Detection of nasal microbiota in pediatric patients with antrochoanal polyps by TLDA

Detection of nasal microbiota in pediatric patients with antrochoanal polyps by TLDA:



Publication date: Available online 5 December 2019

Source: International Journal of Pediatric Otorhinolaryngology

Author(s): Beibei Song, Huiwen Zheng, Shujing Han, Lixing Tang, Xiaojian Yang, Ping Chu, Pengpeng Wang, Jie Lu, Wentong Ge, Xin Ni

Abstract

Objective

To evaluate and compare the microbiological features in ACPs groups and control subjects in pediatric group, further to explore the potential role of microbial in the etiology of ACPs.

Methods

A total of 32 patients with ACPs, and 10 control subjects were enrolled in this study. Demographic datas were collected. The TaqMan low-density array assays were used to detect the microbial of swab specimens and nasal tissue samples from ACPs patients.

Results

A total of 15 species were identified in all groups. Of all the species, Mycoplasma_pneumoniae was the most common species in ACP patients, but was negative in control group. Of all the viruses detected, Adenovirus positivity was significantly higher in control group than that in ACPs middle meatus on uninjured side, ACPs middle meatus on affected side, and ACPs polypous surface group (P<0.05). Cytomegalovirus positivity was significantly higher in control group than that in ACP polypous group (P<0.05). The expression of other microbial differed in middle meatus on uninjured and affected side of ACPs, ACPs polypous surface, ACPs polyp.

Conclusions

Mycoplasma_pneumoniae was the most common species in ACP patients. Streptococcus pneumonia, Bordetella and Moraxella_catarrhalis were the only bacteria detected at certain frequency in nasal polyps and control subjects. Human herpesvirus 6 and C pneumonia had potential role in the development of ACPs. The isolates rate of microbial differed in middle meatus on uninjured and affected side of ACPs, ACPs polypous surface, ACPs polyp, and their role in the etiology of ACPs need to be further studied.