by Chunmei Lin, Jinhao Liu, Hu Sun Purpose A considerable number of diabetic foot ulcer (DFU) patients require amputation every year, which worsens their quality of life, aggravates the social burden, and shortens their life expectancy. Considering these negative effects, it is important to explore the relative risk factors affecting amputation in DFU patients. Methods The PubMed, SCIE and Embase databases were comprehensively searched for prospective or retrospective studies published before October...
by Martí Català, Clara Prats, Daniel López, Pere-Joan Cardona, Sergio Alonso Mycobacterium tuberculosis (Mtb) is the causative agent for tuberculosis, the most extended infectious disease around the world. When Mtb enters inside the pulmonary alveolus it is rapidly phagocytosed by the alveolar macrophage. Although this controls the majority of inhaled microorganisms, in this case, Mtb survives inside the macrophage and multiplies. A posterior chemokine and cytokine cascade generated by the irruption...
by Valeria Ramírez-Castañeda The success of a scientist depends on their production of scientific papers and the impact factor of the journal in which they publish. Because most major scientific journals are published in English, success is related to publishing in this language. Currently, 98% of publications in science are written in English, including researchers from English as a Foreign Language (EFL) countries. Colombia is among the countries with the lowest English proficiency in the...
by Adriana Galistu, Paolo S. D’Aquila In a between-subject comparison of two memantine administration schedules we observed that treatment with the NMDA receptor antagonist memantine before testing sessions reduced ingestion of a 10% sucrose solution in rats, due to reduced licking burst size, thus suggesting a blunted hedonic response. Conversely, daily post-session administration reduced burst number, indicating a reduced level of behavioural activation, likely due to the development of conditioned...
by Youngho Lee, Sun Kyung Kim, Mi-Ran Eom Objectives Schizophrenia is one of the most prevalent mental illnesses contributing to national burden worldwide. It is well known that mental health nursing education, including clinical placement, is still insufficient to reach the optimal level of competency in nursing students. This study suggests a new form of mental health virtual reality (VR) simulation that is user-friendly and engaging to improve education about schizophrenia, thereby improving...
by Halle Johnson, Emel Yorganci, Catherine J. Evans, Stephen Barclay, Fliss E. M. Murtagh, Deokhee Yi, Wei Gao, Elizabeth L. Sampson, Joanne Droney, Morag Farquhar, Jonathan Koffman Purpose To examine the use of Normalisation Process Theory (NPT) to establish if, and in what ways, the AMBER care bundle can be successfully normalised into acute hospital practice, and to identify necessary modifications to optimise its implementation. Method Multi-method process evaluation embedded within a mixed-method...
by Raymond F. Palmer, Carlos R. Jaén, Roger B. Perales, Rodolfo Rincon, Jacqueline N. Forster, Claudia S. Miller The Quick Environmental Exposure and Sensitivity Inventory (QEESI) is a validated questionnaire used worldwide to assess intolerances to chemicals, foods, and drugs, and has emerged as the gold standard for assessing chemical intolerance (CI). Despite a reported prevalence of 8–33%, epidemiological studies and routine primary care clinics rarely assess CI. To help address this gap,...
by Olof Danielsson, Bo Häggqvist, Liv Gröntoft, Karin Öllinger, Jan Ernerudh Polymyositis and inclusion body myositis are idiopathic inflammatory myopathies, with a pathology characterized by partial invasion of non-necrotic muscle fibres by CD8+ cytotoxic T-cells, leading to fibre degeneration. Although the main effector pathway of CD8+ T-cells is to induce apoptosis of target cells, it has remained unclear if apoptosis occurs in these diseases, and if so, if it is mediated by CD8+ T-cells....
by Durga Chapagain, Lisa J. Wallis, Friederike Range, Nadja Affenzeller, Jessica Serra, Zsófia Virányi Dogs demonstrate behavioural changes and cognitive decline during aging. Compared to laboratory dogs, little is known about aging in pet dogs exposed to different environments and nutrition. In this study, we examined the effects of age, an enriched diet and lifelong training on different behavioural and cognitive measures in 119 pet dogs (>6yrs). Dogs were maintained on either an enriched...
by Martin Grimmer, Julian Zeiss, Florian Weigand, Guoping Zhao, Sascha Lamm, Martin Steil, Adrian Heller Lower limb exoskeletons and lower limb prostheses have the potential to reduce gait limitations during stair ambulation. To develop robotic assistance devices, the biomechanics of stair ambulation and the required transitions to level walking have to be understood. This study aimed to identify the timing of these transitions, to determine if transition phases exist and how long they last,...
by Alyse A. Larkin, Allison R. Moreno, Adam J. Fagan, Alyssa Fowlds, Alani Ruiz, Adam C. Martiny In the California Current Ecosystem, El Niño acts as a natural phenomenon that is partially representative of climate change impacts on marine bacteria at timescales relevant to microbial communities. Between 2014–2016, the North Pacific warm anomaly (a.k.a., the “blob”) and an El Niño event resulted in prolonged ocean warming in the Southern California Bight (SCB). To determine whether this “marine...
by Shih-Chuan Chou, Justine M. Nagurney, Jeremiah D. Schuur, Scott G. Weiner Objective The proportion of US emergency department (ED) visits that lead to hospitalization has declined over time. The degree to which advanced imaging use contributed to this trend is unknown. Our objective was to examine the association between advanced imaging use during ED visits and changes in ED hospitalization rates between 2007–2008 and 2015–2016. Methods We analyzed data from the National Hospital Ambulatory...
by Heeju Sohn, Stefan Timmermans, Pamela J. Prickett We examined family isolation, economic hardship, and long-distance migration as potential patterns of an extreme outcome of a lonely death: bodily remains that remain unclaimed and are left to the state. This paper combines a unique dataset—Los Angeles County's records of unclaimed deaths—with the Vital Statistics' Mortality data and the Annual Social and Economic Survey (ASEC) to examine 1) whose remains are more likely to become unclaimed...
by Endalamaw Tesfa, Endalkachew Nibret, Solomon Tebeje Gizaw, Yohannes Zenebe, Zewdie Mekonnen, Sefealem Assefa, Mulatu Melese, Netsanet Fentahun, Abaineh Munshea Introduction Hypertensive disorder of pregnancy is the second commonest causes of maternal death globally. Different public health studies were conducted on hypertensive disorder of pregnancy which presented inconsistent result. Therefore, this systematic review and meta-analysis was commenced to summarize the findings conducted in several...
by Paul R. Hernandez, V. Bede Agocha, Lauren M. Carney, Mica Estrada, Sharon Y. Lee, David Loomis, Michelle Williams, Crystal L. Park The present study tests predictions from the Tripartite Integration Model of Social Influences (TIMSI) concerning processes linking social interactions to social integration into science, technology, engineering, and mathematics (STEM) communities and careers. Students from historically overrepresented groups in STEM were followed from their senior year of high...
by Arun Mitra, Abhijit P. Pakhare, Adrija Roy, Ankur Joshi The Government of India in-network with the state governments has implemented the epidemic curtailment strategies inclusive of case-isolation, quarantine and lockdown in response to ongoing novel coronavirus (COVID-19) outbreak. In this manuscript, we attempt to estimate the impact of these steps across ten selected Indian states using crowd-sourced data. The trajectory of the outbreak was parameterized by the reproduction number (R0),...
by Ng Shiwei, Stylianos Dritsas, Javier G. Fernandez Given plans to revisit the lunar surface by the late 2020s and to take a crewed mission to Mars by the late 2030s, critical technologies must mature. In missions of extended duration, in situ resource utilization is necessary to both maximize scientific returns and minimize costs. While this present a significantly more complex challenge in the resource-starved environment of Mars, it is similar to the increasing need to develop resource-efficient...
by Samikshya Poudel, Pramesh Raj Ghimire, Nawaraj Upadhaya, Lal Rawal Background Despite having the high rate of stillbirth in most of the countries of South Asia, there is a lack of synthesized evidence based on factors associated with stillbirth. This study systematically synthesizes the evidence on factors associated with stillbirth in the four selected countries of South Asia. Methods This review was conducted using Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)...
by Jeannette Sutton, Scott L. Renshaw, Carter T. Butts As the most visible face of health expertise to the general public, health agencies have played a central role in alerting the public to the emerging COVID-19 threat, providing guidance for protective action, motivating compliance with health directives, and combating misinformation. Social media platforms such as Twitter have been a critical tool in this process, providing a communication channel that allows both rapid dissemination of...
by Adam B. Weiner, Stephen Jan, Ketan Jain-Poster, Oliver S. Ko, Anuj S. Desai, Shilajit D. Kundu Introduction We sought to assess the impact of Affordable Care Act Dependent Care Expansion (ACA-DCE), which allowed dependent coverage for adults aged 19–25, and Medicaid expansion on outcomes for men with testicular cancer. Methods Using a US-based cancer registry, we performed adjusted difference-in-difference (DID) analyses comparing outcomes between men aged 19–25 (n = 8,026) and 26–64 (n = 33,303)...
by Andreas G. Nerlich, Lukas Fischer, Stephanie Panzer, Roxane Bicker, Thomas Helmberger, Sylvia Schoske In Graeco-Roman times in the Lower-Egyptian Fayoum region, a painted portrait was traditionally placed over the face of a deceased individual. These mummy portraits show considerable inter-individual diversity. This suggests that those portraits were created separately for each individual. In the present study, we investigated a completely wrapped young infant mummy with a typical mummy portrait...
by Brendan J. McMullan, Gabrielle M. Haeusler, Lisa Hall, Louise Cooley, Andrew J. Stewardson, Christopher C. Blyth, Cheryl A. Jones, Pamela Konecny, Franz E. Babl, Françoise Mechinaud, Karin Thursky, on behalf of the Australian PICNICC study group and the PREDICT network Aminoglycosides are commonly prescribed to children with febrile neutropenia (FN) but their impact on clinical outcomes is uncertain and extent of guideline compliance is unknown. We aimed to review aminoglycoside prescription...
by M. Storme Spencer, Abraham C. Cullom, William J. Rhoads, Amy Pruden, Marc A. Edwards A lack of replicable test systems that realistically simulate hot water premise plumbing conditions at the laboratory-scale is an obstacle to identifying key factors that support growth of opportunistic pathogens (OPs) and opportunities to stem disease transmission. Here we developed the convectively-mixed pipe reactor (CMPR) as a simple reproducible system, consisting of off-the-shelf plumbing materials,...
by Assaf Lev, Yair Galily, Omer Eldadi, Gershon Tenenbaum Goal celebration in sport is mostly spontaneous and is manifested via vocal expressions and bodily gestures aimed at communicating emotions. The aim of this study is to deconstruct the celebratory acts among elite professional football players in the European Champions League following scoring a goal, and to capture the multiple acts and functions of the celebrations. In examining the 2018/19 season of the European Champions League tournament,...
by Charles R. Rogers, Phung Matthews, Lei Xu, Kenneth Boucher, Colin Riley, Matthew Huntington, Nathan Le Duc, Kola S. Okuyemi, Margaret J. Foster Background African-American men have the lowest 5-year survival rate in the U.S. for colorectal cancer (CRC) of any racial group, which may partly stem from low screening adherence. It is imperative to synthesize the literature evaluating the effectiveness of interventions on CRC screening uptake in this population. Materials and methods In this systematic...
by Caspar Chorus, Erlend Dancke Sandorf, Niek Mouter We report and interpret preferences of a sample of the Dutch adult population for different strategies to end the so-called ‘intelligent lockdown’ which their government had put in place in response to the COVID-19 pandemic. Using a discrete choice experiment, we invited participants to make a series of choices between policy scenarios aimed at relaxing the lockdown, which were specified not in terms of their nature (e.g. whether or not to...
by Jasmin C. Lawes, Eveline J. T. Rijksen, Robert W. Brander, Richard C. Franklin, Shane Daw Bystanders who drown during a rescue attempt in aquatic waterways are becoming an increasingly important issue within drowning prevention. In the Australian context, the majority of these incidents occur in coastal water ways. This study documents and characterizes bystander rescuer fatalities within Australian coastal waterways that occurred between 1 July 2004 and 30 June 2019 in order to provide suggestions...
by Jongchan Lee, Jong-chan Lee, Hyoung Woo Kim, Jaihwan Kim, Jin-Hyeok Hwang Background Recent studies have found that muscle depletion may be a prognostic predictor in patients with pancreatic cancer (PC). However, in these studies, limited data were used to assess the relationship between the serial change in body composition and outcomes after PC resection. Hence, we evaluated the changes in body composition during the perioperative period in patients with PC and their association with the overall...
by Anshika Srivastava, Rudra Kumar Pandey, Prajjval Pratap Singh, Pramod Kumar, Avinash Arvind Rasalkar, Rakesh Tamang, George van Driem, Pankaj Shrivastava, Gyaneshwer Chaubey It was shown that the human Angiotensin-converting enzyme 2 (ACE2) is the receptor of recent coronavirus SARS-CoV-2, and variation in this gene may affect the susceptibility of a population. Therefore, we have analysed the sequence data of ACE2 among 393 samples worldwide, focusing on South Asia. Genetically, South Asians...
by Shaikh Terkis Islam Pavel, Hazel Yetiskin, Gunsu Aydin, Can Holyavkin, Muhammet Ali Uygut, Zehra Bestepe Dursun, İlhami Celik, Ceren Cevik, Aykut Ozdarendeli Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and associated with severe respiratory illness emerged in Wuhan, China, in late 2019. The virus has been able to spread promptly across all continents in the world. The current pandemic has posed a great threat to public health...
by Joana Cursach, Juan Rita, Carmelo Gómez-Martínez, Carles Cardona, Miquel Capó, Amparo Lázaro The expansion of agriculture is a major driver of biodiversity loss worldwide, through changes generated in the landscape. Despite this, very little is still known about the complex relationships between landscape composition and heterogeneity and plant taxonomical and functional diversity in Mediterranean ecosystems that have been extensively managed during millennia. Although according to the Intermediate...
by Hoong Chen Teo, Ahimsa Campos-Arceiz, Binbin V. Li, Mingquan Wu, Alex Mark Lechner International attention on the environmental impacts of China’s Belt and Road Initiative (BRI) is increasing, but little is known internationally about the large corpus of Chinese BRI environmental research. We present the first systematic review of the Chinese and English-language BRI environmental research, supported with text mining and sentiment analysis. We found that the research is dominated by Chinese...
by Yitbarek Tenaw Hibstie, Getiye Dejenu Kibret, Asmare Talie, Belisty Temesgen, Mamaru Wubale Melkamu, Animut Alebel Background Although antiretroviral therapy (ART) significantly improves the survival status and quality of life among human immunodeficiency virus (HIV)-infected children, loss to follow-up (LTFU) from HIV-care profoundly affecting the treatment outcomes of this vulnerable population. For better interventions, up-to-date information concerning LTFU among HIV-infected children on...
by Zhefan Piao, Yueqin Lin This study empirically examined the impact of financing innovation on technological innovation efficiency of select internet companies, that were affiliated with China between 2008 and 2017. Analysis was based on their patent and annual report data and used multiple input-output SFA model, system GMM, and panel fixed-effect model. The results are as follows. (1) There is significant variation in overall technological innovation efficiency of listed companies in the...
by Ayesha Nazuk, Sadia Nadir, Ali R. Ansari, Raheel Nawaz This study highlights the need for analysis of online disclosure practices followed by non-governmental organizations; furthermore, it justifies the crucial role of potential correlates of online disclosure practices followed by non-governmental organizations. We propose a novel index for analyzing the extent of online disclosure of non-governmental organizations (NGO). Using the information stored in an auxiliary variable, we propose...
by Pankaj Dhaka, Satya Veer Singh Malik, Jay Prakash Yadav, Manesh Kumar, Sukhadeo B. Barbuddhe, Deepak B. Rawool Coxiella burnetii is a highly infectious zoonotic pathogen infecting wide range of mammals, including humans. In the present study, a total of 711 blood samples from bovines [cattle (n = 543) and buffaloes (n = 168)] from eight farms at different geographical locations in India were screened for C. burnetii targeting the IS1111 and the com1 genes. The anti-C. burnetii antibodies...
by M. Whitney Fry, Salima Saidi, Abdirahman Musa, Vanessa Kithyoma, Pratap Kumar Non-physician clinicians (NPCs) in low and middle-income countries (LMICs) often have little physical proximity to the resources–equipment, supplies or skills–needed to deliver effective care, forcing them to refer patients to distant sites. Unlike equipment or supplies, which require dedicated supply chains, physician/specialist skills needed to support NPCs can be sourced and delivered through telecommunication...
by Hiroyasu Inoue, Yasuyuki Todo This study quantifies the economic effect of a possible lockdown of Tokyo to prevent the spread of COVID-19. The negative effect of such a lockdown may propagate to other regions through supply chains because of supply and demand shortages. Applying an agent-based model to the actual supply chains of nearly 1.6 million firms in Japan, we simulate what would happen to production activities outside Tokyo if production activities that are not essential to citizens’...
by Chika Okada, Hidemi Takimoto Background Although assessing nutrient intake through dietary surveys is desirable, it can be effort- and time-intensive. We aimed to develop a brief screening method for determining sodium intake in order to raise public awareness regarding the Dietary Reference Intakes for Japanese (DRI-J) 2020. Methods Using data from the 2015 National Health and Nutrition Survey, we compared dietary behaviours obtained from a self-administered questionnaire according to sodium...
by Jackrapong Bruminhent, Nattanon Ruangsubvilai, Jeff Nabhindhakara, Atiporn Ingsathit, Sasisopin Kiertiburanakul To manage coronavirus disease 2019 (COVID-19), a national health authority has implemented a case definition of patients under investigation (PUIs) to guide clinicians’ diagnoses. We aimed to determine characteristics among all PUIs and those with and without COVID-19. We retrospectively reviewed clinical characteristics and risk factors for laboratory-confirmed COVID-19 cases among...
by Tom Duchemin, Mounia N. Hocine The identification of sick leave determinants could positively influence decision making to improve worker quality of life and to reduce consequently costs for society. Sick leave is a research topic of interest in economics, psychology, health and social behaviour. The question of choosing an appropriate statistical tool to analyse sick leave data can be challenging. In fact, sick leave data have a complex structure, characterized by two dimensions: frequency...
by Sapphire Crosby, Sarah Younie, Iain Williamson, Katie Laird Effective and culturally appropriate hand-hygiene education is essential to promote health-related practices to control and prevent diseases such as Diarrhoea, Ebola and COVID-19. In this paper we outline and evaluate the Co-Creation processes underpinning a handwashing intervention for young children (A Germ’s Journey) developed and delivered in India, Sierra Leone and the UK, and consider the implications surrounding Imperialist/Colonial...
by Rafał Zdrzałek, Sophien Kamoun, Ryohei Terauchi, Hiromasa Saitoh, Mark J. Banfield Plant NLR immune receptors are multidomain proteins that can function as specialized sensor/helper pairs. Paired NLR immune receptors are generally thought to function via negative regulation, where one NLR represses the activity of the second and detection of pathogen effectors relieves this repression to initiate immunity. However, whether this mechanism is common to all NLR pairs is not known. Here, we show...
by Jenell T. Larsen Tempel, Shannon Atkinson Endocrine profiling is an increasingly utilized tool for detecting pregnancies in wild populations of mammals. Given the difficulty in calculating reproductive rates of Pacific walruses (Odobenus rosmarus divergens) the use of endocrine techniques for determining pregnancy rates could be particularly useful for management of the population. The goals of this study were to 1) determine if progesterone and total estrogen concentrations in ovarian tissues...
by Kathryn I. Sunthankar, Kevin N. Griffith, Stephanie D. Talutis, Amy K. Rosen, David B. McAneny, Matthew H. Kulke, Jennifer F. Tseng, Teviah E. Sachs Patients who are incarcerated are a vulnerable patient population and may suffer from less access to routine cancer screenings compared to their non-incarcerated counterparts. Therefore, a thorough evaluation of potential differences in cancer diagnosis staging is needed. We sought to examine whether there are differences in cancer stage at initial...
by Bettina Suhr, Johanna Dungl, Alexander Stocker Open research data practices are a relatively new, thus still evolving part of scientific work, and their usage varies strongly within different scientific domains. In the literature, the investigation of open research data practices covers the whole range of big empirical studies covering multiple scientific domains to smaller, in depth studies analysing a single field of research. Despite the richness of literature on this topic, there is still...
by Limeng Cui, Makiko Orita, Yasuyuki Taira, Noboru Takamura Following the Fukushima Daiichi Nuclear Power Plant accident in March 2011, radionuclides such as iodine-131, cesium-134 and cesium-137 were released into environment. In this study, we collected wild mushrooms from the Kawauchi Village of Fukushima Prefecture, located less than 30 km southwest of the Fukushima nuclear power plant, to evaluate their radiocesium (134Cs+137Cs) concentrations and the risk of internal radiation exposure...
by Angesom Gebreweld, Temesgen Fiseha, Nibret Girma, Haftay Haileslasie, Daniel Gebretsadik Background Cytopenias affect the outcomes of highly active anti-retroviral therapy that results in higher morbidity, mortality, and impaired quality of life. The purpose of this study was to assess the prevalence of cytopenia and its associated factors among HIV infected adults on highly active antiretroviral therapy at Mehal Meda Hospital, North Shewa Zone, Ethiopia. Method A cross-sectional health facility...
by Emilia N. Inman, Richard J. Hobbs, Zivanai Tsvuura Over the past decade, pastoralists in Kunene Region, Namibia, have endured recurrent drought and flood events that have culminated in the loss of their primary form of livelihood–pastoralism. Most pastoralists are finding it difficult to sustain their livelihoods, and their communities have fallen into extreme poverty. Ecosystem-based Adaptation (EbA) approaches are increasingly acknowledged as having the potential to enhance the adaptive...
by Richard Klavans, Kevin W. Boyack, Dewey A. Murdick The prediction of exceptional or surprising growth in research is an issue with deep roots and few practical solutions. In this study, we develop and validate a novel approach to forecasting growth in highly specific research communities. Each research community is represented by a cluster of papers. Multiple indicators were tested, and a composite indicator was created that predicts which research communities will experience exceptional...
by Peter C. Jentsch, Chris T. Bauch, Denys Yemshanov, Madhur Anand Invasive pests, such as emerald ash borer or Asian longhorn beetle, have been responsible for unprecedented ecological and economic damage in eastern North America. These and other wood-boring invasive insects can spread to new areas through human transport of untreated firewood. Behaviour, such as transport of firewood, is affected not only by immediate material benefits and costs, but also by social forces. Potential approaches...
by Sara Ornaghi, Clelia Callegari, Roberta Milazzo, Laura La Milia, Federica Brunetti, Chiara Lubrano, Chiara Tasca, Stefania Livio, Valeria Maria Savasi, Irene Cetin, Patrizia Vergani Objectives 1. To assess the performance of an extended questionnaire in identifying cases of SARS-CoV-2 infection among obstetric patients. 2. To evaluate the rate of infection among healthcare workers involved in women’s care. Study design A prospective cohort study of obstetric patients admitted to MBBM Foundation...
by Ben O. L. Mellors, Abigail M. Spear, Christopher R. Howle, Kelly Curtis, Sara Macildowie, Hamid Dehghani The objective differentiation of facets of cellular metabolism is important for several clinical applications, including accurate definition of tumour boundaries and targeted wound debridement. To this end, spectral biomarkers to differentiate live and necrotic/apoptotic cells have been defined using in vitro methods. The delineation of different cellular states using spectroscopic methods...
by Guillaume Lhermie, Pierre Sauvage, Loren William Tauer, Leslie Verteramo Chiu, Karun Kanyiamattam, Ahmed Ferchiou, Didier Raboisson, Harvey Morgan Scott, David R. Smith, Yrjo Tapio Grohn The rising public health threat of antimicrobial resistance, the influence of food service companies, as well as the overall lack of positive image of using medical products in intensive farming are major drivers curbing antimicrobial use. In the future, government policies may affect practices of antimicrobial...
by Wenjing Zhang, Shuai Xu, Laner Shi, Zhangzhi Zhu, Xinying Xie Background Patients diagnosed with Oral Floor Squamous Cell Carcinoma (OFSCC) face considerable challenges in physiology and psychology. This study explored prognostic signatures to predict prognosis in OFSCC through a detailed transcriptomic analysis. Method We built an interactive competing endogenous RNA (ceRNA) network that included lncRNAs, miRNAs and mRNAs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG)...
by Na Liu, Min Song, Naifeng Wang, Yuan Wang, Ruifang Wang, Xiaoping An, Jingwei Qi Dandelion (Taraxacum officinale), a common plant worldwide, is used as both a medicine and food. Fermentation is a food processing technology that has many advantages, such as low energy cost, changes in product characteristics, and enhanced product quality. The purpose of this study was to investigate the effect of solid-state fermentation (SSF) on the content, composition and antioxidant activity of dandelion...
by Susheel Gulati, Rajvir Singh, Ram Prakash, Suman Sangwan New and facile one-pot three component approach for the synthesis of substituted dihydropyrimidinones derivatives (4a-4h) from reaction of equimolar substituted aldehydes (1a-1h), methyl acetoacetate (2a) and urea (3a) in presence of nature derived catalyst viz. Cocos nucifera L. juice, Solanum lycopersicum L. juice and Citrus limetta juice, commonly known as coconut juice, tomato juice and musambi juice respectively, at room temperature...
by Xiaofen Wu, Yao Ruan, Ting Chen, Zonghe Yu, Da Huo, Xiaomin Li, Feifei Wu, Xiao Jiang, Chunhua Ren Holothuria leucospilota (Echinodermata: Holothuroidea) is a widespread tropical sea cucumber with strong value for the ecological restoration of coral reefs. Therefore, some studies regarding the artificial breeding and cultivation of H. leucospilota have been undertaken recently. However, the biological functions of the digestive system of this species have not been elucidated. In this study,...
by Emily J. Onufer, Bola Aladegbami, Toru Imai, Kristen Seiler, Adam Bajinting, Cathleen Courtney, Stephanie Sutton, Aiza Bustos, Junjie Yao, Cheng-Hung Yeh, Anne Sescleifer, Lihong V. Wang, Jun Guo, Brad W. Warner Background Short bowel syndrome (SBS) results from significant loss of small intestinal length. In response to this loss, adaptation occurs, with Epidermal Growth Factor Receptor (EGFR) being a key driver. Besides enhanced enterocyte proliferation, we have revealed that adaptation is...
by Nina N. Harke, Jan P. Radtke, Boris A. Hadaschik, Christian Bach, Frank P. Berger, Andreas Blana, Hendrik Borgmann, Florian A. Distler, Sebastian Edeling, Tobias Egner, Christina L. Engels, Mahmoud Farzat, Alexander Haese, Rainer Hein, Markus A. Kuczyk, Andreas Manseck, Rudolf Moritz, Michael Musch, Inga Peters, Sasa Pokupic, Bernardo Rocco, Andreas Schneider, André Schumann, Christian Schwentner, Chiara M. Sighinolfi, Stephan Buse, Jens-Uwe Stolzenburg, Michael C. Truß, Michael Waldner, Christian...
by Gabriella Baio, Marina Fabbi, Michele Cilli, Francesca Rosa, Simona Boccardo, Francesca Valdora, Sandra Salvi, Luca Basso, Laura Emionite, Eliana Gianolio, Silvio Aime, Carlo Emanuele Neumaier Procedures To preliminary assess the relationship between Manganese Enhanced Magnetic Resonance Imaging (MEMRI) and the expression of calcium receptors in human prostate and breast cancer animal models. Methods NOD/SCID mice were inoculated with MDA-MB-231 breast cancer cells and prostate PC3 cancer cells...
by Tsai-Chung Li, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Chih-Hsueh Lin, Shing-Yu Yang, Cheng-Chieh Lin Prediction model mainly focused on specific diseases, such as diabetes, hypertension, cardiovascular disease, or patients with cancer, or populations of Europe and America, thereby limiting its generalization. This study aimed to develop and validate a 10-year mortality risk score by using data from a population-representative sample of adults. Data were collected from 2,221 Taichung Community...
Fire risk assessment of high-rise buildings under construction based on unascertained measure theory
by Wenlong Li, Huimin Li, Yijun Liu, Sunmeng Wang, Xingwang Pei, Qian Li To prevent fire accidents in high-rise buildings under construction, in this paper, the fire risk assessment of such buildings is studied. First, based on project investigation and a literature review, a fire risk assessment index system suitable for high-rise buildings under construction was established. Second, the unascertained measure theory was applied to establish a fire risk assessment model for high-rise buildings...
by Katina F. Olodo, Adeline Barnaud, Ndjido A. Kane, Cédric Mariac, Adama Faye, Marie Couderc, Leïla Zekraouï, Anaïs Dequincey, Diégane Diouf, Yves Vigouroux, Cécile Berthouly-Salazar Cultivated diversity is considered an insurance against major climatic variability. However, since the 1980s, several studies have shown that climate variability and agricultural changes may already have locally eroded crop genetic diversity. We studied pearl millet diversity in Senegal through a comparison of...
by Hyunhee Park, Eunsong Hwang, Miyeon Jang, Chungsik Yoon Enclosed underground excavation worksite has an environment with poor ventilation and exposure to hazardous substances from diesel engine exhaust and construction materials. The objective of this study was to evaluate the exposure level of elemental carbon (EC), organic carbon (OC), total carbon (TC), polycyclic aromatic hydrocarbons (PAHs), dust and crystalline silica (CS) during underground excavation work for top down construction...
by Abdulhakam Dumidae, Pichamon Janthu, Chanakan Subkrasae, Wilawan Pumidonming, Paron Dekumyoy, Aunchalee Thanwisai, Apichat Vitta Cryptozona siamensis, one of the most widespread land snails, is native to Thailand, and plays a key role as an agricultural pest and intermediate host for Angiostrongylus spp. However, its genetic diversity and population structure has not yet been investigated, and are poorly understood. Therefore, a genetic analysis of the C. siamensis population in Thailand...
by Constantino Carlos Reyes-Aldasoro, Kwun Ho Ngan, Ananda Ananda, Artur d’Avila Garcez, Andrew Appelboam, Karen M. Knapp Fractures of the wrist are common in Emergency Departments, where some patients are treated with a procedure called Manipulation under Anaesthesia. In some cases, this procedure is unsuccessful and patients need to revisit the hospital where they undergo surgery to treat the fracture. This work describes a geometric semi-automatic image analysis algorithm to analyse and compare...
by Kang-Jung Lo, Yu-Chieh Ko, De-Kuang Hwang, Catherine Jui-Ling Liu Purpose This study aimed to review previous articles and evaluate the influence of topical non-steroidal anti-inflammatory drugs (NSAIDs) on intraocular pressure (IOP) in glaucoma patients who were treated with prostaglandin analogues (PGs). Method The presenting study was designed as a meta-analysis of previous research. Databases include PubMed, Web of science, Cochrane library, and Embase were searched with keywords of “intraocular...
by Barbara Marcelli, Harma Karsens, Mark Nijland, Ruben Oudshoorn, Oscar P. Kuipers, Jan Kok Lactococcus lactis is a lactic acid bacterium widely used as a starter culture in the manufacture of dairy products, especially a wide variety of cheeses. Improved industrial strains would help to manufacture better food products that can meet the industry’s and consumer’s demands with respect to e.g. quality, taste, texture and shelf life. Bacteriophage infection of L. lactis starter cultures represents...
by Baffour Badu-Apraku, Samuel Adewale, Agre Angelot Paterne, Melaku Gedil, Johnson Toyinbo, Robert Asiedu Striga is an important biotic factor limiting maize production in sub-Saharan Africa and can cause yield losses as high as 100%. Marker-assisted selection (MAS) approaches hold a great potential for improving Striga resistance but requires identification and use of markers associated with Striga resistance for adequate genetic gains from selection. However, there is no report on the discovery...
by Liping Hu, Chunying Zhang, Kevin Yang, Meng Li, Anisa Shaker The pathogenesis of esophageal injury in gastroesophageal reflux disease (GERD) is incompletely understood. We modeled exposure of human esophageal myofibroblasts (HEMFs) to gastroesophageal reflux by repeated treatment with pH 4.5 and pH 4.5 bile salts and determined the effects on the epithelium in a 3D organotypic-like air-liquid interface model. Total, basal and supra-basal thickness of the epithelium were measured and immunostaining...
by Helga Birgit Bjørnarå, Thomas Westergren, Liv Fegran, Saskia J. te Velde, Aslak Fyhri, Benedicte Deforche, Lars Bo Andersen, Sveinung Berntsen, Elling Bere Introduction Cycling for transport could integrate physical activity (PA) into daily routines and potentially increase total PA levels. However, for parents with young children, most factors affecting transport mode choice tend to facilitate car use. Greater insight is necessary into reasons for (not) using sustainable transport modes in...
by Megan Shiroda, Shannon D. Manning The placental membranes that surround the fetus during pregnancy were suggested to contain a low abundance microbiota. Specifically, abundance of Lactobacillus, a probiotic and dominant member of the microbiome of the lower reproductive tract, has been shown to correlate with healthy, term pregnancies. We therefore sought to assess the interactions between four different Lactobacillus strains with immortalized decidualized endometrial cells (dT-HESCs), which...
by Indra Prasad Sharma, Nor Tshering Lepcha, Tshering Lhamo, Leon B. Ellwein, Gopal Prasad Pokharel, Taraprasad Das, Yuddha Dhoj Sapkota, Tandin Dorji, Sonam Peldon Purpose To estimate the nationwide prevalence of visual impairment and associated refractive error in school children in Bhutan. Methods The sample of this prospective cross-sectional national survey comprised of randomly selected classes in levels IV-IX (age 10 to 15 years) from schools throughout Bhutan. The examination included measurement...
by Diana Székely, Dan Cogălniceanu, Paul Székely, Mathieu Denoël Divergence in ecological niche offers organisms the opportunity of exploiting different food and habitat resources, scaling down competition and predation both among species, and within different age or size-classes of the same species. In harsh environments, where abiotic factors determine a clustering of resources during short timespans, competition and predation between organisms is likely to be enhanced. This is the case in...
by Yusuke Yoshikawa, Yodo Tamaki, Takeshi Morimoto, Hidenori Yaku, Erika Yamamoto, Yasutaka Inuzuka, Neiko Ozasa, Takeshi Kitai, Kazuya Nagao, Yukihito Sato, Hirokazu Kondo, Toshihiro Tamura, Yoshihisa Nakagawa, Koichiro Kuwahara, Takao Kato, Takeshi Kimura Objective This observational study aimed to examine the prognostic association of angiotensin-converting enzyme inhibitors (ACE-I)/angiotensin receptor blockers (ARB) in different left ventricular ejection fraction (LVEF) categories. Methods...
by Jamie Moffatt, Kaja Julia Mitrenga, Ben Alderson-Day, Peter Moseley, Charles Fernyhough Ruminative thought is a style of thinking which involves repetitively focusing upon one’s own negative mood, its causes and its consequences. The negative effects of rumination are well-documented, but comparatively little is known about how rumination is experienced. The evaluative nature of rumination suggests that it could involve more inner speech than non-ruminative states. The present study (N =...
by Yushanthini Nair Kumar, Sze-Wan Poong, Claire Gachon, Juliet Brodie, Ahemad Sade, Phaik-Eem Lim The eucheumatoids Kappaphycus and Eucheuma are cultivated in tropical or subtropical regions for the production of carrageenan, a hydrocolloid widely used in the food and cosmetic industries. Kappaphycus alvarezii is a highly valued economic crop in the Coral Triangle, with the Philippines, Indonesia and Malaysia ranked among the largest producers. In the absence of measures to mitigate climate change,...
by Emmanuel Anongeba Anaba, Aaron Asibi Abuosi, Joshua Cobby Azilaku, Jacqueline Nkrumah Introduction Anaemia is prevalent among children in developing countries. The main objective of this study was to assess the association between health insurance membership and anaemia among Ghanaian children under-five years. Methods We obtained Ghana’s Multiple Indicators Cluster Survey, 2011 dataset from the United Nations International Children’s Emergency Fund. Data were analyzed with the aid of Stata/IC,...
by Shawn M. Higdon, Tania Pozzo, Emily J. Tibbett, Colleen Chiu, Richard Jeannotte, Bart C. Weimer, Alan B. Bennett Sierra Mixe maize is a geographically remote landrace variety grown on nitrogen-deficient fields in Oaxaca, Mexico that meets its nutritional requirements without synthetic fertilizer by associating with free-living diazotrophs comprising the microbiota of its aerial root mucilage. We selected nearly 500 diazotrophic (N2-fixing) bacteria isolated from Sierra Mixe maize mucilage...
by Chieko Kibe, Miki Suzuki, Mari Hirano, Ilona Boniwell This study investigated the efficacy of a culturally modified resilience education program on Japanese adolescents’ well-being from a differential susceptibility perspective. First, a culturally modified resilience education intervention was developed by employing the SPARK resilience program and implemented with 407 Japanese high school students in Tokyo (age = 15–16, M = 192, F = 215). To test intervention efficacy, students’ level of...
by Mario Kasović, Lovro Štefan, Martin Zvonar Although previous evidence has shown that deviated foot structure and function are associated with falls, little is known of the association between foot rotations and falls in apparently healthy older adults. Therefore, the main purpose of the study was to determine the associations between foot rotation and falls. In this cross-sectional study, we recruited 120 older women (mean±SD; age 71.01±6.77 years; height 158.92±21.41 cm; weight 70.29±12.97...
by Natalia P. Montoya, Lia C. O. B. Glaz, César C. C. Abad, Lucas A. Pereira, Irineu Loturco The aim of this study was to determine the main characteristics of a “good teacher” through the use of questionnaires designed to assess teaching skills and competences, considering the point of view of teachers, principals, and students. In total, 82 teachers, 14 principals, and 625 middle-school students from 5 public schools in São Paulo state participated in this study. Two questionnaires were applied,...
by Harri Luchsinger, Jan Kocbach, Gertjan Ettema, Øyvind Sandbakk Purpose Biathlon is an Olympic sport combining 3–5 laps of cross-country skiing with rifle shooting, alternating between the prone and standing shooting positions between laps. The individual distance and the sprint are extensively examined whereas the pursuit, with start times based on the sprint results, is unexplored. Therefore, the current study aimed to investigate the contribution from start time, cross-country skiing time,...
by Naroa Martínez, Helena Matute, Edurne Goikoetxea The use of pictures as experimental stimuli is a frequent practice in psychological and educational research. In addition, picture-naming task allows the study of different cognitive processes such as perception, attention, memory and language. Line drawings have been widely used in research to date but it has begun to be highlighted the need for more ecological stimuli such as photographs. However, normative data of a photographic set has...
by Rory F. Little, Markiyan Samborskyy, Peter F. Leadlay The type I polyketide SF2487/A80577 (herein referred to as tetromadurin) is a polyether tetronate ionophore antibiotic produced by the terrestrial Gram-positive bacterium Actinomadura verrucosospora. Tetromadurin is closely related to the polyether tetronates tetronasin (M139603) and tetronomycin, all of which are characterised by containing a tetronate, cyclohexane, tetrahydropyran, and at least one tetrahydrofuran ring. We have sequenced...
by Rasmus Emil Jensen, Carmina Cabral, Annie Enkegaard, Tove Steenberg Inoculating plants with entomopathogenic fungi may influence plant nutrient uptake and growth, and herbivore performance. Knowledge is limited concerning the effects of this symbiosis on higher trophic levels. We examined how fungal treatment of faba bean seeds with the entomopathogenic fungus Beauveria bassiana influenced the choice-behavior and development of the aphid parasitoid Aphidius colemani. We also sampled plant...
by Nathaniel Halide Kalengo, Leah A. Sanga, Rune Nathaniel Philemon, Joseph Obure, Michael J. Mahande Background Preterm birth is a public health problem particularly in low- and middle-income countries especially in sub-Saharan Africa. It is associated with infant morbidity and mortality. Survivor of preterm suffers long term health consequences such as respiratory, hearing and visual problems as well as delivering preterm infants. Preterm birth also tends to recur in subsequent pregnancies. Little...
by Ícaro M. L. G. Barreto, Stela A. Urbano, Chiara A. A. Oliveira, Cláudia S. Macêdo, Luiz H. F. Borba, Bruna M. E. Chags, Adriano H. N. Rangel The objective of this study was to characterize the chemical composition and lipid profile of colostrum and milk of purebred Quarter Horse mares. Thirty-four (34) purebred mares were selected, which were then separated into groups according to age, birth order and lactation stage. Colostrum samples were collected in the first six hours after delivery...
by Wim H. Winthorst, Elisabeth H. Bos, Annelieke M. Roest, Peter de Jonge Mood and behaviour are thought to be under considerable influence of the seasons, but evidence is not unequivocal. The purpose of this study was to investigate whether mood and affect are related to the seasons, and what is the role of neuroticism in this association. In a national internet-based crowdsourcing project in the Dutch general population, individuals were invited to assess themselves on several domains of mental...
by Zafar Zafari, Katherine M. Keyes, Boshen Jiao, Sharifa Z. Williams, Peter Alexander Muennig Objectives Material well-being, beliefs, and emotional states are believed to influence one’s health and longevity. In this paper, we explore racial differences in self-rated health, happiness, trust in others, feeling that society is fair, believing in God, frequency of sexual intercourse, educational attainment, and percent in poverty and their association with mortality. Study designs Age-period-cohort...
by Chad Michael Vachon, Shanaathanan Modchalingam, Bernard Marius ‘t Hart, Denise Y. P. Henriques Knowing where our limbs are in space is essential for moving and for adapting movements to various changes in our environments and bodies. The ability to adapt movements declines with age, and age-related cognitive decline can explain a decreased ability to adopt and deploy explicit, cognitive strategies in motor learning. Age-related sensory decline could also lead to a reduced fidelity of sensory...
by Tegwen Marlais, Tapan Bhattacharyya, Callum Pearson, Bathsheba L. Gardner, Safiyyah Marhoon, Stephanie Airs, Kiera Hayes, Andrew K. Falconar, Om Prakash Singh, Steven G. Reed, Sayda El-Safi, Shyam Sundar, Michael A. Miles Diagnosis of visceral leishmaniasis (VL) relies on invasive and risky aspirate procedures, and confirmation of cure after treatment is unreliable. Detection of Leishmania donovani antigens in urine has the potential to provide both a non-invasive diagnostic and a test of...
by Ewan P. Plant, Hasmik Manukyan, Majid Laassri, Zhiping Ye Understanding the extent and limitation of viral genome evolution can provide insight about potential drug and vaccine targets. Influenza B Viruses (IBVs) infect humans in a seasonal manner and causes significant morbidity and mortality. IBVs are negative-sense single-stranded RNA viruses with a segmented genome and can be divided into two antigenically distinct lineages. The two lineages have been circulating and further evolving...
by Chunling Wang, Yingying Lv, Anzhang Li, Qing Yao, Guangda Feng, Honghui Zhu Myxobacteria are one of the most promising secondary metabolites producers. However, they are difficult to isolate and cultivate. To obtain more myxobacteria and know the effects of environmental factors on myxobacterial community, we characterized myxobacterial communities in Dinghushan acidic forest soils of pH 3.6–4.5 with culture-dependent and -independent techniques, and analyzed environmental factors shaping...
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We present the case of a 42-year-old man with subacute stroke who developed remarkable fear of falling and eventually recovered with an approach based on cognitive behavioral therapy (CBT). The CBT-based approach was implemented after the patient developed significant fear of falling with exacerbated obsessive-compulsive symptoms appeared immediately after a fall. The patient’s anxiety decreased over time, and his ability to perform these tasks and activities of daily living improved accordingly....
The purpose of this prospective study was to determine whether the cost and cost-effectiveness of early rehabilitation after stroke are associated with the degree of initial disability. The data for cost calculations were collected by the bottom-up (micro-costing) method alongside the standard inpatient care. The total sample included 87 patients who were transferred from acute care to early rehabilitation unit of three participating stroke centers at the median time poststroke of 11 days (range...
Low muscle strength appears to increase balance disorders and the tendency to fall. Diagnostic terms indicate that sarcopenia and risks of falling are related. The aim of this study is to verify which diagnostic tools used for the assessment of muscle strength in sarcopenia can be used for fall risk assessment in older women. The study included 56 females [71.77 ± 7.43(SD)]. The results of handgrip strength (HGS) and knee extensors torque [knee extension strength (KES)] were compared to the results...
There is no consensus about the definition or most effective treatment for neglect syndrome. The aim of this review was therefore to evaluate the results of trials that investigated different treatment methods for neglect syndrome. A systematic literature search in PubMed and Web of Science databases was performed to identify studies that investigated the effects of neglect therapies. Authors followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Studies were selected...
It is often difficult for the clinician to choose the most appropriate balance-assessment measure. We wanted to facilitate this decision based on the stroke patient’s functional abilities. The aim of our study was to compare three established scales [Berg Balance Scale (BBS), mini-BESTest (MBT) and Functional Gait Assessment (FGA)] in terms of responsiveness, floor and ceiling effects at different levels of ambulation as defined by the Functional Ambulation Classification (FAC). The 18-month prospective...
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The aim of the study is to estimate the association between spinal cord injuries related medical factors and subjective sleep disturbance in individuals with short-duration chronic spinal cord injury. Seventy-nine individuals with traumatic spinal cord injuries were included in our study and evaluated using the Beck Depression Index for severity of depressive symptoms, Short-Form Health Survey for quality of life, Douleur Neuropathique 4 score for neuropathic pain severity, and the Pittsburgh Sleep...
The purpose of the present study was to examine the main characteristics of clinical trials in physiotherapy aimed at improving walking speed after stroke, as well as the correlation between trials’ methodological quality and journals’ Impact Factor. Searches were conducted on Physiotherapy Evidence Database for all randomized controlled trials aiming at improving walking speed after stroke. Data extracted from the studies were: continent, language, methodological quality, year of publication, number...
Capacitive and resistive electric transfer (CRET) therapy is a physical treatment modality commonly used to treat musculoskeletal pain. It normally uses a longwave radiofrequency of ~0.5 MHz. The system consists of a neutral plate and two different electrodes that can transfer energy in two modalities: capacitive and resistive. The aim of this systematic review was to identify and summarize the available data in the literature on this physical modality. From a search of articles published before...
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Two factors related to the continuation of persistent pain are pain catastrophizing and illness perceptions. Pain neuroscience education is known to positively influence both in patients with persistent pain. As the integration of pain neuroscience education in monodisciplinary physiotherapy treatments is effective, integration in transdisciplinary cognitive-behavioral treatments seems recommendable. When doing so, the moderating effect of pain catastrophizing and perceptions on treatment results...
The factors associated with cognitive functions in patients with multiple sclerosis (PwMS) are not yet clear. The aims of this study were (1) to compare clinical features and physical performance in healthy controls, and PwMS with and without cognitive impairment, and (2) to determine the relationship between cognitive domains and demographics characteristics, clinical features and physical performance in PwMS. A total of 112 PwMS and 25 healthy controls participated in this study. Cognitive functions...
Patients with Guillain–Barré syndrome (GBS) are at high risk for inadequate nutrition throughout their illness, yet the wider impact of malnutrition in this population remains unknown. Thus, the purpose of our study was to investigate the associations between nutritional status and functional status at admission to inpatient rehabilitation for GBS and to determine whether the admission phase angle, a biological marker of cellular health, is a prognostic indicator of functional improvement at the...
Drivers with medical conditions may need to demonstrate their fitness by participating in clinical and on-road assessments. Scores from the clinic-based occupational therapy-drive home maze test (OT-DHMT) can contribute to fitness-to-drive recommendations. The OT-DHMT is a short, timed test that has previously been shown to be valid and reliable, and norms are available for completion with a driver’s dominant hand. Following stroke or trauma, many drivers need to complete assessments and resume driving...
Although epidural corticosteroids have been evaluated for the lumbar spinal stenosis (LSS) as an alternative treatment, oral corticosteroids have not been considered as a possible option for the patients with constant pain who have resistant against routine treatments. Therefore, this study aimed to investigate the efficacy of the short-term, low-dose oral prednisolone for refractory LSS. In this double-blinded randomized placebo-controlled clinical trial, 100 participants with the refractory LSS...
Achieving a sufficient level of functional ambulation remains to be a challenge to most stroke survivors. Different modes of transcranial direct current stimulation (tDCS) have been applied for improving various aspects of walking and mobility following stroke. However, systematic reviews before 2017 provided only general effects of tDCS on limited walking outcomes. Therefore, the aims of this study were to update the evidence of tDCS for improving walking and mobility after stroke with emphasis...
We tested the hypothesis that a regular training program might reduce gait disturbances during dual cognitive-motor tasks in elderly women. This open-label experimental study comprised 53 postmenopausal women aged over 65, who were assigned to a 10-week training program (360 min/week). A BTS SMART system examination during free walking and during dual tasks [i.e., walking while performing either a simple (SCT) or a complex (CCT) cognitive task] was performed prior to the training program and again...
Urinary incontinence (UI) is a common problem after stroke. Risk factors for UI seem to be multifactorial. There is still controversy in which risk factors contribute to UI. The aim of this study was to investigate risk factors for UI in stroke patients during rehabilitation. Study investigated 150 participants after the first stroke consecutively admitted to a post-acute inpatient rehabilitation program. They were divided into continence and incontinence group according to continence status on rehabilitation...
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Everything you wanted to know about Hyperosmolar agents for the Management of ICP and Cerebral Edema EMCrit Project by Neha Dangayach.
Valproic acid poisoning is fortunately uncommon. However, this is a potentially lethal and rather complex intoxication. Management spans the gamut from decontamination and dialysis, to various metabolic manipulations. With an aggressive and organized approach, most patients will do extremely well. The IBCC chapter is located 👉 here. The podcast & comments are below. Follow us […] EMCrit Project by Josh Farkas.
Chris Hicks and I discussing the Labors of Trauma (Blunt edition), everything a trauma team leader needs on their radar screen. EMCrit Project by Scott Weingart.
BRASH syndrome refers to a vicious spiral wherein hyperkalemia and AV nodal blockers synergize to cause progressive renal failure, bradycardia, shock, and hyperkalemia. The treatment is largely a combination of standard therapies for hyperkalemia and bradycardia. Recognizing this syndrome as a specific entity may help us more fully understand our patients' physiology, facilitating a more […] EMCrit Project by Josh Farkas.
Intensivists have long been struggling with the enigma of hemophagocytic lymphohistiocytosis (HLH). For example, this post from 2016 explores the challenge of dissecting HLH away from septic shock. The COVID pandemic has drawn some attention to the topic, although it's not clear to what extent COVID might truly reflect HLH. This chapter attempts to lay […] EMCrit Project by Josh Farkas.
Critical illness leads to a variety of gastrointestinal motility problems (largely due to the constellation of immobility, medications, and metabolic abnormalities). Although these topics don't generally attract much interest, maintaining adequate bowel motility is essential to avoid iatrogenic harm. The chapter on gastroparesis is located 👉 here. The chapter on ileus is located 👉 here. […] EMCrit Project by Josh Farkas.
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