discourse on the topic of the present pandemic presents it as a condition that affects all members of society more...
MedWorm Cancer & Oncology Blogs
3d
G3BP1 is Required for the Senescence-Associated Secretory Phenotype
In this study, we assessed the role of G3BP1 as a regulator of the deleterious effects of senescent cells. We show that G3BP1 is required for the activation of the senescent-associated secretory phenotype (SASP). During senescence, G3BP1 achieves this effect by promoting the association of the cyclic GMP-AMP synthase (cGAS) with cytosolic chromatin fragments. In turn, G3BP1, through cGAS, activates the NF-κB and STAT3 pathways, promoting SASP expression and secretion. G3BP1 depletion or pharmacological...
MedWorm Cancer & Oncology Blogs
5d
Help the public understand what more can be done to support loved ones affected by a serious illness
“Is ere anything more we could have done?” I am not the first person to ask this question, and I will not be the last. This past week I learned that an ex-boyfriend from my graduate school years, who had moved overseas in 2016 and disappeared off the grid, was recently diagnosed with lymphoma, d eveloped […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
MedWorm Cancer & Oncology Blogs
6d
Robotic Probe for Semi-Autonomous Colonoscopies
Researchers at the University of Leeds in the UK have developed a robotic system that can assist a physician or nurse to perform a colonoscopy. The system uses magnets to guide a probe through the body, and its developers claim that the approach is easier for operators and less painful and uncomfortable for patients. The researchers hope that the system could make colonoscopies more widely available. Colonoscopies are vital in detecting a variety of pathologies, including colorectal cancer....
MedWorm Cancer & Oncology Blogs
6d
Health Care 101, continued
Okay, back to where we were before I was so rudely interrupted. As we have established, insurance is about risk pools. Sure, you can offer a cheap policy if you only sell it to people who are young and healthy, and that's what would happen in a non-regulated ( " free " ) market; but that would be largely pointless. As soon as somebody actually needed the insurance, they would not be able to renew it. People who are fortunate enough to have employer-provided insurance (which is an oddity largely specific...
MedWorm Cancer & Oncology Blogs
1w
Towards Harnessing Growth to Create Rejuvenation
A recent pair of open access papers offer an interesting viewpoint on embryonic development, aging, cancer, and possible approaches to rejuvenation in this era of biotechnology. I'm not sure that I agree with more than half of it, but it does make for a good read, even given that the language is somewhat obtuse in places. Tissue growth is the unifying process, wherein: (a) embryonic development is the epitome of regulated, successful, beneficial growth; (b) aging suppresses and damages the shackled...
MedWorm Cancer & Oncology Blogs
1w
C-Myc signaling pathway in treatment and prevention of brain tumors.
Authors: Ashrafizadeh M, Zarabi A, Hushmandi K, Moghadam ER, Hashemi F, Daneshi S, Hashemi F, Tavakol S, Mohammadinejad R, Najafi M, Dudha N, Garg M Abstract Brain tumors are responsible for high morbidity and mortality worldwide. Several factors such as the presence of blood-brain barrier (BBB), sensitive location in the brain, and unique biological features challenge the treatment of brain tumors. The conventional drugs are no longer effective in the treatment of brain tumors, and scientists...
Current Cancer Drug Targets
9h
Tyrosine Kinase Inhibitors (TKIs) in Lung Cancer Treatment: a Comprehensive Analysis.
Authors: Murugesan S, Murugesan J, Palaniappan S, Palaniappan S, Murugan T, Siddiqui SS, Loganathan S Abstract Lung cancer is the leading type of cancer worldwide today. Kinases play a crucial role in mediating the signaling pathways and it directs to control several necessary cellular processes. Conversely, deregulation of tyrosine kinases leads to oncogenic conversion, uncontrolled cell proliferation and tumorigenesis. Tyrosine kinases are largely deregulated in lung cancer and specifically...
Current Cancer Drug Targets
1w
Overexpression of RAD50 is the Marker of Poor Prognosis and Drug Resistance in Breast Cancer Patients.
CONCLUSION: The status of RAD50 promoter's methylation inversely correlates with the expression level of RAD50. While RAD50 is overexpressed in breast cancer patients and thus makes tumor resistant against many anti-cancer drugs. PMID: 33038913 [PubMed - as supplied by publisher] (Source: Current Cancer Drug Targets)
Current Cancer Drug Targets
1w
The activation of procarcinogens by CYP1A1/1B1 and related chemopreventive agents: A review.
Authors: Li Y, Cui J, Jia J Abstract CYP1A1 and CYP1B1 are extrahepatic P450 family members involved in the metabolism of procarcinogens, such as PAHs, heterocyclic amines and halogen-containing organic compounds. CYP1A1/1B1 also participate in the metabolism of endogenous 17-β-estradiol, producing estradiol hydroquinones which are the intermediates of carcinogenic semiquinones and quinones. CYP1A1 and CYP1B1 proteins share approximately half amino acid sequence identity but differ in crystal...
Current Cancer Drug Targets
1w
Tumor penetrating peptide-functionalized Tenascin-C antibody for glioblastoma targeting.
CONCLUSION: The genetic fusion of iRGD tumor penetrating peptide to non-internalizing affinity targeting ligands may improve their tumor tropism and parenchymal penetration for more efficient delivery of imaging and therapeutic agents into solid tumor lesions. PMID: 33001014 [PubMed - as supplied by publisher] (Source: Current Cancer Drug Targets)
Current Cancer Drug Targets
1w
Exosome as a Natural Gene Delivery Vector for Cancer Treatment.
CONCLUSION: In the near future exosomes can become an efficient gene carrier for delivery and a biomarker for the diagnosis and treatment of cancer. PMID: 32972340 [PubMed - as supplied by publisher] (Source: Current Cancer Drug Targets)
Current Cancer Drug Targets
1w
Identification of WDFY3 neoantigens as prognostic markers in long-term survivors of extrahepatic cholangiocarcinoma.
CONCLUSION: We suggest that the WDFY3 neoantigens may affect prognosis by regulating antitumor immunity and that the WDFY3 neoantigens may be harnessed as potential targets for immunotherapy of EHCC. PMID: 32957886 [PubMed - as supplied by publisher] (Source: Current Cancer Drug Targets)
Current Cancer Drug Targets
1w
Clinical outcomes and safety of patients treated with NAb-Paclitaxel plus Gemcitabine in metastatic pancreatic cancer: the NAPA study.
CONCLUSIONS: Our results confirm the efficacy and safety of a first line regimen comprising gemcitabine and Nab-paclitaxel in metastatic PDAC in a real-life population. PMID: 32957885 [PubMed - as supplied by publisher] (Source: Current Cancer Drug Targets)
Current Cancer Drug Targets
1w
Advances in detecting, treating breast cancer
Deep Dive: From Google's AI for mammograms to clinical trial recruitment, digital health is tackling some of the biggest challenges in the breast cancer space. (Source: Healthcare ITNews Videos)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Video
9h
Organoid culture system for patient-derived lung metastatic osteosarcoma
AbstractOsteosarcoma (OS) is the most common primary bone malignancy with high rates of recurrence and metastasis. OS often spreads to lungs, an optimized model for studying lung metastatic OS cells may help develop potential therapies for patients with lung metastasis. Here we firstly report an organoid culture system for lung metastatic OS tissues. We provided a fully described formula that was required for establishing lung metastatic OS organoids (OSOs). Using this protocol, the lung OSOs were...
Medical Oncology
11h
Identification of candidate biomarkers and therapeutic drugs of colorectal cancer by integrated bioinformatics analysis
In conclusion, we found key dysregulated genes associated with CRC and potential small molecules to reverse them.COL1A2,THBS2,TIMP1, andCXCL8 may act as diagnostic and prognostic biomarkers of CRC. (Source: Medical Oncology)
Medical Oncology
1d
The clinical significance of CD49e and CD56 for multiple myeloma in the novel agents era
AbstractMultiple myeloma (MM) is a hematological malignancy characterized by the proliferation of abnormal plasma cells in bone marrow. Flow cytometry distinguishes between normal and abnormal plasma cells by evaluating cluster of differentiation (CD) 56 and CD19 expression patterns. Moreover, immunophenotyping of mature plasma cell 1 (MPC-1) and very late antigen-5 (CD49e) identifies the maturity of MM as mature (MPC-1+, CD49e+), intermediate (MPC-1+, CD49e–), or immature (MPC-1–, CD49e–). We retrospectively...
Medical Oncology
3d
Economic perspective of cancer treatment in India
AbstractFinancial constraints faced by the families play a vital role in cancer treatment refusal, non-adherence, and failure of the prescribed therapy. This review aims to give an insight into the economic perspective of cancer treatment in India, focusing on the accessibility and affordability of oncological drugs, and the move towards generics/biosimilars without compromising on the quality of the treatment. The monthly cost of a set of drugs available in India for the treatment of solid malignancies,...
Medical Oncology
5d
The investigation of the healing effect of active ingredients in traditional medicinal plants on lung cancer
In this study, the effects of the active ingredients in traditional food supplements used in many countries on the lung cancer were calculated based on the drugs used as standard. It will be hope that these active substances with high healing effects will be tested in the clinical field and turned into drugs. (Source: Medical Oncology)
Medical Oncology
5d
Strategies for having a more effective and less toxic CAR T-cell therapy for acute lymphoblastic leukemia
AbstractIn the recent years, using genetically modified T cells has been known as a rapid developing therapeutic approach due to the heartwarming results of clinical trials with patients suffering from relapsed or refractory (R/R) hematologic malignancies such as R/R Acute Lymphoblastic Leukemia (R/R ALL). One of these renowned approaches is Chimeric antigen receptors (CARs). CARs are synthetic receptors with the ability to be expressed on the surface of T lymphocytes and are specifically designed...
Medical Oncology
5d
Synergistic effects of multiple myeloma cells and tumor-associated macrophages on vascular endothelial cells in vitro
In this study, we performed in vitro macrophage coculture studies and studies with RPMI 8226 and TAMs cell-conditioned media to explore their effects on the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs). Our results showed that M2 macrophages and RPMI 8226 cells could synergistically promote HUVEC proliferation, migration, and tube formation, and that VEGFA depletion in both cell types suppressed HUVEC tube formation ability. Conversely, M1 macrophages...
Medical Oncology
1w
 
The prostate-specific membrane antigen (PSMA)-targeted radiotracer 18 F-DCFPyL detects tumor neovasculature in metastatic, advanced, radioiodine-refractory, differentiated thyroid cancer
In this study, we show that18F-DCFPyl might detect neovasculature in advanced, metastatic differentiated thyroid cancer (DTC). We first stained the preserved lymph node samples of three patients with DTC who had undergone total thyroidectomy and neck dissection for cervical lymph node metastatic disease to identify PSMA expression, with the PSMA antibody (DAKO Monoclonal). Then, we performed18F-DCFPyl imaging in two other advanced DTC patients with elevated serum thyroglobulin (Tg), indicative of...
Medical Oncology
1w
The DPP-IV inhibitor saxagliptin promotes the migration and invasion of papillary thyroid carcinoma cells via the NRF2/HO1 pathway
AbstractDipeptidyl peptidase-IV (DPP-IV) inhibitors are used to control blood glucose levels in patients with type 2 diabetes. However, the influence of DPP-IV inhibitors on malignant tumors remains unknown. The present study aimed to investigate the effect of the DPP-IV inhibitor saxagliptin on thyroid carcinoma cells. Transwell assays and a nude mouse lung metastasis model were used to evaluate the invasion and metastasis of thyroid carcinoma cells. Western blotting was used to determine the protein...
Medical Oncology
1w
Restraint stress abates the antioxidant potential of melatonin on dimethyl benz (a) anthracene (DMBA) induced carcinogenesis
AbstractFree radical involvement in initiation, promotion and progression of carcinogenesis, implicates that scavengers of free radicals may act as inhibitors in the carcinogenic process. Melatonin, an antioxidant was used in the present study to evaluate its effectiveness on skin carcinogenesis induced by DMBA both with and without chronic restraint stress (CRS). Fifty Swiss albino young male rats were divided into five groups of 10 rats each as controls, topical DMB alone, Pre CRS-DMBA, melatonin...
Medical Oncology
1w
A phase I/II study of docetaxel in combination with pegylated liposomal doxorubicin in metastatic castration-resistant prostate cancer
AbstractTaxanes and anthracyclines have been among the best-studied chemotherapy classes in castration-resistant prostate cancer (CRPC). Docetaxel (D) 75  mg/m2 every 3  weeks has been the standard first line chemotherapy for CRPC. Encapsulation of doxorubicin in polyethylene glycol-coated liposomes (PLD) was developed to enhance the safety and efficacy of conventional doxorubicin. We hypothesize that the combination of weekly low dose-D and PLD would result in a high response rate and low toxicity....
Medical Oncology
1w
Population mutation properties of tumor evolution
AbstractTumor growth patterns differ depending on the individual tumor, leading to various patterns of genetic heterogeneity across tumors. Despite their importance, the population mutation properties of tumor evolution have not been well studied, especially in terms of overall genetic heterogeneity. The current study aims to examine factors in tumor evolution influencing overall genetic heterogeneity. Extensive simulations of the representative evolutionary patterns of various tumors were conducted...
Medical Oncology
1w
Transcription factor YY1 mediates epithelial –mesenchymal transition through the TGFβ signaling pathway in bladder cancer
In this study, we found Yin Yang 1 (YY1) is a critical regulator of EMT in bladder cancer. First, we showed that YY1 was upregulated in bladder cancer tissues than that in adjacent normal tissues. Then, we proved that YY1 promoted EMT of bladder cancer cells. Further experiments indicated that YY1 affected the EMT of bladder cancer through transforming growth factor-β (TGFβ) signaling pathway. Taken together, our study identifies YY1 as a key EM T driver in bladder cancer, suggesting it as a potential...
Medical Oncology
1w
Letter to the editor regarding “A randomized controlled trial: comparing extracorporeal shock wave therapy versus local corticosteroid injection for the treatment of carpal tunnel syndrome”
(Source: Medical Oncology)
Medical Oncology
1w
Cinnamaldehyde induces endogenous apoptosis of the prostate cancer-associated fibroblasts via interfering the Glutathione-associated mitochondria function
In this study, we investigated the effect and mechanism of action of CA in prostate CAFs. We found that CA induced cell cycle arrest and apoptosis in prostate CAFs via the intrinsic pathway. This was due to the decrease in mitochondrial membrane potential ( ∆Mψ), increased level of intracellular reactive oxygen species (ROS), and calcium ion (Ca2+). In addition, protein expression analysis showed an increase in the expression levels of cytochrome c, bax, cleaved caspase 3 and cleaved PARP, and a...
Medical Oncology
1w
When and how clinical nurses adjust nursing care at the end-of-life among patients with cancer: Findings from multiple focus groups
Defining patients as ‘terminally-ill’ may be difficult. Therefore, determining when to shift the goal of care from curative to comfort care may be extremely challenging. The aim of this study was to merge when and how Registered Nurses (RNs) and Nurses' Assistants (NAs) adjust end-of-life care to pursue patient comf ort at the end of their lives. (Source: European Journal of Oncology Nursing)
European Journal of Oncology Nursing
11h
Symptom experience and self-management for multiple co-occurring symptoms in patients with gastric cancer: A qualitative study
Patients with gastric cancer experience an increased symptom burden with multiple co-occurring symptoms. Knowledge of patients ’ symptom experiences and self-management for these symptoms is limited. The purpose of this study was to describe multiple co-occurring symptoms, symptom experiences, and symptom self-management strategies in patients with gastric cancer. (Source: European Journal of Oncology Nursing)
European Journal of Oncology Nursing
11h
Editorial Board
(Source: European Journal of Oncology Nursing)
European Journal of Oncology Nursing
11h
Relationship among symptoms, resilience, post-traumatic growth, and quality of life in patients with glioma
The aims of this study were to explore the relationship among symptoms, resilience, post-traumatic growth, and quality of life, and to identify the influence of these variables on quality of life in patients with glioma. (Source: European Journal of Oncology Nursing)
European Journal of Oncology Nursing
11h
Facing life-prolonging treatment: The perspectives of men with advanced metastatic prostate cancer – An interview study
Several life-prolonging treatment options have recently become available for metastatic castration-resistant prostate cancer. However, research regarding patient experiences while undergoing these treatments is scarce. The aim was to explore the perspectives of men when facing life-prolonging treatment of metastatic castration-resistant prostate cancer. (Source: European Journal of Oncology Nursing)
European Journal of Oncology Nursing
4d
A quality improvement pilot project of training nurses to use VR educational aids to increase oral cancer patients ’ pretreatment knowledge and satisfaction
Nurses are in the prime position to give pretreatment medical information to patients for increasing patient's satisfaction and treatment compliance to oral cancer, the top ranked high mortality cancer in Taiwan. In particular, comprehensive pretreatment medical information from well-trained nurses can reduce oral cancer patients' psychological distress (Wang et al., 2018). To comfort anxious oral cancer patients, it is necessary to develop educational aids with comprehensive information, to increase...
European Journal of Oncology Nursing
4d
Supportive care needs and quality of care of patients with lung cancer in Mexico: A cross-sectional study
To assess the supportive care needs (SC-needs), quality of patient-centered care (PCC), and factors associated with increased SC-needs of patients with lung cancer (LC) in Mexico. Methods: We conducted a cross-sectional survey in the main oncology hospital of the Mexican Institute of Social Security in Mexico City. The study included LC ambulatory patients aged ≥18 years with at least one hospitalization before the survey, ≤five years since diagnosis, and without memory loss. Participants answered...
European Journal of Oncology Nursing
4d
Acknowledging cancer as a family disease: A systematic review of family care in the cancer setting
Family members are a part of the team to improve the outcomes of the person with cancer. Families require support and information to optimise their care, however, their needs are often unacknowledged and within clinical areas there is a lack of family focused interventions. Studies highlight families ’ needs but lack a family representation. The aim was to explore research with family as the unit-of-care during cancer treatment. (Source: European Journal of Oncology Nursing)
European Journal of Oncology Nursing
4d
The experiences of cancer nurses working in four European countries: A qualitative study
This study by the European Oncology Nursing Society examines comparative features of cancer nursing in Estonia, Germany, the Netherlands (NL) and the United Kingdom (UK). (Source: European Journal of Oncology Nursing)
European Journal of Oncology Nursing
4d
Fear of cancer recurrence following allogeneic haematopoietic stem cell transplantation (HSCT) for haematological malignancy: A cross-sectional study
The aim of this study was to quantify the prevalence of Fear of Cancer Recurrence (FCR) in patients with a prior haematology malignancy surviving more than one year post allogeneic haematopoietic stem cell transplantation (HSCT), and to identify the demographic, medical and psychological factors associated with FCR occurrence. (Source: European Journal of Oncology Nursing)
European Journal of Oncology Nursing
1w
Resilience in women with breast cancer: A systematic review
Resilience refers to a dynamic process that promotes a successful adaptation to cancer-related adversity. The aim of this systematic review was to identify the biopsychosocial factors involved in the resilience of women with breast cancer and to integrate evidence on the interventions that can contribute to significantly enhancing it. (Source: European Journal of Oncology Nursing)
European Journal of Oncology Nursing
1w

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