IJMS, Vol. 21, Pages 7848: Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice International Journal of Molecular Sciences doi: 10.3390/ijms21217848 Authors: Kaspar Gierke Julia von Wittgenstein Maike Hemmerlein Jenny Atorf Anneka Joachimsthaler Jan Kremers Benjamin H. Cooper Frederique Varoqueaux Hanna...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7846: RedquorinXS Mutants with Enhanced Calcium Sensitivity and Bioluminescence Output Efficiently Report Cellular and Neuronal Network Activities International Journal of Molecular Sciences doi: 10.3390/ijms21217846 Authors: Adil Bakayan Sandrine Picaud Natalia P. Malikova Ludovic Tricoire Bertrand Lambolez Eugene S. Vysotski Nadine Peyriéras Considerable efforts have been focused on shifting the wavelength of aequorin Ca2+-dependent blue bioluminescence...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7845: Gastrointestinal Nematode-Derived Antigens Alter Colorectal Cancer Cell Proliferation and Migration through Regulation of Cell Cycle and Epithelial-Mesenchymal Transition Proteins International Journal of Molecular Sciences doi: 10.3390/ijms21217845 Authors: Brittany-Amber Jacobs Sharon Prince Katherine Ann Smith As the global incidences of colorectal cancer rises, there is a growing importance in understanding the interaction between external factors,...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7841: Mitochondrial Function and Protein Turnover in the Diaphragm are Altered in LLC Tumor Model of Cancer Cachexia International Journal of Molecular Sciences doi: 10.3390/ijms21217841 Authors: Megan E. Rosa-Caldwell Conner A. Benson David E. Lee Jacob L. Brown Tyrone A. Washington Nicholas P. Greene Michael P. Wiggs It is established that cancer cachexia causes limb muscle atrophy and is strongly associated with morbidity and mortality; less...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7844: Wnt-Independent and Wnt-Dependent Effects of APC Loss on the Chemotherapeutic Response International Journal of Molecular Sciences doi: 10.3390/ijms21217844 Authors: Casey D. Stefanski Jenifer R. Prosperi Resistance to chemotherapy occurs through mechanisms within the epithelial tumor cells or through interactions with components of the tumor microenvironment (TME). Chemoresistance and the development of recurrent tumors are two of the leading factors of...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7843: Structural Insights into the Interactions of Candidal Enolase with Human Vitronectin, Fibronectin and Plasminogen International Journal of Molecular Sciences doi: 10.3390/ijms21217843 Authors: Dorota Satala Grzegorz Satala Justyna Karkowska-Kuleta Michal Bukowski Anna Kluza Maria Rapala-Kozik Andrzej Kozik Significant amounts of enolase—a cytosolic enzyme involved in the glycolysis pathway¾are exposed on the cell surface...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7842: Role of Post-Translational Modifications of cGAS in Innate Immunity International Journal of Molecular Sciences doi: 10.3390/ijms21217842 Authors: Yakun Wu Shitao Li Cyclic GMP–AMP synthase (cGAS) is the synthase that generates the second messenger cyclic GMP–AMP (cGAMP) upon DNA binding. cGAS was first discovered as the cytosolic DNA sensor that detects DNA exposed in the cytoplasm either from pathogens or cellular damage. Activated...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7839: Comparative Analysis of Proteomes of a Number of Nosocomial Pathogens by KEGG Modules and KEGG Pathways International Journal of Molecular Sciences doi: 10.3390/ijms21217839 Authors: Mikhail V. Slizen Oxana V. Galzitskaya Nosocomial (hospital-acquired) infections remain a serious challenge for health systems. The reason for this lies not only in the local imperfection of medical practices and protocols. The frequency of infection with antibiotic-resistant...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7838: Acute Systemic Inflammatory Response Alters Transcription Profile of Genes Related to Immune Response and Ca2+ Homeostasis in Hippocampus; Relevance to Neurodegenerative Disorders International Journal of Molecular Sciences doi: 10.3390/ijms21217838 Authors: Grzegorz A. Czapski Yuhai Zhao Walter J. Lukiw Joanna B. Strosznajder Acute systemic inflammatory response (SIR) triggers an alteration in the transcription of brain genes related to neuroinflammation,...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7837: Molecular Regulation of the Polycomb Repressive-Deubiquitinase International Journal of Molecular Sciences doi: 10.3390/ijms21217837 Authors: Cameron J. Reddington Matthias Fellner Abigail E. Burgess Peter D. Mace Post-translational modification of histone proteins plays a major role in histone–DNA packaging and ultimately gene expression. Attachment of ubiquitin to the C-terminal tail of histone H2A (H2AK119Ub in mammals) is particularly...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7836: Targeting Autophagy in Breast Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21217836 Authors: Stefania Cocco Alessandra Leone Michela Piezzo Roberta Caputo Vincenzo Di Lauro Francesca Di Rella Giuseppina Fusco Monica Capozzi Germira di Gioia Alfredo Budillon Michelino De Laurentiis Breast cancer is a heterogeneous disease consisting of different biological subtypes, with differences in terms of incidence,...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7835: Preparation of Defined Chitosan Oligosaccharides Using Chitin Deacetylases International Journal of Molecular Sciences doi: 10.3390/ijms21217835 Authors: Bonin Sreekumar Cord-Landwehr Moerschbacher During the past decade, detailed studies using well-defined ‘second generation’ chitosans have amply proved that both their material properties and their biological activities are dependent on their molecular structure, in particular...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7840: Intensive Care Unit-Acquired Weakness: Not just Another Muscle Atrophying Condition International Journal of Molecular Sciences doi: 10.3390/ijms21217840 Authors: Heta Lad Tyler M. Saumur Margaret S. Herridge Claudia C. dos Santos Sunita Mathur Jane Batt Penney M. Gilbert Intensive care unit-acquired weakness (ICUAW) occurs in critically ill patients stemming from the critical illness itself, and results in sustained disability long after...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7833: Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection International Journal of Molecular Sciences doi: 10.3390/ijms21217833 Authors: Yi-Chou Hou Cai-Mei Zheng Tzung-Hai Yen Kuo-Cheng Lu The development of sodium-glucose transporter 2 inhibitor (SGLT2i) broadens the therapeutic strategies in treating diabetes mellitus. By inhibiting sodium and glucose reabsorption from the proximal tubules, the improvement in insulin resistance and natriuresis...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7832: Neonatal Seizures and Purinergic Signalling International Journal of Molecular Sciences doi: 10.3390/ijms21217832 Authors: Aida Menéndez Méndez Jonathon Smith Tobias Engel Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains among infants, with increasing...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7834: Differentiation Induction of Human Stem Cells for Corneal Epithelial Regeneration International Journal of Molecular Sciences doi: 10.3390/ijms21217834 Authors: Kasem Theerakittayakorn Hong Thi Nguyen Jidapa Musika Hataiwan Kunkanjanawan Sumeth Imsoonthornruksa Sirilak Somredngan Mariena Ketudat-Cairns Rangsun Parnpai Deficiency of corneal epithelium causes vision impairment or blindness in severe cases. Transplantation of corneal epithelial...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7830: Hereditary Hypofibrinogenemia with Hepatic Storage International Journal of Molecular Sciences doi: 10.3390/ijms21217830 Authors: Rosanna Asselta Elvezia Maria Paraboschi Stefano Duga Fibrinogen is a 340-kDa plasma glycoprotein constituted by two sets of symmetrical trimers, each formed by the Aα, Bβ, and γ chains (respectively coded by the FGA, FGB, and FGG genes). Quantitative fibrinogen deficiencies (hypofibrinogenemia,...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7829: A Villin-Driven Fxr Transgene Modulates Enterohepatic Bile Acid Homeostasis and Response to an n-6-Enriched High-Fat Diet International Journal of Molecular Sciences doi: 10.3390/ijms21217829 Authors: Spencer N. Wren Micah G. Donovan Ornella I. Selmin Tom C. Doetschman Donato F. Romagnolo A diet high in n-6 polyunsaturated fatty acids (PUFAs) may contribute to inflammation and tissue damage associated with obesity and pathologies of the colon and...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7828: Evaluation of QSAR Equations for Virtual Screening International Journal of Molecular Sciences doi: 10.3390/ijms21217828 Authors: Jacob Spiegel Hanoch Senderowitz Quantitative Structure Activity Relationship (QSAR) models can inform on the correlation between activities and structure-based molecular descriptors. This information is important for the understanding of the factors that govern molecular properties and for designing new compounds with favorable...
Thu Oct 22, 2020 03:00
IJMS, Vol. 21, Pages 7831: Capacity of Retinal Ganglion Cells Derived from Human Induced Pluripotent Stem Cells to Suppress T-Cells International Journal of Molecular Sciences doi: 10.3390/ijms21217831 Authors: Ayaka Edo Sunao Sugita Yoko Futatsugi Junki Sho Akishi Onishi Yoshiaki Kiuchi Masayo Takahashi Retinal ganglion cells (RGCs) are impaired in patients such as those with glaucoma and optic neuritis, resulting in permanent vision loss. To restore visual function,...
Thu Oct 22, 2020 03:00
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