Τρίτη 20 Οκτωβρίου 2020

 


Commentary: 20 years online with “Your Disease Risk”
Abstract The Your Disease Risk tool (yourdiseaserisk.wustl.edu) went live to the public in January 2000 and was one of the first personalized health risk assessment sites on the Internet. Its launch marked the culmination of years of work by a large, multi-disciplinary university team whose primary goal was to translate the science on cancer prevention into accurate, engaging, and useful messages for the public. Today, 20 years on, Your Disease Risk has expanded from its initial...
Latest Results for Cancer/ /Causes/ /
3d
Digoxin use is associated with pancreatic cancer risk but does not affect survival
Abstract Purpose Digoxin affects several cellular pathways involved in tumorigenesis. We sought to determine the association between digoxin use and pancreatic cancer risk and survival. Methods A nested case–control study using The Health Improvement Network (THIN), a population-representative database from the United Kingdom (UK). Cases included all...
Latest Results for Cancer/ /Causes/ /
4d
Is there an association between a history of military service and cancer diagnosis? Results from a US national-level study of self-reported outcomes
Abstract Purpose To examine cancer prevalence in men with and without military service history, using national-level self-reported outcomes. Methods A cross-sectional survey-based US study, including men aged 18 and above from the Health Information National Trends Survey database between 2011 and 2014. The primary endpoint was self-reported cancer...
Latest Results for Cancer/ /Causes/ /
4d
Adiposity over the life course and prostate cancer: unraveling the complexities
Abstract The association between obesity and prostate cancer has been extensively studied, but clear answers have evaded us. Most of the studies have been based on a single time-point measure, most commonly of body mass index (BMI) during adulthood. Emerging data suggest a complex pattern that may be better understood through a life course approach. The data suggest that early life adiposity, possibly before or during puberty, as being associated with lower risk of advanced...
Latest Results for Cancer/ /Causes/ /
6d
Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping
Abstract Introduction There is currently no disease-modifying drug for osteoarthritis (OA), and some safety concerns have been identified about the leading traditional drugs. Therefore, research efforts have focused on alternatives such as supplementation with collagen derivatives. The objective of this scoping review is to examine the extent, range, and nature of research, and to summarize and disseminate research findings on the effects...
Latest Results for Rheumatology and Therapy
3d
Immune Checkpoint Inhibitor-Associated Scleroderma-Like Syndrome: A Report of a Pembrolizumab-Induced “Eosinophilic Fasciitis-Like” Case and a Review of the Literature
Abstract Immune checkpoint inhibitors are a promising new therapeutic strategy in oncology that aims to eliminate cancer cells by enhancing patients' immune response against tumor antigens. Despite their beneficial effects, immune checkpoint inhibitors are also responsible for a plethora of autoimmune manifestations, known as immune-related adverse events. We present a case of eosinophilic fasciitis-like disorder in an 81-year-old patient treated with the programmed death cell...
Latest Results for Rheumatology and Therapy
4d
Long-Term Risk of Comorbidity after IgA Vasculitis in Childhood: A Population-Based Cohort Study
Abstract Introduction Patients with IgA vasculitis (IgAV) may require aggressive treatment and are prone to disease relapses, and IgA deposition in tissues can persist. We investigated whether these factors predispose to long-term morbidity in children with IgAV. Methods Observational cohort study comparing rates for comorbidity development by Charlson comorbidity...
Latest Results for Rheumatology and Therapy
5d
Impact of Enthesitis on Psoriatic Arthritis Patient-Reported Outcomes and Physician Satisfaction with Treatment: Data from a Multinational Patient and Physician Survey
Abstract Introduction Enthesitis is a core outcome domain assessed in psoriatic arthritis (PsA) clinical trials. Limited evidence describes the impact of enthesitis on patient-reported outcomes (PROs) and physician satisfaction with current treatment options. The objective of this analysis is to characterize the impact of enthesitis on PROs and physician satisfaction with currently available treatment in clinical practice settings. ...
Latest Results for Rheumatology and Therapy
6d
Low-frequency ultrasound increase effectiveness of silver nanoparticles in a purulent wound model
Abstract Bacterial biofilm formation and antibiotic resistance are the main factors of surgical wound complications. Traditional treatments in some cases cannot provide complete bacterial eradication and new therapeutic approaches should be developed to overcome antibiotic resistance. Silver nanoparticles (AgNPs) can be the first choice for bacteria treatment but their clinical application is limited due to toxic effects. Combination of AgNPs with the low-frequency ultrasound (US)...
Latest Results for Biomedical Engineering Letters
3d
Joint injection practice variations in pediatric rheumatology – a global survey and call for action
Abstract Background Intraarticular injections (IAI) were first reported in adult rheumatology in the 1950s and subsequently gained acceptance as a safe and efficacious treatment in Juvenile idiopathic arthritis (JIA). IAIs are now widely performed and recommended as the initial or only treatment of oligoarticular JIA and ancillary treatment of actively inflamed joints in other varieties of JIA. However, the performance of the procedure...
Latest Results for Pediatric Rheumatology
3d
Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares
Abstract Background Heme oxygenase-1 (HMOX1) catalyzes the metabolism of heme into carbon monoxide, ferrous iron, and biliverdin. Through biliverdin reductase, biliverdin becomes bilirubin. HMOX1-deficiency is a rare autosomal recessive disorder with hallmark features of direct antibody negative hemolytic anemia with normal bilirubin, hyperinflammation and features similar to macrophage activation syndrome. Clinical findings have...
Latest Results for Pediatric Rheumatology
4d
Glitches in the utilization of telehealth in pediatric rheumatology patients during the COVID-19 pandemic
Abstract Telehealth is an extraordinary advancement of modern medicine. It has increased access to care for underserved populations and, in the case of pediatric rheumatology, has expanded the reach of a limited work force. During the Coronavirus Disease 2019 (COVID-19) pandemic, telehealth has radically changed the way healthcare workers have been able to deliver care while maintaining social distance. In addition to the infectious havoc of COVID-19, the pandemic has further...
Latest Results for Pediatric Rheumatology
5d
Determinants of disease activity change over time in Enthesitis related arthritis: effect of structured outcome monitoring and clinical decision support
Abstract Background We aimed to test if standardized point-of-care outcome monitoring and clinical decision support (CDS), as compared to standard care, improves disease activity and patient-reported pain in children with enthesitis-related arthritis (ERA). Methods This was a retrospective cohort study of outcomes of children with ERA after...
Latest Results for Pediatric Rheumatology
5d
Improved online LC-MS/MS identification of O-glycosites by EThcD fragmentation, chemoenzymatic reaction, and SPE enrichment
Abstract O-glycosylation is a highly diverse and complex form of protein post-translational modification. Mucin-type O-glycosylation is initiated by the transfer of N-acetyl-galactosamine (GalNAc) to the hydroxyl group of serine, threonine and tyrosine residues through catalysis by a family of glycosyltransferases, the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (E.C. 2.4.1.41) that are conserved across metazoans. In the last decade, structural characterization of...
Latest Results for Glycoconjugate Journal
3d
A novel glycosidase plate-based assay for the quantification of galactosylation and sialylation on human IgG
Abstract Changes in human IgG galactosylation and sialylation have been associated with several inflammatory diseases which are a major burden on the health care system. A large body of work on well-established glycomic and glycopeptidomic assays has repeatedly demonstrated inflammation-induced changes in IgG glycosylation. However, these assays are usually based on specialized analytical instrumentation which could be considered a technical barrier for uptake by some laboratories....
Latest Results for Glycoconjugate Journal
4d
A chronic strain of the cystic fibrosis pathogen Pandoraea pulmonicola expresses a heterogenous hypo-acylated lipid A
Abstract Pandoraea sp. is an emerging Gram-negative pathogen in cystic fibrosis causing severe and persistent inflammation and damage of the lungs. The molecular mechanisms underlying the high pathogenicity of Pandoraea species are still largely unknown. As Gram-negatives, Pandoraea sp. express lipopolysaccharides (LPS) whose recognition by the host immune system triggers an inflammatory response aimed at the bacterial eradication from the infected tissues. The degree of the inflammatory...
Latest Results for Glycoconjugate Journal
1w
State feedback control and observer-based adaptive synchronisation of chaos in a memristive Murali–Lakshmanan–Chua circuit
Abstract In this paper we report the control and synchronisation of chaos in a memristive Murali–Lakshmanan–Chua (MLC) circuit. This circuit, introduced by the present authors in 2013, is basically a non-smooth system having two discontinuity boundaries by virtue of it having a flux-controlled active memristor as its nonlinear element. While the control of chaos has been effected using state feedback techniques, the concept of adaptive synchronisation and observer-based approaches...
Latest Results for Pramana
3d
Quasi-exact and asymptotic iterative solutions of Dirac equation in the presence of some scalar potentials
Abstract In this paper, the Dirac equation in the presence of some scalar potentials based on sl(2) Lie algebra is solved by quasi-exact solvability theory. The configuration of the classes III and VI potentials in the Turbiner’s classification is constructed. Then, the Bethe ansatz equations are calculated so that the energy eigenvalues and eigenfunctions are obtained. Also, we study the problem by using asymptotic iteration method. Finally, we compare the results obtained by...
Latest Results for Pramana
6d
Contributory effect of diffusive heat conduction and Brownian motion on thermal conductivity enhancement of nanofluids
Abstract The effect of diffusive heat conduction and Brownian motion on the enhancement of thermal conductivity in nanofluids is presented here. \({\hbox {Al}}_{2} {\hbox {O}}_{3}\) and \({\hbox {TiO}}_{2}\) nanofluids were prepared at four different wt. fractions of 1%, 0.5%, 0.1% and 0.05% and their thermal conductivity values were measured over temperatures ranging from 25 to \(55^{\circ }\hbox {C}\) for every \(10...
Latest Results for Pramana
6d
Influence of excluded volume interactions on the dynamics of dendrimer and star polymers in layered random flow
Abstract The influence of excluded volume interactions (EVIs) governs the dynamics of branched polymeric structures. Therefore, we developed a theory with the inclusion of ubiquitous EVIs on average square displacement (ASD) of the centre of mass in layered random flow (LRF). The mean-field approach is used to account for effective EVIs between non-bonded monomers of generalised Gaussian structures. The effect of polymer topology is analysed under the influence of ...
Latest Results for Pramana
6d
Energy deposition of heavy-ion beams in neutronless fusion reaction
Abstract Recent advances in laser-plasma accelerators have made possible the production of high-power beams with very low divergence. In this paper, the carbon heavy-ion beam was used to provide optimal conditions for the ignition of P– \(^{\mathrm {11}}\) B clean fuel pellets using the Deira-4 simulation code. The calculations showed that generating maximum ion heating of about 140 keV requires a laser with an intensity of \(10^{\mathrm {21}}\,\hbox {W}/\hbox...
Latest Results for Pramana
1w
Approximate technique for solving fractional variational problems
Abstract The purpose of this paper is to suggest a numerical technique to solve fractional variational problems (FVPs). These problems are based on Caputo fractional derivatives. Rayleigh–Ritz method is used in this technique. First we approximate the objective function by the trapezoidal rule. Then, the unknown function is expanded in terms of the Bernstein polynomials. By this method, a system of algebraic equations is driven. We provide examples to show the effectiveness of...
Latest Results for Pramana
1w
Some Bianchi I dark energy models in Brans–Dicke theory
Abstract The present article deals with the study of interacting and non-interacting dark energy (DE) and dark matter (DM) in the spatially homogeneous and anisotropic Bianchi I space–time within the framework of Brans–Dicke (BD) scalar–tensor theory of gravitation. As the set of field equations is not closed, exact solutions are obtained using power-law relation and assuming a linearly varying deceleration parameter. The physical acceptability and stability of the obtained model...
Latest Results for Pramana
1w
Neuromelanin imaging analyses of the substantia nigra in patients with Machado-Joseph disease
Abstract Purpose Machado-Joseph disease (MJD/SCA3) is the most frequent spinocerebellar ataxia worldwide. Pathological studies revealed less melanin-containing dopaminergic neurons in the substantia nigra (SN) pars compacta in MJD/SCA3 patients. The purpose of this study was to quantify the damage in the SN reported for MJD/SCA3 patients in vivo using neuromelanin MR imaging. ...
Latest Results for Neuroradiology
3d
Treatment with flow diverter stent during pregnancy
Abstract Intracranial aneurysms are rarely diagnosed during pregnancy. If treatment is necessary, surgery was traditionally preferred over embolization in case of ongoing pregnancy, due to concerns regarding foetal radiation exposure. We present a case of 21 mm unruptured carotid-ophthalmic aneurysm diagnosed during pregnancy and treated with flow diversion. Foetal radiation dose was estimated between 1 and 5 mGy, well below recommended limits. Double antiplatelet therapy with...
Latest Results for Neuroradiology
3d
Discrimination of intracranial aneurysm rupture status: patient-specific inflow boundary may not be a must-have condition in hemodynamic simulations
Abstract Background Computational fluid dynamics (CFD) are important in evaluating the hemodynamics of intracranial aneurysm rupture, and the setting of inflow boundary conditions is critical. We evaluated intracranial aneurysm hemodynamics based on generalized versus patient-specific inflow boundary conditions to examine the effect of different hemodynamic results on the discrimination of intracranial aneurysm rupture status. ...
Latest Results for Neuroradiology
3d
Potential of iterative reconstruction for maxillofacial cone beam CT imaging: technical note
Abstract Iterative reconstruction has been proven to be an effective tool for low-dose computed tomography imaging. However, this technology is currently not available in commercial diagnostic maxillofacial cone beam CT. For this technical note, an iterative reconstruction technique was applied to cone beam CT raw data of two maxillofacial clinical cases to explore its potential for dose reduction and metal artifact reduction. Low-dose imaging was emulated by using only fractions...
Latest Results for Neuroradiology
3d
The 49th Annual Meeting Japanese Society of Neuroradiology June 10 - July 15 2020, Held on the Web
Latest Results for Neuroradiology
3d
Microstructural damage of the cortico-striatal and thalamo-cortical fibers in Fabry disease: a diffusion MRI tractometry study
Abstract Purpose Recent evidences have suggested the possible presence of an involvement of the extrapyramidal system in Fabry disease (FD), a rare X-linked lysosomal storage disorder. We aimed to investigate the microstructural integrity of the main tracts of the cortico-striatal-thalamo-cortical loop in FD patients. Methods Forty-seven FD...
Latest Results for Neuroradiology
3d
Automated MRI-based volumetry of basal ganglia and thalamus at the chronic phase of cortical stroke
Abstract Purpose We aimed at assessing the potential of automated MR morphometry to assess individual basal ganglia and thalamus volumetric changes at the chronic phase after cortical stroke. Methods Ninety-six patients (mean age: 65 ± 18 years, male 55) with cortical stroke at the chronic phase were retrospectively included. Patients were scanned...
Latest Results for Neuroradiology
3d
Multi-parametric qualitative and quantitative MRI assessment as predictor of histological grading in previously treated meningiomas
Abstract Purpose Meningiomas are mainly benign tumors, though a considerable proportion shows aggressive behaviors histologically consistent with atypia/anaplasia. Histopathological grading is usually assessed through invasive procedures, which is not always feasible due to the inaccessibility of the lesion or to treatment contraindications. Therefore, we propose a multi-parametric MRI assessment as a predictor of meningioma histopathological...
Latest Results for Neuroradiology
3d
Association between draining vein diameters and intracranial arteriovenous malformation hemorrhage: a multicentric retrospective study
Abstract Purpose Intracranial arteriovenous malformations (AVMs) cause hemorrhage, and the role of draining vein diameters in rupture risk is controversial. The aims of the present study were to investigate the variables related with intracranial AVM rupture and to examine the association of draining vein diameters and AVM hemorrhage. Methods ...
Latest Results for Neuroradiology
3d
Structural MRI and tract-based spatial statistical analysis of diffusion tensor imaging in children with hemimegalencephaly
Abstract Purpose To investigate the gross white matter abnormalities in the structural brain MR imaging as well as white matter microstructural alterations using tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) in both affected and contralateral cerebral hemispheres of children with hemimegalencephaly (HMEG). Methods ...
Latest Results for Neuroradiology
3d
Risk factors of cemented vertebral refracture after percutaneous vertebral augmentation: a systematic review and meta-analysis
Abstract To evaluate the risk factors of cemented vertebral refracture after percutaneous vertebral augmentation (PVA) for patients with osteoporotic vertebral compression fractures (OVCFs). We performed a literature search on cemented vertebral refracture after PVA using the PubMed, EMBASE, and Cochrane Library medical databases. The clinical data, including literature information, basic patient information, observational factors, and interventional factors, were extracted by...
Latest Results for Neuroradiology
3d
Use of intracranial stent as rescue therapy after mechanical thrombectomy failure—9-year experience in a comprehensive stroke centre
Abstract Purpose There is no established rescue treatment in patients with mechanical thrombectomy (MT) failure. Our aim is to analyse whether the use of an intracranial stent improves prognosis in these patients. Methods Retrospective analysis of a prospective cohort of patients with ischemic stroke due to middle cerebral artery occlusion (MCA)...
Latest Results for Neuroradiology
3d
Intracranial and extracranial vascular manifestations of patients with a clinical diagnosis of Klippel–Trenaunay syndrome
Abstract Background and purpose While numerous reports have demonstrated intracranial CNS anomalies associated with Klippel–Trenaunay syndrome, to our knowledge, there has not been a large consecutive study examining these anomalies. The aim of this study was to determine the spectrum of intracranial neurovascular manifestations in patients with a clinical diagnosis of Klippel–Tranaunay syndrome. ...
Latest Results for Neuroradiology
4d
Evaluation of cerebral arteriovenous shunts: a comparison of parallel imaging time-of-flight magnetic resonance angiography (TOF-MRA) and compressed sensing TOF-MRA to digital subtraction angiography
Abstract Purpose Time-of-flight (TOF)-MR angiography (MRA) is an important imaging sequence for the surveillance and analysis of cerebral arteriovenous shunt (AVS), including arteriovenous malformation (AVM) and arteriovenous fistula (AVF). However, this technique has the disadvantage of a relatively long scan time. The aim of this study was to compare diagnostic accuracy between compressed sensing (CS)-TOF and conventional parallel imaging...
Latest Results for Neuroradiology
5d
Altered local and distant functional connectivity density in chronic migraine: a resting-state functional MRI study
Abstract Purpose Previous studies have indicated disrupted functional connectivity in multiple brain regions and resting-state networks in episodic migraine, but it is unclear how brain network property is disrupted in chronic migraine. Methods Using resting-state functional magnetic resonance imaging and voxel-wise functional connectivity density analysis,...
Latest Results for Neuroradiology
6d
Investigating the parameters that affect the radiation exposure and establishing typical values based on procedure complexity for cerebral angiography and brain aneurysm embolization
Abstract Purpose The purpose of this study is to investigate the parameters that affect the radiation exposure and to establish typical values (TV) based on procedure complexity for cerebral angiography (CA) and brain aneurysm embolization (BAE). Methods Clinical parameters and exposure data were retrospectively reviewed for 348 examinations performed between...
Latest Results for Neuroradiology
6d
Intra-osseous basivertebral nerve radiofrequency ablation (BVA) for the treatment of vertebrogenic chronic low back pain
Abstract Study design Prospective experimental uncontrolled trial. Background Vertebrogenic pain is a frequently underestimated cause of chronic low back pain (LBP). Vertebral endplate degeneration, characterized by cortical bone damage and subchondral bone inflammatory reaction, is a significant source of LBP, the responsible of the pain transmission being...
Latest Results for Neuroradiology
1w
European Society of Neuroradiology (ESNR)
Latest Results for Neuroradiology
1w
Morbidity and Mortality of Large-Vessel Vasculitides
Abstract Purpose of Review Giant cell arteritis (GCA) and Takayasu arteritis (TAK) comprise the primary systemic large-vessel vasculitides. In these conditions, arterial stenosis, occlusion, aneurysm, and dissection can lead to severe disease-related consequences. This review focuses on disease-related manifestations of GCA and TAK, emphasizing the impact of these findings on long-term morbidity and mortality. ...
Latest Results for Current Rheumatology Reports
3d
Stabilized generalized interpolation material point method for coupled hydro-mechanical problems
Abstract The material point method (MPM) has been increasingly used to simulate coupled hydro-mechanical problems involving large deformations. However, when addressing saturated porous media with an almost incompressible liquid phase, the classic explicit MPM with low-order interpolation functions is not stable if no further stabilization approach is used. In this study, a solid-velocity–liquid-velocity-based hydro-mechanical governing formulation is adopted to construct a two-phase...
Latest Results for Computational Particle Mechanics
4d
Karamelo: an open source parallel C++ package for the material point method
Abstract A simple and robust C++ code for the material point method (MPM) called Karamelo is presented here. It was designed to provide an open source, fast, light and easy-to-modify framework for both conducting research on the MPM and research using the MPM, instead of a finite element package. This paper presents the overall philosophy, the main design choices and some of the original algorithms implemented in Karamelo. Simulations of solids and fluids involving extreme deformation...
Latest Results for Computational Particle Mechanics
6d
Morbidity and Mortality of Large-Vessel Vasculitides
Abstract Purpose of Review Giant cell arteritis (GCA) and Takayasu arteritis (TAK) comprise the primary systemic large-vessel vasculitides. In these conditions, arterial stenosis, occlusion, aneurysm, and dissection can lead to severe disease-related consequences. This review focuses on disease-related manifestations of GCA and TAK, emphasizing the impact of these findings on long-term morbidity and mortality. ...
Latest Results for Current Rheumatology Reports
4d
Correction to: Disturbed Gastrointestinal Contractility in a Polycystic Ovary Syndrome Rat Model
The original version of the article unfortunately contained an error in the legend of Figure 5B. Corrected version of Figure 5 is given below.
Latest Results for Digestive Diseases and Sciences
4d
Lnc-ing RNA Expression with Disease Pathogenesis: MALAT1 and ANRIL in Ulcerative Colitis
Latest Results for Digestive Diseases and Sciences
4d
Transjugular Intrahepatic Portosystemic Shunts for Hepatorenal Syndrome: TIPping the Scales in Whose Favor?
Latest Results for Digestive Diseases and Sciences
4d
Non-emergent Weekend ERCP: It Makes Sense—Now, Make It Work
Latest Results for Digestive Diseases and Sciences
4d
Hold the Foam: Why Topical Budesonide Remains Relevant for IBD Therapy
Latest Results for Digestive Diseases and Sciences
4d
GI Training in the COVID-19 Era: A Problem of Global Concern
Latest Results for Digestive Diseases and Sciences
4d
Gastrointestinal Infections in IBD Flares: Can PCR-Based Stool Tests Differentiate the Smoke from the Fire?
Latest Results for Digestive Diseases and Sciences
4d
Impaired Quality of Working Life in Inflammatory Bowel Disease Patients
Abstract Background Work-related aspects are important determinants of health for inflammatory bowel disease (IBD) patients. Aims We aimed to describe quality of working life (QWL) in IBD patients and to assess variables that are associated with QWL. Methods Employed...
Latest Results for Digestive Diseases and Sciences
5d
Factors Associated with Up-to-Date Colonoscopy Use Among Puerto Ricans in New York City, 2003–2016
Abstract Background Colorectal cancer is the second leading cause of cancer death among Hispanic Americans. Puerto Ricans are the second largest Hispanic subgroup in the USA and the largest in New York City, but little is known about predictors of colorectal cancer screening uptake in this population. Aims We used the New York City Community Health...
Latest Results for Digestive Diseases and Sciences
5d
Importance of Hepcidin in the Etiopathogenesis of Anemia in Inflammatory Bowel Disease
Abstract Anemia is the most common extraintestinal systemic complication of inflammatory bowel disease. Iron deficiency anemia and anemia of chronic disease are among the most frequent types. Intestinal iron absorption is controlled by the activity of ferroportin. Cells with high expression of ferroportin include enterocytes, and also macrophages and hepatocytes. Iron homeostasis is controlled by the hepcidin-ferroportin axis. Hepcidin is a central regulator of iron metabolism...
Latest Results for Digestive Diseases and Sciences
5d
Bad “Good” Bile Acids and Gut Microbiota Dysbiosis in Inflammatory Bowel Disease: Mice and Humans Are Not the Same
Abstract The effects of deoxycholic acid (DCA) on the intestinal microbiota, bile acid (BA) metabolism, and intestinal epithelium can be influenced by various factors. Depending on the specific conditions, DCA can be “bad” (proinflammatory) or “good” (anti-inflammatory). Mouse models of colitis show an increase in conjugated BAs and gut dysbiosis, including DCA-related dysbiosis, with a significant decrease in bile salt hydrolase (bsh) gene-containing taxa. Human patients with...
Latest Results for Digestive Diseases and Sciences
5d
Pilot Validation of a New Wireless Patch System as an Ambulatory, Noninvasive Tool That Measures Gut Myoelectrical Signals: Physiologic and Disease Correlations
Abstract Background and Aims Limited means exist to assess gastrointestinal activity in a noninvasive, objective way that is highly predictive of underlying motility disorders. The aim of this paper is to demonstrate the feasibility of recording myoelectric gastrointestinal activity by cutaneous patches and to correlate myoelectric signals with gastrointestinal function in various clinical settings. ...
Latest Results for Digestive Diseases and Sciences
5d
Microscopic Colitis Is Not an Independent Risk Factor for Low Bone Density
Abstract Background Microscopic colitis (MC) is a subtype of inflammatory bowel disease (IBD) with overlapping risk factors for low bone density (LBD). While LBD is a known complication of IBD, its association with MC is not well-established. Aims Assess the prevalence of LBD in MC compared to control populations, and evaluate if MC predicts LBD when...
Latest Results for Digestive Diseases and Sciences
5d
PLCD1: A Potential Therapeutic Target in the Treatment of Esophageal Squamous Cell Carcinoma?
Latest Results for Digestive Diseases and Sciences
6d
Artificial Intelligence and Its Role in Identifying Esophageal Neoplasia
Abstract Randomized trials have demonstrated that ablation of dysplastic Barrett’s esophagus can reduce the risk of progression to cancer. Endoscopic resection for early stage esophageal adenocarcinoma and squamous cell carcinoma can significantly reduce postoperative morbidity compared to esophagectomy. Unfortunately, current endoscopic surveillance technologies (e.g., high-definition white light, electronic, and dye-based chromoendoscopy) lack sensitivity at identifying subtle...
Latest Results for Digestive Diseases and Sciences
6d
Red Between the Lines: Evolution of Eosinophilic Esophagitis as a Distinct Clinicopathologic Syndrome
Abstract Eosinophilic esophagitis (EoE) is characterized by eosinophilic infiltration of the esophageal mucosa and symptoms of esophageal dysfunction, including dysphagia. While EoE is still considered a rare disease, in practice it seems that more and more cases are diagnosed every week, research in the field is exploding, and the pipeline for treatments contains multiple agents, some of which are quite far along the development pathway. After only scattered cases and small series...
Latest Results for Digestive Diseases and Sciences
6d
Kounis syndrome after patent blue dye injection for sentinel lymph node biopsy
Abstract Background Kounis syndrome (KS) has been described as an acute coronary syndrome (ACS) associated with an anaphylactic reaction. Several triggers have been identified and the diagnostic and treatment process can be challenging. Case A 58-year-old, female patient diagnosed with breast cancer and no history of allergies had subcutaneous...
Latest Results for Breast Cancer
4d
Pure ground glass opacity (GGO) on chest CT: a rare presentation of lung metastasis of Malignant Phyllodes Tumor
Abstract Lung is the most common target organ for distant metastasis of phyllodes tumor (PT), where the metastatic tumors are mostly seen as nodules or masses. We report here a rare case in which pure ground-glass opacity (GGO) was observed on chest CT about 3 years after the initial treatment of breast PT. After the lung lobectomy, we histologically confirmed that it should be diagnosed as a metastasis of PT. GGO rarely shows on metastatic tumors, and no reports have been made...
Latest Results for Breast Cancer
4d
3-Dimensional objective aesthetic evaluation to replace panel assessment after breast-conserving treatment
Abstract Background Two-thirds of patients with early breast cancer undergo breast-conserving treatment (BCT). Aesthetic outcome is important and has long term implications for psychosocial wellbeing. The aesthetic goal of BCT is symmetry for which there is no gold-standard measure. Panel scoring is the most widely adopted assessment but has well-described limitations. This paper describes a model to objectively report aesthetic...
Latest Results for Breast Cancer
4d
XPC as breast cancer susceptibility gene: evidence from genetic profiling, statistical inferences and protein structural analysis
Abstract Background Gene polymorphisms that affect nucleotide excision repair (NER) pathway may link with higher susceptibility of breast cancer (BC); however, the significance of these associations may vary conferring to the individual ethnicity. Xeroderma pigmentosum complementation gene (XPC) plays a substantial role in recognizing damaged DNA during NER process. ...
Latest Results for Breast Cancer
4d
Interleukin-34 contributes to poor prognosis in triple-negative breast cancer
Abstract Triple-negative breast cancer (TNBC) is a subtype characterized by the absence of therapeutic targets. It shows rapid progression, higher relapse, and poor prognosis, so the establishment of an effective therapeutic target is required. We focused on interleukin-34 (IL-34) that is a novel cytokine relating to inflammation and tumorigenesis. It has been reported that IL-34 correlates with poor prognosis of various cancers. In this study, we evaluated the relationship...
Latest Results for Breast Cancer
4d
Fertility under uncertainty: exploring differences in fertility-related concerns and psychosocial aspects between breast cancer survivors and non-cancer infertile women
Abstract Background The threat to fertility due to anticancer treatments can be distressing to women who wish to complete their family. The current study assessed the fertility-related concerns, psychological distress and health-related quality of life (HRQoL) of breast cancer survivors in comparison to non-cancer women with infertility history and to healthy controls from the general population. ...
Latest Results for Breast Cancer
4d
Correction to: “When should primary angiitis of the central nervous system (PACNS) be suspected?”: literature review and proposal of a preliminary screening algorithm
The above article was published online with inverted given and family names. The correct presentation has been corrected above. The original article has been corrected.
Latest Results for Neurological Sciences
4d
Neurological reasons for consultation and hospitalization during the COVID-19 pandemic
Abstract Background COVID-19 disease affects the nervous system and led to an increase in neurological consults for patients at admission and through the period of hospitalization during the peak of the pandemic. Methods Patients with clinical and laboratory diagnosis of COVID-19 that required a neurologic consultation or those who presented...
Latest Results for Neurological Sciences
4d
Correction to: Clinical and demographic characteristics of primary progressive multiple sclerosis in Argentina: Argentinean registry cohort study (RelevarEM)
The above article was published online with incorrect figure 1.
Latest Results for Neurological Sciences
4d
Fahr’s syndrome presenting with seizures in SARS-CoV-2 (COVID-19) pneumonia—a case report
Abstract Background Fahr’s syndrome (or Fahr’s disease) is a rare, neurological disorder characterized by bilateral calcification in the cerebellum, thalamus, basal ganglia, and cerebral cortex as a result of calcium and phosphorus metabolism disorder. The patients may be asymptomatic and clinical symptoms represent a wide range of neurologic manifestations and nonspecific neuropsychiatric disorders. We report an unusual case of...
Latest Results for Neurological Sciences
4d
Correction to: Guillain-Barre syndrome during COVID-19 pandemic: an overview of the reports
The article was published with incorrect sequence of references citation in Table 2 and Reference section from References 30–63 and reference 64 was removed during processing.
Latest Results for Neurological Sciences
4d
Fulminant encephalitis as a sole manifestation of COVID-19
Abstract Novel coronavirus (SARS-CoV-2) occurred in December 2019 in Wuhan, China, and has become a global health emergency. Coronavirus primarily is a respiratory virus, but it has been detected in the brain and cerebrospinal fluid of infected individuals. The present report describes a case of fulminant encephalitis in a patient affected by COVID-19.
Latest Results for Neurological Sciences
4d
Patient tolerability of suprascapular and median nerve blocks for the management of pain in post-stroke shoulder-hand syndrome
Abstract Background Current management options for pain in stroke patients with the shoulder-hand syndrome (SHS) are limited and often ineffective. The use of peripheral nerve blocking in SHS has been limited due to concerns of hyperalgesia and allodynia in these patients. This study assessed the tolerability of suprascapular nerve (SSN) and median nerve blocks for acute control of pain in patients with post-stroke SHS. ...
Latest Results for Neurological Sciences
4d
Reliability of the six-minute walk test in individuals with stroke: systematic review and meta-analysis
Abstract Purpose The six-minute walking test (6MWT) is a simple and widely used measure of functional capacity. The aim of this systematic review is to summarize findings on reliability of 6MWT in subjects who have had a stroke. Methods Two independent investigators conducted an extensive search in multidisciplinary electronic databases from inception to...
Latest Results for Neurological Sciences
4d
Detection of MOG-IgG by cell-based assay: moving from discovery to clinical practice
Abstract Myelin oligodendrocyte glycoprotein (MOG) is a unique CNS-specific mammalian protein that is expressed on the surface of compact myelin and oligodendrocyte cell bodies. MOG is an accessible target for autoantibodies, associated with immune-mediated demyelination in the central nervous system. The identification of MOG reactive immunoglobulin G antibodies (MOG-IgG) helps to distinguish a subgroup of patients from multiple sclerosis and other CNS disorders, reducing the...
Latest Results for Neurological Sciences
5d
Admission blood cell counts are predictive of stroke-associated infection in acute ischemic stroke patients treated with endovascular therapy
Abstract Stroke-associated infection (SAI) is a major medical complication in acute ischemic stroke patients (AIS) treated with endovascular therapy (EVT). Three hundred thirty-three consecutive patients with AIS caused by a large vessel occlusion in the anterior circulation who received EVT (142 (42.6%) of them were given IV tPA as bridging therapy) and 337 AIS patients who received IV tPA only (non-EVT) were enrolled in the study and evaluated to determine the association of...
Latest Results for Neurological Sciences
6d
Dynamic functional connectivity in temporal lobe epilepsy: a graph theoretical and machine learning approach
Abstract Purpose Functional magnetic resonance imaging (fMRI) in resting state can be used to evaluate the functional organization of the human brain in the absence of any task or stimulus. The functional connectivity (FC) has non-stationary nature and consented to be varying over time. By considering the dynamic characteristics of the FC and using graph theoretical analysis and a machine learning approach, we aim to identify the laterality...
Latest Results for Neurological Sciences
6d
Utility of Hounsfield unit in the diagnosis of tandem occlusion in acute ischemic stroke
Abstract Background Tandem occlusions can complicate medical and endovascular stroke treatment. To identify these occlusions, computed tomography angiography (CTA) represents the best imaging modality. However, CTA is still not initially performed in some patients not admitted directly to stroke centers. Early identification of an additional occlusion of the proximal extracranial internal carotid artery may improve the best suitable treatment...
Latest Results for Neurological Sciences
6d
New-onset anosmia and taste distortion: see beyond COVID-19
Latest Results for Neurological Sciences
6d
Neurological manifestations and comorbidity associated with COVID-19: an overview
Abstract First in 2002, severe acute respiratory syndrome coronavirus (SARS-CoV), second in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV), and now the third in the December 2019, emergence of tremendously pathogenic and large-scale epidemic novel coronavirus (SARS-CoV-2) has brought the worst conditions into the human inhabitants of the twenty-first century. The SARS-CoV-2 uses the resembling receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV,...
Latest Results for Neurological Sciences
6d
Critical illness neuro-myopathy (CINM) and focal amyotrophy in intensive care unit (ICU) patients with SARS-CoV-2: a case series
Abstract We found four patients with some characteristic phenotype in our ICU, characterized by focal hypotrophies of the shoulder girdle and the bilateral peroneal district and underlying critical illness neuro-myopathy. In our opinion, these hypotrophies are secondary to the prone position. Is our intention to start early treatment protocol with electrostimulation to evaluate the effectiveness in the prevention of critical illness and focal hypotrophies in ICU SARS-CoV-2 patients,...
Latest Results for Neurological Sciences
1w
CACNA1B gene variants in adult-onset isolated focal dystonia
Abstract Background Isolated focal dystonia (IFD) is a heterogeneous group of potentially invalidating movement disorders. The etiopathogenesis is complex, both genetic and environmental factors playing a role, but remains elusive. The CACNA1B gene codes for the N-type neuronal voltage-gated calcium channels CaV2.2, which may play a role in the development of some IFD. Methods...
Latest Results for Neurological Sciences
1w
Association of lipid profiles with severity and outcome of acute ischemic stroke in patients with and without chronic kidney disease
Abstract Background Contribution of lipid profiles to stroke severity and outcome was inconclusive, whether chronic kidney disease (CKD) (estimated glomerular filtration rate < 60 mL/min/1.73 m2) affects the association has not been investigated. We aim to evaluate this relationship. Methods A retrospective study of consecutive acute ischemic stroke patients...
Latest Results for Neurological Sciences
1w
Spinocerebellar ataxia type 48: last but not least
Latest Results for Neurological Sciences
1w
Opportunities for broadening the application of cell wall lytic enzymes
Abstract In light of emerging antibiotic resistance, bacterial cell wall lytic enzymes are promising antimicrobial agents that degrade bacterial peptidoglycan while specifically recognizing the target bacterium. The efficacy of lytic enzymes against several multi-drug-resistant pathogens infecting humans has led to many efforts focused on in vivo therapeutic applications. However, the potential for lytic enzymes to combat bacterial contamination in...
Latest Results for Applied Microbiology and Biotechnology
4d
Mercury in traditionally foraged species of fungi (macromycetes) from the karst area across Yunnan province in China
Abstract The objective of this study is to better quantify the occurrence, intake, and potential risk from Hg in fungi traditionally foraged in SW China. The concentrations and intakes of Hg were measured from 42 species including a “hard” flesh type polypore fungi and a” soft” flesh type edible species that are used in traditional herbal medicine, collected during the period 2011–2017. Three profiles of forest topsoil from the Zhenyuan site in 2015...
Latest Results for Applied Microbiology and Biotechnology
4d
High-level expression of aryl-alcohol oxidase 2 from Pleurotus eryngii in Pichia pastoris for production of fragrances and bioactive precursors
Abstract The fungal secretome comprises various oxidative enzymes participating in the degradation of lignocellulosic biomass as a central step in carbon recycling. Among the secreted enzymes, aryl-alcohol oxidases (AAOs) are of interest for biotechnological applications including production of bio-based precursors for plastics, bioactive compounds, and flavors and fragrances. Aryl-alcohol oxidase 2 (PeAAO2) from the fungus Pleurotus eryngii was heterologously...
Latest Results for Applied Microbiology and Biotechnology
4d
A tunable l -arabinose-inducible expression plasmid for the acetic acid bacterium Gluconobacter oxydans
Abstract The acetic acid bacterium (AAB) Gluconobacter oxydans incompletely oxidizes a wide variety of carbohydrates and is therefore used industrially for oxidative biotransformations. For G. oxydans, no system was available that allows regulatable plasmid-based expression. We found that the l-arabinose-inducible PBAD promoter and the transcriptional regulator AraC from Escherichia coli MC4100 performed very well in G. oxydans. The respective pBBR1-based...
Latest Results for Applied Microbiology and Biotechnology
4d
Enhancing the decolorization activity of Bacillus pumilus W3 CotA-laccase to Reactive Black 5 by site-saturation mutagenesis
Abstract Reactive Black 5 (RB5) is a typical refractory azo dye. Widespread utilization of RB5 has caused a variety of environmental and health problems. The enzymatic degradation of RB5 can be a promising solution due to its superiority as an eco-friendly and cost-competitive process. Bacterial CotA-laccase shows great application prospect to eliminate hazardous dyes from wastewater. However, efficient decolorization of RB5 CotA-laccase generally...
Latest Results for Applied Microbiology and Biotechnology
4d
A novel thermostable serine protease from a metagenomic library derived from marine sediments in the East China Sea
Abstract Thermal activity and stability are important characteristics for proteases applied in the detergent, pharmaceutical, food, and other green industries. With the intent to discover thermostable novel proteases, we constructed a fosmid metagenomic library from marine sediments in the East China Sea and isolated a clone endowed with high proteolytic activity from this library. Sequence analysis of the positive subclones allowed the identification...
Latest Results for Applied Microbiology and Biotechnology
4d
New multiplex conventional PCR and quadruplex real-time PCR assays for one-tube detection of Phyllosticta citricarpa , Elsinoë fawcettii , Elsinoë australis , and Pseudocercospora angolensis in Citrus : development and validation
Abstract Phyllosticta citricarpa, Elsinoë fawcettii, Elsinoë australis, and Pseudocercospora angolensis are major pathogens of citrus crops worldwide and can cause non-characteristic symptoms that may lead to confusion regarding the causative agent. These fungi are subject to international phytosanitary regulations, and testing on fruits or leaves requires accurate and easy-to-use tools. New multiplex conventional PCR and real-time PCR assays were...
Latest Results for Applied Microbiology and Biotechnology
4d
Towards green extraction methods from microalgae learning from the classics
Abstract Microalgae started receiving attention as producers of third generation of biofuel, but they are rich in many bioactive compounds. Indeed, they produce many molecules endowed with benefic effects on human health which are highly requested in the market. Thus, it would be important to fractionate algal biomass into its several high-value compounds: this represents the basis of the microalgal biorefinery approach. Usually, conventional extraction methods have been used...
Latest Results for Applied Microbiology and Biotechnology
4d
Evolution of an Escherichia coli PTS − strain: a study of reproducibility and dynamics of an adaptive evolutive process
Abstract Adaptive laboratory evolution (ALE) has been used to study and solve pressing questions about evolution, especially for the study of the development of mutations that confer increased fitness during evolutionary processes. In this contribution, we investigated how the evolutionary process conducted with the PTS− mutant of Escherichia coli PB11 in three parallel batch cultures allowed the restoration of rapid growth with glucose as the carbon source. The significant...
Latest Results for Applied Microbiology and Biotechnology
4d
Fungal bioremediation of soil co-contaminated with petroleum hydrocarbons and toxic metals
Abstract Much research has been carried out on the bacterial bioremediation of soil contaminated with petroleum hydrocarbons and toxic metals but much less is known about the potential of fungi in sites that are co-contaminated with both classes of pollutants. This article documents the roles of fungi in soil polluted with both petroleum hydrocarbons and toxic metals as well as the mechanisms involved in the biotransformation of such substances. Soil...
Latest Results for Applied Microbiology and Biotechnology
4d
A novel one-day phage-based test for rapid detection and enumeration of viable Mycobacterium avium subsp. paratuberculosis in cows’ milk
Abstract Bacteriophage-based methods for the rapid detection of viable Mycobacterium avium subsp. paratuberculosis (MAP) in veterinary specimens are a recent addition to the Johne’s disease diagnostic toolbox. Here, we report the use of D29 mycobacteriophage-coated tosylactivated paramagnetic beads to capture and concentrate MAP cells from samples (termed phagomagnetic separation, PhMS) and then naturally lyse viable MAP cells (from the inside out)...
Latest Results for Applied Microbiology and Biotechnology
4d
Effects of glycosylation on the bioactivity of rapamycin
Abstract The macrolactone rapamycin (RAP) presents a broad range of bioactivities, but its clinical applications are compromised due to the poor water solubility and low bioavailability, which could probably be overcome by glycosylation. In this study, we tested a set of promiscuous glycosyltransferases (GTs) to modify rapamycin with four different sugar donors. BsGT-1 displayed the best glycosylation activity with a preference for UDP-glucose, and...
Latest Results for Applied Microbiology and Biotechnology
4d
The impact of anthelmintic treatment on gut bacterial and fungal communities in diagnosed parasite-free sika deer Cervus nippon
Abstract The gut microbiota, including both bacterial and fungal communities, plays vital roles in the gut homeostasis of animals, and antibiotics can lead to disorders of these microbial communities. The use of anthelmintic treatment to control parasitic infection has long been a standard practice, although its impact on the gut microbiota of healthy sika deer is relatively unknown. This study used next-generation sequencing based on 16S/18S/ITS rRNA genes to investigate the...
Latest Results for Applied Microbiology and Biotechnology
4d
Soy bioactive peptides and the gut microbiota modulation
Abstract The balance of protein, carbohydrate, and fat affect the composition and functions of the gut microbiota. The complexities involved thereof require insights into the roles and impacts of individual dietary components due to the difficulty of defining such in a group of others. Peptides and proteins from several animal and plant sources have been widely explored in relation to the gut microbiome modulation, but the effects of soy peptides and other soy derivatives on...
Latest Results for Applied Microbiology and Biotechnology
4d
Rational design of the carbonyl reductase EbSDR8 for efficient biosynthesis of enantiopure ( R )-3-chloro-1-phenyl-1-propanol
Abstract (R)-3-Chloro-1-phenyl-1-propanol ((R)-CPPO) is an important chiral intermediate for antidepressants. For its efficient biosynthesis, the carbonyl reductase EbSDR8 was engineered to asymmetrically reduce the unnatural substrate 3-chloro-1-phenyl-1-propanone (3-CPP) at high concentrations. Molecular docking and molecular dynamics simulations of the resulting mutants suggested enlarged substrate binding pocket and more reasonable interactions between...
Latest Results for Applied Microbiology and Biotechnology
4d
Towards next-generation model microorganism chassis for biomanufacturing
Abstract Synthetic biology provides powerful tools and novel strategies for designing and modifying microorganisms to function as cell factories for biomanufacturing, which is a promising approach for realizing chemical production in a green and sustainable manner. Recent advances in genetic component design and genome engineering have enabled significant progresses in the field of synthetic biology chassis that have been developed for enzymes or biochemical...
Latest Results for Applied Microbiology and Biotechnology
4d
A maltose-regulated large genomic region is activated by the transcriptional regulator MalT in Actinoplanes sp. SE50/110
Abstract Actinoplanes sp. SE50/110 is the industrially relevant producer of acarbose, which is used in the treatment of diabetes mellitus. Recent studies elucidated the expression dynamics in Actinoplanes sp. SE50/110 during growth. From these data, we obtained a large genomic region (ACSP50_3900 to ACSP50_3950) containing 51 genes, of which 39 are transcribed in the same manner. These co-regulated genes were found to be stronger transcribed on maltose...
Latest Results for Applied Microbiology and Biotechnology
4d
Current advance in biological production of short-chain organic acid
Abstract As natural metabolites, organic acids have been widely applied in food, pharmaceutical, and bio-based materials industries. Particularly, the short-chain organic acids, including C2, C3, C4, C5, and C6 organic acids, are necessary intermediate metabolites in cells and are also alternatives to some commercial chemical products. As the necessary metabolites in cells, most major short-chain organic acids can be produced through microbial fermentation. Specifically, with...
Latest Results for Applied Microbiology and Biotechnology
4d
New knowledge about the biosynthesis of lovastatin and its production by fermentation of Aspergillus terreus
Abstract Lovastatin, and its semisynthetic derivative simvastatine, has great medical and economic importance, besides great potential for other uses. In the last years, a deeper and more complex view of secondary metabolism regulation has emerged, with the incorporation of cluster-specific and global transcription factors, and their relation to signaling cascades, as well as the new level of epigenetic regulation. Recently, a new mechanism, which...
Latest Results for Applied Microbiology and Biotechnology
4d
Mitogenome of Tolypocladium guangdongense
Abstract Tolypocladium guangdongense is a high-value edible fungus with various medicinal and food safety properties. However, its evolutionary and genetic information is still limited. Mitochondrial genomes are potential models for molecular evolution and phylogenetic studies. In this study, we sequenced the complete mitogenome of T. guangdongense, demonstrating circular sequence of 46,102 bp, containing 14 standard protein-coding genes (PCGs), 2...
Latest Results for Applied Microbiology and Biotechnology
4d
Alterations of Akkermansia muciniphila in the inflammatory bowel disease patients with washed microbiota transplantation
Abstract Akkermansia muciniphila is a promising probiotic in the gut. This study aimed to determine the presence and abundance of Akkermansia in patients with inflammatory bowel disease (IBD) who underwent washed microbiota transplantation (WMT) in order to elucidate the relationship between its level and patients’ clinical data and outcomes. A cohort of Chinese volunteers including 80 healthy controls (HC), 43 patients with ulcerative colitis (UC), and...
Latest Results for Applied Microbiology and Biotechnology
4d
Nitrate reductase-dependent nitric oxide plays a key role on MeJA-induced ganoderic acid biosynthesis in Ganoderma lucidum
Abstract Ganoderma lucidum, which contains numerous biologically active compounds, is known worldwide as a medicinal basidiomycete. Because of its application for the prevention and treatment of various diseases, most of artificially cultivated G. lucidum is output to many countries as food, tea, and dietary supplements for further processing. Methyl jasmonate (MeJA) has been reported as a compound that can induce ganoderic acid (GA) biosynthesis, an important...
Latest Results for Applied Microbiology and Biotechnology
4d
Metabolic engineering of Escherichia coli for polyamides monomer δ-valerolactam production from feedstock lysine
Abstract Nylon 5 and nylon 6,5 are recently explored as new commercial polyamides, of which the monomer includes δ-valerolactam. In this study, a novel catalytic activity of lysine 2-monooxygenase (DavB) was explored to produce δ-valerolactam from l-pipecolic acid (L-PA), functioning as oxidative decarboxylase on a cyclic compound. Recombinant Escherichia coli BS01 strain expressing DavB from Pseudomonas putida could synthesize δ-valerolactam from l-pipecolic...
Latest Results for Applied Microbiology and Biotechnology
4d
Proteomic and metabolic characterization of membrane vesicles derived from Streptococcus mutans at different pH values
Abstract Bacterial membrane vesicles (MVs) are used as a tool for intercellular communication and seem essential for bacterial survival. However, few data are available on MVs generated by Streptococcus mutans, which is the main aetiological agent of dental caries. The present study presents an integrated proteomics and metabolomics analysis of MVs isolated from S. mutans at initial pH values of 7.5 and 5.5 and explores their function. The results showed...
Latest Results for Applied Microbiology and Biotechnology
4d
A novel XRE family regulator that controls antibiotic production and development in Streptomyces coelicolor
Abstract Although the genome of the Streptomyces model strain S. coelicolor was sequenced nearly two decades ago, the function of many annotated genes has not been verified, including that of gene sco1979, which was predicted to encode a transcriptional regulator of the xenobiotic response element (XRE) family. In this study, we showed that SCO1979 represses its own transcription and that deletion of sco1979 from S. coelicolor markedly enhanced production...
Latest Results for Applied Microbiology and Biotechnology
5d
Identification of a gene from Streptomyces rimosus M527 negatively affecting rimocidin biosynthesis and morphological differentiation
Abstract The polyene macrolide rimocidin, produced by Streptomyces rimosus M527, was found to be highly effective against a broad range of fungal plant pathogens. Current understanding of the regulatory mechanism of rimocidin biosynthesis and morphological differentiation in S. rimosus M527 is limited. NsdA is considered a negative regulator involved in morphological differentiation and biosynthesis of secondary metabolites in some Streptomyces species....
Latest Results for Applied Microbiology and Biotechnology
5d
Helicobacter pylori treatment in the post-antibiotics era—searching for new drug targets
Abstract Helicobacter pylori, a member of Epsilonproteobacteria, is a Gram-negative microaerophilic bacterium that colonizes gastric mucosa of about 50% of the human population. Although most infections caused by H. pylori are asymptomatic, the microorganism is strongly associated with serious diseases of the upper gastrointestinal tract such as chronic gastritis, peptic ulcer, duodenal ulcer, and gastric cancer, and it is classified as a group I carcinogen....
Latest Results for Applied Microbiology and Biotechnology
1w

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Αρχειοθήκη ιστολογίου