Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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Κυριακή 18 Οκτωβρίου 2020
Utility of NKX3.1 immunohistochemistry in the differential diagnosis of seminal vesicles versus prostatic tissue in needle biopsy
Utility of NKX3.1 immunohistochemistry in the differential diagnosis of seminal vesicles versus prostatic tissue in needle biopsy:
Publication date: Available online 17 October 2020
Source: Annals of Diagnostic Pathology
Author(s): Pitra Tomas, Pivovarcikova Kristyna, Alaghehbandan Reza, Eva Maria Compérat, Hora Milan, Joanna Rogala, Maryna Slisarenko, Michal Michal, Hes Ondrej
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Annals of Diagnostic Pathology
Available online 17 October 2020, 151644
In Press, Journal Pre-proofWhat are Journal Pre-proof articles?
Utility of NKX3.1 immunohistochemistry in the differential diagnosis of seminal vesicles versus prostatic tissue in needle biopsy☆
Author links open overlay panelPitraTomasaPivovarcikovaKristynabAlaghehbandanRezacEva MariaCompératdeHoraMilanaJoannaRogalabMarynaSlisarenkobMichalMichalbHesOndrejbShow more
https://doi.org/10.1016/j.anndiagpath.2020.151644Get rights and content
Highlights
•
NKX3.1 is considered reliable marker of prostatic origin.•
NKX3.1 reactivity in seminal vesicles tested by 2 antibodies.•
NKX3.1 tested in a total of 63 non-neoplastic seminal vesicles.•
Seminal vesicles were completely negative (both antibodies).
Abstract
NKX3.1 is considered a reliable immunohistochemical marker of prostatic origin with high specificity and sensitivity. However, NKX3.1 positivity has been described in other neoplastic and non-neoplastic tissues, such as mesenchymal chondrosarcoma, sex-cord stromal tumors, rete testis adenocarcinoma, lobular and ductal carcinoma of the breast, salivary glands, peribronchial submucosal glands, and Sertoli cells. We analyzed expression of two antibodies (mono and polyclonal) of NKX3.1 in a total of 63 non-neoplastic seminal vesicles. We used 52 resection materials (12 seminal vesicles without prostatic adenocarcinoma, 26 seminal vesicles with prostatic adenocarcinoma infiltration, and 14 cases of seminal vesicles infiltrated by urothelial carcinoma) and 11 prostatic core needle biopsies with incidentally sampled fragment of seminal vesicles. In all cases, tissues from seminal vesicles were completely negative for NKX3.1, despite using polyclonal and monoclonal NKX3.1 antibodies, and regardless of the detection system utilized (diaminobenzidine (DAB) versus alkaline phosphatase (AF)). However, prostatic adenocarcinoma was negative in several cases (n = 6), when AF detection system was used. Reaction with DAB was strong and robust in all cases. Based on our data, we can recommend NKX3.1 as a negative immunohistochemical marker of seminal vesicles.
Keywords
Prostate
Seminal vesicles
Immunohistochemistry
NKX3.1
Prostatic adenocarcinoma
☆
The study was supported by the Charles University Research Fund (project number Q39), by Institutional Research Fund FN 00669806, and by Biobank Research on Telemedical Approaches for Human Biobanks in a European Region, Bavarian-Czech University Agency (BTHA)View full text
© 2020 Elsevier Inc. All rights reserved.
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