Abstract Background The COVID-19 pandemic has transformed the practice of physical therapy (PT), from a model based on in-person delivery to one that includes telehealth. However, research is needed to assess value, patient satisfaction, and clinical outcomes in the delivery of telehealth PT. Purposes We sought to compare patient satisfaction with in-person...
1d
In the original version of the publication, the UVA dose and irradiation time were miscalculated.
1d
Abstract Mounting evidence indicates that the long non-coding RNA (lncRNA) LINC00460 plays an oncogenic role in tumor progression; however, the role of LINC00460 in cervical cancer (CC) remains unknown. In this study, we found that LINC00460 was frequently upregulated in CC tissues and cell lines. Knockdown of LINC00460 repressed CC cell growth and invasion in vitro and attenuated tumorigenesis in vivo. Mechanistically, miR-361-3p was predicted as a direct target of LINC00460 by...
5d
Abstract Currently, multiple myeloma (MM) is still an incurable disease. Deciphering its pathogenesis will bring new targets for clinical diagnosis and treatment. In the present study, we identified a MM-associated circular RNA (circRNA), circ-MYBL2, which was dramatically decreased in MM tissue and serum samples in comparison to normal samples. Low circ-MYBL2 level was closely correlated with high clinical stage and unfavorable outcome, and serum circ-MYBL2 had excellent accuracy...
6d
Abstract Hantavirus infection is a global health challenge, causing widespread public concern. In recent years, cases of hantavirus infection in pregnant women have been reported in many countries. The infected pregnant women and their fetuses appear to have more severe clinical symptoms and worse clinical outcomes. Hence, to study the prevalence of hantavirus infection in pregnant women, this study will focus on the epidemiological distribution of the virus, different virus species...
1d
Abstract The recent emergence and rapid global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pose an unprecedented medical and socioeconomic crisis, and the disease caused by it, Coronavirus disease 2019 (COVID-19), was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Chinese scientists and physicians rapidly identified the causative pathogen, which turned out to be a novel betacoronavirus with high sequence similarities...
3d
Abstract Attraction effects arise when a comprehender erroneously retrieves a distractor instead of a target item during memory retrieval operations. In Korean, considerable processing difficulties occur in the agreement relation checking between a subject and an honorific-marked predicate when an intervening distractor carries a non-honorific feature. We investigate how attraction effects are managed during the processing of Korean subject-predicate honorific agreement by two...
1d
Abstract The present investigation aimed at studying emotional terms (ETs) in Persian and English bed-night stories for children by adopting a contrastive analysis approach within two phases. Emotional terms were categorized into two theoretical models (tokens and types) in phase one of the study, and in the second phase, the effect of teaching emotive narratives on learners’ pragmatic knowledge of controlling emotions was scrutinized. To this aim, 30 English bed-night stories...
4d
Abstract In this study, we analysed patterns of spatial variation in the basal area of live and dead trees and structural complexity in close-to-primeval forests in the Dinaric Mts. The results were compared with an analogous study conducted in the Western Carpathians. The research was carried out in the Janj, Lom and Perucića forest reserves (Bosnia and Herzegovina) in mixed-species stands of silver fir Abies alba Mill., European beech Fagus sylvatica L. and Norway spruce Picea...
1d
Abstract Seed stand is a natural forest population that is one of the essential seed sources for global seed supply. Individual fertility is an ability to produce progeny to next generation. Prediction of fertility variation is useful for seed quality, ecosystem management and gene conservation. Fertility variation and gene diversity in seed stands of Taurus cedar were estimated based on the difference in strobilus production between female and male parents. A total of 50 trees...
4d
Abstract Purpose This study investigated the effects of psychosocial working conditions on mental health-related long-term sickness absence and whether distress, work satisfaction, burnout, engagement, and work ability mediated the associations between psychosocial working conditions and mental health-related long-term sickness absence. Methods This cohort study included 53,833 non-sick listed workers who participated in occupational health surveys between 2010 and 2013. The effects...
1d
Abstract Comorbidity is common among long-term sick-listed and many prognostic factors for return to work (RTW) are shared across diagnoses. RTW interventions have small effects, possibly due to being averaged across heterogeneous samples. Identifying subgroups based on prognostic RTW factors independent of diagnoses might help stratify interventions. The aim of this study was to identify and describe subgroups of long-term sick-listed workers, independent of diagnoses, based...
6d
Abstract Background Delayed arterial hemorrhage after pancreaticoduodenectomy is a life-threatening complication. There are no reports about infected aneurysms of the superior mesenteric artery after pancreaticoduodenectomy without clinically relevant pancreatic fistula. Case presentation A 78-year-old woman with borderline resectable pancreatic...
1d
Abstract Background The prognosis of patients with recurrent gastric cancer is poor despite chemotherapy being clinically recommended as the first therapeutic strategy. Recent clinical trials have established the clinical utility of nivolumab in the third-line treatment of such patients. Immune-related adverse events (irAE) have been focused as a promising predictor for tumor response to nivolumab. This report aims to present a long-term...
1d
Abstract Background Neuroendocrine tumors (NETs) originate from neuroendocrine cells, which are found throughout the body. NETs occur principally in the gastrointestinal tract (approximately 65%) and bronchopulmonary tract (approximately 25%) but rarely occur in the presacral space. Aside from primary and metastatic lesions, there have been reports of NETs occurring in the presacral space arising from tailgut cysts, teratomas, and...
3d
Abstract Background 18F-fluorodeoxyglucose (18F-FDG) uptake in hepatocellular carcinoma (HCC) is significantly associated with early recurrence and survival after curative surgical resection. However, there are no reports regarding the relationship between 18F-FDG uptake and outcomes after radiofrequency ablation (RFA). A prospective cohort study was conducted to evaluate the prognostic value of 18F-FDG positron emission tomography...
1d
Abstract Background Previous studies have found abnormal structural and functional brain alterations in breast cancer survivors undergoing chemotherapy. However, the network-level brain changes following chemotherapy remain unknown. The purpose of this study was to investigate the dynamic changes of large-scale within- and between-network functional connectivity in chemotherapy-treated breast cancer patients. ...
4d
Abstract Introduction Several pharmacological treatments aiming at a better symptomatic control of osteoarthritis (OA) are used in daily practice but their efficacy is often disputed. The purpose of this network meta-analysis (NMA) is to assess the efficacy on pain and function of the drugs that are most widely prescribed against knee OA. Methods Medline,...
1d
Abstract Background Based on current evidence, recent guidelines of the National Institute of Health, USA indicated the use of remdesivir and dexamethasone for the treatment of COVID-19 patients with mild-moderate disease, not requiring high-flow oxygen. No therapeutic agent directed against the immunologic pathogenic mechanisms related to the cytokine release syndrome complicating the disease was indicated. ...
3d
Abstract Imlifidase (IdefirixTM), a cysteine protease derived from the immunoglobulin G (IgG)‑degrading enzyme of Streptococcus (S.) pyogenes is being developed by Hansa Biopharma AB for treatment of transplant rejection and rare IgG-mediated autoimmune conditions. In August 2020, intravenous imlifidase received its first global approval in the EU for desensitization treatment of highly sensitized adult kidney transplant patients with positive crossmatch against an available deceased...
5d
Abstract The spectrum of Mesostigmata mite species that are phoretic on the bark beetle Ips typographus has been well described. However, phoretic mite abundance has mostly been quantified by researchers who used only a single method for capturing bark beetles: pheromone traps. We therefore compared mite abundance using two beetle-capture methods. At a single location with high numbers of I. typographus in the eastern Czech Republic in 2013, beetles were collected with pheromone...
1d
Abstract Salicylic acid (SA) is a signaling molecule that can induce plant resistance to certain herbivores. Although the role of jasmonic acid in mediating mite-tomato plant interactions has been well studied, the role of salicylic acid has not. This study examined how the application of exogenous SA, via its effects on tomato plant physiology, alters the activity of mite digestive enzymes, mite energy reserves, and mite susceptibility to spirodiclofen. Enzymatic activity—including...
3d
Gurpreet Singh Suri and Mohammad AlSuwaidi
1d
Marwa Boussaid, Syrine Azza Manoubi, Mohamed Amin Mesrati, Hiba Limem, Yosra Mahjoub, Meriem Boughattas, Randa Salem, Abir Aissaoui
1d
Abstract Multimedia event detection has received a great deal of interest due to developments in video technology and an increase in multimedia data. However, complexities of video content such as noisy, overlapping, repeated interaction between individuals, and various scenes are becoming difficult for characterizing the subjects and concepts. In particular, Internet users find it difficult to search for a specified event. To solve the above problem, a method is proposed that...
1d
Abstract High-resolution computed tomography (CT) can provide accurate diagnostic information for clinical applications. However, using CT scanning equipment to obtain high-resolution CT directly may cause significant radiation damage to human body. Low-dose CT super-resolution using generative adversarial network (GAN) can improve the visual quality of CT while maintaining a low radiation dose to human body. The existing GAN networks for super-resolution still suffer from the...
1d
Abstract Video shot boundary detection (SBD) is a basic work of content-based video retrieval and analysis. Various SBD methods have been proposed; however, there exist limitations in the complexity of boundary detection process. In this paper, a simple yet efficient SBD method is proposed, and the aim here is to speed up the boundary detection and simplify the detection process without loss of detection recall and accuracy. In our proposed model, we mainly use a top-down zoom...
3d
Abstract Functional magnetic resonance imaging (fMRI) is an imaging tool that is used to analyze the brain’s functions. Brain functional connectivity analysis based on fMRI signals often calculated correlations among time series in different areas of the brain. For FC analysis most prior research works generate the brain graphs based on linear correlations, however, the nonlinear behavior of the brain can lower the accuracy of such graphs. Usually, the Pearson correlation coefficient...
3d
Abstract Developing remote sensing technology enables the production of very high-resolution (VHR) images. Classification of the VHR imagery scene has become a challenging problem. In this paper, we propose a model for VHR scene classification. First, convolutional neural networks (CNNs) with pre-trained weights are used as a deep feature extractor to extract the global and local CNNs features from the original VHR images. Second, the spectral residual-based saliency detection...
3d
Abstract Human activity recognition (HAR) is a wide research topic in a field of computer science. Improving HAR can lead to massive breakthrough in humanoid robotics, robots used in medicine and in the field of autonomous vehicles. The system that is able to recognise human and its activity without any errors and anomalies would lead to safer and more empathetic autonomous systems. During this research work, multiple neural networks models, with different complexity, are being...
4d
Abstract In this paper, we present an automatic recognition system of diseases and damages on plant leaves. The proposed system is based on classifiers combination technique, in which we have two variants of combination: serial combination of two classifiers, and hybrid combination of three classifiers including a serial combination of two classifiers in parallel with an individual classifier. Three types of features are adopted including color, texture and shape. The tests of...
1w
Abstract Objective Parathyroidectomy (PTx) has an established benefit in patients with symptomatic primary hyperparathyroidism (PHPT). However, its efficacy in mild asymptomatic PHPT has not been proven. This study aimed to systematically review and meta-analyze the best available evidence from randomized-controlled trials comparing the efficacy of PTx over conservative management (non-PTx) on skeletal outcomes [fractures and bone mineral...
1d
Abstract Purpose Angiopoietin-like 8 (ANGPTL8) is a liver- and adipose tissue-produced protein that predicts non-alcoholic fatty liver disease (NAFLD) and altered metabolic homeostasis in the general population as well as in persons with common and genetic obesity, including the Prader–Willi syndrome (PWS). However, its metabolic correlate in paediatric patients with respect to PWS is unknown. ...
4d
Abstract Preliminary clinical evidence suggests that metformin has TSH lowering effects in patients with T2DM and hypothyroidism or in those with TSH serum levels in the upper normal value. Also, metformin may exert a protective role against thyroid nodules growth in patients without insulin-resistance. The cross-talk between tyrosine kinase receptors and the G protein-coupled receptors (which the TSHR belongs to) has been already shown and IRS1 may represent the hub link between...
6d
Abstract Mobile ad-hoc network (MANET) is a theoretical and experimental approach for achieving the applications to the best using VANETs. Given the mobility of nodes in the mobile ad-hoc networks, it is hard to depict the nature of the network or the structure of the network. With static nodes, it is easy to monitor a network. In a mobile environment, any node can come and join the network based on the distance covered by the entire network. A node that enters the region joins...
2d
Abstract In this article, a novel voltage stability index is proposed for the optimal placement and an analytical as well as particle swarm optimization method is implemented for optimal sizing of different types of distributed generation (DG) in a radial distribution system. The three types of DG considered are Type I, Type II and Type IV model. The methods account for changes in long-term system load profile in the planning phase to enhance power system performance. The load...
3d
Abstract Text streams are a continuous flow of high-dimensional text, transmitted at high-volume and high-velocities. They are expected to be classified in real-time, which is challenging due to the high dimensionality of feature space. Applying feature selection algorithms is one solution to reduce text streams feature space and improve the learning process. However, since text streams are potentially unbounded, it is expected a change in their probabilistic distribution over...
3d
Abstract Purpose Patients with peritoneal carcinomatosis (PC) are increasingly treated with multidisciplinary combined approaches. The study aim was to assess current practice and perceptions of treatment modalities of PC. Methods Indian Society of Peritoneal Surface Malignancies (ISPSM) members were invited to complete an online survey. Current practice...
2d
Abstract Introduction Neoadjuvant treatment is a widely accepted approach for locally advanced rectum cancer. Efforts to explore a surrogate endpoint for clinical trials revealed a new prognostic scoring system which is named as neoadjuvant rectal score (NAR) in patients who received neoadjuvant treatment for rectal cancer. Material and Methods 88 patients...
5d
Abstract Background Pancreatoduodenectomy (PD) is the only curative procedure for resectable periampullary cancers. This study aims to survey the various outcome variables of the procedure at our institute, which is in the early process of evolving into a high-volume center for PDs. Methods Data of patients, who underwent PDs, was collected retrospectively...
1w
Abstract Introduction Gastric cancer is the fifth most common cancer worldwide and the third cause of cancer deaths and disability-adjusted life years (DALYs) worldwide. The countries of the Middle East and North Africa are similar in many determinants of health, but there are significant differences in the incidence of gastric cancer in these countries. Therefore, the purpose of this study was to compare the burden of gastric cancer in...
1w
Abstract Purpose Data related to the role of epigenetic modifications in gallbladder carcinoma (GBC) is limited. We intended to assess the role of crucial epigenetic modifiers pertaining to histone modification and DNA-methylation system in gallbladder carcinogenesis. Methods The expression of EZH2, H3K27me3, and DNA methyltransferases (DNMTs) was analyzed...
1w
Abstract Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used incretin-based therapy for the treatment of type 2 diabetes. We investigated the cardioprotective effect of a DPP-4 inhibitor, vildagliptin (vilda), on myocardial metabolism and cardiac performance under pressure overload. Mice were treated with either vehicle or vilda, followed by transverse aortic constriction (TAC). After 3 weeks of TAC, cardiac hypertrophy and impairment of systolic function were attenuated...
2d
Abstract Bicuspid aortic valve (BAV) is characterized by elevated risk of aortic dilatation and aneurysm. Although genetic susceptibility is suspected to influence on the development of BAV aortopathy, clinical application of genetic markers still needs validation in BAV entities with strictly defined phenotypic features. The ‘root phenotype’ represents a young, male predominant, and severely aortic regurgitant BAV population prone to aortic root dilatation. The present study launched...
5d
Abstract Coronary computed tomography angiography (CCTA) has low specificity for detecting significant functional coronary stenosis. We developed a new transluminal attenuation gradient (TAG)-derived dynamic CCTA with dose modulation, and we investigated its diagnostic performance for myocardial ischemia depicted by 13N-ammonia positron emission tomography (PET). Data from 48 consecutive patients who had undergone both dynamic CCTA and 13N-ammonia PET were retrospectively analyzed....
1w
Abstract Background Increasing evidence for the use of the aspirin in patients undergoing an orthopaedic surgery for venous thromboembolism prophylaxis has led to a change in the national guidelines substituting anticoagulants with aspirin. Little is known about the impact of such substitution on real-world outcomes from clinical practice. Objective The study was designed to examine clinical outcomes associated with the use of aspirin and apixaban. Setting Two large-scale general...
2d
Abstract Background The off-label use of drugs to treat children is a global practice attributed to the traditional exclusion of children from clinical trials mainly due to practical and ethical reasons. Off-label drug use carries both benefits and risks, but data regarding this use pattern are scanty in sub-Saharan Africa. Objective To determine the incidence and predictors of off-label antibiotic use in children less than 5 years admitted at Mbarara Regional Referral Hospital...
2d
Abstract Namibia has previously relied on external training of pharmacists but began in-country training in 2011. In response to an identified need for postgraduate clinical pharmacy development and training in the country, a Master’s degree was set up at the University of Namibia in 2016. The country has a considerable health burden of HIV and TB as well as a shortage of healthcare professionals. A UK clinical diploma model was adapted to meet the specific needs of the country...
6d
Abstract Objective Evaluate the clinical, economic, and organizational impact of pharmaceutical interventions performed during medication review in a cognitive-behavioral unit. Setting Study conducted in a cognitive-behavioral unit with retrospective data from January 2011 to june 2017. Methods This study was conducted from retrospective data of medication review in a cognitive-behavioral unit. During medication review, pharmacists identified relevant drug related problems lead...
6d
Abstract Objective To determine FDG-PET biomarkers associated with long-term benefit (LTB) and survival in advanced non-small cell lung cancer (NSCLC) patients receiving first-line immunotherapy. Methods In this multicenter study, we retrospectively analyzed advanced NSCLC patients with a PD-L1 tumor proportion score (TPS) ≥ 50%, who underwent FDG-PET/CT...
2d
Abstract Purpose The aim of this work was to develop a digital dynamic cardiac phantom able to mimic gated myocardial perfusion single photon emission computed tomography (SPECT) images. Methods A software code package was written to construct a cardiac digital phantom based on mathematical ellipsoidal model utilizing powerful numerical and mathematic...
3d
Abstract Objective Glucagon-like peptide-1 receptor agonist (GLP-1RA) has been reported to have therapeutic effects on diabetes and various diseases. Precise detection of GLP-1 receptor (GLP-1R) can be useful to diagnose and elucidate the mechanism of such diseases. Here we aimed to develop an imaging probe based on GLP-1RA that has high molar activity and sensitivity for detection of low-level GLP-1R expression in non-pancreatic diseases....
4d
Abstract Purpose The prognostic value of 18F-FDG PET/CT for primary intestinal diffuse large B-cell lymphoma (PI-DLBCL) patients has not been determined. This prompted us to explore the value of 18F-FDG PET/CT for prognostic stratification in patients with PI-DLBCL treated with an R-CHOP-like regimen. Materials and methods Seventy-three PI-DLBCL patients...
5d
Abstract Objective Aging decreases dopamine transporter (DAT) availability of striatum both in humans and rodents. We aimed to investigate the relationship of DAT availabilities from ventral striatum, caudate nucleus, and putamen with aging in healthy subjects. Methods 123I-FP-CIT single photon emission computed tomography (SPECT) was performed in...
6d
Abstract Objective Copper-64 is a useful theranostic radioisotope that is attracting renewed interest from the nuclear medicine community in the recent times. This study aims to demonstrate the utility of research reactors to produce clinical-grade 64Cu via 63Cu(n,γ)64Cu reaction and use it in the form of [64Cu]CuCl2 as a radiopharmaceutical for PET imaging of cancer in human patients. ...
1w
Abstract Purpose To evaluate the impact of the COVID-19 pandemic-related lockdown on management and outcomes of children with acute appendicitis. Methods A retrospective cohort study was conducted, including children treated for acute appendicitis (January 20th–May 11th, 2020). The data regarding the severity of appendicitis and outcome were collected...
2d
Abstract Purpose The COVID-19 pandemic has placed extraordinary demands on healthcare services worldwide. Some have reported increased viral transmission to healthcare workers during aerosol-generating procedures such as intubation. We report our experience with universal preoperative and preprocedural screening for COVID-19 in children requiring general anaesthesia with low risk of having the infection. ...
3d
Abstract Purpose Midgut volvulus is associated with intestinal ischemia/reperfusion (IR) injury and can progress to severe intestinal damage. Remote ischemic conditioning (RIC) reduces IR-induced injury in distant organs. The aim of this study was to investigate whether RIC protects the intestine from IR injury. Methods We investigated intestinal IR...
3d
Abstract Purpose The ideal colostomy type indicated for patients with anorectal malformation (ARM) is disputed. The aim of this study was to analyze the clinical factors associated with urinary tract infection (UTI) prior to corrective surgery in male ARM without perineal fistula having undergone diverting enterostomy. Methods A retrospective review...
4d
Abstract Introduction Congenital diaphragmatic hernia (CDH) is a life-threatening disease associated with pulmonary hypoplasia. CDH occurs approximately 1 in every 2000–3000 live births, and the pathophysiology is unknown. MicroRNAs are short, non-coding RNAs that control gene expression through post-transcriptional regulation. Based on our previous work, we hypothesized that the miR-200 family is differentially expressed in normal...
1w
Abdallahi Abdurehman1, SafiHussen2, Mohammed Jafer2, Fayisa Aliye2, Abadir Jemal2, Sharif Abdusemed1
2d
Abstract Background and Objective Patients with cancer are at high risk of major depressive disorder (MDD), but little is known about their MDD treatment. We investigated the use of antidepressants and other drugs for MDD after cancer diagnosis, and patient characteristics associated with their use. Methods Adults with a new cancer diagnosis were matched...
2d
Mishal Liaqat, Sumaira Sharif, Kashif Ali
3d
Sajid Hussain, Aqsa Akram, Rubaida Mehmood, Rehana Mumtaz
3d
Abstract AR (Augmented reality) is a research hotspot in the current computer application field. AR technology enhances people’s understanding and experience of the real environment by adding virtual objects to real scenes to integrate virtual objects with the real environment. Aiming at the weak processing power of intelligent terminals and the characteristics of limited hardware resources, this paper proposes a more effective human motion feature extraction and descriptor algorithm....
3d
Abstract At this stage of augmented reality, simple feature descriptions are mainly used in camera real-time motion tracking, but this is prone to the problem of unstable camera motion tracking. Aiming at the balance between real-time performance and stability, a new method model of real-time camera motion tracking based on mixed features was proposed. By comprehensively using feature points and feature lines as scene features, feature extraction, optimization, and fusion are used...
4d
Abstract Purpose While cancer mortality has declined by 27% between 1991 and 2016 in the United States, there are large disparities in cancer mortality by racial/ethnic groups, socioeconomic status and access to care. The purpose of this analysis is to compare trends in cancer mortality among regions (Service Planning Areas, SPAs) in Los Angeles (LA) County that vary with respect to racial/ethnic distribution and social determinants...
3d
Abstract Purpose Our aim is to examine the associations between high-sensitivity C-reactive protein (hsCRP) and hemoglobin A1c (HbA1c), common biomarkers of inflammation and insulin resistance, respectively, with breast cancer risk, while adjusting for measures of excess body size. Methods We conducted a nested case–control study within...
3d
Abstract Purpose Diets with a high glycemic load (GL) or glycemic index (GI) may increase cancer risk. Findings from prior studies on the relationship between GL, GI, and lung cancer risk are inconsistent. We investigated this relationship in a large prospective cohort. Methods We analyzed data from the Southern Community Cohort Study,...
3d
Abstract The Your Disease Risk tool (yourdiseaserisk.wustl.edu) went live to the public in January 2000 and was one of the first personalized health risk assessment sites on the Internet. Its launch marked the culmination of years of work by a large, multi-disciplinary university team whose primary goal was to translate the science on cancer prevention into accurate, engaging, and useful messages for the public. Today, 20 years on, Your Disease Risk has expanded from its initial...
3d
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