Τρίτη 20 Οκτωβρίου 2020

 

Vorinostat and fenretinide synergize in preclinical models of T-cell lymphoid malignancies
T-cell lymphoid malignancies (TCLMs) are in need of novel and more effective therapies. The histone deacetylase (HDAC) inhibitors and the synthetic cytotoxic retinoid fenretinide have achieved durable clinical responses in T-cell lymphomas as single agents, and patients who failed prior HDAC inhibitor treatment have responded to fenretinide. We have previously shown fenretinide synergized with the class I HDAC inhibitor romidepsin in preclinical models of TCLMs. There exist some key differences between...
Anti-Cancer Drugs - Published Ahead-of-Print
36m
SRY-related high-mobility-group box 6 suppresses cell proliferation and is downregulated in breast cancer
Breast cancer is one of the most common cancers endangering women’s health. SRY-related high-mobility-group box 6 (SOX6) is associated with many cancers, though its role has not been reported in breast cancer. Here, we aimed to explore the expression and function of SOX6 in breast cancer. On the basis of the analysis of SOX6 in The Cancer Genome Atlas, Cancer Cell Line Encyclopedia and Genotype-Tissue Expression databases, we revealed that SOX6 was downregulated in breast cancer, and we verified...
Anti-Cancer Drugs - Published Ahead-of-Print
36m
Dabrafenib and trametinib induced pancreatitis: a case report and review of the literature
Approximately 50% of melanomas are characterized by BRAF mutation (V600E in 90% of cases), that predicts more aggressive behaviour. This mutation is the target of dabrafenib, an anti-BRAF tyrosine-kinase inhibitor (TKI), that together with trametinib, anti-MEK TKI, is approved for first-line treatment of metastatic melanoma due to significant benefit in overall and progression-free survival. Most common treatment-related adverse events are pyrexia, chills, fatigue, rash, nausea, vomiting, and diarrhoea....
Anti-Cancer Drugs - Published Ahead-of-Print
36m
Irreversible epidermal growth factor receptor inhibitor Z25h exhibits pronounced inhibition on non-small cell lung adenocarcinoma cell line Hcc827
The epidermal growth factor receptor (EGFR) signaling is frequently activated in lung cancer. In our previous study, a new class of compounds containing pyrido[3,4-d]pyrimidine scaffold with an acrylamide moiety was designed as irreversible EGFR-tyrosine kinase inhibitors to overcome acquired EGFR-T790M resistance. In this study, we selected the most promising compound Z25h to further investigate its effects and the underlying mechanism against non-small cell lung adenocarcinoma cells in vitro. Four...
Anti-Cancer Drugs - Published Ahead-of-Print
36m
Uterine Cancer Mortality in White and African American Females in Southeastern North Carolina.
Conclusion. White females living in adjacent to hog CAFOs areas of southeastern NC have lower rates of mortality from uterine cancer than African American females, but they have higher odds of death compared to their counterparts living in other NC areas. African American females living near CAFOs also have modest increases from their high baseline mortality. While the observed associations do not prove a causation, improving access to screening and medical care is important to mitigate this health...
MedWorm Cancer & Oncology Research
48m
The development of β-selective glycosylation reactions with benzyl substituted 2-deoxy-1,4-dithio-D-erythro-pentofuranosides: enabling practical multi-gram syntheses of 4'-Thio-2'-deoxycytidine (T-dCyd) and 5-aza-4'-thio-2'-deoxycytidine (aza-T-dCyd) to support clinical development.
Authors: Wishka DG, Lopez OD, Rudchenko VF, Huang G, Bahde R, Kumar V, Denysenko SM, Zhang L, Zhang M, Teicher BA, Morris J Abstract The lack of effective methods to perform direct β-selective glycosylation reactions with 2-deoxy-1,4-dithio-D-erythro-pentofuranosides has long been a significant stumbling block for the multi-gram synthesis of 4'-thio-2'-deoxy nucleosides. In addition, previously reported methods for the preparation of appropriately substituted 2-deoxy-1,4-dithio-D-erythro-pentofuranosides...
MedWorm Cancer & Oncology Research
48m
Synthesis and evaluation of antitumor activities of 4-selenopyrimidine derivatives.
In this study, 12 new 4-selenopyrimidine derivatives that are unstable in acidic solutions but very stable in alkaline and neutral solutions avoiding light were synthesized, and the antitumor activities on HepG2 cell lines of these compounds were evaluated by MTT assay. The results have shown that these compounds could reduce the proliferation of HepG2 cells in a dose-dependent fashion, and the inhibitory activity of compounds a6 was greater than that of positive control 5-fluorouracil (5-FU), the...
MedWorm Cancer & Oncology Research
48m
Modeling the Impact of Delaying the Diagnosis of Non-Small Cell Lung Cancer during COVID-19
Publication date: Available online 19 October 2020Source: The Annals of Thoracic SurgeryAuthor(s): Maren E. Shipe, Diane N. Haddad, Stephen A. Deppen, Benjamin D. Kozower, Eric L. Grogan (Source: The Annals of Thoracic Surgery)
MedWorm Cancer & Oncology Research
48m
Actin cytoskeleton in mesenchymal-to-amoeboid transition of cancer cells.
Authors: Alexandrova AY, Chikina AS, Svitkina TM Abstract During development of metastasis, tumor cells migrate through different tissues and encounter different extracellular matrices. An ability of cells to adapt mechanisms of their migration to these diverse environmental conditions, called migration plasticity, gives tumor cells an advantage over normal cells for long distant dissemination. Different modes of individual cell motility-mesenchymal and amoeboid-are driven by different...
MedWorm Cancer & Oncology Research
48m
Two sides of the coin: Cytoskeletal regulation of immune synapses in cancer and primary immune deficiencies.
Authors: Saeed MB, Record J, Westerberg LS Abstract Actin cytoskeleton remodeling facilitates and fine-tunes diverse cellular processes. Cells have evolved to use the same building blocks of actin monomers to form filaments through the sequential and synchronous use of actin filament regulators. This is best illustrated in immune cells which rely on a highly dynamic cytoskeleton to patrol the body and recognize and respond to cancer cells. Here, we highlight key actin regulators that are...
MedWorm Cancer & Oncology Research
48m
Myosins: Driving us towards novel targets and biomarkers in cancer.
Authors: Koncina E, Letellier E Abstract The view that myosins, which are actin based molecular motors, are only driving muscle contraction evolved a lot during the last decades. Nowadays, it is known that they reshape the actin skeleton, anchor or transport vesicles, organelles as well as protein complexes. Here, we review how their role in cell division, polarization, migration and death is related to the cancer phenotype. We will further focus our attention on recent evidences suggesting...
MedWorm Cancer & Oncology Research
48m
The microenvironment and cytoskeletal remodeling in tumor cell invasion.
Authors: Azadi S, Tafazzoli Shadpour M Abstract The physical cues of tumor microenvironment (TME) contribute greatly to the initiation and progression of cancer. Tumor tissues usually become stiffer than healthy tissues with more aligned fibers and changed porosity. In recent years, numerous studies attempted to investigate whether biophysical cues from the surrounding environment affect the biophysical, biochemical, and biological behavior of cells and consequently attribute to the development...
MedWorm Cancer & Oncology Research
48m
Actin regulators in cancer progression and metastases: From structure and function to cytoskeletal dynamics.
Authors: Biber G, Ben-Shmuel A, Sabag B, Barda-Saad M Abstract The cytoskeleton is a central factor contributing to various hallmarks of cancer. In recent years, there has been increasing evidence demonstrating the involvement of actin regulatory proteins in malignancy, and their dysregulation was shown to predict poor clinical prognosis. Although enhanced cytoskeletal activity is often associated with cancer progression, the expression of several inducers of actin polymerization is remarkably...
MedWorm Cancer & Oncology Research
48m
Predictive biomarkers for immunotherapy efficacy in non-small-cell lung cancer: current status and future perspectives.
Authors: C Guven D, Sahin TK, Dizdar O, Kilickap S Abstract In recent years, immune checkpoint inhibitors have rapidly changed treatment paradigms and have been pivotal for the treatment of advanced NSCLC patients. However, many patients don't respond to immunotherapy, and toxicities are a concern. Mounting evidence suggests that PD-L1 expression and tumor mutational burden are useful biomarkers in NSCLC and widely used in clinical practice. Given various limitations of PD-L1 and tumor...
MedWorm Cancer & Oncology Research
1h
Identification prognosis-associated immune genes and exploration immune cell infiltration of colorectal cancer.
Conclusion: The risk score was an independent prognostic biomarker for CRC patients. The research excavated immune genes that were associated with survival and that could be potential biomarkers for prognosis and treatment for CRC patients. PMID: 33064017 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
1h
Liquid biopsy and their application progress in head and neck cancer: focus on biomarkers CTCs, cfDNA, ctDNA and EVs.
Authors: Meng Y, Bian L, Zhang M, Bo F, Lu X, Li D Abstract Head and neck cancer (HNC) is the sixth leading cause of cancer death worldwide. Due to the low early diagnosis rate of HNC, local recurrence and high distant metastasis rate are the main reasons for treatment failure. Therefore, it is important to establish a method of diagnosis and monitoring, which is convenient, safe, reproducible, sensitive and specific. Compared with tissue biopsy, liquid biopsy is an emerging biopsy technique,...
MedWorm Cancer & Oncology Research
1h
Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer.
Conclusion: High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer. PMID: 33064013 [PubMed - as supplied by publisher] (Source: Future Medicine: Biomarkers in Medicine)
MedWorm Cancer & Oncology Research
1h
Release Notice - Canadian Cancer Statistics: A 2020 special report on lung cancer.
Authors: PMID: 33064075 [PubMed - in process] (Source: Health Promotion and Chronic Disease Prevention in Canada)
MedWorm Cancer & Oncology Research
2h
Risk of exposure to acrylamide.
CONCLUSIONS: Dietary intake of acrylamide, as well as occupational exposure, cigarette smoking, cosmetics usage and other environmental sources could have a significant effect on human health. PMID: 33069180 [PubMed - in process] (Source: Central European Journal of Public Health)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
2h
Occurrence of asbestos-related occupational diseases in the Czech Republic in the last 20 years.
CONCLUSION: The authors emphasize the importance of work history for the diagnostic process of asbestos-related diseases and also the need to perform follow-up examinations for their early detection. PMID: 33069179 [PubMed - in process] (Source: Central European Journal of Public Health)
MedWorm Cancer & Oncology Research
2h
Study design, size, and adequate exposure data as the crucial aspects in cancer risk assessment and implementation of the precautionary principle.
Authors: Bencko V, Tuček M, Quinn JM Abstract Traditional approaches and study design in cancer epidemiology have not been very successful in identifying and evaluating adequately the potential risk and/or protective factors associated with the disease. The main reasons for the failure are often due the small study sample size, and inadequate exposure information. In this paper, issues and approaches relevant to these two challenges are discussed. Multicentre study is proposed as a way...
MedWorm Cancer & Oncology Research
2h
Exploring Reproductive Health Education Needs in Infertile Women in Iran: A Qualitative Study.
CONCLUSIONS: In infertile women, the educational needs associated with reproductive health are multifaceted. Satisfying these needs can help achieve optimal treatment results and promote reproductive health. PMID: 33070507 [PubMed - in process] (Source: Journal of Preventive Medicine and Public Health)
MedWorm Cancer & Oncology Research
2h
Copper metabolism as a unique vulnerability in cancer
Publication date: Available online 20 October 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Vinit C. Shanbhag, Nikita Gudekar, Kimberly Jasmer, Christos Papageorgiou, Kamal Singh, Michael J. Petris (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
MedWorm Cancer & Oncology Research
3h
64Copper labelled nanoparticles for PET Imaging: a review of the recent literature.
CONCLUSIONS: The results showed that nanoparticles can be considered a promising radiopharmaceutical for PET imaging of different type of cancer. PMID: 33073558 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
MedWorm Cancer & Oncology Research
3h
Digging deeper through glucose metabolism and its regulators in cancer and metastasis
Publication date: Available online 20 October 2020Source: Life SciencesAuthor(s): Majid Ghanavat, Mehdi Shahrouzian, Zeinab Deris Zayeri, Sara Banihashemi, Seyedeh Maryam Kazemi, Najmaldin Saki (Source: Life Sciences)
MedWorm Cancer & Oncology Research
3h
Molecular mechanisms of breast cancer chemoresistance by immune checkpoints
Publication date: Available online 20 October 2020Source: Life SciencesAuthor(s): Narges Dastmalchi, Reza Safaralizadeh, Amir Baghbanzadeh, Khalil Hajiasgharzadeh, Elmira Roshani Asl, Mohammad Amini, Behzad Baradaran (Source: Life Sciences)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
3h
A novel bioreducible and pH-responsive magnetic nanohydrogel based on β-cyclodextrin for chemo/hyperthermia therapy of cancer
Publication date: 15 January 2021Source: Carbohydrate Polymers, Volume 252Author(s): Khadijeh Soleimani, Elham Arkan, Hossein Derakhshankhah, Babak Haghshenas, Rana Jahanban-Esfahlan, Mehdi Jaymand (Source: Carbohydrate Polymers)
MedWorm Cancer & Oncology Research
3h
Significance of aldo-keto reductase 1C3 and ATP-binding cassette transporter B1 in gain of irinotecan resistance in colon cancer cells
Publication date: Available online 20 October 2020Source: Chemico-Biological InteractionsAuthor(s): Toshiyuki Matsunaga, Naoko Okumura, Haruhi Saito, Yoshifumi Morikawa, Koichi Suenami, Aki Hisamatsu, Satoshi Endo, Akira Ikari (Source: Chemico Biological Interactions)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
4h
Rhamnose modified bovine serum albumin as a carrier protein promotes the immune response against sTn antigen
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC05263A, CommunicationHan Lin, Haofei Hong, Jinfeng Wang, Chen Li, Zhifang Zhou, Zhimeng Wu Rhamnose and sTn antigen were co-conjugated to bovine serum albumin (BSA) for cancer vaccine development. The immune responses against sTn have been significantly augmented with the involvement of Rha-specific antibodies to enhance antigen uptake. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this...
MedWorm Cancer & Oncology Research
4h
Hedgehog inhibitors in the treatment of advanced basal cell carcinoma: risks and benefits.
Authors: Villani A, Cinelli E, Fabbrocini G, Lallas A, Scalvenzi M Abstract INTRODUCTION: Basal cell carcinoma (BCC) is the most common non melanoma skin cancer (NMSC). Although surgery is the first-line therapy for BCC, some cases can progress to an advanced or, rarely, a metastatic state and targeted therapy are required. The main pathway involved in BCC tumorigenesis is the Hedgehog (Hh) signaling pathway and its inhibition is among the few treatment options available for patients with...
MedWorm Cancer & Oncology Research
4h
The sesquiterpene lactone eupatolide induces apoptosis in non-small cell lung cancer cells by suppressing STAT3 signaling
Publication date: Available online 20 October 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Xiaoxu Ma, Kai Wu, Aiguo Xu, Pengfei Jiao, Huiling Li, Lihua Xing (Source: Environmental Toxicology and Pharmacology)
MedWorm Cancer & Oncology Research
4h
An Up-to-date Assessment of US Prostate Cancer Incidence Rates by Stage and Race: A Novel Approach Combining Multiple Imputation with Age and Delay Adjustment
Publication date: Available online 20 October 2020Source: European UrologyAuthor(s): Michael B. Cook, Lauren M. Hurwitz, Ashley M. Geczik, Eboneé N. Butler (Source: European Urology)
MedWorm Cancer & Oncology Research
4h
Evaluating the efficacy of a low-cost cognitive MRI-targeted prostate biopsy protocol: is there still a role for lower volume centers in the Prostate Imaging Reporting and Data System (PI-RADS) version 2 era?
ConclusionsBoth pre-biopsy MRI and cognitive-targeted biopsy contributed to improvement of cancer yield. Future alterations of possible benefit included increasing target cores per lesion, and combining PI-RADS score and PSA density as indicators for biopsy. Similar protocols may represent an on-going role for lower volume centers in the diagnosis of prostate cancer. (Source: International Urology and Nephrology)
MedWorm Cancer & Oncology Research
4h
Influence of border-age on survival of sporadic renal cell carcinoma: young adults versus octogenarians
ConclusionSporadic RCC was associated with a more favorable CSS and OS in young adults compared to the octogenarians. Although two border-age groups had similar pathologies, they have different prognosis and survival rates. (Source: International Urology and Nephrology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
4h
Lesion Mask-Based Simultaneous Synthesis of Anatomic and Molecular MR Images Using a GAN.
Authors: Guo P, Wang P, Zhou J, Patel VM, Jiang S Abstract Data-driven automatic approaches have demonstrated their great potential in resolving various clinical diagnostic dilemmas for patients with malignant gliomas in neuro-oncology with the help of conventional and advanced molecular MR images. However, the lack of sufficient annotated MRI data has vastly impeded the development of such automatic methods. Conventional data augmentation approaches, including flipping, scaling, rotation,...
MedWorm Cancer & Oncology Research
4h
Unusual giant chromophobe renal cancer totally managed with laparoscopic technique: report of a case
Publication date: Available online 19 October 2020Source: International Journal of Surgery Case ReportsAuthor(s): Giuseppe Di Buono, Salvatore Buscemi, Giulia Bonventre, Elisa Maienza, Leonardo Gulotta, Giorgio Romano, Antonino Agrusa (Source: International Journal of Surgery Case Reports)
MedWorm Cancer & Oncology Research
7h
The surgical management of metastatic pancreatic acinar cell carcinoma and associated pancreatic panniculitis—A case report and literature review
Publication date: Available online 19 October 2020Source: International Journal of Surgery Case ReportsAuthor(s): Edward M. Clarke, Sean G. Stevens, Tim Bennett, Peter Crowley, Graham Starkey (Source: International Journal of Surgery Case Reports)
MedWorm Cancer & Oncology Research
7h
Primary intraosseous carcinoma arising in dentigerous cyst: case report
Publication date: Available online 20 October 2020Source: International Journal of Surgery Case ReportsAuthor(s): Alix Marchal, Éric Gérard, Rémi Curien, Geoffrey Bourgeois (Source: International Journal of Surgery Case Reports)
MedWorm Cancer & Oncology Research
7h
Three simultaneous primary urologic malignancies in a single patient: a case report and review of the literature
Publication date: Available online 20 October 2020Source: International Journal of Surgery Case ReportsAuthor(s): Ilias Hassan, Larbi Hamedoun, Mohamed Tetou, Mohamed Mrabti, Mohamed Alami, Ahmed Ameur (Source: International Journal of Surgery Case Reports)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
7h
Emerging roles for non-selenium containing ER-resident glutathione peroxidases in cell signaling and disease.
Authors: Buday K, Conrad M Abstract Maintenance of cellular redox control is pivotal for normal cellular functions and cell fate decisions including cell death. Among the key cellular redox systems in mammals, the glutathione peroxidase (GPX) family of proteins is the largest conferring multifaceted functions and affecting virtually all cellular processes. The endoplasmic reticulum (ER)- resident glutathione peroxidases, designated as GPX7 and GPX8, are the most recently added members of...
MedWorm Cancer & Oncology Research
7h
PCAT1 induced by transcription factor YY1 promotes cholangiocarcinoma proliferation, migration and invasion by sponging miR-216a-3p to up-regulate oncogene BCL3.
This study was designed to illustrate the function and role of PCAT1 in CCA. The relative expression was confirmed by RT-qPCR and western blot. The biological function of PCAT1 was evaluated by CCK8, EdU, colony formation, wound healing, transwell, and subcutaneous tumor formation assays. Protein levels of EMT markers were measured by western blot. The binding relationship was predicted by JASPAR and starBase. The binding of YY1 to PCAT1 promoter was assessed by ChIP and luciferase reporter. The...
MedWorm Cancer & Oncology Research
7h
A case of simultaneous occurrence of hepatitis and pancreatitis during the combination immunochemotherapy for Non-small Cell Lung Carcinoma
Publication date: Available online 20 October 2020Source: Respiratory Medicine Case ReportsAuthor(s): Satoshi Tanaka, Ryo Asakawa, Kiyohide Komuta, Satoshi Tanizaki, Tomohiro Kanai, Muneyoshi Kuroyama, Kohki Shimazu, Junji Uchida, Takayuki Yakushijin, Kiyonobu Ueno (Source: Respiratory Medicine Case Reports)
MedWorm Cancer & Oncology Research
7h
Clinical risk factors for mortality in patients with cancer and COVID-19: a systematic review and meta-analysis of recent observational studies.
CONCLUSIONS: Various demographic and clinical characteristics, such as male gender, advanced age, comorbidities, and symptoms, were identified as risk factors for mortality in patients with cancer and COVID-19. Our findings suggest recent anti-cancer treatments do not increase mortality. TRIAL REGISTRATION: Registration in PROSPERO (CRD42020201514). PMID: 33054414 [PubMed - as supplied by publisher] (Source: Expert Review of Anticancer Therapy)
MedWorm Cancer & Oncology Research
7h
Abemaciclib, a third CDK 4/6 inhibitor for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced or metastatic breast cancer.
Authors: El Hachem G, Gombos A, Awada A Abstract INTRODUCTION: The field of metastatic luminal breast cancer (hormone receptor positive, HER-2 negative) is dynamic and evolving, harboring some of the most significant therapeutic advances in medical oncology. Over the last decade, many pivotal trials showed excellent results with drastic improvements in survival as well as the quality of life of metastatic luminal breast cancer patients. AREAS COVERED: The successful inhibition of the...
MedWorm Cancer & Oncology Research
7h
Monoclonal antibodies as an addition to current myeloma therapy strategies.
Authors: Jullien M, Touzeau C, Moreau P Abstract INTRODUCTION: Immunotherapy has emerged as a major class in the therapeutic arsenal of multiple myeloma. Cell-based immunotherapy (CAR T-cells) and monoclonal antibody-based immunotherapy (naked monoclonal antibodies, antibody-drug conjugates and bispecific T-cell engagers) are the two cornerstones of this novel approach for myeloma patients. Among numerous targets evaluated in the previous decade; CD38, SLAMF7 and, more recently, BCMA stand...
MedWorm Cancer & Oncology Research
7h
Metronomic therapy in advanced breast cancer and NSCLC: vinorelbine as a paradigm of recent progress.
Authors: Xu B, Sun T, Wang S, Lin Y Abstract INTRODUCTION: Metronomic chemotherapy (MCT) is based on frequent dosing of the drug - typically using an oral formulation - at below the maximum tolerated dose. This leads to pharmacologically active but low plasma concentrations that reduce toxicity and allow treatment to be administered for a longer time. Mechanistically, MCT seems to work primarily via indirect effects on tumor cells and their microenvironment, rather than direct antitumor...
MedWorm Cancer & Oncology Research
7h
Luteinized thecoma (thecomatosis) with sclerosing peritonitis: a systematic review of the literature of the last 25 years.
Authors: Muratori L, Trevisi E, Delcuratolo MD, Sperone P, Di Maio M Abstract INTRODUCTION: Luteinized thecoma (thecomatosis) with sclerosing peritonitis (LTSP) is a very uncommon syndrome, characterized by the presence of single or bilateral ovarian thecomas and peritoneal fibrotic lesions. The disease occurs in young women and it can lead to peritoneal fibrosis and bowel obstruction. The pathogenesis of this syndrome remains still largely unknown. Surgery represents the cornerstone of...
MedWorm Cancer & Oncology Research
7h
A novel DNA methylation 10-CpG prognostic signature of disease-free survival reveal that MYBL2 is associated with high risk in prostate cancer.
CONCLUSIONS: We developed a DNA methylation 10-CpG prognostic signature to predict the prognosis of PC patients. And the high expression of MYBL2 in PC may be related to poor prognosis. PMID: 33073649 [PubMed - as supplied by publisher] (Source: Expert Review of Anticancer Therapy)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
7h
Therapy for acute myelogenous leukemia revisited: moving away from a one-size-fits-all approach.
Authors: Reikvam H, Hemsing AL, Smith C PMID: 33059507 [PubMed - as supplied by publisher] (Source: Expert Review of Anticancer Therapy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
7h
UHRF1 knockdown attenuates cell growth, migration, and invasion in cutaneous squamous cell carcinoma.
Authors: Li Q, Chu Z, Geng S Abstract Ubiquitin like with PHD and ring finger domains 1 (UHRF1) contributes to the progression of many cancers. Here, we firstly observed UHRF1 was elevated in cutaneous squamous cell carcinoma (cSCC) and related to the differentiation stages. Knockdown of UHRF1 in A431 and Scl-1 attenuated cell proliferation, migration, and invasion, leading to G2/M cell cycle arrest and apoptosis. Through a mouse xenograft model, we found UHRF1 deficiency ameliorated tumor...
MedWorm Cancer & Oncology Research
7h
Comparative Analysis of Outcomes and Clinicopathological Characteristics of duodenal adenocarcinoma: A SEER analysis.
Authors: Zhu Z, Zhong F Abstract Duodenal adenocarcinoma is an uncommon, malignant tumor usually accompanied by a poor prognosis. We identified 3,150 duodenal adenocarcinoma cases from the SEER database(1988-2013) to analyze clinical characteristics and outcomes. The Kaplan-Meier method was used to evaluate cancer-specific survival (CSS). Cox regression analysis was used to explore the prognostic factors of CSS. Adverse prognostic factors include higher tumor grade, later stage, tumor size...
MedWorm Cancer & Oncology Research
7h
EP4 Receptor as a Novel Promising Therapeutic Target in Colon Cancer: Running title: EP4 receptor in colon cancer
Publication date: Available online 19 October 2020Source: Pathology - Research and PracticeAuthor(s): Vahid Karpisheh, Navneet Joshi, Angelina Olegovna Zekiy, Behzad Beyzai, Mohammad Hojjat-Farsangi, Afshin Namdar, Mahdi Edalati, Farhad Jadidi-Niaragh (Source: Pathology Research and Practice)
MedWorm Cancer & Oncology Research
8h
Strategies to maximize clinical efficiency while maintaining patient safety during the COVID-19 pandemic: an interview-based study from private practice dermatologists.
CONCLUSION: Improving patient communication, implementing protocols to facilitate social distancing, and utilizing teledermatology were reported to be essential to optimizing efficiency and safety. As the COVID-19 pandemic continues to evolve, it is important that dermatologists identify specific ways to practice efficiently and effectively, while mitigating the spread of the virus. PMID: 33054453 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)MedWorm Message:...
MedWorm Cancer & Oncology Research
8h
Sentinel Lymph Node Biopsy for Early Stage Endometrial and Cervical Cancer Performed By Surgeons in Training
Publication date: November–December 2020Source: Journal of Minimally Invasive Gynecology, Volume 27, Issue 7, SupplementAuthor(s): A.D.L. Munhoz, C.S. Silva, A.E. Vargas, J.C. Linhares, R. Ribeiro, F. Schamne, A.T. Tsunoda (Source: Journal of Minimally Invasive Gynecology)
MedWorm Cancer & Oncology Research
8h
Robotic TOTAL Pelvic Exenteration for Primary Carcinoma of Cervix, STAGE IV a
Publication date: November–December 2020Source: Journal of Minimally Invasive Gynecology, Volume 27, Issue 7, SupplementAuthor(s): S.P. Puntambekar, A. Puntambekar, S. Puntambekar, S.P. Barse, S. Bharambe (Source: Journal of Minimally Invasive Gynecology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
8h
Laparoscopic Excision of Recurrent Pelvic Lymphocyst Following Pelvic Lymph Node Dissection for Clear Cell Carcinoma of Ovary
Publication date: November–December 2020Source: Journal of Minimally Invasive Gynecology, Volume 27, Issue 7, SupplementAuthor(s): S. Addley, M. Alazzam, E. Jackson, M.H. Soleymani (Source: Journal of Minimally Invasive Gynecology)
MedWorm Cancer & Oncology Research
8h
Impact of COVID-19 on Outcomes and Productivity in a Gynecologic Oncology and Minimally Invasive Surgery Practice
Publication date: November–December 2020Source: Journal of Minimally Invasive Gynecology, Volume 27, Issue 7, SupplementAuthor(s): V. Palvia, K. Kossl, L. Rosen, S. Khalil, H.F. Gretz (Source: Journal of Minimally Invasive Gynecology)
MedWorm Cancer & Oncology Research
8h
Commentary on Cost-Effectiveness of Metastasis-Directed Therapy in Oligorecurrent Hormone-Sensitive Prostate Cancer.
Authors: Spencer KL, Tree AC PMID: 33069354 [PubMed - in process] (Source: Health Physics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
8h
CT assessment of preoperative nutritional status in gastric cancer: Severe low skeletal muscle mass and obesity-related low skeletal muscle mass are unfavorable factors of postoperative complications.
CONCLUSIONS: LSMM was not significantly correlated with postoperative complications. Severe LSMM and obesity-related LSMM are unfavorable factors for postoperative complications with GC after gastrectomy. PMID: 33063547 [PubMed - as supplied by publisher] (Source: Expert Review of Gastroenterology and Hepatology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate...
MedWorm Cancer & Oncology Research
9h
Efficacy and safety profile of calcineurin inhibitor salvage therapy in autoimmune hepatitis.
CONCLUSION: CNI salvage therapy is well tolerated and moderately effective achieving remission in around 50% of AIH who failed standard therapy. PMID: 33070650 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
MedWorm Cancer & Oncology Research
9h
Adenosquamous carcinoma of the digestive system: a literature review.
Authors: Li HS, He T, Yang LL Abstract Adenosquamous carcinoma (ASC), containing both adenocarcinoma and squamous cell carcinoma components, is rare in the digestive system. Limited data is available on ASC of the digestive system (AS-ASC), and the current evidence is available mainly in the form of case reports and case series. We performed a thorough search of the available literature and compiled a review on the epidemiology, histopathology, pathogenesis, clinical manifestations, diagnosis,...
MedWorm Cancer & Oncology Research
9h
COVID-19 Won't Be the Last (Or Worst) Pandemic: It's Time to Build Resilience Into Our Cervical Cancer Elimination Goals.
Authors: Steben M, Norris T, Rosberger Z, HPV Global Action PMID: 33059877 [PubMed - in process] (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)
MedWorm Cancer & Oncology Research
9h
La pand émie de COVID-19 ne sera pas la dernière (ni la pire) : Il est temps d'intégrer la résilience à nos objectifs d'élimination du cancer du col de l'utérus.
La pandémie de COVID-19 ne sera pas la dernière (ni la pire) : Il est temps d'intégrer la résilience à nos objectifs d'élimination du cancer du col de l'utérus. J Obstet Gynaecol Can. 2020 Oct;42(10):1197-1199 Authors: Steben M, Norris T, Rosberger Z, au nom de HPV Global Action PMID: 33059878 [PubMed - in process] (Source: Journal of Obstetrics and Gynaecology Canada : JOGC)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your...
MedWorm Cancer & Oncology Research
9h
Gut microbiota-derived metabolites and colorectal cancer: New insights and updates
Publication date: December 2020Source: Microbial Pathogenesis, Volume 149Author(s): Amir Hossein Mohseni, Sedigheh Taghinezhad-S, Xiangsheng Fu (Source: Microbial Pathogenesis)
MedWorm Cancer & Oncology Research
10h
Sun Awareness and Sun Protection Practices.
Conclusion: Most of the respondents are aware about sun protection. However, the sun protection level of the residents is still inadequate. An efficient strategy of increasing the awareness of the effective use of sun protection systems must be established based on the significant factors to prevent skin cancer. PMID: 33061512 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with...
MedWorm Cancer & Oncology Research
10h
Multiple Skin Neoplasms at One Site (MUSK IN A NEST): A Comprehensive Review of Basal Cell Carcinoma and Benign or Malignant "Collision" Tumors at the Same Cutaneous Location.
Multiple Skin Neoplasms at One Site (MUSK IN A NEST): A Comprehensive Review of Basal Cell Carcinoma and Benign or Malignant "Collision" Tumors at the Same Cutaneous Location. Clin Cosmet Investig Dermatol. 2020;13:731-741 Authors: Cohen PR, Calame A Abstract Multiple skin neoplasms at one site (MUSK IN A NEST), initially referred to as a collision tumor, describes the occurrence of two or more benign or malignant neoplasms that are adjacent or intermingled at the same cutaneous...
MedWorm Cancer & Oncology Research
10h
Repurposing denosumab in breast cancer beyond prevention of skeletal related events: could nonclinical data be translated into clinical practice?
Authors: Deligiorgi MV, Panayiotidis MI, Trafalis DT Abstract INTRODUCTION: Denosumab is a human monoclonal antibody inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL). Initially approved as anti-osteοporotic agent, denosumab is being currently pursued as a candidate for drug repurposing in oncology, especially breast cancer. AREAS COVERED: The present review provides an overview of the therapeutic potential of denosumab in breast cancer beyond prevention of...
MedWorm Cancer & Oncology Research
10h
Futibatinib, an investigational agent for the treatment of intrahepatic cholangiocarcinoma: evidence to date and future perspectives.
Authors: Rizzo A, Ricci AD, Brandi G Abstract INTRODUCTION: Biliary tract cancers (BTCs) are poor prognosis malignancies usually classified in intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma, gallbladder cancer, and ampulla of Vater cancer. In the last few years, novel treatment targets have been identified in iCCA patients, including fibroblast growth factor receptor (FGFR) aberrations; thus, several FGFR inhibitors are currently being developed, some of which have...
MedWorm Cancer & Oncology Research
10h
Dr Sandi Dunn illuminates emerging key treatment approaches and companion diagnostics for triple negative breast cancer.
Authors: Dunn S PMID: 33070643 [PubMed - as supplied by publisher] (Source: Expert Opinion on Investigational Drugs)
MedWorm Cancer & Oncology Research
10h
The impact of modulating the gastrointestinal microbiota in cancer patients
Publication date: Available online 19 October 2020Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Egidijus Morkūnas, Jurgita Skiecevičienė, Juozas Kupčinskas (Source: Best Practice and Research Clinical Gastroenterology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
10h
Catalytic hairpin assembly-triggered DNA walker for electrochemical sensing of tumor exosomes sensitized with Ag@C core-shell nanocomposites.
Authors: Guo Y, Cao Q, Feng Q Abstract The detection of a small number of exosomes provides the possibility for early cancer diagnosis and prognosis. Here, a multi-signal amplified electrochemical sensing platform was explored for the ultrasensitive detection of tumor exosomes relying on catalytic hairpin assembly-triggered DNA walker, entropy beacon-based DNA assembly and Ag@C core-shell nanocomposites. In this work, the utilization of Ag@C nanocomposites as electrode interface effectively...
MedWorm Cancer & Oncology Research
10h
Determination of hydrogen peroxide released from cancer cells by a Fe-Organic framework/horseradish peroxidase-modified electrode.
Authors: Jiang T, Sun X, Wei L, Li M Abstract Multi-walled carbon nanotubes (MWCNTs) were used as conductive carrier on the glassy carbon electrode (GCE), and the hybrid of metal organic framework [NH2-MIL-53(Fe)] and horseradish peroxidase (HRP) was prepared by simple physical mechanical mixture. The GCE modified by the above material with immobilization, namely NH2-MIL-53(Fe)/HRP/MWCNTs/GCE, was used to construct an electrochemical biosensor toward H2O2. The results indicated that the...
MedWorm Cancer & Oncology Research
10h
Molecular Therapeutics of Pancreatic Ductal Adenocarcinoma: Targeted Pathways and the Role of Cancer Stem Cells
Publication date: Available online 19 October 2020Source: Trends in Pharmacological SciencesAuthor(s): Andrei-Florian Stoica, Chao-Hui Chang, Siim Pauklin (Source: Trends in Pharmacological Sciences)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
11h
Role of tissue and circulating microRNA and DNA as biomarkers in medullary thyroid cancer
Publication date: Available online 20 October 2020Source: Pharmacology & TherapeuticsAuthor(s): Martina Chiacchiarini, Sofia Trocchianesi, Zein Mersini Besharat, Agnese Po, Elisabetta Ferretti (Source: Pharmacology and Therapeutics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
11h
Benign Feminizing Adrenal Tumor in an Adult Male.
Conclusion: Given the ambiguity in distinguishing between malignant and benign feminizing adrenal tumors, we suggest that radiologic (via Hounsfield units), clinical (via trending hormone levels), and histopathologic (via Weiss and Ki-67 scores) findings are sufficient to confirm the benign nature of this commonly malignant tumor. PMID: 33071666 [PubMed] (Source: Ochsner Journal)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social...
MedWorm Cancer & Oncology Research
11h
Management of Hepatocellular Carcinoma in the Era of Individualized Therapy: The Experience of a Greek Tertiary Center.
Conclusion: In this study, patients treated with hepatic resection had higher survival rates than patients treated with locoregional treatments. However, this superiority did not reach statistical significance (P=0.426). Thus, locoregional treatments are highlighted as a valuable alternative to surgery, particularly when hepatic resection is not feasible. Finally, patients who received locoregional treatment following surgery had significantly higher survival compared to patients treated with surgery...
MedWorm Cancer & Oncology Research
11h
Ileal Signet Ring Cell Carcinoma Masked by Crohn Disease.
Conclusion: This case of metastatic ileal SRCC occurred in the setting of long-standing, clinically controlled CD. Although the absolute risk of small-bowel adenocarcinoma in CD is low, active surveillance for small-bowel adenocarcinoma in patients with longstanding CD may be prudent, given the overlapping symptomology of SRCC and CD, the aggressiveness of SRCC, and the association of SRCC with subclinical inflammation. PMID: 33071669 [PubMed] (Source: Ochsner Journal)
MedWorm Cancer & Oncology Research
11h
Importance of microRNAs in Skin Oncogenesis and Their Suitability as Agents and Targets for Topical Therapy
Skin cancer is the most common cancer worldwide, with rapidly increasing incidence and consistent mortality. Skin cancer encompasses melanoma and non-melanoma skin cancer, which in turn is mainly divided into cutaneous squamous cell carcinoma and basal cell carcinoma. Small noncoding micro ­RNAs (miRNAs) regulate protein expression after transcription and play a role in the development and progression of skin cancer. Deregulated expression of miRNAs in skin cancer is associated with cell proliferation,...
MedWorm Cancer & Oncology Research
11h
Extensive Review Based on a Rare Case of Histiocytic Sarcoma.
Authors: Tocut M, Vaknine H, Potachenko P, Elias S, Zandman-Goddard G Abstract BACKGROUND: Histiocytic sarcoma (HS) is a rare hematopoietic malignancy originating from the monocyte/macrophage bone marrow lineage. HS can occur in isolation or in association with other hematological neoplasms such as non-Hodgkin lymphoma (NHL), myelodysplasia, or acute leukemia. Clinically, HS can affect lymph nodes, gastrointestinal tract, skin, bone marrow, and spleen as well as the central nervous system....
MedWorm Cancer & Oncology Research
12h

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου

Αρχειοθήκη ιστολογίου