Antibody drug conjugates (ADCs) provide targeted delivery of cytotoxic agents directly inside tumor cells. However, many ADCs targeting solid tumors have exhibited limited clinical efficacy, in part, due to insufficient penetration within tumors. To better understand the relationship between ADC tumor penetration and efficacy, previously applied Krogh cylinder models that explore tumor growth dynamics following ADC administration in preclinical species were expanded to a clinical framework by integrating...
Mon Oct 19, 2020 11:42
Abstract Enzyme replacement with Ectonucleotide Pyrophosphatase Phospodiesterase‐1 (ENPP1) eliminates mortality in a murine model of the lethal calcification disorder ‘Generalized Arterial Calcification of Infancy’ (GACI). We used protein engineering, glycan optimization, and a novel biomanufacturing platform to enhance potency by employing a 3‐prong strategy. First, we added new N‐glycans to ENPP1; second, we optimized pH‐dependent cellular recycling by protein engineering of the Fc neonatal receptor...
Fri Oct 16, 2020 20:55
Publication date: Available online 19 October 2020Source: Photodiagnosis and Photodynamic TherapyAuthor(s): Eisha Abrar, Mustafa Naseem, Qaiser Ali Baig, Fahim Vohra, Ahmed M Maawadh, Thamer Almohareb, Mohammed Q. AlRifaiy, Tariq Abduljabbar
Tue Oct 20, 2020 15:22
Publication date: Available online 20 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Kevin C. Lee, John J. Costandi, Vincent Carrao, Sidney B. Eisig, Michael A. Perrino
Tue Oct 20, 2020 15:19
Publication date: Available online 20 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): James Hupp
Tue Oct 20, 2020 15:19
Publication date: Available online 19 October 2020Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Hossein E. Jazayeri, Joseph Lopez, Emily C. Sluiter, Devin O'Brien-Coon, Rachel Bluebond-Langner, William M. Kuzon, Jens U. Berli, Stan J. Monstrey, Jordan C. Deschamps-Braly, Amir H. Dorafshar, Loren S. Schechter
Tue Oct 20, 2020 15:19
Publication date: Available online 19 October 2020Source: Pathology - Research and PracticeAuthor(s): Vahid Karpisheh, Navneet Joshi, Angelina Olegovna Zekiy, Behzad Beyzai, Mohammad Hojjat-Farsangi, Afshin Namdar, Mahdi Edalati, Farhad Jadidi-Niaragh
Tue Oct 20, 2020 14:54
Patient–ventilator asynchrony is common in mechanically ventilated patients and may be related to adverse outcomes. Few studies have reported the occurrence of asynchrony in brain-injured patients. We aimed to...
Mon Oct 19, 2020 03:00
Publication date: January 2021Source: World Neurosurgery, Volume 145Author(s): Shuangjiang Zhang, Lili Wang, Li Bao, Haibo Sun, Fei Feng, Jianlin Shan, Hai Tang
Tue Oct 20, 2020 13:47
Publication date: January 2021Source: World Neurosurgery, Volume 145Author(s): Domenico Policicchio, Riccardo Boccaletti, Giosuè Dipellegrini, Artan Doda, Andrea Stangoni, Santonio Filippo Veneziani
Tue Oct 20, 2020 13:47
Publication date: Available online 20 October 2020Source: World NeurosurgeryAuthor(s): Andy Ton, Ram K. Alluri, Hyunwoo P. Kang, Andrew Kim, Raymond J. Hah
Tue Oct 20, 2020 13:47
Publication date: Available online 20 October 2020Source: World NeurosurgeryAuthor(s): Charles Champeaux Depond, Panayotis Constantinou, Joconde Weller
Tue Oct 20, 2020 13:47
Publication date: Available online 20 October 2020Source: World NeurosurgeryAuthor(s): Miriam M. Shao, Olga Khazen, Abigail Hellman, Margaret Czerwinski, Rachel Dentinger, Marisa DiMarzio, Michael Gillogly, Amir Hadanny, Charles Argoff, Julie G. Pilitsis
Tue Oct 20, 2020 13:47
Publication date: Available online 20 October 2020Source: World NeurosurgeryAuthor(s): Andrei Fernandes Joaquim, Ratko Yurac, Marcelo Valacco, Orlando Righesso Neto, Charles André Carazzo, Juan Pablo Cabrera, Alisson R. Teles, Ericson Sfreddo, Asdrubal Falavigna
Tue Oct 20, 2020 13:47
Publication date: Available online 19 October 2020Source: World NeurosurgeryAuthor(s): Rebecca A. Reynolds, Arnold Bhebhe, Roxanna M. Garcia, Heidi Chen, Christopher M. Bonfield, Sandi Lam, Kachinga Sichizya, Chevis Shannon
Tue Oct 20, 2020 13:47
Publication date: Available online 19 October 2020Source: World NeurosurgeryAuthor(s): Ryan G. Chiu, Neha Siddiqui, Ravi S. Nunna, Saavan Patel, Clayton L. Rosinski, Anisse N. Chaker, Jonathan G. Hobbs, Ankit I. Mehta
Tue Oct 20, 2020 13:47
Publication date: December 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 139Author(s): S. Ghadersohi, C.R. Francom, J.D. Prager
Tue Oct 20, 2020 13:43
Publication date: December 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 139Author(s): Beatriz Pallarés Martí, Natsuki Oishi, José Ramón Alba, Francisco Javier García Callejo, Enrique Zapater
Tue Oct 20, 2020 13:43
Publication date: December 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 139Author(s): Chanan Shaul, J.Thomas Roland, Jean-Yves Sichel, Riki Salem, Ronen Perez
Tue Oct 20, 2020 13:43
Publication date: December 2020Source: International Journal of Pediatric Otorhinolaryngology, Volume 139Author(s): Skylar Trott, Nicole Colgrove, Philip Westgate, Matthew Bush, Kenneth Iverson
Tue Oct 20, 2020 13:43
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (Covid-19), emerged in China in late 2019 from a zoonotic source. The majority of Covid-19 infections are either asymptomatic or result in only mild disease. However, in a substantial proportion of…
Thu Oct 08, 2020 03:00
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Ali Nili, Ehsan Zarei, Azin Ghamari, Ali Salehi Farid, Soheil Tavakolpour, Maryam Daneshpazhooh, Hamidreza Mahmoudi
Tue Oct 20, 2020 13:36
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Zhenyu Xie, Xin Li, Yu Lun, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Shijie Xin, Jian Zhang
Tue Oct 20, 2020 13:36
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Hao Zeng, Meng Luo, Linyan Chen, Xinyu Ma, Xuelei Ma
Tue Oct 20, 2020 13:36
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Wenyan Gao, Xiaodan Sun, Danni Li, Lin Sun, Yang He, Huanping Wei, Feng Jin, Yaming Cao
Tue Oct 20, 2020 13:36
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Shan He, Jinhua Xu, Jinfeng Wu
Tue Oct 20, 2020 13:36
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Shifu Mo, Liyun Gu, Wei Xu, Jia Liu, Dong Ding, Zhichao Wang, Jie Yang, Lingdong Kong, Yong Zhao
Tue Oct 20, 2020 13:36
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Jifei Miao, Peng Ye, Jiao Lan, Sen Ye, Jun Zhong, Austin Gresham, Siyan Li, Aijia You, Xianjie Chen, Xiaoyi Liu, Hui Li
Tue Oct 20, 2020 13:36
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Kun Gao, Dong-Mei Xu, Xiao-Rong Lin, Xiao-Zhen Zhu, Hui-Lin Zhang, Man-Li Tong
Tue Oct 20, 2020 13:36
Publication date: December 2020Source: International Immunopharmacology, Volume 89, Part BAuthor(s): Chenxi Zhang, Zhenxuan Shao, Xiaofen Hu, Zhengtai Chen, Baolong Li, Renhao Jiang, Najeeb Bsoul, Jiaoxiang Chen, Cong Xu, Weiyang Gao
Tue Oct 20, 2020 13:36
Mutation-Independent Therapies for Retinal Diseases: Focus on Gene-Based Approaches. Front Neurosci. 2020;14:588234 Authors: Carrella S, Indrieri A, Franco B, Banfi S Abstract Gene therapy is proving to be an effective approach to treat or prevent ocular diseases ensuring a targeted, stable, and regulated introduction of exogenous genetic material with therapeutic action. Retinal diseases can be broadly categorized into two groups, namely monogenic...
Tue Oct 20, 2020 13:30
Oxytocin Promotes Accurate Fear Discrimination and Adaptive Defensive Behaviors. Front Neurosci. 2020;14:583878 Authors: Olivera-Pasilio V, Dabrowska J Abstract The nonapeptide, oxytocin (OT), known for its role in social bonding and attachment formation, has demonstrated anxiolytic properties in animal models and human studies. However, its role in the regulation of fear responses appears more complex, brain site-specific, sex-specific, and...
Tue Oct 20, 2020 13:30
The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary Symptoms of Alzheimer's Disease. Front Neurosci. 2020;14:583097 Authors: Kim S, Nam Y, Shin SJ, Park YH, Jeon SG, Kim JI, Kim MJ, Moon M Abstract Although the major causative factors of Alzheimer's disease (AD) are the accumulation of amyloid β and hyperphosphorylated tau, AD can also be caused by metabolic dysfunction. The major clinical symptom of AD is cognitive dysfunction....
Tue Oct 20, 2020 13:30
Oxytocin Elicits Itch Scratching Behavior via Spinal GRP/GRPR System. Front Neurosci. 2020;14:581977 Authors: Guo J, Ba X, Matsuda M, Wei P, Jiang C, Sun W, Xiao L, Xiong D, Liao X, Hao Y Abstract Oxytocin (OT), a neuropeptide involved in the regulation of complex social and sexual behavior in mammals, has been proposed as a treatment for a number of psychiatric disorders including pain. It has been well documented that central administration...
Tue Oct 20, 2020 13:30
Gene Therapy for Neurodegenerative Diseases: Slowing Down the Ticking Clock. Front Neurosci. 2020;14:580179 Authors: Martier R, Konstantinova P Abstract Gene therapy is an emerging and powerful therapeutic tool to deliver functional genetic material to cells in order to correct a defective gene. During the past decades, several studies have demonstrated the potential of AAV-based gene therapies for the treatment of neurodegenerative diseases....
Tue Oct 20, 2020 13:30
A Semiquantitative Non-invasive Measurement of PcomA Patency in C57BL/6 Mice Explains Variance in Ischemic Brain Damage in Filament MCAo. Front Neurosci. 2020;14:576741 Authors: Knauss S, Albrecht C, Dirnagl U, Mueller S, Harms C, Hoffmann CJ, Koch SP, Endres M, Boehm-Sturm P Abstract Numerous studies on experimental ischemic stroke use the filament middle cerebral artery occlusion (fMCAo) model in C57BL/6 mice, but lesion sizes in this strain...
Tue Oct 20, 2020 13:30
Oxytocin Receptor Signaling in Vascular Function and Stroke. Front Neurosci. 2020;14:574499 Authors: McKay EC, Counts SE Abstract The oxytocin receptor (OXTR) is a G protein-coupled receptor with a diverse repertoire of intracellular signaling pathways, which are activated in response to binding oxytocin (OXT) and a similar nonapeptide, vasopressin. This review summarizes the cell and molecular biology of the OXTR and its downstream signaling...
Tue Oct 20, 2020 13:30
Evidence of Progenitor Cell Lineage Rerouting in the Adult Mouse Hippocampus After Status Epilepticus. Front Neurosci. 2020;14:571315 Authors: Moura DMS, Brandão JA, Lentini C, Heinrich C, Queiroz CM, Costa MR Abstract Cell lineage in the adult hippocampus comprises multipotent and neuron-committed progenitors. In the present work, we fate-mapped neuronal progenitors using Dcx-CreERT2 and CAG-CAT-EGFP double-transgenic mice (cDCX/EGFP). We...
Tue Oct 20, 2020 13:30
Neuromorphic Computing Using NAND Flash Memory Architecture With Pulse Width Modulation Scheme. Front Neurosci. 2020;14:571292 Authors: Lee ST, Lee JH Abstract A novel operation scheme is proposed for high-density and highly robust neuromorphic computing based on NAND flash memory architecture. Analog input is represented with time-encoded input pulse by pulse width modulation (PWM) circuit, and 4-bit synaptic weight is represented with adjustable...
Tue Oct 20, 2020 13:30
Altered Cerebellar-Cerebral Circuits in Patients With Type 2 Diabetes Mellitus. Front Neurosci. 2020;14:571210 Authors: Zhang D, Qi F, Gao J, Yan X, Wang Y, Tang M, Zhe X, Cheng M, Wang M, Xie Q, Su Y, Zhang X Abstract The role of the cerebellum in type 2 diabetes mellitus (T2DM) has been receiving increased attention. However, the functional connectivity (FC) between the cerebellar subregions and the cerebral cortex has not been investigated...
Tue Oct 20, 2020 13:30
Aberrant White Matter Microstructure as a Potential Diagnostic Marker in Alzheimer's Disease by Automated Fiber Quantification. Front Neurosci. 2020;14:570123 Authors: Chen H, Sheng X, Qin R, Luo C, Li M, Liu R, Zhang B, Xu Y, Zhao H, Bai F Abstract Neuroimaging evidence has suggested white matter microstructure are heavily affected in Alzheimer's disease (AD). However, whether white matter dysfunction is localized at the specific regions of...
Tue Oct 20, 2020 13:30
Snowball ICA: A Model Order Free Independent Component Analysis Strategy for Functional Magnetic Resonance Imaging Data. Front Neurosci. 2020;14:569657 Authors: Hu G, Waters AB, Aslan S, Frederick B, Cong F, Nickerson LD Abstract In independent component analysis (ICA), the selection of model order (i.e., number of components to be extracted) has crucial effects on functional magnetic resonance imaging (fMRI) brain network analysis. Model order...
Tue Oct 20, 2020 13:30
Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals. Front Neurosci. 2020;14:568930 Authors: Diotel N, Lübke L, Strähle U, Rastegar S Abstract In contrast to mammals, the adult zebrafish brain shows neurogenic activity in a multitude of niches present in almost all brain subdivisions. Irrespectively, constitutive neurogenesis in the adult zebrafish and mouse telencephalon share many...
Tue Oct 20, 2020 13:30
Amyotrophic Lateral Sclerosis: A Neurodegenerative Motor Neuron Disease With Ocular Involvement. Front Neurosci. 2020;14:566858 Authors: Rojas P, Ramírez AI, Fernández-Albarral JA, López-Cuenca I, Salobrar-García E, Cadena M, Elvira-Hurtado L, Salazar JJ, de Hoz R, Ramírez JM Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes degeneration of the lower and upper motor neurons and is the most prevalent motor...
Tue Oct 20, 2020 13:30
Heart Rate Variability in the Perinatal Period: A Critical and Conceptual Review. Front Neurosci. 2020;14:561186 Authors: Chiera M, Cerritelli F, Casini A, Barsotti N, Boschiero D, Cavigioli F, Corti CG, Manzotti A Abstract Neonatal intensive care units (NICUs) greatly expand the use of technology. There is a need to accurately diagnose discomfort, pain, and complications, such as sepsis, mainly before they occur. While specific treatments...
Tue Oct 20, 2020 13:30
Neural Transplants From Human Induced Pluripotent Stem Cells Rescue the Pathology and Behavioral Defects in a Rodent Model of Huntington's Disease. Front Neurosci. 2020;14:558204 Authors: Yoon Y, Kim HS, Hong CP, Li E, Jeon I, Park HJ, Lee N, Pei Z, Song J Abstract Huntington's disease (HD) is a devastating, autosomal-dominant inheritance disorder with the progressive loss of medium spiny neurons (MSNs) and corticostriatal connections in the...
Tue Oct 20, 2020 13:30
Blocking Opioid Receptors in a Songbird Cortical Region Modulates the Acoustic Features and Levels of Female-Directed Singing. Front Neurosci. 2020;14:554094 Authors: Kumar S, Mohapatra AN, Pundir AS, Kumari M, Din U, Sharma S, Datta A, Arora V, Iyengar S Abstract The organization of the anterior forebrain pathway (AFP) of songbirds important for context-dependent singing is similar to that of cortical basal ganglia loops (CBG) in mammals,...
Tue Oct 20, 2020 13:30
Low-Temperature Atomic Layer Deposited Oxide on Titanium Nitride Electrodes Enables Culture and Physiological Recording of Electrogenic Cells. Front Neurosci. 2020;14:552876 Authors: Dollt M, Reh M, Metzger M, Heusel G, Kriebel M, Bucher V, Zeck G Abstract The performance of electrode arrays insulated by low-temperature atomic layer deposited (ALD) titanium dioxide (TiO2) or hafnium dioxide (HfO2) for culture of electrogenic cells and for recording...
Tue Oct 20, 2020 13:30
Subjectivity as an Emergent Property of Information Processing by Neuronal Networks. Front Neurosci. 2020;14:548071 Authors: Fesce R Abstract Here, we examine subjectivity and consciousness as emergent properties of the computational complexity of information processing by the brain, rather than metaphysical phenomena. While Psychology concentrates on the emergent properties and Neurobiology examines the properties of the biological substrate,...
Tue Oct 20, 2020 13:30
Generation of Common Marmoset Model Lines of Spinocerebellar Ataxia Type 3. Front Neurosci. 2020;14:548002 Authors: Tomioka I, Nagai Y, Seki K Abstract Animal models are indispensable tools in the development of innovative treatments for rare and incurable diseases. To date, there is almost no effective treatment for neurodegenerative diseases, and animal models that properly simulate human disease pathologies are eagerly anticipated to identify...
Tue Oct 20, 2020 13:30
Instantaneous Cardiac Baroreflex Sensitivity: xBRS Method Quantifies Heart Rate Blood Pressure Variability Ratio at Rest and During Slow Breathing. Front Neurosci. 2020;14:547433 Authors: Wessel N, Gapelyuk A, Weiß J, Schmidt M, Kraemer JF, Berg K, Malberg H, Stepan H, Kurths J Abstract Spontaneous baroreflex sensitivity (BRS) is a widely used tool for the quantification of the cardiovascular regulation. Numerous groups use the xBRS method,...
Tue Oct 20, 2020 13:30
Electrophysiological Dynamics of Visual-Tactile Temporal Order Perception in Early Deaf Adults. Front Neurosci. 2020;14:544472 Authors: Scurry AN, Chifamba K, Jiang F Abstract Studies of compensatory plasticity in early deaf (ED) individuals have mainly focused on unisensory processing, and on spatial rather than temporal coding. However, precise discrimination of the temporal relationship between stimuli is imperative for successful perception...
Tue Oct 20, 2020 13:30
The Functional Tactile Object Recognition Test: A Unidimensional Measure With Excellent Internal Consistency for Haptic Sensing of Real Objects After Stroke. Front Neurosci. 2020;14:542590 Authors: Carey LM, Mak-Yuen YYK, Matyas TA Abstract Introduction: Our hands, with their exquisite sensors, work in concert with our sensing brain to extract sensory attributes of objects as we engage in daily activities. One in two people with stroke experience...
Tue Oct 20, 2020 13:30
Molecular Imaging of Striatal Dopaminergic Neuronal Loss and the Neurovascular Unit in Parkinson Disease. Front Neurosci. 2020;14:528809 Authors: Ivanidze J, Skafida M, Pandya S, Patel D, Osborne JR, Raj A, Gupta A, Henchcliffe C, Dyke JP Abstract Parkinson disease (PD) is the second most common neurodegenerative disorder, characterized by loss of nigrostriatal dopaminergic neurons. Impairment of the neurovascular unit (NVU) has been hypothesized...
Tue Oct 20, 2020 13:30
Dynamic Neural Network Changes Revealed by Voxel-Based Functional Connectivity Strength in Left Basal Ganglia Ischemic Stroke. Front Neurosci. 2020;14:526645 Authors: Li QG, Zhao C, Shan Y, Yin YY, Rong DD, Zhang M, Ma QF, Lu J Abstract Objective: This study intends to track whole-brain functional connectivity strength (FCS) changes and the lateralization index (LI) in left basal ganglia (BG) ischemic stroke patients. Methods: Twenty-five...
Tue Oct 20, 2020 13:30
Identification of a Novel CCM1 Frameshift Mutation in a Chinese Han Family With Multiple Cerebral Cavernous Malformations. Front Neurosci. 2020;14:525986 Authors: Zhang F, Xue Y, Zhang F, Wei X, Zhou Z, Ma Z, Wang X, Shen H, Li Y, Cui X, Liu L Abstract Cerebral cavernous malformations (CCMs) are vascular lesions that predominantly occur in the brain. CCMs can be sporadic or hereditary in an autosomal dominant manner. The genes harboring variants...
Tue Oct 20, 2020 13:30
Local Sleep and Alzheimer's Disease Pathophysiology. Front Neurosci. 2020;14:525970 Authors: Mander BA Abstract Even prior to the onset of the prodromal stages of Alzheimer's disease (AD), a constellation of sleep disturbances are apparent. A series of epidemiological studies indicate that multiple forms of these sleep disturbances are associated with increased risk for developing mild cognitive impairment (MCI) and AD, even triggering disease...
Tue Oct 20, 2020 13:30
Knockdown of SNHG14 Alleviates MPP+-Induced Injury in the Cell Model of Parkinson's Disease by Targeting the miR-214-3p/KLF4 Axis. Front Neurosci. 2020;14:930 Authors: Zhou S, Zhang D, Guo J, Zhang J, Chen Y Abstract Background: Parkinson's disease (PD) is the second most common neurodegenerative disease. Long non-coding RNA (lncRNA) small nucleolar RNA host gene 14 (SNHG14) has been demonstrated as an important regulator in PD pathology. However,...
Tue Oct 20, 2020 13:30
Penetrating Ballistic-Like Brain Injury Leads to MicroRNA Dysregulation, BACE1 Upregulation, and Amyloid Precursor Protein Loss in Lesioned Rat Brain Tissues. Front Neurosci. 2020;14:915 Authors: Thangavelu B, Wilfred BS, Johnson D, Gilsdorf JS, Shear DA, Boutté AM Abstract Severe traumatic brain injury (TBI) is a risk factor for neurodegenerative diseases. Yet, the molecular events involving dysregulated miRNAs that may be associated with...
Tue Oct 20, 2020 13:30
Imaging the Neuroimmune Dynamics Across Space and Time. Front Neurosci. 2020;14:903 Authors: Carrier M, Robert MÈ, González Ibáñez F, Desjardins M, Tremblay MÈ Abstract The immune system is essential for maintaining homeostasis, as well as promoting growth and healing throughout the brain and body. Considering that immune cells respond rapidly to changes in their microenvironment, they are very difficult to study without affecting their structure...
Tue Oct 20, 2020 13:30
Neural Representation Enhanced for Speech and Reduced for Background Noise With a Hearing Aid Noise Reduction Scheme During a Selective Attention Task. Front Neurosci. 2020;14:846 Authors: Alickovic E, Lunner T, Wendt D, Fiedler L, Hietkamp R, Ng EHN, Graversen C Abstract Objectives: Selectively attending to a target talker while ignoring multiple interferers (competing talkers and background noise) is more difficult for hearing-impaired (HI)...
Tue Oct 20, 2020 13:30
Lipoxin A4 Inhibits NLRP3 Inflammasome Activation in Rats With Non-compressive Disc Herniation Through the JNK1/Beclin-1/PI3KC3 Pathway. Front Neurosci. 2020;14:799 Authors: Jin J, Xie Y, Shi C, Ma J, Wang Y, Qiao L, Li K, Sun T Abstract Background: Non-compressive disc herniation is induced by an inflammatory response from the nucleus pulposus tissue and nerve roots. Lipoxins (LXs) are important endogenous anti-inflammatory mediators in the...
Tue Oct 20, 2020 13:30
Quantitative Profiling of Oxylipins in Acute Experimental Intracerebral Hemorrhage. Front Neurosci. 2020;14:777 Authors: Yuan JJ, Chen Q, Xiong XY, Zhang Q, Xie Q, Huang JC, Yang GQ, Gong CX, Qiu ZM, Sang HF, Zi WJ, He Q, Xu R, Yang QW Abstract Oxylipins are a series of bioactive lipid metabolites derived from polyunsaturated fatty acids that are involved in cerebral homeostasis and the development of intracerebral hemorrhage (ICH). However,...
Tue Oct 20, 2020 13:30
Identification and Classification of Alzheimer's Disease Patients Using Novel Fractional Motion Model. Front Neurosci. 2020;14:767 Authors: Du L, Xu B, Zhao Z, Han X, Gao W, Shi S, Liu X, Chen Y, Wang Y, Sun S, Zhang L, Gao J, Ma G Abstract Most diffusion magnetic resonance imaging (dMRI) techniques use the mono-exponential model to describe the diffusion process of water in the brain. However, the observed dMRI signal decay curve deviates...
Tue Oct 20, 2020 13:30
Gender-Specific Risk Factors and Comorbidities of Bothersome Tinnitus. Front Neurosci. 2020;14:706 Authors: Basso L, Boecking B, Brueggemann P, Pedersen NL, Canlon B, Cederroth CR, Mazurek B Abstract Objective: This study aims to identify gender-specific risk factors associated with the presence of bothersome tinnitus (compared with non-bothersome tinnitus), including sociodemographic and lifestyle factors, tinnitus-associated phenomena (hearing...
Tue Oct 20, 2020 13:30
55 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "J Clin Neurosci"[jour] These pubmed results were generated on 2020/10/20PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Tue Oct 20, 2020 13:19
Publication date: Available online 19 October 2020Source: TalantaAuthor(s): H.B. Zengin, R. Gürkan
Tue Oct 20, 2020 13:13
Publication date: Available online 19 October 2020Source: TalantaAuthor(s): Ningning Zhao, Tiantian Zhao, Meiling Fan, Zhiqiang Liu, Zifeng Pi, Fengrui Song, Junpeng Xing, Shu Liu
Tue Oct 20, 2020 13:13
Publication date: Available online 19 October 2020Source: TalantaAuthor(s): Shi-En Chen, Jingwen Hu, Ping Yan, Jing Sun, Wenhui Jia, Shuyun Zhu, Xian-En Zhao, Huwei Liu
Tue Oct 20, 2020 13:13
Abstract Hamilton’s theory of local mate competition (LMC) describes how competition between male relatives for mating opportunities favours a female‐biased parental investment. LMC theory has been extended in many ways to explore a range of genetic and life‐history influences on sex allocation strategies, including showing that increasing genetic homogeneity within mating groups should favour greater female bias. However, there has been no quantitative theoretical prediction as to how females should...
Tue Oct 20, 2020 11:22
Abstract Sleep disturbance is a common symptom encountered by cannabis‐dependent individuals abstaining from cannabis use. In the present study, we investigated the effect of daily aerobic cycling exercise versus control stretching on sleep quality during inpatient cannabis withdrawal in treatment‐seeking dependent cannabis users. The protocol incorporated three consecutive phases: a 4‐Day (4‐Night) (at‐home) ‘Baseline’ phase, a 6‐Day (5‐Night) ‘Treatment’ phase (within a 7‐Day inpatient hospital...
Mon Oct 19, 2020 15:40
Abstract Scedosporium apiospermum (also known as Pseudallescheria boydii) is a ubiquitous filamentous fungus. This fungus is known as a cause of mycetoma, which may occur in a normal immune host following trauma and nonmycetoma‐localized skin infections without grain production which are much rarer. However, in an immunocompromised host, S. apiospermum may cause a life‐threatening infection. We describe a case of S. apiospermum infection of the left middle finger in an immunocompetent patient, which...
Mon Oct 19, 2020 17:46
Abstract Background Quality control in cytology must be established through reliable and easily measurable indicators. Methods From the Catalan Society of Cytopathology a group of experts has been established to write a document with 13 indicators that cover the entire cytological process, based on its Cytopathology Quality Guide. It has been elaborated through guides and documents with scientific evidence and DELPHI methodology in order to reach a structured consensus on the opinions of...
Mon Oct 19, 2020 17:44
Rotavirus remains the main causative agent of gastroenteritis in young children in countries that have not yet introduced the vaccine. In Benin, rotavirus vaccine was introduced late December 2019 into the EPI...
Mon Oct 19, 2020 03:00
Prediction models assist health-care providers in making patient care decisions. This study aimed to externally validate the REduction of Atherothrombosis for Continued Health (REACH) prediction model for recu...
Mon Oct 19, 2020 03:00
Abstract Background The molecular drivers of human papillomavirus‐related head and neck squamous cell carcinoma (HPV + HNSCC) are not entirely understood. This study evaluated the relationship between HPV integration, expression of E6/E7, and patient outcomes in p16+ HNSCCs. Methods HPV type was determined by HPV PCR‐MassArray, and integration was called using detection of integrated papillomavirus sequences polymerase chain reaction (PCR). We investigated whether fusion transcripts were...
Mon Oct 19, 2020 11:42
The cover image is based on the Original Article Versatile design of compound vastus lateralis muscle and anterolateral thigh musculocutaneous perforator free flaps for customized reconstruction of complex skin and soft tissue defects in the extremities by Jiqiang He et al., https://doi.org/10.1002/micr.30644
Mon Oct 19, 2020 14:19
The cover image is based on the Original Article Experience on primary closure of fibular flap donor sites and development of an algorithm for closure based on different flap designs by Kuan‐Ming Feng et al., https://doi.org/10.1002/micr.30621.
Mon Oct 19, 2020 14:19
Abstract Myocardial bridges are anatomical entities characterized by myocardium covering segments of coronary arteries. In some patients, the presence of a myocardial bridge is benign and is only incidentally found on autopsy. In other patients, however, myocardial bridges can lead to compression of the coronary artery during systolic contraction and delayed diastolic relaxation, resulting in myocardial ischemia. This ischemia in turn can lead to myocardial infarction, ventricular arrhythmias and...
Mon Oct 19, 2020 20:34
Abstract Osteosarcoma (OS) is the most common primary bone malignancy with high rates of recurrence and metastasis. OS often spreads to lungs, an optimized model for studying lung metastatic OS cells may help develop potential therapies for patients with lung metastasis. Here we firstly report an organoid culture system for lung metastatic OS tissues. We provided a fully described formula that was required for establishing lung metastatic OS organoids (OSOs). Using this protocol,...
Tue Oct 20, 2020 03:00
Background: Vascular endothelial growth factor (VEGF) is a subfamily of growth factors involved in angiogenesis; CD34+ cells are normally found in endothelial progenitor cells and endothelial cells of blood vessels. Colonic adenomatous polyps may not always be completely removable endoscopically, and a preoperative diagnosis might still be necessary. The aim of the study was to evaluate whether VEGF-A, VEGF-C and CD34 mRNA expression along colorectal carcinogenesis steps can implement NICE (Narrow-Band...
Tue Oct 20, 2020 08:45
Future Oncology, Ahead of Print.
Mon Oct 19, 2020 11:35
Future Oncology, Ahead of Print.
Mon Oct 19, 2020 05:23
Abstract Background Management of children with disorders of cerebrospinal fluid (CSF) circulation is a common aspect of paediatric neurosurgical practice. Sport and physical activity play an integral role in the lives of patients in this age group. However, there is little evidence to support the dissemination of appropriate advice to children regarding such activities. The aim of this study was to evaluate the perspectives of...
Tue Oct 20, 2020 09:49
Abstract Purpose Elbow flexion is a key indicator of functional recovery in obstetric brachial plexus palsy (OBPP). However, lack of flexion could be a result of an entrapped musculocutaneous nerve during the healing period. The purpose of this study was to investigate the possible compression of the musculocutaneous nerve and outcomes of decompression. Methods...
Tue Oct 20, 2020 09:49
Abstract Rosette-forming glioneuronal tumor (RGNT) is a rare tumor entity which has been reported mainly occurring in the fourth ventricle. It has been described as a benign lesion with limited extension into surrounding structures, including the cerebellar vermis, midbrain, and cerebral aqueduct. More recently, few cases involving also other midline structures have been documented as well. Here, we report about diagnosis and treatment of RGNT in the septum pellucidum in a pediatric...
Tue Oct 20, 2020 09:49
Abstract Background Torcular dural sinus malformations (tDSMs) are congenital complex vascular anomalies often referred as a single unit. Nevertheless, they possess distinct anatomical features, clinical diversity, and markedly different outcomes. Objective On the basis of our institutional experience and analysis of published data, we...
Tue Oct 20, 2020 09:49
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo assess the strabismus prevalence and associated factors among children aged ≤15 years.MethodsThis hospital-based cross-sectional study was conducted from March 2017 to October 2017 in the Department of Ophthalmology & Optometry, Hawassa University Comprehensive Specialized Hospital. Interviewer-administered questionnaires were used to collect relevant data and clinical examinations were performed for patient...
Tue Oct 20, 2020 09:41
Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo assess the influence of pressure recovery (PR)-corrected haemodynamic parameters on outcome in patients with aortic stenosis.MethodsAortic stenosis severity parameters were corrected for PR (increase in static pressure due to decreasing dynamic pressure), assessed using transthoracic echocardiography (TTE) or cardiac magnetic resonance imaging (CMR), in patients with aortic stenosis. PR, indexed PR (iPR) and...
Tue Oct 20, 2020 09:41
Robotic rehabilitation of stroke survivors with upper extremity dysfunction may yield different outcomes depending on the robot type. Considering that excessive dependence on assistive force by robotic actuato...
Mon Oct 19, 2020 03:00
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