Cancerization Field Treatment using Topical Photodynamic Therapy: a comparison between two Aminolevulinate Derivatives

Cancerization Field Treatment using Topical Photodynamic Therapy: a comparison between two Aminolevulinate Derivatives:



Publication date: Available online 9 December 2019

Source: Photodiagnosis and Photodynamic Therapy

Author(s): Elisangela Ramos de Oliveira, Natalia M. Inada, Kate Cristina Blanco, Vanderlei S. Bagnato, Ana Gabriela Salvio

Abstract

Cancerization field presents photodamaged skin with potential for the development of Precancerous lesions such as actinic keratosis (AK). The objective of this study was to evaluate and compare the clinical response to PDT in field cancerization using two aminolevulinate derivatives. Forty patients with multiple AK on forearms and hands scattered received two sessions of ALA and MAL-PDT at 630 nm (36 J/cm²). The AK clearance rate was 72% for both drugs with a significant decrease in AK observed clinically (p < 0,0001). Clinical improvement in field cancerization using two aminolevulinate derivatives in PDT is proven and no significant difference in the efficacy of drugs.