Food Funct. 2021 Jul 29. doi: 10.1039/d1fo01073e. Online ahead of print.
ABSTRACT
Radioactive iodine (RAI) is commonly used to treat differentiated thyroid cancer (DTC). A major challenge is the dedifferentiation of DTC with the loss of radioiodine uptake. Patients with distant metastases have persistent or recurrent disease and develop resistance to RAI therapy due to tumor dedifferentiation. Hence, tumor redifferentiation to restore sensitivity to RAI therapy is considered a prom ising strategy to overcome RAI resistance. In the present study, curcumin, a natural polyphenolic compound, was found to re-induce cell differentiation and increase the expression of thyroid-specific transcription factors, TTF-1, TTF-2 and transcriptional factor paired box 8 (PAX8), and iodide-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase (TPO) and sodium iodide symporter (NIS) in dedifferentiated thyroid cancer cell lines, BCPAP and KTC-1. Importantly, curcumin enhanced NIS glycosylation and its membrane trafficking, resulting in a significant improvement of radioiodine uptake in vitro. Additionally, AKT knockdown phenocopied the restoration of thyroid-specific gene expression; however, ectopic expressed AKT inhibited curcumin-induced up-regulation of NIS protein, demonstrating that curcumin might improve radioiodine sensitivity via the inhibition of the PI3K-AKT-mTOR signaling pathway. Our study demonstrates that curcumin could re present a promising adjunctive therapy for restoring iodide avidity and improve radioiodine therapeutic efficacy in patients with RAI-refractory thyroid carcinoma.
PMID:34323243 | DOI:10.1039/d1fo01073e
Hello everyone, I want to say a special thanks to Dr OGU. for helping me get cured from herpes virus 2019 , I contacted him base on the testimonies I saw about him on the internet I was diagnosed of HERPES Virus i have tried all I can to get cured but all to know avail, until i saw a post in a health forum about a herbal man who prepare herbal medication to cure all kind of diseases including HERPES virus, at first i doubted if it was real but decided to give it a try I was cured by his herbal medicine and natural herbs, kindly contact him today through his email: drogugusolutionhome@gmail.com or text/call: +1 (719) 629 0982
ΑπάντησηΔιαγραφήHe’s waiting to help you.
HE ALSO SPECIALIZE IN THE FOLLOWING Illness;
If you have any sickness like : H I V/AIDS , CANCER , HERPES HSV 1 or 2 , GENITAL WARTS, Yeast-infection's (HPV), and Hepatitis A, B. Stroke, Chlamydia, Genital herpes, Alzheimer’s, Trichomoniasis , Tuberculosis, CAD, Gonorrhea, Epilepsy, and Syphilis.