Association between carbonic anhydrase 9 expression and poor prognosis in sinonasal squamous cell carcinoma

Association between carbonic anhydrase 9 expression and poor prognosis in sinonasal squamous cell carcinoma:



Publication date: Available online 17 October 2020

Source: Annals of Diagnostic Pathology

Author(s): Chunyan Hu, Huan Wang, Lan Lin, Xicai Sun, Dehui Wang




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Annals of Diagnostic Pathology
Available online 17 October 2020, 151643
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Original ContributionAssociation between carbonic anhydrase 9 expression and poor prognosis in sinonasal squamous cell carcinoma
Author links open overlay panelChunyanHua1HuanWangb1LanLinaXicaiSunbDehuiWangbShow more
https://doi.org/10.1016/j.anndiagpath.2020.151643Get rights and content


Highlights


•

This is the first study demonstrating CA9 expression in 63 patients diagnosed with SNSCC in 2013-2017.•

CA9 is an independent prognostic marker for tumor recurrence and poor prognosis in SNSCC patients who have undergone surgical treatment.•

CA9 may serve as a novel therapeutic target for SNSCC.



Abstract

Objectives

Carbonic anhydrase 9 (CA9), as a member of the carbonic anhydrase enzyme family, was an endogenous marker of hypoxia. Previous studies suggested CA9 expression was correlated with poor prognosis in multiple types of malignancies. Therefore, this study was to evaluate the role of CA9 in sinonasal squamous cell carcinoma (SNSCC) and to determine whether this biomarker was associated with patient clinicopathologic characteristics and prognosis.

Methods

We assessed 63 patients diagnosed with SNSCC in 2013–2017 who underwent curative surgery. Tumor specimens was immunohistochemically analyzed for CA9 expression. The expression levels of CA9 was evaluated in relation to clinicopathological factors and prognosis.

Results

Positive expression of CA9 was observed in 21 (33.3%) patients and was significantly correlated with local recurrence (p = 0.016), overall survival (OS) (p = 0.003) and disease-free survival (DFS) (p = 0.002). In Cox's multivariate analysis, CA9 expression was an independent negative prognostic factor for OS (p = 0.048) and DFS (p = 0.019).

Conclusions

Our findings demonstrated that CA9 overexpression could be used as an independent prognostic biomarker and therapeutic target in SNSCC.

Keywords
Carbonic anhydrase 9
Sinonasal squamous cell carcinoma
Prognosis

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Chunyan Hu and Huan Wang contributed equally to this study.View full text
© 2020 Published by Elsevier Inc.