Τρίτη 20 Οκτωβρίου 2020

 


Kinetic factors may reshape the dependence of crystal nucleation rate on temperature in protein bulk solution
Abstract Here we provide an analysis of primary results obtained from a study of apoferritin crystal nucleation in compositionally invariant bulk solution at constant supersaturation ratio of the protein. The temperature dependence of the stationary crystal nucleation rate in the protein bulk solution is obtained with the help of experimentally determined probability for detection of at least one crystal per solution volume until a given time. The stationary crystal nucleation...
Latest Results for Journal of Biological Physics
4d
The rich inner life of the cell nucleus: dynamic organization, active flows, and emergent rheology
Abstract The cell nucleus stores the genetic material essential for life, and provides the environment for transcription, maintenance, and replication of the genome. Moreover, the nucleoplasm is filled with subnuclear bodies such as nucleoli that are responsible for other vital functions. Overall, the nucleus presents a highly heterogeneous and dynamic environment with diverse functionality. Here, we propose that its biophysical complexity can be organized around three inter-related...
Latest Results for Biophysical Reviews
4d
Structural and functional diversity of Entamoeba histolytica calcium-binding proteins
Abstract Entamoeba histolytica (E. histolytica) is an etiological agent of human amoebic colitis, and it causes a high level of morbidity and mortality worldwide, particularly in developing countries. Ca2+ plays a pivotal role in amoebic pathogenesis, and Ca2+-binding proteins (CaBPs) of E. histolytica appear to be a major determinant in this process. E. histolytica has 27-EF-hand containing CaBPs, suggesting that this organism has complex Ca2+ signaling cascade. E. histolytica...
Latest Results for Biophysical Reviews
5d
Course of the thoracic nerves around the umbilicus within the posterior layer of the rectus sheath: a cadaver study
Abstract Rectus sheath block is used to anesthetize thoracic nerves around the umbilicus. However, the appropriate point for anesthetic injection during rectus sheath block has not been determined anatomically. Here, we examined the course of thoracic nerve T10 at the posterior layer of the rectus sheath and the anatomical relationship between the nerve and the rectus abdominis and transversus abdominis muscles in formalin-fixed adult cadavers. The cranio-caudal distance from...
Latest Results for Journal of Anesthesia
4d
Evaluation of postoperative kidney function after administration of 6% hydroxyethyl starch during living-donor nephrectomy for transplantation
Abstract Purpose We aimed to investigate whether 6% HES 130/0.4 was associated with postoperative reduction of estimated glomerular filtration rate (eGFR) in donor patients who underwent nephrectomy for living kidney transplantation. Methods This retrospective study included 213 living kidney transplant donors treated at Kyushu University Hospital...
Latest Results for Journal of Anesthesia
1w
How to administer remimazolam for anesthesia induction
Latest Results for Journal of Anesthesia
1w
The Cardiovascular Effects of Newer Antidepressants in Older Adults and Those With or At High Risk for Cardiovascular Diseases
Abstract Depression is common in older adults and those with cardiovascular disease. Although selective serotonin reuptake inhibitors generally have been shown to be safe to treat depression in these patients, it is important to identify additional antidepressants when selective serotonin reuptake inhibitors are not effective. This qualitative narrative review summarizes what is known about the cardiovascular side effects of some of the newer antidepressants. Twelve novel non-selective...
Latest Results for CNS Drugs
4d
A Systematic Review of Factors Relating to Parental Satisfaction with the Diagnostic Process for Autism Spectrum Disorder
Abstract Diagnostic assessment for autism spectrum disorder (ASD) is a complex and often stressful process for parents. This systematic review synthesized results of 26 articles that reported on factors related to parental (dis)satisfaction with the diagnostic process for ASD. The results are described in terms of factors related to satisfaction and those related to dissatisfaction (with some overlap between these), in the context of temporality within the diagnostic process....
Latest Results for Review Journal of Autism and Developmental Disorders
4d
Intracellular Pharmacokinetics of Pyrimidine Analogues used in Oncology and the Correlation with Drug Action
Abstract Pyrimidine analogues can be considered as prodrugs, like their natural counterparts, they have to be activated within the cell. The intracellular activation involves several metabolic steps including sequential phosphorylation to its monophosphate, diphosphate and triphosphate. The intracellularly formed nucleotides are responsible for the pharmacological effects. This review provides a comprehensive overview of the clinical studies that measured the intracellular nucleotide...
Latest Results for Clinical Pharmacokinetics
4d
Correction: Clinical characteristics of systemic lupus erythematosus patients in long-term remission without treatment
The original published version of the above article contained errors in Key Points and Conclusion sections.
Latest Results for Clinical Rheumatology
4d
Tumoral calcinosis in dermatomyositis
Latest Results for Clinical Rheumatology
4d
COVID-19 reinfection or relapse: an intriguing dilemma
Latest Results for Clinical Rheumatology
4d
Mitochondrial DNA in osteoarthritis disease
Latest Results for Clinical Rheumatology
4d
Virtual rheumatology appointments during the COVID-19 pandemic: an international survey of perspectives of patients with rheumatic diseases
Latest Results for Clinical Rheumatology
4d
Correction to: Efficacy and safety results from a randomized double-blind study comparing proposed biosimilar ABP 798 with rituximab reference product in subjects with moderate-to-severe rheumatoid arthritis
This article originally published with the family name and given names of all authors transposed.
Latest Results for Clinical Rheumatology
4d
Ultrasound versus dual-energy computed tomography in patients with different stages of acute gouty arthritis: methodological issues on diagnostic value
Latest Results for Clinical Rheumatology
4d
Clinical impact of COVID-19 on a French population of spondyloarthritis patients
Latest Results for Clinical Rheumatology
4d
High levels of anti-SSA/Ro antibodies in COVID-19 patients with severe respiratory failure: a case-based review
Abstract We treated two patients with severe respiratory failure due to coronavirus disease 2019 (COVID-19). Case 1 was a 73-year-old woman, and Case 2 was a 65-year-old-man. Neither of them had a history of autoimmune disease. Chest computed tomography scans before the antiviral therapy showed bilateral multiple patchy ground-glass opacities (GGO) consistent with COVID-19 pneumonia. The GGO regressed over the course of the antiviral treatment; however, new non-segmental patchy...
Latest Results for Clinical Rheumatology
4d
Clinical image: chronic skin ulcers in a patient with rheumatoid arthritis on immunosuppressant therapy
Latest Results for Clinical Rheumatology
4d
IgG4-related kidney disease: experience from a Mexican cohort
Abstract To evaluate the clinical/serological phenotype and outcomes of IgG4-related kidney disease. Case series of IgG4-related kidney disease from a cohort of 69 patients with IgG4-related disease. We defined kidney involvement as the presence of at least one of the following conditions: (A) laboratory parameters of kidney injury (proteinuria and/or elevated creatinine levels and/or hematuria); and/or (B) contrast-enhanced computed tomography features (multiple low-density...
Latest Results for Clinical Rheumatology
4d
Facial necrotic ulcerative lesions in an adolescent female with granulomatosis with polyangiitis (GPA)
Latest Results for Clinical Rheumatology
4d
Cultural adaptation, translation and validation of Cochin Hand Function Scale and evaluation of hand dysfunction in systemic sclerosis
Abstract Objectives Hand dysfunction causes significant reduction in quality of life in systemic sclerosis. We assessed the validity and reliability of the culturally adapted Indian version of Cochin Hand Function Scale (I-CHFS). We determined the factors contributing to hand dysfunction and its burden on quality of life. Method I-CHFS was formulated by replacing...
Latest Results for Clinical Rheumatology
5d
Co-occurring Wilson’s disease and non-penicillamine-induced systematic lupus erythematosus: a case report and literature review
Abstract Although lupus induced by penicillamine, the first-line medication for Wilson’s disease, is well-documented, primary systematic lupus erythematosus (SLE) co-occurring with Wilson’s disease has only rarely been reported. Symptom overlap can add to difficulties in making the correct and complete diagnosis of these two systemic diseases. An 18-year-old female was diagnosed with simultaneous Wilson’s disease and SLE and was successfully treated with hydroxychloroquine and...
Latest Results for Clinical Rheumatology
5d
QuantiFERON®-TB Gold In-Tube test can be used for screening latent tuberculosis before biological treatment in a Bacille Calmette-Guérin (BCG)-vaccinated country: the HUR-BIO single-center real-life results
Abstract Objectives The Turkish population is vaccinated with Bacille Calmette-Guérin (BCG), and the BCG vaccination decreases the specificity of the tuberculin skin test (TST). The purpose of this study was to investigate the incidence of active tuberculosis (TBC) among rheumatic patients who were screened only with the QuantiFERON®-TB Gold In-Tube (QFT-GIT) test for latent TBC prior to biological treatment. ...
Latest Results for Clinical Rheumatology
5d
Correction to: In shoulder adhesive capsulitis, ultrasound-guided anterior hydrodilatation in rotator interval is more effective than posterior approach: a randomized controlled study
The authors of the original version of the above article requested to add the name of the instrument that was used in the Intervention section.
Latest Results for Clinical Rheumatology
6d
Investigating the safety and compliance of using csDMARDs in rheumatoid arthritis treatment through face-to-face interviews: a cross-sectional study in China
Abstract Rheumatoid arthritis (RA) significantly impacts the health of Chinese patients. Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) are used as the standard treatment for patients with RA. However, Chinese patients with RA have reported poor compliance with csDMARDs. This study aims to better understand the safety and compliance of using csDMARDs in RA treatment. Face-to-face interviews were conducted by questionnaires on safety and compliance of csDMARDs...
Latest Results for Clinical Rheumatology
6d
Biological therapy in rheumatoid vasculitis: a systematic review
Abstract Rheumatoid vasculitis (RV) is one of the most severe extra-articular manifestations of rheumatoid arthritis, with significant morbidity and mortality, requiring aggressive treatment with corticosteroids and/or immunosuppressants. Recently, biological drugs were included in its therapeutic armamentarium. The objective of this study was to perform a systematic review on the use of biological drugs in the treatment of RV. A systematic literature review was performed based...
Latest Results for Clinical Rheumatology
6d
Combination of methotrexate and sulfasalazine is an efficacious option for axial spondyloarthritis in a resource-limited, real-world clinical setting: a prospective cohort study
Abstract Objective Evaluation of response to combination conventional synthetic DMARD (csDMARD) therapy with methotrexate (MTX) and sulfasalazine (SSZ) in active axial spondyloarthritis (axSpA) patients without peripheral arthritis (group 1) as compared to active axSpA with peripheral arthritis (group 2), who are economically constrained for biologicals. Methods ...
Latest Results for Clinical Rheumatology
6d
Chondroid chordoma of the parapharyngeal space: A case report and review of literature
Volume 5, Issue 1, December 2020, Page 69-73.
Taylor & Francis: Acta Oto-Laryngologica Case Reports: Table of Contents
4d
Association of intestinal and systemic inflammatory biomarkers with immune reconstitution in HIV+ patients on ART
Abstract Background HIV infection is characterized by CD4+ T-cells depletion related to gut damage, microbial translocation, immune activation and intestinal and systemic low-grade inflammation. With the use of antiretroviral treatment, these alterations in HIV+ patients reach similar levels to HIV- controls. However, almost 20% patients have deficient immune reconstitution of CD4+ T-cells, which make them more susceptible to develop...
Latest Results for Journal of Inflammation
5d
Size Composition, Exploitation Structure and Sex Ratio of Clupisoma garua (Hamilton) from Middle Stretch of the Ganga River at Allahabad, India
Abstract Clupisoma garua is a medium-sized freshwater catfish with very high market value in Indian sub-continent. Besides immense food value, the fish is also known as a game fish. The fish samples for this study were randomly collected from middle stretch of the river Ganga at Allahabad during July 2014–June 2015. The size composition of the samples varied from 135 to 446 mm. The maximum exploitation was observed in 171–210 mm size group (29.04%), while minimum in 411–450 mm...
Latest Results for National Academy Science Letters
5d
Expression and functions of N-type Cav2.2 and T-type Cav3.1 channels in rat vasopressin neurons under normotonic conditions
Abstract Arginine vasopressin (AVP) neurons play essential roles in sensing the change in systemic osmolarity and regulating AVP release from their neuronal terminals to maintain the plasma osmolarity. AVP exocytosis depends on the Ca2+ entry via voltage-gated Ca2+ channels (VGCCs) in AVP neurons. In this study, suppression by siRNA-mediated knockdown and pharmacological sensitivity of VGCC currents evidenced molecular and functional expression of N-type Cav2.2 and T-type Cav3.1...
Latest Results for The Journal of Physiological Sciences
5d
The relationship between olfaction and cognitive function in the elderly
Abstract This study investigated the relationship between olfaction and cognitive function in 12 elderly people (age: 80.9 ± 1.6) living in the community. Olfactory function was assessed by the identification threshold for rose odor. Four cognitive measures consisting general cognitive ability assessed by Mini-Mental State Examination (MMSE), its sub-domains, and attentional ability assessed by drawing a line to connect the numbers consecutively (trail-making test part A; TMT-A),...
Latest Results for The Journal of Physiological Sciences
6d
Comparative analysis of developing grain transcriptome reveals candidate genes and pathways improving GPC in wheat lines derived from wild emmer
Abstract The grain protein content (GPC) in modern wheat is inherently low. Wild emmer wheat (Triticum turgidum ssp. dicoccoides, 2n = 4x = 28, AABB) gene pool harbors wide genotypic variations in GPC. However, the characterization of candidate genes associated with high GPC is a challenge due to the complex characteristic of this trait. In the current study, we performed RNA-seq analysis on developing grains of wild emmer genotype D1, common wheat CN16, and their hexaploid wide...
Latest Results for Journal of Applied Genetics
5d
Strategies for children’s hospital in response to COVID-19 pandemic: perspective and practice at a designated pediatric hospital in Shanghai, China
Latest Results for World Journal of Pediatrics
5d
Transformation Temperature Predictions Through Computational Intelligence for NiTi-Based Shape Memory Alloys
Abstract Shape memory alloys (SMAs) are a class of metallic compounds that can return to their original forms, shapes, or sizes, when subjected to environmental stimuli, such as temperature and magnetic fields. Due to their unique shape memory effects and pseudoelasticity, SMAs, particularly NiTi-based ones, are of great interest in structures and composites, electronics, automobiles, biomedicine, and robotics. To tailor phase transformation temperature for practical applications,...
Latest Results for Shape Memory and Superelasticity
5d
Response to Letter to the Editor Regarding “A Multicentre, Randomised Clinical Trial to Compare a Topical Nitrizinc ® Complex Solution Versus Cryotherapy for the Treatment of Anogenital Warts”
Latest Results for Dermatology and Therapy
5d
Letter to the Editor Regarding ‘A Multicentre, Randomised Clinical Trial to Compare a Topical Nitrizinc® Complex Solution Versus Cryotherapy for the Treatment of Anogenital Warts’
Latest Results for Dermatology and Therapy
5d
Adjunctive Use of Calcipotriene/Betamethasone Dipropionate Foam in a Real-World Setting Curtails the Cost of Biologics Without Reducing Efficacy in Psoriasis
Abstract Introduction Although the efficacy of monotherapy with biologics for psoriasis is well established, many patients fail to achieve complete plaque clearance from their initial biologic treatment alone. Adjunctive treatment with topical calcipotriene plus betamethasone dipropionate (Cal/BD) foam may offer substantial clinical benefit and potential cost savings. Methods...
Latest Results for Dermatology and Therapy
1w
Uncertain distance-based outlier detection with arbitrarily shaped data objects
Abstract Enabling information systems to face anomalies in the presence of uncertainty is a compelling and challenging task. In this work the problem of unsupervised outlier detection in large collections of data objects modeled by means of arbitrary multidimensional probability density functions is considered. We present a novel definition of uncertain distance-based outlier under the attribute level uncertainty model, according to which an uncertain object is an object that...
Latest Results for Journal of Intelligent Information Systems
5d
Empirical study of sentiment analysis tools and techniques on societal topics
Abstract A surge in public opinions mining against various societal topics using publicly available off-the-shelf sentiment analysis tools is evident in recent times. Since sentiment analysis is a domain-dependent problem, and the majority of the tools are built for customer reviews, the suitability of using such existing off-the-the-shelf tools for a societal topic is subject to investigation. None of the existing studies has thoroughly investigated on societal issues. This paper...
Latest Results for Journal of Intelligent Information Systems
6d
Numerical and experimental analysis of the structural performance of AM components built by fused filament fabrication
Abstract This work analyses the performance of parts built by Additive Manufacturing (AM) using fused filament fabrication (FFF) demonstrating the correlation between the printing orientation and structural performance. FFF components present two regions showing different mechanical behaviour: the external contour and the inner structure (in-fills or lattice). The respective mechanical properties of the contour and the inner structure are obtained. In this work the inner structure...
Latest Results for International Journal of Mechanics and Materials in Design
5d
Is Porphyromonas gingivalis involved in Parkinson’s disease?
Abstract Porphyromonas gingivalis, a major subgingival plaque bacterium in periodontitis, has recently attracted much attention as a possible microbial driver in Alzheimer’s disease. In the present paper, another common neuroinflammatory disease, Parkinson’s disease (PD), is discussed. A recent study found major virulence factors of P. gingivalis such as gingipain R1 (RgpA) and lipopolysaccharide in the blood circulation of a PD population. The current review reveals how features...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Influenza and respiratory syncytial virus infections in the oldest-old continent
Abstract SARS-CoV-2 dramatically revealed the sudden impact of respiratory viruses in our lives. Influenza and respiratory syncytial virus (RSV) infections are associated with high rates of morbidity, mortality, and an important burden on healthcare systems worldwide, especially in elderly patients. The aim of this study was to identify severity predictors in the oldest-old admitted with influenza and/or RSV infections. This is a multicenter, retrospective study of all oldest-old...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Urinary tract infection and antibiotic use around ureteral stent insertion for urolithiasis
Abstract Urolithiasis is the main indication for a ureteral JJ stent. Our aim was to determine the incidence of urinary tract infections (UTIs) after a JJ stent for urolithiasis, with an emphasis on antibiotic use. Prospective, multicenter, cohort study over a 4-month period including all of the patients with urolithiasis requiring JJ stent insertion. The clinical and microbiological data and therapeutic information were recorded until removal of the JJ stent. Two hundred twenty-three...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Population differentiation, antifungal susceptibility, and host range of Trichophyton mentagrophytes isolates causing recalcitrant infections in humans and animals
Abstract The major problems in determining the causative factors of the high prevalence of dermatophytoses include the lack of a well-standardized antifungal susceptibility testing method, the low consistency of in vitro and clinical minimal inhibitory concentration values, the high genomic diversity of the population, and the unclear mechanism of pathogenicity. These factors are of particular importance when the disease is recalcitrant and relapses. Herein, we identified and...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Multicenter evaluation of the RAPIDEC® CARBA NP assay for the detection of carbapenemase production in clinical isolates of Enterobacterales and Pseudomonas aeruginosa
Abstract Carbapenem-resistant Gram-negative bacilli are a major public health problem. Accurate and rapid detection of carbapenemase-producing organisms can facilitate appropriate infection prevention measures. The objective was to evaluate the performance of the RAPIDEC® CARBA NP assay (RAPIDEC), a screening assay that utilizes a pH indicator to detect carbapenem hydrolysis within 2 h. A multicenter study evaluated 306 clinical bacterial strains of Enterobacterales (n = 257)...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
How is the microbial diagnosis of bacterial vertebral osteomyelitis performed? An 11-year retrospective study
Abstract Vertebral osteomyelitis (VOM) is often diagnosed with delays, resulting in poorer outcomes. Microbial documentation is particularly challenging and obtained using blood cultures (BCs) and vertebral biopsies (VBs; CT-guided or surgical). We retrospectively analysed VOM cases in a tertiary reference centre between 2004 and 2015, focusing on how and how quickly microbiological diagnosis was performed. Among 220 VOM, 88.2% had documentation, including Gram-positive cocci...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Antibiotic modification versus withhold in febrile patients without evidence of bacterial infection, unresponsive to initial empiric regimen: a multicentre retrospective study conducted in Israel
Abstract Prescribing antibiotics for febrile patients without proof of bacterial infection contributes to antimicrobial resistance. Lack of clinical response in these patients often leads to antibiotic escalation, although data supporting this strategy are scarce. This study compared outcomes of modifying, withholding, or continuing the same antibiotic regimen for such patients. Febrile or hypothermic stable patients with suspected infection, unresponsive to empiric antibiotic...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Real-time PCR-based quantitation of viable Mycobacterium leprae strain from clinical samples and environmental sources and its genotype in multi-case leprosy families of India
Abstract The potential role of environmental M. leprae in the transmission of leprosy remains unknown. We investigated role of environment as a possible source of viable M. leprae responsible for transmission of leprosy. The samples were collected from 10 multi-case leprosy families comprising, slit skin smear (SSS) from 9 multibacillary (MB), 16 paucibacillary cases (PB), 22 household contacts, and 38 environmental soil samples. The quantum of viable M. leprae was estimated...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Antimicrobial resistance, genetic characterization, and molecular epidemiology of Ureaplasma species in males with infertility
Abstract This study aimed to study the antimicrobial resistance, genetic characterization, and molecular epidemiology of Ureaplasma species in order to provide clinicians sufficient data to select optimal strategies of treatment for genitourinary tract infections of infertile male patients. Firstly, a total of 817 clinical semen specimens were detected for Ureaplasma species by molecular detection. Secondly, culture and identification of Ureaplasma species were achieved by using...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Management and outcomes of Burkholderia cepacia complex bacteremia in patients without cystic fibrosis: a retrospective observational study
Abstract Burkholderia cepacia complex (BCC) is an emerging pathogen of nosocomial infection in chronic or critically ill patients without cystic fibrosis (CF). The objective was to evaluate the management and outcomes of BCC bacteremia in patients without CF. We conducted a retrospective study of non-CF adult patients with BCC bacteremia between January 1997 and December 2016 at 4 tertiary hospitals in South Korea. A total of 216 non-CF patients with BCC bacteremia were identified....
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Epidemiology of skeletal tuberculosis in Beijing, China: a 10-year retrospective analysis of data
Abstract Skeletal tuberculosis (STB) is one of the most common forms of extrapulmonary tuberculosis; however, limited epidemiological data are available on this public health concern worldwide, especially in developing countries. The aims of this study were to analyze the epidemiological characteristics of STB cases and to identify risk factors associated with drug resistance among STB cases in China. We included STB inpatients at Beijing Chest Hospital from January 2009 through...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Hypervitaminosis A is associated with immunological non-response in HIV-1-infected adults: a case-control study
Abstract For people living with HIV, determinants of immunological non-response (INR) to combined antiretroviral therapy (cART) have not been fully elucidated. In a case-control study, we evaluated the influence of the nutritional and antioxidant status in HIV-1 adults whose cART was initiated between January 2001 and December 2013. Cases had persistent CD4 counts < 350/μL vs. > 350/μL for controls, after at least 2 years of cART with persistent viral loads (VL) < 50...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
5d
Description of an influenza outbreak in a French university hospital and risk factors of nosocomial influenza
Abstract Our objective was to evaluate risk factors of nosocomial influenza (NI) in an university hospital during the 2015/2016 influenza season. All hospitalized patients with influenza-like illness associated with laboratory confirmation by polymerase chain reaction were included in a prospective observational study. We identified 44 cases (19%) of NI among the 233 cases of influenza: 38/178 (21%) in adults and 6/55 (11%) in children. Among adults, hospitalization in a double...
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
6d
Laboratory evaluation of the Sigma Transwab® transport system for the recovery of Candida species using the Clinical and Laboratory Standards Institute (CLSI) document M40-A2
Abstract Rising healthcare complications due to fungal infections increase the importance of efficient specimen collection and maintenance systems for correct identification and diagnosis. The CLSI M40-A2 protocol provides guidelines for laboratories assessing quality of medical transport devices, including swab transport systems (STS). This study assessed the efficiency of the Sigma Transwab® foam and flock swab in recovering and maintaining viability of different Candida spp....
Latest Results for European Journal of Clinical Microbiology & Infectious Diseases
1w
Hotline Use in the United States: Results from the Collaborative Psychiatric Epidemiology Surveys
Abstract Crisis hotlines are a fixture in providing mental health services to individuals experiencing mental and behavioral problems in the United States (U.S.). Despite this, and the growing need for easily-accessible, anonymous, and free services amidst the suicide and opioid crises, there is no study reporting U.S. national prevalence and correlates of hotline use. Data on n = 18,909 participants from the Collaborative Psychiatric Epidemiology Surveys (CPES), a group of three...
Latest Results for Administration and Policy in Mental Health and Mental Health Services Research
5d
Help-Seeking Patterns Among the General Population in Singapore: Results from the Singapore Mental Health Study 2016
Abstract This study aimed to establish lifetime mental health service utilisation among the general population of Singapore. The sociodemographic correlates of those seeking help from different service provider groups and changes in lifetime mental health service utilisation between 2010 and 2016 among those with mental disorders were also explored. A population-based cross-sectional epidemiological household survey of the Singapore resident population aged 18 years and above...
Latest Results for Administration and Policy in Mental Health and Mental Health Services Research
5d
Altitudinal and Seasonal Variation in the Structure of Nocturnal Primate Assemblages on Mount Cameroon
Abstract Mountain ecosystems cover a large proportion of Earth and represent important environments for a range of different taxa, including nocturnal primates. This group of primates is generally understudied because of their small size and their cryptic and nocturnal nature. Thus, much of their ecology and distribution still remains unknown, especially in mountain ecosystems. We investigated the effects of altitude and seasonality (wet vs. dry season) on observed species richness...
Latest Results for International Journal of Primatology
6d
Shoulder muscle activation strategies differ when lifting or lowering a load
Abstract Purpose Lowering a load could be associated with abnormal shoulder and scapular motion. We tested the hypothesis that lowering a load involves different shoulder muscle coordination strategies compared to lifting a load. Methods EMG activity of 13 muscles was recorded in 30 healthy volunteers who lifted and lowered a 6, 12 or...
Latest Results for European Journal of Applied Physiology
6d
Adaptative mechanism of the equilibrative nucleoside transporter 1 (ENT-1) and blood adenosine levels in elite freedivers
Abstract Purpose Long static or intense dynamic apnoea-like high-altitude exposure is inducing hypoxia. Adenosine is known to participate to the adaptive response to hypoxia leading to the control of heart rate, blood pressure and vasodilation. Extracellular adenosine level is controlled through the equilibrative nucleoside transporter 1 (ENT-1) and the enzyme adenosine deaminase (ADA). The aim of this study was to determine the control...
Latest Results for European Journal of Applied Physiology
6d
Effects of a lower limb muscular fatigue on posture–movement interaction during a lower limb pointing task
Abstract Purpose The aim of the present study was to investigate the effects of muscular fatigue on the interaction between posture and movement during a lower limb pointing task. Methods Participants (n = 16), aged 18–30 years, kicked a ball toward a target in four conditions of fatigue: No muscular fatigue (NF), fatigue in the kicking (FM) or postural...
Latest Results for European Journal of Applied Physiology
6d
The long and short of residual force enhancement non-responders
Latest Results for European Journal of Applied Physiology
1w
Missing data techniques in classification for cardiovascular dysautonomias diagnosis
Abstract Missing data (MD) is a common and inevitable problem facing data mining (DM)–based decision systems in e-health since many medical historical datasets contain a huge number of missing values. Therefore, a pre-processing stage is usually required to deal with missing values before building any DM–based decision system. The purpose of this paper is to evaluate the impact of MD techniques on classification systems in cardiovascular dysautonomias diagnosis. We analyzed and...
Latest Results for Medical & Biological Engineering & Computing
6d
Effect of viscoelastic properties on passive torque variations at different velocities of the knee joint extension and flexion movements
Abstract This study aimed to investigate the rate of passive torque variations of human knee joint in the different velocities of knee flexion and extension movements. Ten healthy men were invited to participate in the tests. All passive torque tests were performed for the knee joint extension and flexion on the sagittal plane in three different angular velocities of 15, 45, and 120°/s; in 5 consecutive cycles; and within 0° to 100° range of motion. The electrical activity of...
Latest Results for Medical & Biological Engineering & Computing
6d
Analysis and decision based on specialist self-assessment for prognosis factors of acute leukemia integrating data-driven Bayesian network and fuzzy cognitive map
Abstract The purpose of the present study is to analyze the prognostic factors of acute leukemia and to construct a decision model based on a causal relationship between the factors of this disease to assist medical specialists. In medical decisions, to reach effective, quick, and reliable results, there is a need for a simple decision-making model based on a specialist’s self-assessment. It may help the medical team before final diagnosis by costly and time-consuming procedures...
Latest Results for Medical & Biological Engineering & Computing
6d
Novel approach for electromyography-controlled prostheses based on facial action
Abstract Individuals with severe tetraplegia frequently require to control their complex assistive devices using body movement with the remaining activity above the neck. Electromyography (EMG) signals from the contractions of facial muscles enable people to produce multiple command signals by conveying information about attempted movements. In this study, a novel EMG-controlled system based on facial actions was developed. The mechanism of different facial actions was processed...
Latest Results for Medical & Biological Engineering & Computing
6d
Noise suppression–guided image filtering for low-SNR CT reconstruction
Abstract In practical computed tomography (CT) applications, projections with low signal-to-noise ratio (SNR) are often encountered due to the reduction of radiation dose or device limitations. In these situations, classical reconstruction algorithms, like simultaneous algebraic reconstruction technique (SART), cannot reconstruct high-quality CT images. Block-matching and 3D filtering (BM3D)-based iterative reconstruction algorithm (POCS-BM3D) has remarkable effect in dealing...
Latest Results for Medical & Biological Engineering & Computing
6d
DZC DIAG: mobile application based on expert system to aid in the diagnosis of dengue, Zika, and chikungunya
Abstract Dengue, Zika, and chikungunya are epidemic diseases transmitted by the Aedes mosquito. These virus infections can be so severe to the point of bringing on mobility and neurological problems, or even death. Expert systems (ES) can be used as tools for the identification of patterns intended to solve problems in the same way as a professional specialist would. This work aimed to develop an ES in the form of an Android application to serve as a supportive tool in the diagnosis...
Latest Results for Medical & Biological Engineering & Computing
6d
Classification of error-related potentials from single-trial EEG in association with executed and imagined movements: a feature and classifier investigation
Abstract Error-related potentials (ErrPs) have been proposed for designing adaptive brain–computer interfaces (BCIs). Therefore, ErrPs must be decoded. The aim of this study was to evaluate ErrP decoding using combinations of different feature types and classifiers in BCI paradigms involving motor execution (ME) and imagination (MI). Fifteen healthy subjects performed 510 (ME) and 390 (MI) trials of right/left wrist extensions and foot dorsiflexions. Sham BCI feedback was delivered...
Latest Results for Medical & Biological Engineering & Computing
6d
Development of new descriptor for melanoma detection on dermoscopic images
Abstract Early detection of melanoma has critical importance for the success of the treatment. However, a successful early diagnosis is only possible with the existence of discriminative features. In this study, a new descriptor based on the number of colors was developed in order to successfully diagnose lesions of melanoma. The number of colors is the main feature in the identification of melanoma-type skin lesions. The user must select a threshold value when calculating the...
Latest Results for Medical & Biological Engineering & Computing
6d
Cascade marker removal algorithm for thyroid ultrasound images
Abstract During thyroid ultrasound diagnosis, radiologists add markers such as pluses or crosses near a nodule’s edge to indicate the location of a nodule. For computer-aided detection, deep learning models achieve classification, segmentation, and detection by learning the thyroid’s texture in ultrasound images. Experiments show that manual markers are strong prior knowledge for data-driven deep learning models, which interferes with the judgment mechanism of computer-aided...
Latest Results for Medical & Biological Engineering & Computing
6d
Automated measurement network for accurate segmentation and parameter modification in fetal head ultrasound images
Abstract Measurement of anatomical structures from ultrasound images requires the expertise of experienced clinicians. Moreover, there are artificial factors that make an automatic measurement complicated. In this paper, we aim to present a novel end-to-end deep learning network to automatically measure the fetal head circumference (HC), biparietal diameter (BPD), and occipitofrontal diameter (OFD) length from 2D ultrasound images. Fully convolutional neural networks (FCNNs)...
Latest Results for Medical & Biological Engineering & Computing
6d
Breastfeeding improves dynamic reorganization of functional connectivity in preterm infants: a temporal brain network study
Abstract Substantial evidences have shown the benefits of breastfeeding to infants in terms of better nutrition and neurodevelopmental outcome. However, the relationship between brain development and feeding in preterm infants, who are physiologically and developmentally immature at birth, is only beginning to be quantitatively assessed, coinciding with the recent advent of neuroimaging techniques. In the current work, we studied a sample of 50 preterm infants—born between 29...
Latest Results for Medical & Biological Engineering & Computing
6d
Identification of significant risks in pediatric acute lymphoblastic leukemia (ALL) through machine learning (ML) approach
Abstract Pediatric acute lymphoblastic leukemia (ALL) through machine learning (ML) technique was analyzed to determine the significance of clinical and phenotypic variables as well as environmental conditions that can identify the underlying causes of child ALL. Fifty pediatric patients (n = 50) included who were diagnosed with acute lymphoblastic leukemia (ALL) according to the inclusion and exclusion criteria. Clinical variables comprised of the blood biochemistry (CBC, LFTs,...
Latest Results for Medical & Biological Engineering & Computing
6d
The influence of motor tasks and cut-off parameter selection on artifact subspace reconstruction in EEG recordings
Abstract Advances in EEG filtering algorithms enable analysis of EEG recorded during motor tasks. Although methods such as artifact subspace reconstruction (ASR) can remove transient artifacts automatically, there is virtually no knowledge about how the vigor of bodily movements affects ASRs performance and optimal cut-off parameter selection process. We compared the ratios of removed and reconstructed EEG recorded during a cognitive task, single-leg stance, and fast walking...
Latest Results for Medical & Biological Engineering & Computing
6d
Image-based state-of-the-art techniques for the identification and classification of brain diseases: a review
Abstract Detection and classification methods have a vital and important role in identifying brain diseases. Timely detection and classification of brain diseases enable an accurate identification and effective management of brain impairment. Brain disorders are commonly most spreadable diseases and the diagnosing process is time-consuming and highly expensive. There is an utmost need to develop effective and advantageous methods for brain diseases detection and characterization....
Latest Results for Medical & Biological Engineering & Computing
6d
A memory optimization method combined with adaptive time-step method for cardiac cell simulation based on multi-GPU
Abstract Cardiac electrophysiological simulation is a very complex computational process, which can be run on graphics processing unit (GPU) to save computational cost greatly. The use of adaptive time-step can further effectively speed up the simulation of heart cells. However, if the adaptive time-step method applies to GPU, it suffers synchronization problem on GPU, weakening the acceleration of adaptive time-step method. The previous work ran on a single GPU with the adaptive...
Latest Results for Medical & Biological Engineering & Computing
6d
LncRNA A2M-AS1 lessens the injury of cardiomyocytes caused by hypoxia and reoxygenation via regulating IL1R2
Abstract Background Myocardial ischemia and reperfusion injury (MI/RI) is a complex pathophysiological process, which can lead to severe myocardial injury. The long noncoding RNA alpha-2-macroglobulin antisense RNA 1 (A2M-AS1) has been revealed to be abnormally expressed in MI, However, its function in MI and the potential mechanism are still unclear. Objective ...
Latest Results for Genes & Genomics
6d
A simplified approach to control cell adherence on biologically derived in vitro cell culture scaffolds by direct UV-mediated RGD linkage
Abstract In this work, we present a method to fabricate a hyaluronic acid (HA) hydrogel with spatially controlled cell-adhesion properties based on photo-polymerisation cross-linking and functionalization. The approach utilises the same reaction pathway for both steps meaning that it is user-friendly and allows for adaptation at any stage during the fabrication process. Moreover, the process does not require any additional cross-linkers. The hydrogel is formed by UV-initiated...
Latest Results for Journal of Materials Science: Materials in Medicine
6d
Norms of Testimony in Broad Interdisciplinarity: The Case of Quantum Mechanics in Critical Theory
Abstract While much interdisciplinarity brings together proximate fields, broad interdisciplinarity sees integration between disciplines that are perceived to be non-neighboring. This paper argues that the heterogeneity among disciplines in broad interdisciplinarity calls for stricter epistemic norms of testimony for experts that act as translators between the disciplines than those suggested for intra-scientific testimony. The paper is structured around two case studies: the...
Latest Results for Journal for General Philosophy of Science
6d
Diagnostic value of clusterin immunostaining in hepatocellular carcinoma
Abstract Background Histologic distinction between well differentiated hepatocellular carcinoma (HCC) and benign hepatocellular mass lesions is a known challenge. Existing biomarkers are of limited diagnostic value. Our previous studies observed an enhanced canalicular expression pattern of clusterin (CLU) in HCC, which was not observed in benign hepatocellular mass lesions such as hepatocellular adenoma. The aim of this study was...
Latest Results for Diagnostic Pathology
6d
Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma
Abstract Background Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenesis of ESCC and thus is a potential therapeutic target. PIK3CA, KRAS, and BRAF mutations, microsatellite instability (MSI) caused by deficient mismatch repair (dMMR), and human papillomavirus (HPV) can potentially...
Latest Results for Diagnostic Pathology
6d
Mild-cold water swimming does not exacerbate white adipose tissue browning and brown adipose tissue activation in mice
Abstract The present study investigated the effects of swimming physical training either thermoneutral or below thermoneutral water temperature on white (WAT) and brown (BAT) adipose tissue metabolism, morphology, and function. C57BL/6J male mice (n = 40; weight 25.3 ± 0.1 g) were divided into control (CT30), cold control (CT20), trained (TR30), and cold trained (TR20) groups. Swimming training consisted of 30-min exercise at 30°C (control) or 20°C (cold) water temperature. After...
Latest Results for Journal of Physiology and Biochemistry
1w
JAB1 promotes palmitate-induced insulin resistance via ERK pathway in hepatocytes
Abstract Insulin resistance (IR) is the primary pathological mechanism underlying Type 2 diabetes mellitus (T2DM). Many researches have reported the relationship between chronic inflammation and IR, while the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway is rapidly activated in inflammatory conditions. However, the functional role of ERK1/2 in IR remains to be identified. We here reported that C-Jun activation domain-binding protein-1 (JAB1) was upregulated in IR....
Latest Results for Journal of Physiology and Biochemistry
1w
A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans
Abstract Background Unlike infections with mycobacteria, reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce. Therefore, discussion about increased susceptibility to viral infections in these patients is ongoing. Case presentation We describe a 51-year-old male with dominant partial interferon-gamma-receptor-1...
Latest Results for Molecular and Cellular Pediatrics
1w
Immune Cell Paracrine Signaling Drives the Neutrophil Response to A. fumigatus in an Infection-on-a-Chip Model
Abstract Introduction Neutrophils act as first responders during an infection, following signals from the pathogen as well as other host cells to migrate from blood vessels to the site of infection. This tightly regulated process is critical for pathogen clearance and, in many cases, eliminates the pathogen without the need for an additional immune response. It is, therefore, critical to understand what signals drive neutrophil migration...
Latest Results for Cellular and Molecular Bioengineering
1w
The 2020 Young Innovators of Cellular and Molecular Bioengineering
Latest Results for Cellular and Molecular Bioengineering
1w
Development of Coagulation Factor XII Antibodies for Inhibiting Vascular Device-Related Thrombosis
Abstract Introduction Vascular devices such as stents, hemodialyzers, and membrane oxygenators can activate blood coagulation and often require the use of systemic anticoagulants to selectively prevent intravascular thrombotic/embolic events or extracorporeal device failure. Coagulation factor (F)XII of the contact activation system has been shown to play an important role in initiating vascular device surface-initiated thrombus formation....
Latest Results for Cellular and Molecular Bioengineering
1w
Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike Protein
Abstract Purpose SARS-CoV-2 is a SARS-like novel coronavirus strain first identified in December 2019 in Wuhan, China. The virus has since spread globally, resulting in the current ongoing coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 spike protein is a critical factor in the COVID-19 pathogenesis via interactions with the host cell angiotensin-converting enzyme 2 (ACE2) PD domain. Worldwide, numerous efforts are being made...
Latest Results for Cellular and Molecular Bioengineering
1w
Patient-Specific Hemodynamics of New Coronary Artery Bypass Configurations
Abstract Purpose This study aims to quantify the patient-specific hemodynamics of complex conduit routing configurations of coronary artery bypass grafting (CABG) operation which are specifically suitable for off-pump surgeries. Coronary perfusion efficacy and local hemodynamics of multiple left internal mammary artery (LIMA) with sequential and end-to-side anastomosis are investigated. Using a full anatomical model comprised of aortic...
Latest Results for Cardiovascular Engineering and Technology
1w
Oropouche virus disease - French Guiana, France
On 30 September 2020, the French Guiana Regional Health Agency (ARS) reported the first detection of Oropouche virus (OROV) in French Guiana. On 22 September 2020 the Pasteur Institute in Cayenne (a member of the French National Reference Laboratory for arboviruses) notified the France IHR National Focal Point of seven laboratory-confirmed cases of Oropouche virus infection in the village of Saül. These cases were identified following clinical investigations of an unusually high number of dengue-like...
Disease Outbreak News
1w
Human Papillomavirus (HPV)-Related Carcinoma of the Oropharynx with Squamous Cell and Adenoid Cystic Carcinoma-Like Features: Report of a Case
Abstract We describe the heretofore unreported case of an HPV-related carcinoma of the palatine tonsil with distinct areas of squamous cell- and adenoid cystic carcinoma-like differentiation in a 54-year old patient. The morphological, immunophenotypic and molecular findings of the tumor are illustrated. We discuss the parallels between the tumor and HPV-related multiphenotypic sinonasal carcinoma (HMSC) which is well-known to exhibit adenoid cystic carcinoma-like features. A review...
Latest Results
1w
Laryngeal Oncocytic Cystadenoma with Rare Location and Clinicopathological Aspects
Abstract Laryngeal oncocytic cysts and cystadenomas are uncommon and observed in 0.1–1% of laryngeal biopsy specimens. A 66-year-old male was admitted to the hospital with a hoarse voice of 6 months duration. On laryngoscopic examination, a lesion of the left anterior vocal cord was present. It was excised by direct laryngoscopy and histopathologic examination revealed a cystic cavity with papillary projections into the lumen. The epithelial lining comprised bland oncocytic epithelium....
Latest Results
1w
Variations in Relationships Between Perceived Stress and Birth Outcomes by Immigration Status
Abstract Introduction Past research shows that stress during pregnancy predicts adverse birth outcomes. These patterns might differ based on immigration status. Our objective was to analyze differences in relationships between perceived stress during pregnancy and birth outcomes by immigration status. Methods We recruited 81 pregnant women in Canada...
Latest Results for Maternal and Child Health Journal
1w
Variations in Relationships Between Perceived Stress and Birth Outcomes by Immigration Status
Abstract Introduction Past research shows that stress during pregnancy predicts adverse birth outcomes. These patterns might differ based on immigration status. Our objective was to analyze differences in relationships between perceived stress during pregnancy and birth outcomes by immigration status. Methods We recruited 81 pregnant women in Canada...
Latest Results for Maternal and Child Health Journal
1w

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