While cancer is often related to hyperfibrinogenemia, it is rarely related to hypofibrinogenemia. Specifically, gastric cancer concomitant with unprovoked hypofibrinogenemia and the corresponding treatment approach have been rarely reported. We presented a case of gastric cancer in a 78-year-old Chinese woman in whom sudden, unprovoked refractory hypofibrinogenemia had been found during the whole brain radiotherapy despite stable clinical condition. Fibrinogen supplementation was not useful for controlling...
BackgroundLiver cancer is a frequent malignancy with poor prognosis and high mortality all over the world. It has been reported many lncRNAs could modulate the tumorigenesis of liver cancer. To identify novel potential targets for liver cancer, the differential expressed lncRNAs between liver cancer and adjacent normal tissues was analyzed with bioinformatics tool.MethodsThe differential expressed lncRNAs between liver cancer and adjacent normal tissues were analyzed with bioinformatics tool. Cell...
Background: Existing research shows that p-coumaric acid (p-CA) can inhibit the proliferation of a variety of tumor cells in vitro. However, there are no reports on the anti-tumor effects of p-CA on melanoma cells. In this study, the inhibitory effects of p-CA on mouse melanoma B16 and human melanoma A375 cells are reported, and the related mechanisms are investigated.Methods: CCK-8 assay was used to detect the effects of p-CA on cell vitality, colony formation assay was used to observe the effects...
Partial hepatectomy (PH) is the main treatment for early-stage hepatocellular carcinoma (HCC). Yet, a significant number of patients undergo recursion of the disease that could be linked to the fate of innate immune cells during the liver regeneration process. In this study, using a murine model, we investigated the impact of PH on HCC development by bioluminescence imaging and flow cytometry. While non-resected mice were able to control and reject orthotopic implanted Hepa1-6 hepatocarcinoma cells,...
Objective: To evaluate the importance of preoperative blood platelet to lymphocyte ratio (PLR) in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after liver surgery and to examine the connection with CD8+ lymph cell infiltration.Methods: Between 2009 and 2014, consecutive HCC patients who received curative liver surgery were included into this retrospective study. Baseline clinicopathological characteristics were analyzed to identify predictors of recurrence-free and...
PurposeThe tripartite motif-containing family member TRIM37 is involved in a number of important biological and pathological processes, and it has recently been shown to be an essential regulator of protein ubiquitination and a contributor to tumorigenesis. We previously showed that TRIM37 is overexpressed in and promotes the proliferation and invasion of pancreatic cancer (PC).MethodsSphere formation, flow cytometric, qRT-PCR, western blot, colony formation, EdU incorporation, mouse xenograft model,...
PurposeTo assess the performance of deep neural network (DNN) and machine learning based radiomics on 3D computed tomography (CT) and clinical characteristics to predict benign or malignant sacral tumors.Materials and methodsThis single-center retrospective analysis included 459 patients with pathologically proven sacral tumors. After semi-automatic segmentation, 1,316 hand-crafted radiomics features of each patient were extracted. All models were built on training set (321 patients) and tested on...
PurposeTo compare long-term outcomes of percutaneous radiofrequency ablation for colorectal liver metastases in perivascular versus non-perivascular locations.MethodsThis retrospective study included 388 consecutive patients with colorectal liver metastases (246 men, 142 women; age range 27–86 years) who underwent percutaneous radiofrequency ablation between January 2006 and December 2018. Propensity-score matching was performed for groups with perivascular and non-perivascular colorectal liver metastases....
Pediatric osteosarcoma outcomes have improved over the last decades; however, patients who do not achieve a full resection of the tumor, even after aggressive chemotherapy, have the worst prognosis. At a genetic level, osteosarcoma presents many alterations, but there is scarce information on alterations at metabolomic levels. Therefore, an untargeted nuclear magnetic resonance metabonomic approach was used to reveal blood serum alterations, when samples were taken from 21 patients with osteosarcoma...
Purpose/ObjectivesNode-positive breast cancer patients often receive chemotherapy and regional nodal irradiation. The cardiotoxic effects of these treatments, however, may offset some of the survival benefit. Cardiac magnetic resonance (CMR) is an emerging modality to assess cardiac injury. This is a pilot trial assessing cardiac damage using CMR in patients who received anthracycline-based chemotherapy and three-dimensional conformal radiotherapy (3DCRT) regional nodal irradiation using heart constraints.Materials...
Monocarboxylate transporter 1 (MCT1) participates in the transport of lactate to facilitate metabolic reprogramming during tumor progression. Tumor-associated macrophages (TAMs) are also involved in the inflammatory adaptation of the tumor microenvironment (TME). This study aimed to determine the correlation between metabolite changes and the polarization of macrophages in the TME. We demonstrated that the expression of CD163 on macrophages was significantly higher in breast cancer tissues than in...
This study aims to investigate the antitumor effect and the possible mechanism of a microecological preparation (JK5G) in mice. The mice treated with AOM/DSS were then randomly divided into the two model groups and the JK5G group, and the blank control group was included. Fecal samples were used for liquid chromatography–mass spectrometry and 16S rRNA gene sequencing analyses to reveal metabolic perturbations and gut flora disorders to demonstrate the effects of JK5G. Compared with the mice in the...
Gastric cancer (GC) is the third leading cause among all cancer deaths globally. Although the treatment outcome of GC has improved, the survival of patients with GC at stages III and IV remains unsatisfactory. Among several types of GC, scirrhous type GC (SGC) shows highly aggressive growth and invasive activity, leading to frequent peritoneal metastasis. SGC is well known to accompany abundant stromal cells that compose the tumor microenvironment (TME) along with the produced extracellular matrix...
BackgroundAutophagy, a highly conserved self-digesting process, has been deeply involved in the development and progression of oral squamous cell carcinoma (OSCC). However, the prognostic value of autophagy-related genes (ARGs) for OSCC still remains unclear. Our study set out to develop a multigene expression signature based on ARGs for individualized prognosis assessment in OSCC patients.MethodsBased on The Cancer Genome Atlas (TCGA) database, we identified prognosis-related ARGs through univariate...
Esophageal squamous cell cancer (ESCC) is a common malignancy with a poor 5-year overall survival in China. Altered DNA damage repair (DDR) pathways are associated with a predisposition to cancer and contribute to therapeutic response and resistance in cancers. However, alterations of DDR pathway genes in ESCC are still largely unknown. In this study, we employed genome sequencing data of 192 samples, comparative genomic hybridization data of 123 cases, and gene expression microarray data of 119...
Melanoma is the deadliest skin tumor and is prone to distant metastases. The incidence of melanoma has increased rapidly in the past few decades, and current trends indicate that this growth is continuing. This study was aimed to explore the molecular mechanisms of melanoma pathogenesis and discover underlying pathways and genes associated with melanoma. We used high-throughput expression data to study differential expression profiles of related genes in melanoma. The differentially expressed genes...
PurposeAlthough adjuvant chemoradiotherapy (CRT) used to be recommended as a standard of care for locally advanced gastric cancer, this suggestion has been strongly challenged recently. However, clear evidence regarding the optimization of radiotherapy is lacking. The purpose of this study was to compare the effectiveness of preoperative CRT versus that of postoperative CRT for resectable or potentially resectable gastric cancer.MethodsFrom January 2005 to December 2017, patients with clinical stage...
Background: Statin, a lipid-lowering drug, has been suggested to confer anticancer efficacy. However, previous studies evaluating the association between statin use and prognosis in breast cancer showed inconsistent results. A meta-analysis was performed to evaluate the association between statin use and clinical outcome in women with breast cancer.Methods: Cohort studies comparing recurrence or disease-specific mortality in women with breast cancer with and without using of statins were identified...
PurposeAlthough intensity-modulated radiotherapy (IMRT) is now a preferred option for conventionally fractionated RT in lung cancer, the commonly used cutoff values of the dosimetric constraints are still mainly derived from the data using three-dimensional conformal radiotherapy (3D-CRT). We aimed to compare the prediction performance among different dosimetric parameters for acute radiation pneumonitis (RP) in patients with lung cancer received IMRT.MethodsA total of 236 patients treated with IMRT...
Breast cancer patients with metastatic disease have a higher incidence of deaths from breast cancer than patients with early-stage cancers. Recent findings suggest that there are differences in immune cell function between metastatic and non-metastatic cases, even years before diagnosis. We have analyzed whole blood gene expression by Illumina bead chips in blood samples taken using the PAXgene blood collection system up to two years before diagnosis. The final study sample included 197 breast cancer...
BYSL, which encodes the human bystin protein, is a sensitive marker for astrocyte proliferation during brain damage and inflammation. Previous studies have revealed that BYSL has important roles in embryo implantation and prostate cancer infiltration. However, the role and mechanism of BYSL in glioblastoma (GBM) cell migration and invasion remain unknown. We found that knockdown of BYSL inhibited cell migration and invasion, downregulated the expression of mesenchymal markers (e.g., β-catenin and...
Background: REQUITE (validating pREdictive models and biomarkers of radiotherapy toxicity to reduce side effects and improve QUalITy of lifE in cancer survivors) is an international prospective cohort study. The purpose of this project was to analyse a cohort of patients recruited into REQUITE using a deep learning algorithm to identify patient-specific features associated with the development of toxicity, and test the approach by attempting to validate previously published genetic risk factors.Methods:...
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Abstract Background/ Objectives Phototherapy is used commonly in adult psoriasis; however, there is little data on its use in the paediatric population. We performed a systematic review and meta‐analysis on current available literature to review the safety and efficacy of NBUVB in paediatric psoriasis. Methods A systematic review and meta‐analysis according to PRISMA guidelines. Meta‐analysis of proportions was used to obtain efficacy, and meta‐regression was used to explore the impact...
Abstract The aim of the study is to evaluate the effectiveness of water as a substitute for sodium bicarbonate plus solution in the neutralisation process of chemical peeling using a 35% glycolic acid solution. This randomised, double‐blind, split‐face, controlled trial was conducted in an outpatient setting. A total of 126 healthy patients with skin phototypes IV–V aged between 18 and 60 years old were recruited. Chemical peeling was performed with 35% glycolic acid solution. One side of the face...
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Abstract Purpose To retrospectively analyze the off‐label prescriptions at a plastic surgery hospital in China and conduct a literature review. Methods The prescriptions in outpatient department from January 1, 2018 to December 31, 2018 were collected and compared with the related drug instructions in indications, dosage, frequency and route of administration to identify the off‐label prescriptions. According to related literatures, guidelines, and MICROMEDEX, the rationality of off‐label...
ABSTRACT Psoriasis is one of the leading dermatological diseases that can result in degradation in quality of life (QOL). We aimed to evaluate the effects of disease severity on QOL in psoriasis patients living in our region. 59 female and 41 male patients diagnosed with psoriasis were included in the study. The Psoriasis Area Severity Index (PASI) was used to determine disease severity. The Psoriasis Quality of Life Questionnaire (PQLQ) was used to evaluate QOL. The mean PASI score was 14.3±10.1....
ABSTRACT Data regarding the use of biologic therapies for psoriasis during pregnancy are scarce with even more limited knowledge about the long‐term safety of in utero exposure. We retrospectively evaluated nine pregnancies in six women with psoriasis who were exposed to biologic therapies between 2006 and 2019 in our psoriasis clinic, a tertiary referral center in Turkey. Pregnancy outcomes included the delivery of seven healthy babies without any complications, one elective abortion, and one ectopic...
ABSTRACT Tattoos have long become a part of human civilization. However, as the number of people who get tattoos increases, so is the number of people who wish to have their tattoos removed. Compared to other methods, laser‐based devices are associated with the best efficacy and least side effects in tattoo removal. Lack of understanding of the fundamental principles of laser and managing its parameters may result in suboptimal result and increased risk of side effects. Recognizing and mastering...
Abstract Introduction The rise in popularity and demand for non‐surgical injectable aesthetic procedures is inherently accompanied by an increase in reported complications, particularly those related to infection. Aseptic technique is under the control of aesthetic practitioners and can be modified to minimise the potential for cross‐contamination and infection. This should be a key consideration during all clinical procedures, particularly those involving breach of the skin's natural defences...
Abstract Vitiligo is a common and refractory disease worldwide. The limited efficiency and side effects of the conventional treatment options create demands towards the development of strategies. Excellent repigmentation is demonstrated after several filiform fire needle sessions in the vitiligo lesions. In this observational study, we aimed to observe the response to filiform fire needle therapy in patients with vitiligo, and determine whether there was a difference of efficiency with respect to...
Abstract Background Basal cell carcinoma (BCC) is the most common skin cancer in white skin individuals. The treatment of choice is surgical excision, but several other therapeutic choices are available and might also be efficient and cost‐effective in selected cases of low‐risk BCC or when surgery is complicate or contraindicated. The aim of the current study was to analyze the applied treatments for BCC in the real‐life practice of a tertiary hospital, and investigate factors associated to...
Abstract Background Although various factors were reported to be related to post‐herpetic neuralgia (PHN), studies based on adequate and comprehensive data were absent. Methods Data was extracted from cases of hospitalized patients with herpes zoster in dermatology department, Sichuan hospital of traditional Chinese medicine range from December, 2011 to February, 2018, and then cleaned to build prediction model with TREENET algorithms. Following evaluated the prediction model by ROC and...
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Publication date: Available online 17 October 2020Source: Gait & PostureAuthor(s): Evi Verbecque, Charlotte Johnson, Eugène Rameckers, Angelina Thijs, Ingrid van der Veer, Pieter Meyns, Bouwien Smits-Engelsman, Katrijn Klingels
Publication date: Available online 17 October 2020Source: Gait & PostureAuthor(s): Ronaldo Valdir Briani, Jordan Cannon, Marina Cabral Waiteman, Rúben de Faria Negrão Filho, Fernando Henrique Magalhães, Fábio Mícolis de Azevedo
Publication date: Available online 16 October 2020Source: Gait & PostureAuthor(s): Brian Horsak, Caterine Schwab, Fabien Leboeuf, Andreas Kranzl
Publication date: Available online 16 October 2020Source: Gait & PostureAuthor(s): Ronaldo V. Briani, Danilo de Oliveira Silva, Matheus H.M. Ducatti, Helder S. Lopes, Amanda S. Ferreira, Benjamin F. Mentiplay, Fábio M. de Azevedo, Christian J. Barton
Publication date: Available online 16 October 2020Source: Gait & PostureAuthor(s): Sutton B. Richmond, Tyler T. Whittier, Daniel S. Peterson, Brett W. Fling
Publication date: Available online 16 October 2020Source: Gait & PostureAuthor(s): Gerda Strutzenberger, Lisa Claußen, Maria Flecker, Hermann Schwameder
Publication date: Available online 16 October 2020Source: Gait & PostureAuthor(s): Apoorva M. Shankaranarayana, Sanjana Gururaj, Manikandan Natarajan, Chitra K. Balasubramanian, John M. Solomon
Publication date: Available online 16 October 2020Source: Gait & PostureAuthor(s): Justin Liu, Vincent Santucci, Steven Eicholtz, Trisha Kesar
Publication date: Available online 16 October 2020Source: Gait & PostureAuthor(s): Steven A. Garcia, Michael N. Vakula, Skylar C. Holmes, Derek N. Pamukoff
Publication date: Available online 15 October 2020Source: Gait & PostureAuthor(s): Evelyne Wiskerke, Margaretha van Dijk, Rhea Thuwis, Chesny Vandekerckhove, Charlotte Myny, Jan Kool, Eddy Dejaeger, Hilde Beyens, Geert Verheyden
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Publication date: Available online 17 October 2020Source: Archives of Oral BiologyAuthor(s): Sijing Yu, Hao Chen, Bo Gao
Publication date: Available online 16 October 2020Source: Archives of Oral BiologyAuthor(s): Rayssa Ferreira Zanatta, Taciana Marco Ferraz Caneppele, Tais Scaramucci, Regina El Dib, Lucianne Cople Maia, Daniele Masterson Tavares Pereira Ferreira, Alessandra Bühler Borges
Publication date: Available online 16 October 2020Source: Archives of Oral BiologyAuthor(s): Patrícia Daniela Melchiors Angst, Juliana Maier, Rafaela dos Santos Nogueira, Isabella Schönhofen Manso, Tamara Kerber Tedesco
Publication date: Available online 16 October 2020Source: Archives of Oral BiologyAuthor(s): Elizabeth Madla-Cruz, Myriam De la Garza-Ramos, César I. Romo-Saenz, Patricia Tamez-Guerra, Marco A. Garza-Navarro, Victor Urrutia-Baca, María A. Martínez-Rodríguez, Ricardo Gomez-Flores
Publication date: Available online 15 October 2020Source: Archives of Oral BiologyAuthor(s): Seul Ah Lee, Bo-Ram Park, Sung-Min Moon, Sang Hun Shin, Jae-Sung Kim, Do Kyung Kim, Chun Sung Kim
Publication date: Available online 15 October 2020Source: Archives of Oral BiologyAuthor(s): Hui-Min Liu, Yan Huang, Li Li, Yan Zhang, Xin Cong, Li-Ling Wu, Ruo-Lan Xiang
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Abstract The kidney controls body fluids, electrolyte and acid–base balance. Previously, we demonstrated that hyperpolarization-activated and cyclic nucleotide-gated (HCN) cation channels participate in ammonium excretion in the rat kidney. Since acid–base balance is closely linked to potassium metabolism, in the present work we aim to determine the effect of chronic metabolic acidosis (CMA) and hyperkalemia (HK) on protein abundance and localization of HCN3 in the rat kidney....
Abstract Renal ischemia–reperfusion (IR) injury is a common issue in urological surgery, and the renal tubules, particularly the proximal tubules, are extremely vulnerable to IR injury. In this work, we detected the differently expressed genes (DEGs) between normal rabbit kidneys and IR kidneys by RNA-sequencing, then identified that matrix metalloproteinase–7 (MMP7) played an important role in the progress of IR injury. Indeed, A time-dependent promotion of renal injury was detected...
Abstract Adipose-derived mesenchymal stem cell (ADSC) with a high capacity of chondrogenic differentiation was a promising candidate for cartilage defect treatment. This study’s objective is to study the roles of integrin β1 (ITGB1) in regulating ADSC chondrogenic differentiations as well as the underlying mechanisms. The identity of ADSC was confirmed by flow cytometry. ITGB1 gene was overexpressed in human ADSC (hADSC) by transfection with LV003-recombinant plasmids. Gene mRNA...
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Abstract BACKGROUND Spitz nevi are benign melanocytic neoplasms that typically present as rapidly growing solitary lesions on the head, neck, or lower extremities. Very rare reports have been described in African Americans. METHODS A single institution 29‐year retrospective review of African Americans patients diagnosed with Spitz nevi was thoroughly analyzed in order to characterize these rare clinical and histologic presentations. RESULTS Eleven African Americans with Spitzoid lesions...
Abstract Respiratory cysts are benign lesions lined by normal respiratory epithelium. There are few reported cases localized to the orbit, while those of the eyelid are exceedingly rare. Respiratory cysts usually arise either from a non‐hereditary congenital malformation, where they are distinguished as choristomatous, or from trauma. Here, we report a case of a 53‐year‐old man who presented with a large right lower eyelid cyst that was histopathologically diagnosed as a respiratory cyst. This...
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Abstract Background Antimicrobial therapy is recommended to eradicate Helicobacter (H.) pylori in infected individuals. As first‐line treatments are empiric, knowledge of antimicrobial resistance is key to successful eradication. Aims We investigated primary resistance in an eastern German region to derive recommendations for eradication treatment. Methods We used molecular genetic methods to examine Helicobacter rapid urease test (RUT) positive gastric specimens of 533 patients from...
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Publication date: Available online 16 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Jay Patel
Virtual ARCP assessment and trainee feedback meetings: facilitating the best experience and practice
Publication date: Available online 14 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Rachel S. Oeppen, Elizabeth Rutherford, Paul Sadler, Robert Isaac, Peter A. Brennan
Publication date: Available online 14 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S. Akram, N. Shah, S. Ahmad
Publication date: Available online 14 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Xiaona Lu, Antonio Jorge Forte, Fei Fan, Zhiyong Zhang, Li Teng, Bin Yang, Michael Alperovich, Derek M. Steinbacher, Nivaldo Alonso, John A. Persing
Publication date: Available online 14 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Akinori Moroi, Yuki Saito, Akihiro Takayama, Kunio Yoshizawa, Koichiro Ueki
Publication date: Available online 14 October 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Leandro Napier de Souza, Ana Cristina Rodrigues Antunes de Souza
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Abstract This study was conducted in order to compare the safety and efficacy of LLLT, 5% minoxidil, and combination therapy in the treatment of FPHL. A randomized controlled trial was developed to study the effect of LLLT on FPHL using a device called iHelmet®, which is equipped with 200 5mW laser diode source (650 nm) arrays. Ninety Ludwig’s types II–III FPHL patients were randomly divided into 3 groups: LLLT group (A), 5% minoxidil group (B), and combination group(C). Hair...
Abstract The evaluation of pigmented lesions on tattooed skin poses a diagnostic challenge for dermatologists, as a nevus may be partially or completely obscured by tattoo pigment. Because of incidences of melanoma arising from tattooed skin, the current gold standard is to biopsy these lesions. Reflectance confocal microscopy (RCM) is a noninvasive imaging modality used in the diagnosis and management of skin diseases that may allow for diagnosis, while preserving the tattoo...
Abstract Deep dyspareunia affects almost half of the women with endometriosis and is associated with vaginal endometriotic lesions. Our pilot study’s objective is to assess the feasibility and effectiveness of CO2-laser ablation under colposcopic guidance for the treatment of symptomatic vaginal endometriosis. A non-comparative pilot study has been performed. Only women with histologically proven vaginal endometriosis, who declared the presence of moderate or severe deep dyspareunia,...
Abstract Healing wounds represent a major public health problem, mainly when it is infected. Besides that, the antibiotics misuse and overuse favor the development of bacterial resistance. This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) combined with artificial skin on disinfection of infected skin wound in rats. Twenty-four Wistar rats were randomly distributed into 4 groups (n = 6): (i) control—untreated; (ii) aPDT—treated with curcumin-mediated...
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Several national breast implant registries, designed as Clinical Quality Registries (CQRs), have been founded over the past decade, including Australia, Netherlands, Denmark, Sweden, the United States, the United Kingdom and Italy (Table 1). This occurred in response to worldwide breast implant controversies,1-3 and is supported by the European New regulation on Medical devices.4 More recently, questions about breast implant safety have been raised in mainstream and social media related to Breast...
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Publication date: Available online 17 October 2020Source: CortexAuthor(s): Mar Martín-Signes, Cristina Cano-Melle, Ana B. Chica
Publication date: Available online 17 October 2020Source: CortexAuthor(s): John F. Magnotti, Kristen B. Dzeda, Kira Wegner-Clemens, Johannes Rennig, Michael S. Beauchamp
Publication date: Available online 17 October 2020Source: CortexAuthor(s): Frederic R. Danion, James Mathew, Niels Gouirand, Eli Brenner
Publication date: Available online 15 October 2020Source: CortexAuthor(s): Silvio Ionta, Marcello Costantini, Antonio Ferretti, Gaspare Galati, Gian Luca Romani, Salvatore M. Aglioti
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Abstract Background Severe Early Childhood Caries (S-ECC) is an aggressive form of tooth decay that often requires pediatric dental rehabilitative surgery. The Early Childhood Oral Health Impact Scale (ECOHIS) measures oral health-related quality of life (OHRQL). The purpose of this study was to determine whether there is an association between ECOHIS scores and surgery wait times for children undergoing dental treatment for S-ECC...
Abstract Background Poor oral hygiene and high hormone levels during pregnancy can lead to a deterioration in periodontal health. This study assessed the effectiveness of a family-centered behavioral and educational counselling program on improving the periodontal health of women during pregnancy and postpartum. Methods A randomized controlled...
Abstract Background The aim of this study was to assess the association between serum and salivary Immunoglobulin (Ig) Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) specific antibodies in healthy controls (HC) and periodontitis (PT) patients. Furthermore, the objectives were to determine whether PT influenced serum A. actinomycetemcomitans specific antibodies and whether serum or salivary antibodies against...
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Summary Background The Bullous‐Pemphigoid‐Disease‐Area‐Index (BPDAI) score has been proposed to provide an objective measure of bullous pemphigoid (BP) activity. Objective To calculate BPDAI cut‐off values defining mild, moderate and severe BP, and to assess the inter‐rater reliability, and the correlation with the number of daily new blisters, and anti‐BP180 and anti‐BP230 antibodies. Methods Severity scores were recorded by two blinded investigators. Anti‐BP180 and anti‐BP230 antibodies...
Abstract Weather and climate exist on a massive scale: over the last 650,000 years, only seven glacial cycles have occurred. The end of the last ice age 12,000 years ago marked the beginning of modern civilization – since then, an estimated 400 generations have passed. Yet it is only since the 1950s that greenhouse gas concentrations and global surface, atmospheric, and ocean temperatures have climbed to their highest levels in millennia, destabilizing climate systems and causing extreme weather...
Abstract Lifetime skin cancer prevalence is 25% higher among gay men and 46% higher among bisexual men compared to heterosexual men, making sexual minority men (SMM) an at‐risk group for skin cancer.1 These elevated skin cancer rates may be attributed in part to indoor tanning among SMM, some of whom are motivated to indoor tan by perceived body image standards, appearance concerns, and affect regulation.2
Abstract First, we would like to thank M. Gill and colleagues for their interest shown in our study.1,2 We agree on the importance to determine the place of reflectance confocal microscopy (RCM) as a diagnostic tool in real‐world clinical practice, which is why we originally initiated our study. We chose to include patients with clinically suspected primary basal cell carcinoma (BCC), in which dermatoscopic evaluation was usually performed as well, as part of daily clinical practice examination...
Abstract Patients who are being treated with Janus‐Kinase (JAK) inhibitors for hematologic conditions have a higher risk of developing non‐melanoma skin cancers (NMSC) with an aggressive course1,2. This has been attributed to relative immune‐suppression that can accompany the use of JAK inhibitors, from their effects on T‐cell signaling pathways3. Acquired inactivating mutations in JAK 1 and JAK 2 genes have been reported to lead to a loss of programmed death ligand‐1 (PD‐L1) expression and a lack...
Abstract Melanoma is more aggressive with poorer outcomes in older than younger patients. Older age has been associated with greater tumour thickness, higher rates of ulceration, and high mitotic rates,1,2 but it is not clear whether poorer outcomes in the elderly are solely due to these tumour‐specific features or to additional effects of age‐related decline in in immune surveillance, greater comorbidity, and age‐related behaviours such as delayed diagnosis.
Abstract In ‘Biopsy Outperforms Reflectance Confocal Microscopy in Diagnosing and Subtyping Basal Cell Carcinoma: Results and Experiences from a Randomized Controlled Multicentre Trial’, the authors found that reflectance confocal microscopy (RCM) identifies basal cell carcinoma (BCC) with 99% sensitivity and, impressively, distinguishes superficial BCCs from more aggressive BCCs with 88.9% sensitivity compared to punch biopsy (PB) at 91%,1 a difference without statistical significance.
Abstract Alkyl glucosides (AG), of which decyl glucoside (DG) and lauryl glucoside (LG) are those most commonly implicated in causing allergic contact dermatitis (ACD), are surfactants increasingly used in a wide range of products, including cosmetics, sunscreens and foam wound dressings.1 DG is also a stabiliser in the UV light filter methylene bis‐benzotriazolyl tetramethylbutylphenol (Tinosorb® M) and is occasionally an undeclared constituent.2
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Abstract Purpose Insulinomas are pancreatic endocrine tumors characterized by hypoglycemia resulting from hypersecretion of insulin. The long-term impact of surgical treatment of insulinomas, particularly the risk of glucose metabolism disorders, remains largely unknown. Methods We retrospectively evaluated all patients with insulinoma submitted to...
Abstract Backgrounds Sex differences in depressive disorder (DD) and subclinical hypothyroidism (SCH) have been well recognized. However, few studies focus on the sex differences in DD patients with SCH. The purpose of this study is to address the sex differences in DD inpatients with SCH and further investigate the clinical characteristics and associations between DD and SCH among female and male depressed inpatients. ...
Abstract Purpose Replicating the physiological cortisol secretion is key in the treatment of glucocorticoid insufficient individuals and optimization may enhance quality of life. The study investigates fatigue measured by ecological momentary assessments in patients treated with conventional hydrocortisone compared with once-daily dual-release hydrocortisone (Plenadren). ...
Abstract Background Overweight and obesity are increasingly spread in our society. Low testosterone levels are often present in these patients, the so-called metabolic hypogonadism, that further alters the metabolic balance in a sort of vicious cycle. Very low-calorie ketogenic diet (VLCKD) has been reported to efficiently reduce body weight, glycaemia, and the serum levels of insulin, glycated hemoglobin, but its effects on β-cell...
Abstract Purpose To verify the prevalence of autoimmune thyroiditis (AIT) and the ultrasound characteristics (composition and volume) of thyroid nodules with respect to the area of residence in the province of Messina, some areas having environmental issues. Methods Fine-needle aspiration-interrogated nodules (n = 902) of 809 patients were evaluated...
Abstract Purpose Primary hyperparathyroidism (PHPT) is associated with increased risk of cardiovascular morbidity and mortality. We aim to determine whether parathyroidectomy (PTX) can change cardiometabolic risk factors including serum lipids, glycemic parameters, systolic and diastolic blood pressure, C reactive protein (CRP), and body mass index (BMI). Methods ...
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Exp Clin Endocrinol DiabetesDOI: 10.1055/a-1257-0774 Objective Glypican4 is an interesting new adipokine, which seems to play an important role in developmental processes and is potentially associated with metabolic changes in obesity and type 2 diabetes mellitus. Currently, only a few studies examined glypican4 in human blood, mainly in adults. Design, Patients and Measurements...
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Abstract Bariatric surgery is the most effective and durable means of treating obesity and its comorbidities. Women make up 80% of those receiving weight loss surgery and they experience improvements in fertility. Unfortunately, bariatric surgery in the context of pregnancy is associated with complications including growth‐restriction and small‐for‐gestational age offspring (SGA). SGA offspring have a greater risk for obesity in adulthood, but the mechanism for this SGA‐induced obesity is unknown....
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Abstract Introduction The causal relationship between obesity and high blood pressure is established; however, the detailed pathways for such association are still under research. This work aims to assess the changes in neprilysin, vasoconstrictor, and vasodilatory molecules in obese hypertensive patients undergoing laparoscopic sleeve gastrectomy (LSG). Patients The present prospective study was done on 59 hypertensive obese patients in whom LGS was performed. Blood pressure, as well as...
Abstract Context Studies find surgery superior to medications in treatment of primary aldosteronism (PA). It would be ideal to compare surgical and medical therapy in patients with unilateral PA only, who have the option between these treatment modalities. However, this is challenging as most patients with unilateral PA on adrenal vein sampling (AVS) undergo surgery. Objective To compare outcomes of surgery and medications in patients with confirmed or likely unilateral PA. Design...
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Rejuvenation Research, Volume 23, Issue 5, Page 434-438, October 2020.
Rejuvenation Research, Volume 23, Issue 5, Page 439-445, October 2020.
Rejuvenation Research, Volume 23, Issue 5, Page 446-450, October 2020.
Rejuvenation Research, Volume 23, Issue 5, Page 365-366, October 2020.
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Abstract Purpose Angiopoietin-like 8 (ANGPTL8) is a liver- and adipose tissue-produced protein that predicts non-alcoholic fatty liver disease (NAFLD) and altered metabolic homeostasis in the general population as well as in persons with common and genetic obesity, including the Prader–Willi syndrome (PWS). However, its metabolic correlate in paediatric patients with respect to PWS is unknown. ...
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Abstract In this invited discussion, we applaud the authors of “Awareness of Facial Asymmetry and Its Impact on Postoperative Satisfaction of Rhinoplasty Patient” for their efforts to reinforce the importance of recognizing facial asymmetry preoperatively in the rhinoplasty patient. They can be applauded for translating this known key factor into data in the form of validated patient-reported outcomes tools. The study could be improved by better defining...
Abstract Background The latissimus dorsi (LD) flap represents one of the most reliable methods for autologous breast reconstruction. However, in many patients, the exclusive use of this technique may not guarantee the restoration of an adequate volume and projection. We report our experience with the extended latissimus dorsi kite flap (ELD-K flap), an alternative surgical approach to maximize the volume of the fleur-de-lis pattern LD...
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Jochen Lorch Harvard Medical School, Boston, MA October 16, 2020 Anaplastic or undifferentiated thyroid cancer is a rare but extremely deadly form of thyroid cancer. It constitutes only 1-2% of thyroid cancer cases but accounts for over 30% of thyroid cancer related mortality. It has, for the longest time, escaped all attempts to change its dismal prognosis – historically having a median survival of 4-6 months and very few, if any, long-term survivors. Progress in anaplastic thyroid cancer...
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Abstract Purpose Atherosclerotic plaque development and progression signifies a complex inflammatory disease mediated by a multitude of proinflammatory leukocyte subsets. Using single photon emission computed tomography (SPECT) coupled with computed tomography (CT), this study tested a new dual-isotope acquisition protocol to assess each radiotracer’s capability to identify plaque phenotype and inflammation levels pertaining to...
The authors regret to inform readers that the following error was detected in the original article. The values for entorhinal, limbic and neortical SUVr were switched between SCD Aβ + and Aβ- in Table 1 and have now been corrected. Unnecessary symbols in Table 2 have been removed.
Abstract Purpose Differentiation among parkinsonian syndromes may be clinically challenging, especially at early disease stages. In this study, we used 18F-FDG-PET brain imaging combined with an automated image classification algorithm to classify parkinsonian patients as Parkinson’s disease (PD) or as an atypical parkinsonian syndrome (APS) at the time when the clinical diagnosis was still uncertain. In addition to validating...
Abstract Purpose Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as...
Abstract Purpose The folate receptor (FR) is frequently overexpressed in a variety of tumor types and, hence, an interesting target for radionuclide therapy. The aim of this study was to evaluate a new class of albumin-binding radioconjugates comprising 5-methyltetrahydrofolate (5-MTHF) as a targeting agent and to compare their properties with those of the previously established folic acid-based [177Lu]Lu-OxFol-1. ...
Executive Summary The EC Directive 2013/59/Euratom states in article 56 that exposures of target volumes in nuclear medicine treatments shall be individually planned and their delivery appropriately verified. The Directive also mentions that medical physics experts should always be appropriately involved in those treatments. Although it is obvious that, in nuclear medicine practice, every nuclear medicine physician and physicist should follow national rules and legislation, the...
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Abstract Background Melasma is a chronic pigmentary condition that can have significant negative effects on quality of life. Vitamin C can be effective in the treatment melasma, but its delivery often proves to be challenging due to instability of the drug and subsequent cutaneous irritation at higher concentrations. Aim In this prospective, open‐label, evaluator‐blinded study we aimed to assess the efficacy and tolerability of twice daily application of a novel, highly potent, non‐irritating...
Abstract Background At present, it is no longer possible to use animal testing for ingredients and cosmetic products in the Organisation for Economic Co‐operation and Development (OECD) member states. However, in vitro tests are widely used to determine the safety and efficacy of ingredients and medicines. Objective Obviously, 3D skin models with natural human features can be used to analyze cosmetic ingredients and formulations. Skin irritation by cosmetic products is studied less than...
Abstract Introduction Cellulite is a multifactor and controversial condition. Several methods have been explored to reduce it, not always with favorable results. Shock Wave Therapy has been shown to be effective, but the results of its association with an Aerobic Exercise Program are unknown. Purpose To verify whether Shock Wave Therapy in association with an Aerobic Exercise Program reduces the degree of severity of Cellulite in the gluteal region and in the ⅓ of the proximal posterior...
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Publication date: December 2020Source: Clinical Neurology and Neurosurgery, Volume 199Author(s): Ronan J. Doherty, Yagiz U. Yolcu, Waseem Wahood, Jad Zreik, Anshit Goyal, Halena M. Gazelka, Elizabeth B. Habermann, Kingsley Abode-Iyamah, Brett A. Freedman, Mohamad Bydon
Publication date: December 2020Source: Clinical Neurology and Neurosurgery, Volume 199Author(s): Mayur Sharma, Hyunchul Lee, Fabian C. Madrigal, Merryl J. Terry, Eyas M. Hattab, Thomas Altstadt
Publication date: December 2020Source: Clinical Neurology and Neurosurgery, Volume 199Author(s): Christine Park, Alessandra N. Garcia, Chad Cook, Oren N. Gottfried
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There exist only two case reports to date of open cardiac defibrillation with deep brain stimulator system (DBS) implantation. We report a 64-year-old male with DBS system in place for essential tremor who underwent cardiac defibrillation after cardiac arrest. Afterwards, his device impedances were all high and his tremor symptoms returned. Both problems resolved with implantation of a new generator and required no changes to the intracranial leads or extension cables. This is significantly different...
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Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 603-619DOI: 10.1055/a-0967-1586Die „kritische“ Blutung ist definiert durch ihr lebensbedrohliches Ausmaß und stellt die häufigste prähospital vermeidbare Todesursache dar. Für äußere Blutungen existieren adäquate prähospitale Therapiestrategien – sie müssen aber stets in ein Gesamtkonzept entsprechend dem <C>ABCDE-Algorithmus (<C> für „critical bleeding“) eingebettet sein. In diesem Beitrag wird auf lokale manuelle Maßnahmen zur...
Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 582-583DOI: 10.1055/a-1258-0927Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 586-587DOI: 10.1055/a-1210-5720Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 583-584DOI: 10.1055/a-1258-1721Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 635-642DOI: 10.1055/a-1011-2078Die S3-Leitlinie zur intensivmedizinischen Versorgung herzchirurgischer Patienten – Hämodynamisches Monitoring und Herz-Kreislauf 1 vereint aktuelles Wissen zu Empfehlungen für das hämodynamische Monitoring und die differenzierte Kreislauftherapie bei herzchirurgischen Intensivpatienten. Zudem werden anzustrebende Zielparameter der Kreislauftherapie, Behandlungsstrategien bei Links- und Rechtsherzinsuffizienz...
Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 584-584DOI: 10.1055/a-1258-1734Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 588-602DOI: 10.1055/a-0967-1368Eine extrakorporale kardiopulmonale Reanimation (eCPR) gilt als Therapieoption bei therapierefraktärem Herz-Kreislauf-Versagen. Sie kann die Überlebensrate mit günstigem neurologischem Ergebnis bei hochselektierten Patienten deutlich verbessern. Dieser Beitrag schildert das Verfahren, die Kriterien bei der Entscheidung zur eCPR sowie die Vor- und Nachteile der beiden Optionen – In-Hospital- und Out-of-Hospital-Variante...
Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 585-585DOI: 10.1055/a-1234-4751Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 620-633DOI: 10.1055/a-0967-1563Das Thoraxtrauma ist ein komplexes Verletzungsmuster, dessen Diagnostik und Therapie einem Notfallteam alles abverlangen. Der Begriff beschreibt Verletzungen des Brustkorbs in allen Facetten – von der Prellmarke eines Sicherheitsgurtes bis zum tödlichen Überrolltrauma mit Quetschung oder Zerreißung der Thoraxorgane. Bei der Therapie können sonografische Diagnostik und invasive Notfalltechniken erforderlich werden,...
Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 644-647DOI: 10.1055/a-1142-1664Die Entfernung eines zentralvenösen Katheters auf einer Normalstation führt bei einem 53-jährigen Patienten mit einem bis dato nicht bekannten Ventrikelseptumdefekt zu einer paradoxen Luftembolie. Der Patient wird reanimationspflichtig und erleidet ein Multiinfarktsyndrom mit verheerenden neurologischen Ausfällen. Dieser Beitrag zeigt die Pathogenese und die erforderlichen Maßnahmen zur Vermeidung der paradoxen...
Anästhesiol Intensivmed Notfallmed Schmerzther 2020; 55: 582-582DOI: 10.1055/a-1224-2847Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals:Table of contents | Full text
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Abstract While minimally invasive follicular thyroid cancer (miFTC) generally has low risk of recurrence or death, encapsulated angioinvasive (eaFTC) or widely invasive (wiFTC) histological subtypes display significantly worse prognosis. Drivers of invasion are incompletely understood. Therefore, tissue samples including miFTC, eaFTC, and wiFTC tumors, as well as histologically normal thyroid adjacent to benign follicular adenomas, were selected from a cohort (n = 21) of thyroid...
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Abstract Background According to past research, lesbian, gay, bisexual, and transgender (LGBT) individuals experience a higher prevalence of psychopathology, which is attributable to the increased stress (i.e., stigma and prejudice) that they experience, as detailed by the minority stress model (MSM). Main This current literature review examined...
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J Reconstr MicrosurgDOI: 10.1055/s-0040-1718549 Background Detection and selection of the lymphatic vessels are important for maximizing therapeutic efficacy of lymphaticovenular anastomosis (LVA). Some imaging modalities have been reported to be useful for intraoperative identification of the lymphatic vessels, but they have limitations. In this article, we present new capabilities of intraoperative laser tomography, which was used to evaluate the lumen of the lymphatic vessel and to...
J Reconstr MicrosurgDOI: 10.1055/s-0040-1718395Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
J Reconstr MicrosurgDOI: 10.1055/s-0040-1717151 Background The timing of soft tissue reconstruction for soft-tissue defect in patients with open fractures in the lower extremity is known to be critical for successful outcomes. However, medical advances, including development of dressing materials and refinement in the microsurgical techniques, might have undergone modifications in this “critical period.” There have been no studies on the role of timing on reconstructive outcomes. Thus,...
J Reconstr MicrosurgDOI: 10.1055/s-0040-1718548 Background The double stitch everting (DSE) technique, in which time is won by leaving the needle inside the vessel wall in-between stitching, is a modification of the end-to-side (ETS) anastomosis in the interest of reducing anastomosis time. This ensures proper wall eversion, intima-to-intima contact, and improved suture symmetry. Materials and Methods We designed an N-of-1 randomized trial with each microsurgeon as their own...
J Reconstr MicrosurgDOI: 10.1055/s-0040-1718547 Background Active treatment (targeted muscle reinnervation [TMR] or regenerative peripheral nerve interfaces [RPNIs]) of the amputated nerve ends has gained momentum to mitigate neuropathic pain following amputation. Therefore, the aim of this study is to determine the predictors for the development of neuropathic pain after major upper extremity amputation. Methods Retrospectively, 142 adult patients who underwent 148 amputations...
J Reconstr MicrosurgDOI: 10.1055/s-0040-1718550 Background After anterolateral thigh (ALT) flap harvesting, skin graft of the donor site is commonly performed. When the defect width exceeds 8 cm or 16% of thigh circumference, it can determine lower limb function impairment and poor aesthetic outcomes. In our comparative study, we assessed the functional and aesthetic outcomes related to ALT donor-site closure with split-thickness skin graft compared with thigh propeller flap. ...
J Reconstr MicrosurgDOI: 10.1055/s-0040-1718394 Background Massive bone defects after wide resection of malignant bone tumors or a serious injury require treatment using vascularized bone grafts. Although cadaveric bone allografts combined with vascularized bone autografts are currently thought to be ideal in terms of size and durability, this treatment requires the scarification of healthy bone tissue. In a previous study, we attempted to improve this situation by prefabricating a vascularized...
J Reconstr MicrosurgDOI: 10.1055/s-0040-1718367Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Full text
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