Surgical resection for pulmonary metastases from colorectal cancer (PM-CRC) has been found to be associated with prolonged relapse-free survival, and it has been considered a practical standard therapy [1,2]. According to a systematic review of patients undergoing pulmonary metastasectomy for CRC, the median 5-year overall survival (OS) was 52.5 % [3]. Along with the development of molecular targeted therapy, 5-year OS has improved to more than 70 % in the last decade [4]. Completeness of resection...
Obesity is responsible for multiple chronic diseases, including type 2 diabetes, hypertension, coronary artery disease, stroke, and several types of cancer [1]. The body mass index (BMI) —as an easy-to obtain, acceptable proxy for thinness and fatness—has been found to be associated with health risk and death in many populations. According to the World Health Organization definition, the normal range of BMI is defined as 18.5 to (Source: Lung Cancer)
Optimal treatment in the relapsed-refractory setting for patients with advanced thymic epithelial tumors (TETs) is poorly understood. The current standard of care first line treatment for advanced thymoma and thymic carcinoma is a platinum-based regimen based on data from several small single-arm phase 2 studies. Cyclophosphamide/doxorubicin/cisplatin (CAP) and carboplatin/paclitaxel are both options for TETs, although the former is more commonly used for advanced thymoma [1,2] and the latter for...
The prognosis of advanced non-small –cell lung cancer (NSCLC) has been dramatically improved by promising new treatments: targeted therapies for oncogenic addictions and immune-checkpoint inhibitors (ICIs), including anti-programmed cell-death protein-1 (PD-1) nivolumab and pembrolizumab. (Source: Lung Cancer)
Mark above section as read
ConclusionMeningiomas in children are very rare and have a slight male predominance. Pediatric meningiomas are more commonly located in intraventricular and have higher incidence rate of high-grade than that in adults. Although being challenging, the gross total excision should be underdone to achieve a better prognosis. (Source: Journal of Neuro-Oncology)
ConclusionData suggest a tumor dependent ITH in radiosensitivity. The existence of ITH in radiosensitivity may impact not only the initial therapeutic response but also the effectiveness of retreatment protocols. (Source: Journal of Neuro-Oncology)
ConclusionsLITT is an effective approach for treating pathology in the posterior fossa. The average target size is smaller than what has been reported in the supratentorial space. Care must be taken to prevent injury to surrounding structures given the close proximity of critical structures in this region. (Source: Journal of Neuro-Oncology)
ConclusionThe RP2D of lenalidomide administered daily during radiation therapy is 116 mg/m2/day. Children with malignant gliomas tolerate much higher doses of lenalidomide during radiation therapy compared to adults. This finding is critical as activity was observed primarily at higher dose levels suggesting a dose response. (Source: Journal of Neuro-Oncology)
(Source: Journal of Neuro-Oncology)
ConclusionsA significant proportion of AYAs treated for IGCTs experience late effects from treatment, including neurocognitive impairment, ototoxicity, and hormone deficiency. Suprasellar/hypothalamic tumor location and cisplatin were associated with a higher risk of treatment-induced hormone deficiency and ototoxicity, respectively. (Source: Journal of Neuro-Oncology)
ConclusionsTumor-infiltrating immune cells confer important clinical and biological implications. Our results of immune-infiltrate levels in PAs may inform effective cancer vaccine and checkpoint blockade therapies and make it possible to take immunotherapy into invasive PAs. (Source: Journal of Neuro-Oncology)
ConclusionsRibociclib administered following radiotherapy is feasible in DIPG and DMG. Increased tumor necrosis may represent a treatment effect. These data warrant further prospective volumetric analyses of tumors with necrosis. Feasibility and stabilization findings support further investigation of ribociclib in combination therapies.Trial registrationNCT02607124. (Source: Journal of Neuro-Oncology)
In the original publication, there are errors in Fig. 3D and Fig. 5C and are corrected as follows. (Source: Journal of Neuro-Oncology)
ConclusionsTrametinib was an active and feasible treatment for progressive pLGG leading to disease control in all patients. However, treatment related toxicity interfered with treatment in individual patients, and disease control after MEKi withdrawal was not sustained in a fraction of patients. Our data support in-class efficacy of MEKi in pLGGs and necessity for upfront randomized testing of trametinib against current standard chemotherapy regimens. (Source: Journal of Neuro-Oncology)
For the reference citation '[57]' in the second paragraph of theResults section of the original article there was no corresponding entry in the References section. It should have referred to the below mentioned article by Ebrahimkhani et al. (2018). (Source: Journal of Neuro-Oncology)
ConclusionsSMARCB1 loss is the key genetic event in ATRT pathogenesis that leads to widespread epigenetic dysregulation and loss of lineage-specific enhancers. Current work is defining subtype-specific treatments that target underlying molecular derangements that drive tumorigenesis. (Source: Journal of Neuro-Oncology)
ConclusionsRecruitment and retention feasibility issues were identified. Promising preliminary change and treatment satisfaction scores however suggest that further research with the AMT is warranted. Reduced assessment burden and more regular engagement during treatment is recommended to enhance retention. Large sample sizes however will be needed to address the heterogeneity of this group. (Source: Journal of Neuro-Oncology)
ConclusionsKnowledge of additional alterations that co-occur withBRAF-mutations in gliomas may improve diagnosis and help identify patients that could benefit from targeted therapies. Furthermore, we provide examples of two patients whose tumors responded toBRAF pathway inhibitors, arguing in favor of these therapies in patients withBRAF-mutant gliomas. (Source: Journal of Neuro-Oncology)
ConclusionsThe present study concludes that both increased frailty and comorbidity burden are significantly associated with poor OS in geriatric patients with glioblastoma. Further, the present series suggests an obesity paradox in geriatric glioblastoma patients. (Source: Journal of Neuro-Oncology)
ConclusionWith regard to ATL and GTR as differing onco-surgical approaches these data suggest ATL in terms of an aggressive supra-total resection strategy to preserve perioperative standard safety metric profiles. (Source: Journal of Neuro-Oncology)
ConclusionIncreasing number of meningiomas has a significant negative impact on OS, with a progressive decrease on survival for every additional lesion. Furthermore, female patients had increased OS and decreased risk to develop MM. (Source: Journal of Neuro-Oncology)
Conclusion GKRS is not associated with an increase in CNAs or alteration of the CNA profile in VS, lending support to its low risk. This also implies that there is no major issue with GKRS treatment failure being due to CNAs. In agreement with previous studies, chromosome 22 aberration is the only recurrent CNA. VS consist of several genetic clones, addressing the need for further studies on the composition of cells in this tumor. (Source: Journal of Neuro-Oncology)
(Source: Journal of Neuro-Oncology)
ConclusionIn the present series, HFSRT was associated with limited RN risk. Incidence of RN was higher with dose regimens delivering a higher biologically effective dose, as well as in patients having received immunotherapy within 3 months of HFSRT. (Source: Journal of Neuro-Oncology)
ConclusionsAlthough responses to immune-modulating drugs in the body and the brain tend to be concordant, differences were found in MVD and T-cell content between these sites. Studies of these markers should be incorporated into prospective therapeutic clinical trials to determine their prognostic and predictive value. (Source: Journal of Neuro-Oncology)
ConclusionThe ability to resume professional activities following brain tumor surgery is an important patient-oriented outcome parameter. We found that the majority of patients with gliomas were able to return to work following surgical and adjuvant treatment. Preservation of neurological function is of utmost relevance for individual patients ´ quality of life. (Source: Journal of Neuro-Oncology)
ConclusionsOur models predicting postoperative outcomes allow for individualized risk-estimation for patients following surgery for metastatic brain tumors. Our results may be useful in helping clinicians to provide resource-conscious, high-value care. (Source: Journal of Neuro-Oncology)
ConclusionThis is a review of recent advancements in our understanding of the epigenetic basis of ependymoma and discussion of how these findings reveal potential therapeutic opportunities. (Source: Journal of Neuro-Oncology)
ConclusionsFusion genes occur infrequently in meningiomas and are more likely to be found in tumors with greater degree of genomic instability (expression type C) or in patients with history of cranial irradiation. (Source: Journal of Neuro-Oncology)
Mark above section as read
Summary Background The Wnt pathway is aberrantly activated in chronic lymphocytic leukemia (CLL) and contributes to the antiapoptotic and mitogenic characteristics of CLL cells. Lymphoid enhancer-binding factor‑1 (LEF1) acts as a mediator and key transcription factor of the Wnt/β-catenin pathway. LEF1 helps to regulate important genes involved in tumor cell death mechanisms. ...
Mark above section as read
Abstract Introduction Meningioma is a heterogeneous disease and patients may suffer from long-term tumor- and treatment-related sequelae. To help identify patients at risk for these late effects, we first assessed variables associated with impaired long-term health-related quality of life (HRQoL) and impaired neurocognitive function on group level (i.e. determinants). Next, prediction models were developed to predict the risk for long-term...
Abstract Objective The purpose of this article was to study the characteristics of pediatric meningiomas, including the clinical symptom, anatomic location, radiological finding, treatment approaches, and long-term surgical outcome as well as the possible influence factors of the prognosis. Methods We retrospectively reviewed the medical records and...
Abstract Purpose Glioblastoma (GBM) is characterized by extensive clonal diversity suggesting the presence of tumor cells with varying degrees of treatment sensitivity. Radiotherapy is an integral part of glioblastoma treatment. Whether GBMs are comprised of spatially distinct cellular populations with uniform or varying degrees of radiosensitivity has not been established. ...
Abstract Purpose Magnetic resonance-guided laser interstitial thermal therapy (LITT) has been increasingly used to treat a number of intracranial pathologies, though its use in the posterior fossa has been limited to a few small series. We performed a multi-institutional review of targets in the posterior fossa, reporting the efficacy and safety profile associated with laser ablation in this region of the brain. ...
Mark above section as read
Abstract Objectives Venous thromboembolism (VTE) is a significant and preventable cause of mortality and morbidity in thoracic surgery. It usually deep venous thromboembolism (DVT) and pulmonary thromboembolism (PE). We conducted this article to perform a systematic review on prophylaxis of perioperative VTE in patients undergoing thoracic surgery especially lung surgery and esophageal surgery and to identify potential areas for future research. Methods The systematic review we conducted...
Immune checkpoint inhibitors (ICIs) have improved survival across tumor types, however they cause immune‐related toxicities through removal of the inhibition of auto‐reactive T cells. In this case review, we present four patients with metastatic cancer who developed de‐novo neuromuscular side effects of myositis with overlapping seropositive MG after ICI treatment. Abstract Immune checkpoint inhibitors (ICI) have improved survival across tumor types however they cause immune‐related toxicities...
Abstract Aim Cervical basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with little recognition. Our objective was to identify difference in characteristics and outcomes between BSCC and squamous cell carcinoma, usual type (SSC, UT). Methods A total of 32 BSCC patients and 6387 SCC, UT patients, diagnosed from 2004 to 2014, were identified using the Surveillance, Epidemiology, and End Results database. Results More BSCC patients presented with older...
Abstract Aim Low participation in cancer clinical trials by culturally and linguistically diverse (CALD) patients limits access to cutting‐edge treatments and generalizability of results. This is the first study exploring trials knowledge/attitudes and their association with trial participation in Vietnamese‐ and Anglo‐Australian cancer patients. Methods Eligible patients diagnosed with cancer in the past 10 years were invited to complete a self‐report questionnaire comprising validated...
Abstract Aim La protein is a multifunctional RNA‐binding protein involved in RNA metabolism that has been reported to promote the growth of some solid tumors. However, potential role of La in hepatocellular carcinoma (HCC) has not been fully elucidated. This study aimed to investigate the expression of La and its function in HCC. Methods Quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blot analysis were conducted to detect the expression levels of La mRNA and protein...
Abstract Aim To provide guidance for appropriate imaging examinations for diagnosing spinal tumors or tumor‐like lesions. Methods A total of 121 patients with suspected spinal tumors were included this retrospective study. Each patient underwent ≥2 imaging examinations, including computerized tomography (CT), magnetic resonance (MR), and/or emission computed tomography (ECT). All patients were diagnosed by pathology after core needle or surgical biopsies. The results were compared with...
Abstract With the development of cancer immunotherapy, the combination strategy is becoming prevalent. Multiple relevant clinical trials are ongoing in this field. However, immune‐related adverse events (irAEs) occurred more frequently, showing a different pattern from single‐agent therapy. It is necessary for clinicians to learn about the characteristics of AEs from combination immunotherapy, and master the skills to deal with them. In this article, we reviewed presently published data about AEs...
Abstract Introduction Oxaliplatin‐induced peripheral neuropathy (OIPN) is a common adverse events that can limit a patient's quality of life during/after chemotherapy. However, no appropriate methods have been established yet for monitoring the risk of progression of OIPN. Methods A simple assessment tool using gem clips, the CLIP test, was established and its performance in predicting the risk of progression to ≥grade 2 peripheral sensory neuropathy (CTCAE ver. 4.0) was investigated in...
Abstract Aim The routine use of prophylactic percutaneous endoscopic gastrostomy (PEG) tubes for nutrition support during radical chemoradiation for head and neck cancer has been suggested to result in PEG dependency. This research aimed to determine the rates of gastrostomy dependency at the Calvary Mater Newcastle (CMN) where PEGs are routinely used and to identify potentially modifiable risk factors. Methods All patients with head and neck cancer planned for curative chemoradiation with...
Abstract Objective The prognostic nutritional index (PNI) has been shown to be prognostic value for many types of cancer of the gastrointestinal system. However, there are limited data on its value for metastatic colorectal cancer (mCRC). This study aimed to evaluate the prognostic value of PNI in newly diagnosed mCRC patients. Methods The data of 468 patients who had been admitted to our center upon being diagnosed with mCRC between January 2010 and December 2017 were reviewed retrospectively,...
Abstract Aim The metabolic behavior and the prognostic value of 18F‐FDG‐PET/CT in gastrointestinal stromal tumor (GIST) is not well investigated. The aim of this study was to analyze the metabolic behavior of GIST and the prognostic role of pretreatment PET/CT features. Methods In this retrospective study, we included 35 patients with a diagnosis of GIST who underwent a pretreatment 18F‐FDG‐PET/CT scan. We analyzed PET images visually and semiquantitatively by measuring several metabolic...
Abstract Programmed cell death receptor‐1 and its ligand‐1 (PD‐1/PD‐L1) inhibitors have been applied to many cancers, but the difference of treatment‐related adverse events (AEs) across cancer types remains unknown. We performed a meta‐analysis and systemic review to compare the incidences of commonly reported all‐grade AEs across cancer types and found that the most frequent AEs were fatigue, rash/pruritus, loss of appetite/nausea and diarrhea. However, each cancer type also had its higher incidences...
Abstract Background To determine the diagnostic accuracy of preoperative T/N stage with magnetic resonance imaging (MRI) in lower and middle rectal cancer patients and the impacts on clinical decision‐making. Patients and methods A total of 211 patients were recruited from October 2015 to March 2017 in this retrospective study. High‐resolution MRI was performed within 2 weeks before surgery. Histopathologic results were evaluated for the postoperative T/N stage and the diagnostic accuracy...
Abstract Purpose Cancer treatment can alter patient appearance, leading to psychological, social, and behavioral issues. This study aimed to investigate distress and difficulties related to appearance concerns in Japanese cancer patients and to identify information and support needs among them. Methods We conducted a questionnaire survey using the Derriford Appearance Scale 59 (DAS59) among cancer patients with a prior history of chemotherapy, molecular targeted therapy, or immunotherapy,...
Abstract Aim Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. In this study, we aimed to show the relationship between temporal muscle thickness (TMT) measurement and survival in newly diagnosed patients with GBM. Methods Forty‐seven patients with newly diagnosed GBM were evaluated, retrospectively. TMT at diagnosis of GBM before any surgical procedure was measured on the contrast‐enhanced axial longitudinal relaxation time (T1)‐weighted magnetic...
Abstract Cutaneous toxicities are the most prevalent immune‐related adverse events. Various reactions have been reported. In this review, we summarized the clinicopathologic manifestations, treatment strategies, relevance to tumor outcomes, and rechallenge considerations of cutaneous immune‐related adverse events.
Abstract Aim In advanced gastric cancer, chemotherapy, given either perioperatively or as an adjuvant treatment, has been shown to improve survival when compared to surgery alone. However, no trial has compared these two approaches head‐to‐head. Hence, we aimed to compare the short‐ and long‐term outcomes of patients with gastric cancer who received either perioperative chemotherapy or adjuvant chemotherapy. Methods Retrospective analysis of patients with gastric cancers treated from 2010...
Our study provided an estimation of the effect of establishing new radiotherapy facilities on patient accessibility in Pacific Island Countries and Territories (PICTs). Our unique modelling approach of spatial distribution of population density versus service availability would lead to improved patient access and cancer outcomes in the region. Abstract Background Pacific Island Countries and Territories (PICTs) have experienced an increase in cancer burden in the recent years. There...
Primary central nervous system lymphoma (PCNSL) is a rare subtype of non‐Hodgkin's lymphoma and its prognosis is still very poor. We have updated our results of high‐dose MTX monochemotherapy with deferred radiotherapy for newly‐diagnosed PCNSL. We have identified that age and response to induction high‐dose MTX are significantly prognostic factors for survival. We recommend that an effective additional treatment should be considered without delay for patients with nonresponders to high‐dose MTX....
Abstract Aim Colorectal cancer (CRC) is the third most common cancer in Australia, and survival after diagnosis of metastatic disease is improving. Our aim was to assess trends in epidemiology, treatment, molecular testing and survival in patients with metastatic CRC (mCRC). Methods Clinical data from February 2013 to December 2018 was recorded in a prospective, observational, multicenter cohort study conducted in Queensland, Australia, examining clinical and molecular biomarkers in cases...
Abstract Purpose There has been an increase in the use of gold fiducial markers to ensure precise radiotherapy delivery in prostate cancer patients. However, metal artifacts may affect the quality of subsequent imaging used to assess disease status following treatment. In this study, we evaluated the effect of gold fiducial markers on magnetic resonance imaging (MRI), particularly on diffusion‐weighted imaging (DWI). Material and methods Among 57 patients with prostate cancer, 21 patients...
Abstract Although surgical lobectomy with systematic mediastinal lymph node evaluation is considered as the “gold standard” for management of early stage non–small cell lung cancer (NSCLC), image‐guided percutaneous thermal ablation has been increasingly used for medically inoperable patients. Radiofrequency ablation (RFA) is a research‐based technique that has the most studies for medically inoperable early‐stage NSCLC. Other thermal ablation techniques used to treat pulmonary tumors include microwave...
There is a rising incidence of gastric cancer in Sri Lanka, which is more pronounced among the older populations, based on the National Cancer Registry Data. This appears to be a true increase, although some contribution of better diagnosis and reporting towards this increase is likely. Abstract Objectives Varying patterns in incidence of gastric cancer (GC) have been reported globally. We aimed to examine the trends of GC incidence in Sri Lanka. Methods All newly diagnosed patients...
Abstract A hallmark feature of tumorigenesis is uncontrolled cell division. Autophagy is regulated by more than 30 genes and it is one of several mechanisms by which cells maintain homeostasis. Autophagy promotes cancer progression and drug resistance. Several genes play important roles in autophagy‐induced tumorigenesis and drug resistance including Beclin‐1, MIF, HMGB1, p53, PTEN, p62, RAC3, SRC3, NF‐2, MEG3, LAPTM4B, mTOR, BRAF and c‐MYC. These genes alter cell growth, cellular microenvironment...
Docetaxel chemotherapy in combination with androgen depravation therapy (D‐ADT) is an established treatment for patients with newly diagnosed metastatic prostate cancer. The purpose of this study was to define the activity of treatments given following the failure of D‐ADT. No significant differences were identified between treatment options. Prospective trials are needed to identify the optimal therapy for patients in this setting. Abstract Aim Optimal treatment for newly diagnosed...
Rates of cetuximab anaphylaxis have been shown to be significantly higher in areas of high tick prevalence. This retrospective study reviews the experience of two community cancer centers in high tick exposure areas in Sydney with cetuximab anaphylaxis and proposes a protocol to avoid this. Abstract Background Cetuximab is an anti‐epidermal growth factor receptor mouse‐human chimeric monoclonal antibody used to treat advanced colorectal cancers. Initial data suggest that severe infusion...
Long noncoding RNAs (lncRNAs) are supposed to be one of the main contributors in colorectal cancer development. lncRNA polymorphisms can influence the risk of tumorigenesis. lncRNAs can be served as promising diagnostic or prognostic biomarkers and also desired therapeutic targets in CRC. Abstract Colorectal cancer (CRC) is one of the most common cancers globally. Although a variety of CRC screening methods have been developed, many patients are diagnosed at advanced stages of CRC with...
We constructed three constructs of second‐generation CAR T cells expressing CD19 scFV‐CD28‐CD3ζ, with different lengths of the spacer region, and determined whether the difference in length of the spacer would affect the cytotoxic potential of the CD19 CAR T cells against the leukemic cells. We chose the intermediate CD19 CAR T cells for the clinical efficacy of our CD19 CAR T cells in one patient with refractory/relapsed acute B‐cell lymphoblastic leukemia. Abstract Aims The purpose...
Abstract To inform about the impact of COVID‐19 on cancer patients, a literature review was carried out, using the descriptors “COVID‐19,” “SARS‐CoV‐2,” “Oncology,” and “Coronavirus,” in the Pubmed, Sciencedirect, and Scifinder databases. Fifty‐three articles were included after analyzing the inclusion and exclusion criteria, being divided into five sessions: Epidemiological aspects of COVID‐19; Pathophysiology of COVID‐19; Clinical aspects of cancer patients; Risks to cancer patients...
Patients with metastatic castration‐resistant prostate cancer who received ≥ 4 cycles of cabazitaxel showed a ≥ 30% reduction in the serum prostate‐specific antigen levels, and did not have visceral metastasis might achieve longer overall survival. Abstract Aim To date, the optimal sequencing of life‐prolonging therapies for patients with metastatic castration‐resistant prostate cancer (mCRPC) remains unclear owing to a lack of prospective trials. This study aimed to evaluate the efficacy...
We retrospectively evaluated a moderate cohort of patients with treatment‐naïve advanced stage FL. Results showed that rituximab maintenance after chemoimmunotherapy induction can prolong both PFS and OS. Abstract Aim The prognosis and treatment options for follicular lymphoma (FL) remain heterogenous. This study aimed to analyze the prognostic impact of rituximab maintenance and evaluate the prognostic models in Chinese FL patients. Methods We retrospectively evaluated patients...
Patients with chronic rhinosinusitis have relationship with developing nasopharyngeal carcinoma within 1 year of follow‐up, but not for longer intervals. The short‐term association may be due to reversed causation or biased diagnosis. Abstract Aims Chronic inflammation is linked to cancer. This study aims to evaluate the association between chronic rhinosinusitis (CRS) and nasopharyngeal carcinoma (NPC) through a Taiwanese nationwide database. Methods We used the National Health...
Valproic acid and hydralazine can be cytotoxicity modulators by suppressing DNA repair caused by doxorubicin, cisplatin, gemcitabine and dacarbazine. Sequential valproic acid‐ and hydralazine‐combined gemcitabine/cisplatin and doxorubicin/dacarbazine was demonstrated to be effective (OS: 14.6 months) with manageable toxicity in mixed sorafenib‐naïve and sorafenib‐experienced patients with advanced HCC. Abstract Background Survival benefit from chemotherapy in advanced hepatocellular...
Sarcomatoid carcinomas are extremely rare lung tumors with survival rates and prognoses significantly worse than other non‐small‐cell carcinoma types. Treatments targeting the PD1/PD‐L1 pathway have recently emerged as a promising therapeutic approach for sarcomatoid lung carcinomas. This study investigated PD‐L1 expression and clinicopathologic features of surgically resected sarcomatoid lung carcinomas. Abstract Aim To determine the programmed death ligand‐1 (PD‐L1) expression rates...
Abstract Aim Public subsidy of the oxycodone/naloxone controlled release (CR) combination in December 2011 expanded the overall market for oxycodone CR in the general public in Australia; we evaluate its impact in people with cancer. Methods We used Repatriation Pharmaceutical Benefits dispensing data linked with the NSW Cancer Registry for Department of Veterans’ Affairs (DVA) healthcare card holders 65 years and older residing in NSW between 2004 and 2013 to identify clients with cancer...
Mark above section as read
Abstract Most colorectal cancer (CRC) patients are diagnosed with advanced stages and low prognosis. We aimed to identify potential diagnostic and prognostic biomarkers, as well as active small molecules of CRC. Microarray data (GSE9348, GSE35279, and GSE106582) were obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified by the GEO2R platform. Common DEGs were selected for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and...
Abstract Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation of abnormal plasma cells in bone marrow. Flow cytometry distinguishes between normal and abnormal plasma cells by evaluating cluster of differentiation (CD) 56 and CD19 expression patterns. Moreover, immunophenotyping of mature plasma cell 1 (MPC-1) and very late antigen-5 (CD49e) identifies the maturity of MM as mature (MPC-1+, CD49e+), intermediate (MPC-1+, CD49e–), or immature...
Abstract The healing effect of herbal active compounds on lung cancer has been recently investigated. Lung cancer is one of the leading types of cancer. The causes and prevention of lung cancer diagnosis have an important role as the inhibition of proteins in the initial treatment of the disease. The docking score was used to investigate the effect of some active compounds in traditional medicinal plants. The use of widespread medicinal plants and determination of active substances...
Abstract Financial constraints faced by the families play a vital role in cancer treatment refusal, non-adherence, and failure of the prescribed therapy. This review aims to give an insight into the economic perspective of cancer treatment in India, focusing on the accessibility and affordability of oncological drugs, and the move towards generics/biosimilars without compromising on the quality of the treatment. The monthly cost of a set of drugs available in India for the treatment...
Mark above section as read
ConclusionsIn this review, we will address combined anti-cancer therapeutic strategies described so far which involve the use of CX-4945. Data from preclinical studies clearly show the ability of CX-4945 to synergistically cooperate with different classes of anti-neoplastic agents, thereby contributing to an orchestrated anti-tumour action against multiple targets. Overall, these promising outcomes support the translation of CX-4945 combined therapies into clinical anti-cancer applications. (Source:...
ConclusionOur data revealed a tumor-suppressing role of circ-102,166 in HCC. Down-regulation of circ-102,166 enhanced the proliferation and invasion of HCC cells by releasing the oncomiRs miR-182 and miR-184. (Source: Cellular Oncology)
ConclusionBased on our results, we conclude that the BRD4/c-Myc- and integrin/FAK-dependent pathways act in concert to promote breast cancer cell survival and poor clinical outcomes. As such, they represent promising targets for a synthetic lethal-type of therapy against TNBC. (Source: Cellular Oncology)
ConclusionZNF503-AS1 can recruit transcription factor GATA6 to up-regulate SLC8A1 expression, thereby increasing the intracellular Ca2+ concentration and repressing the proliferation, invasion and migration, and enhancing the apoptosis of bladder cancer cells. (Source: Cellular Oncology)
ConclusionsOur data revealed novel functional roles for miR-650 in glioma development and may provide new avenues for future clinical applications. (Source: Cellular Oncology)
ConclusionOur results highlight new cell-specific roles of cN-II and CD73 in cancer cell biology and provide insight into their interactions with different intracellular pathways. (Source: Cellular Oncology)
ConclusionsInhibition of ER β and the IL-6/gp130/STAT3 signaling pathway by raloxifene leads to potent reduction of PDAC growth in vitro and in vivo. Our results suggest that ERβ signaling and IL-6/gp130 interaction may serve as promising drug targets for pancreatic cancer and that raloxifene may serve as an attractive ther apeutic option for PDAC patients expressing the ERβ isotype. (Source: Cellular Oncology)
ConclusionsCombination of honokiol and paclitaxel may represent a novel strategy for the treatment of paclitaxel-resistant NSCLC. (Source: Cellular Oncology)
ConclusionsOur data indicate an involvement of aberrant SNHG3 over-expression in the acquisition of both cisplatin resistance and stemness of gastric cancer cells, and of the IL-6/STAT3/SNHG3/miR-3619-5p/ARL2 signaling cascade in the oncogenic properties of SNHG3. (Source: Cellular Oncology)
Mark above section as read
ConclusionsThis post hoc analysis suggests that OIC occurs rapidly in patients with GI cancer after initiating opioid therapy, and negatively impacts QOL. Early and effective intervention strategies may be particularly useful in this group.Additional InformationCoauthor Makio Gamoh is deceased. (Source: International Journal of Clinical Oncology)
ConclusionsOur findings indicate the reality of fertility preservation in 2014, before the guideline were issued. Further studies are warranted to investigate the improvement in fertility preservation since the guidelines were issued. (Source: International Journal of Clinical Oncology)
ConclusionsOur novel nomogram for patients with resected RLPS could improve recurrence risk stratification to explore molecular analysis associated with recurrence. (Source: International Journal of Clinical Oncology)
ConclusionsThe oncological outcomes of patients receiving the first-line therapy of nivolumab plus ipilimumab in real-world practice were significantly improved in comparison with first-line TKIs therapy. (Source: International Journal of Clinical Oncology)
ConclusionTaxane-based second-line chemotherapy was effective and safe for patients with AGC who present with SPM. Attention must be provided when treating patients with inadequate oral intake as they are likely to have short prognosis and serious toxicities. (Source: International Journal of Clinical Oncology)
ConclusionThe PFS and ORR were consistent between Japanese patients and the overall population. A longer median OS was observed in Japanese patients. Our results would be a useful reference when planning and conducting MRCTs that include Japan for global simultaneous drug development. (Source: International Journal of Clinical Oncology)
ConclusionOur meta ‐analysis indicated that NPC patients with a low PNI level had worse OS, PFS and DMFS, and a low PNI level was associated with female patients, higher tumor stage, a lower ALT level and a lower WBC level. These findings indicate that PNI is a promising prognostic biomarker. (Source: International Journal of Clinical Oncology)
ConclusionsThe present study demonstrates that low-dose everolimus treatment is safe and effective for TSC-associated AML. This treatment was well tolerated and adverse events were mild in all cases. (Source: International Journal of Clinical Oncology)
ConclusionsCombination treatment with S-1 and cetuximab was effective and tolerated well by patients with platinum-ineligible R/M SCCHN.Registered clinical trial number: UMIN000015123 (Source: International Journal of Clinical Oncology)
ConclusionsNSCLC patients with poor PS and PD-L1 ≥ 50% are expected to benefit from anti-PD-1/PD-L1 therapy, despite a modest overall response among NSCLC patients with poor PS. Accordingly, PD-L1 expression provides useful information regarding decision-making for anti-PD-1/PD-L1 therapy even in these populations. (Source: International Journal of Clinical Oncology)
ConclusionsReplacement the platinum agent resulted in equivalent efficacy, with reduced toxicity, in women with locally advanced cervical cancer. This strategy could considerably diminish the application of radiation therapy without reduced survival. A study to identify those patients who will benefit from this new multidisciplinary strategy is warranted. (Source: International Journal of Clinical Oncology)
ConclusionRetroperitoneal lymph node dissection with negative surgical margin is essential for patients with viable residual tumor after chemotherapy. Need for second-line chemotherapy shows risk of progression. (Source: International Journal of Clinical Oncology)
ConclusionMultiple urine tests using UroVysion® after RNU could be a useful predictor for IVR. (Source: International Journal of Clinical Oncology)
ConclusionIn conclusion, HCMV-induced miR-34c or miR-138 involves in the activation of IL6/STAT3 signaling. Targeting the IL6 –STAT3 axis or miRNAs represent a promising strategy for HCMV-related tumor formation. (Source: International Journal of Clinical Oncology)
ConclusionPreoperative blood glucose to lymphocyte ratio is an independent biomarker to predict the overall survival for pancreatic ductal adenocarcinoma patients who underwent curative resection. (Source: International Journal of Clinical Oncology)
ConclusionsAbnormal FDG uptake in the LN is an important prognostic factor. Increased glucose metabolism on FDG-PET appears to be a more efficient postoperative prognostic marker than pathological n-stage in patients with lung cancer. (Source: International Journal of Clinical Oncology)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου