Antibiotics, Vol. 8, Pages 270: The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors Antibiotics doi: 10.3390/antibiotics8040270 Authors: Gajdács Spengler Background: The emergence of multidrug-resistant organisms (MDROs) is a global public health issue, severely hindering clinicians in administering appropriate antimicrobial therapy. Drug repurposing is a drug development strategy, during...
Tue Dec 17, 2019 02:00
Antioxidants, Vol. 8, Pages 650: Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort Antioxidants doi: 10.3390/antiox8120650 Authors: Pierre Philip Patricia Sagaspe Jacques Taillard Claire Mandon Joël Constans Line Pourtau Camille Pouchieu Donato Angelino Pedro Mena Daniela Martini Daniele Del Rio David Vauzour Despite an increasing level of evidence...
Tue Dec 17, 2019 02:00
Arts, Vol. 8, Pages 167: The Question of Appropriateness. Museums Established in Synagogues in Communist Poland: The Cases of Łańcut and Włodawa Arts doi: 10.3390/arts8040167 Authors: Migalska World War II and the subsequent period of communist rule severely diminished the amount of historic Jewish architecture in Poland. It is estimated that in the mid-1990s there were about 321 synagogues and prayer houses in the country, all in various states of preservation. This article examines...
Tue Dec 17, 2019 02:00
Arts, Vol. 8, Pages 166: Cultural Ecology and Cultural Critique Arts doi: 10.3390/arts8040166 Authors: Rowan Bailey Claire Booth-Kurpnieks Kath Davies Ioanni Delsante In 2015, the Arts and Humanities Research Council (AHRC) commissioned John Holden, visiting professor at City University, London, and associate at the think-tank Demos, to write a report on culture as part of its Cultural Value Project. The claim within the report was to redirect culture away from economic prescriptions...
Tue Dec 17, 2019 02:00
Atmosphere, Vol. 11, Pages 1: Is Contact Nucleation Caused by Pressure Perturbation? Atmosphere doi: 10.3390/atmos11010001 Authors: Fan Yang Will H. Cantrell Alexander B. Kostinski Raymond A. Shaw Andrew M. Vogelmann The reason why ice nucleation is more efficient by contact nucleation than by immersion nucleation has been elusive for over half a century. Six proposed mechanisms are summarized in this study. Among them, the pressure perturbation hypothesis, which arose from...
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Bioengineering, Vol. 6, Pages 115: Tequila Agave Bagasse Hydrolysate for the Production of Polyhydroxybutyrate by Burkholderia sacchari Bioengineering doi: 10.3390/bioengineering6040115 Authors: Yolanda González-García Janessa Grieve Juan Carlos Meza-Contreras Berenice Clifton-García José Antonio Silva-Guzman Tequila agave bagasse (TAB) is the fibrous waste from the Tequila production process. It is generated in large amounts and its disposal is an environmental problem....
Tue Dec 17, 2019 02:00
Biology, Vol. 8, Pages 94: The Gametic Non-Lethal Gene Gal on Chromosome 5 Is Indispensable for the Transmission of the Co-Induced Semidwarfing Gene d60 in Rice Biology doi: 10.3390/biology8040094 Authors: Tomita Tanisaka The gametic lethal gene gal in combination with the semidwarfing gene d60 causes complementary lethality in rice. Here, we attempted to ascertain the existence of gal and clarify male gamete abortion caused by d60 and gal. Through the F2 to F4 generations derived...
Tue Dec 17, 2019 02:00
Biomolecules, Vol. 10, Pages 2: High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in ‘Glutamine Addiction’ Biomolecules doi: 10.3390/biom10010002 Authors: Dorai Dorai Pinto Grasso Cooper Abstract: Many tumors readily convert l-glutamine to α-ketoglutarate. This conversion is almost invariably described as involving deamidation of l-glutamine to l-glutamate followed by a transaminase (or dehydrogenase) reaction. However,...
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Biomolecules, Vol. 10, Pages 1: Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides Biomolecules doi: 10.3390/biom10010001 Authors: Reidenbach Minikel Zhao Guzman Leed Mesleh Kordasiewicz Schreiber Vallabh Antisense oligonucleotides (ASOs) designed to lower prion protein (PrP) expression in the brain through RNase H1-mediated degradation of PrP RNA are in development as prion disease therapeutics. ASOs were previously...
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Biomolecules, Vol. 10, Pages 3: Thrombolytic Potential of Novel Thiol-Dependent Fibrinolytic Protease from Bacillus cereus RSA1 Biomolecules doi: 10.3390/biom10010003 Authors: Sharma Salem Sharma Gautam Singh The present study demonstrates the production and thrombolytic potential of a novel thermostable thiol-dependent fibrinolytic protease by Bacillus cereus RSA1. Statistical optimization of different parameters was accomplished with Plackett–Burman design...
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Biomolecules, Vol. 9, Pages 891: Preclinical Evaluation of the Antimicrobial-Immunomodulatory Dual Action of Xenohormetic Molecules against Haemophilus influenzae Respiratory Infection Biomolecules doi: 10.3390/biom9120891 Authors: Fernández-Calvet Euba Caballero Díez-Martínez Menéndez Solórzano Leiva Micol Barrajón-Catalán Garmendia Chronic obstructive pulmonary disease (COPD) is characterized by abnormal inflammation and impaired airway immunity,...
Tue Dec 17, 2019 02:00
Biomolecules, Vol. 9, Pages 892: N-Acetylcysteine Protects against the Anxiogenic Response to Cisplatin in Rats Biomolecules doi: 10.3390/biom9120892 Authors: Vukovic Kumburovic Joksimovic Jovic Jovicic Katanic Stankovic Mihailovic Djuric Velickovic Arnaut Selakovic Rosic Since cisplatin therapy is usually accompanied with numerous toxicities, including neurotoxicity, that involve tissue oxidative damage, the aim of this study was to evaluate...
Tue Dec 17, 2019 02:00
Biomolecules, Vol. 9, Pages 890: Protective Effect of Panaxynol Isolated from Panax vietnamensis against Cisplatin-Induced Renal Damage: In Vitro and In Vivo Studies Biomolecules doi: 10.3390/biom9120890 Authors: Lee Lee Vu-Huynh Le Do Hwang Park Kang Nguyen Yamabe Polyacetylenic compounds isolated from Panax species are comprised of non-polar C17 compounds, exhibiting anti-inflammatory, antitumor, and antifungal activities. Panaxynol represents the...
Tue Dec 17, 2019 02:00
Biomolecules, Vol. 9, Pages 888: Advanced Glycation End Products (AGEs) May Be a Striking Link Between Modern Diet and Health Biomolecules doi: 10.3390/biom9120888 Authors: Gill Kumar Singh Kumar Kim The Maillard reaction is a simple but ubiquitous reaction that occurs both in vivo and ex vivo during the cooking or processing of foods under high-temperature conditions, such as baking, frying, or grilling. Glycation of proteins is a post-translational modification that...
Tue Dec 17, 2019 02:00
Biomolecules, Vol. 9, Pages 889: Exploration of the Misfolding Mechanism of Transthyretin Monomer: Insights from Hybrid-Resolution Simulations and Markov State Model Analysis Biomolecules doi: 10.3390/biom9120889 Authors: Zhou Cheng Yang Ma Zhang Yuan Lo Dou Misfolding and aggregation of transthyretin (TTR) is widely known to be responsible for a progressive systemic disorder called amyloid transthyretin (ATTR) amyloidosis. Studies suggest that TTR aggregation...
Tue Dec 17, 2019 02:00
Biomolecules, Vol. 9, Pages 886: Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin System Biomolecules doi: 10.3390/biom9120886 Authors: Jan Wysocki Arndt Schulze Daniel Batlle ACE2 is a monocarboxypeptidase which generates Angiotensin (1–7) from Angiotensin II (1–8). Attempts to target the kidney Renin Angiotensin System using native ACE2 to treat kidney disease are hampered by its large molecular...
Tue Dec 17, 2019 02:00
Biomolecules, Vol. 9, Pages 887: A Sight to Wheat Bran: High Value-Added Products Biomolecules doi: 10.3390/biom9120887 Authors: Agne Katileviciute Gediminas Plakys Aida Budreviciute Kamil Onder Samar Damiati Rimantas Kodzius Recently more consideration has been given to the use of renewable materials and agricultural residues. Wheat production is increasing yearly and correspondingly, the volume of by-products from the wheat process is increasing, as well. It is important...
Tue Dec 17, 2019 02:00
Biomolecules, Vol. 9, Pages 884: Clinical Trials with Herbal Products for the Prevention of Dental Caries and Their Quality: A Scoping Study Biomolecules doi: 10.3390/biom9120884 Authors: Robert Ancuceanu Adriana Iuliana Anghel Camelia Ionescu Marilena Viorica Hovaneț Maria Cojocaru-Toma Mihaela Dinu It is currently recognized that an injudicious strategy about caries in the last decades has been not only focusing of research mostly in children, but also the narrow focusing...
Tue Dec 17, 2019 02:00
Biomolecules, Vol. 9, Pages 885: Characterization of a New Rhamnolipid Biosurfactant Complex from Pseudomonas Isolate DYNA270 Biomolecules doi: 10.3390/biom9120885 Authors: Gina S. Shreve Ronald Makula The chemical and physical properties of extracellular rhamnolipid synthesized by a nonfluorescent Pseudomonas species soil isolate, identified as DYNA270, is described, along with characteristics of rhamnolipid production under varying growth conditions and substrates. The biosurfactant...
Tue Dec 17, 2019 02:00
Biosensors, Vol. 9, Pages 145: Flexible and Transparent Substrates Based on Gold Nanoparticles and TiO2 for in Situ Bioanalysis by Surface-Enhanced Raman Spectroscopy Biosensors doi: 10.3390/bios9040145 Authors: Mandrile Giovannozzi Sacco Martra Rossi Flexible and transparent substrates are emerging as low cost and easy-to-operate support for surface-enhanced Raman spectroscopy (SERS). In particular, in situ SERS detection approach for surface characterization in transmission...
Tue Dec 17, 2019 02:00
Biosensors, Vol. 9, Pages 144: Carbon Nanotube-Based Electrochemical Biosensor for Label-Free Protein Detection Biosensors doi: 10.3390/bios9040144 Authors: Jesslyn Janssen Mike Lambeta Paul White Ahmad Byagowi There is a growing need for biosensors that are capable of efficiently and rapidly quantifying protein biomarkers, both in the biological research and clinical setting. While accurate methods for protein quantification exist, the current assays involve sophisticated techniques,...
Tue Dec 17, 2019 02:00
Brain Sciences, Vol. 9, Pages 383: Neurologic Injury and Brain Growth in the Setting of Long-Gap Esophageal Atresia Perioperative Critical Care: A Pilot Study Brain Sciences doi: 10.3390/brainsci9120383 Authors: Samuel S. Rudisill Jue T. Wang Camilo Jaimes Chandler R. L. Mongerson Anne R. Hansen Russell W. Jennings Dusica Bajic We previously showed that infants born with long-gap esophageal atresia (LGEA) demonstrate clinically significant brain MRI findings following...
Tue Dec 17, 2019 02:00
Brain Sciences, Vol. 9, Pages 382: Reports of L-Norvaline Toxicity in Humans May Be Greatly Overstated Brain Sciences doi: 10.3390/brainsci9120382 Authors: Baruh Polis Michael A. Gilinsky Abraham O. Samson Recently, a study published in “Toxicology In Vitro” (Kate Samardzic and Kenneth J. Rodgers) was entitled: “Cytotoxicity and Mitochondrial Dysfunction Caused by the Dietary Supplement L-Norvaline”. The title may be greatly overstated, and...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2043: A Novel Inhibitor of STAT5 Signaling Overcomes Chemotherapy Resistance in Myeloid Leukemia Cells Cancers doi: 10.3390/cancers11122043 Authors: Brachet-Botineau Deynoux Vallet Polomski Juen Hérault Mazurier Viaud-Massuard Prié Gouilleux Signal transducers and activators of transcription 5A and 5B (STAT5A and STAT5B) are crucial downstream effectors of tyrosine kinase oncogenes (TKO) such as BCR-ABL in chronic myeloid leukemia...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2042: The Benzimidazole-Based Anthelmintic Parbendazole: A Repurposed Drug Candidate That Synergizes with Gemcitabine in Pancreatic Cancer Cancers doi: 10.3390/cancers11122042 Authors: Rosalba Florio Serena Veschi Viviana di Giacomo Sara Pagotto Simone Carradori Fabio Verginelli Roberto Cirilli Adriano Casulli Antonino Grassadonia Nicola Tinari Amelia Cataldi Rosa Amoroso Alessandro Cama Laura De Lellis Pancreatic cancer...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2040: Magnetic Silica-Coated Iron Oxide Nanochains as Photothermal Agents, Disrupting the Extracellular Matrix, and Eradicating Cancer Cells Cancers doi: 10.3390/cancers11122040 Authors: Jelena Kolosnjaj-Tabi Slavko Kralj Elena Griseti Sebastjan Nemec Claire Wilhelm Anouchka Plan Sangnier Elisabeth Bellard Isabelle Fourquaux Muriel Golzio Marie-Pierre Rols Cancerous cells and the tumor microenvironment are among key elements involved...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2039: Simultaneous Multi-Organ Metastases from Chemo-Resistant Triple-Negative Breast Cancer Are Prevented by Interfering with WNT-Signaling Cancers doi: 10.3390/cancers11122039 Authors: Iram Fatima Ikbale El-Ayachi Hilaire C. Playa Jackelyn A. Alva-Ornelas Aysha B. Khalid William L. Kuenzinger Peter Wend Jackelyn C. Pence Lauren Brakefield Raisa I. Krutilina Daniel L. Johnson Ruth M. O’Regan Victoria Seewaldt Tiffany N. Seagroves...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2041: A Review of Key Biological and Molecular Events Underpinning Transformation of Melanocytes to Primary and Metastatic Melanoma Cancers doi: 10.3390/cancers11122041 Authors: Louise A. Jackett Richard A. Scolyer Melanoma is a major public health concern that is responsible for significant morbidity and mortality, particularly in countries such as New Zealand and Australia where it is the commonest cause of cancer death in young adults. Until recently, there...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2038: GSTO1*CC Genotype (rs4925) Predicts Shorter Survival in Clear Cell Renal Cell Carcinoma Male Patients Cancers doi: 10.3390/cancers11122038 Authors: Tanja Radic Vesna Coric Zoran Bukumiric Marija Pljesa-Ercegovac Tatjana Djukic Natasa Avramovic Marija Matic Smiljana Mihailovic Dejan Dragicevic Zoran Dzamic Tatjana Simic Ana Savic-Radojevic Omega class glutathione transferases, GSTO1-1 and GSTO2-2, exhibit different activities...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2037: Pain Management in Patients with Multiple Myeloma: An Update Cancers doi: 10.3390/cancers11122037 Authors: Flaminia Coluzzi Roman Rolke Sebastiano Mercadante Most patients with multiple myeloma (MM) suffer from chronic pain at every stage of the natural disease process. This review focuses on the most common causes of chronic pain in MM patients: (1) pain from myeloma bone disease (MBD); (2) chemotherapy-induced peripheral neuropathy as a possible...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2034: Nanosecond Pulsed Electric Fields Induce Endoplasmic Reticulum Stress Accompanied by Immunogenic Cell Death in Murine Models of Lymphoma and Colorectal Cancer Cancers doi: 10.3390/cancers11122034 Authors: Alessandra Rossi Olga N. Pakhomova Peter A. Mollica Maura Casciola Uma Mangalanathan Andrei G. Pakhomov Claudia Muratori Depending on the initiating stimulus, cancer cell death can be immunogenic or non-immunogenic. Inducers of immunogenic...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2036: Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia Cancers doi: 10.3390/cancers11122036 Authors: Laura M. Kettyle Charles-Étienne Lebert-Ghali Ivan V. Grishagin Glenda J. Dickson Paul G. O’Reilly David A. Simpson Janet J. Bijl Ken I. Mills Guy Sauvageau Alexander Thompson High expression of the HOXA cluster correlates with poor clinical outcome in acute myeloid leukemias, particularly...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2033: Clinicopathologic and Imaging Features of Non-Small-Cell Lung Cancer with MET Exon 14 Skipping Mutations Cancers doi: 10.3390/cancers11122033 Authors: Subba R. Digumarthy Dexter P. Mendoza Eric W. Zhang Jochen K. Lennerz Rebecca S. Heist MET exon 14 (METex14) skipping mutations are an emerging potentially targetable oncogenic driver mutation in non-small-cell lung cancer (NSCLC). The imaging features and patterns of metastasis of NSCLC with primary...
Tue Dec 17, 2019 02:00
Cancers, Vol. 11, Pages 2035: Companion Animals as Models for Inhibition of STAT3 and STAT5 Cancers doi: 10.3390/cancers11122035 Authors: Matthias Kieslinger Alexander Swoboda Nina Kramer Barbara Pratscher Birgitt Wolfesberger Iwan A. Burgener The use of transgenic mouse models has revolutionized the study of many human diseases. However, murine models are limited in their representation of spontaneously arising tumors and often lack key clinical signs and pathological...
Tue Dec 17, 2019 02:00
Cells, Vol. 9, Pages 3: PlexinB1 Promotes Nuclear Translocation of the Glucocorticoid Receptor Cells doi: 10.3390/cells9010003 Authors: Williamson Garg Wells Androgen receptor (AR) and glucocorticoid receptor (GR) are nuclear receptors whose function depends on their entry into the nucleus where they activate transcription of an overlapping set of genes. Both AR and GR have a role in resistance to androgen deprivation therapy (ADT), the mainstay of treatment for late stage prostate...
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Cells, Vol. 9, Pages 2: Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology Cells doi: 10.3390/cells9010002 Authors: Richter Katsanos Schroeder Tsivgoulis Paraskevas Müller Alexandrov Gold Tönges Krogias The hyperechogenicity of the substania nigra (SN) has been established as a valid finding in patients with Parkinson´s disease (PD), probably caused...
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Cells, Vol. 9, Pages 1: Repaglinide Silences the FOXO3/Lumican Axis and Represses the Associated Metastatic Potential of Neuronal Cancer Cells Cells doi: 10.3390/cells9010001 Authors: Salcher Spoden Huber Golderer Lindner Ausserlechner Kiechl-Kohlendorfer Geiger Obexer The transcription factor FOXO3 is associated with poor outcome in high-stage neuroblastoma (NB), as it facilitates chemoprotection and tumor angiogenesis. In other tumor entities, FOXO3...
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Cells, Vol. 8, Pages 1659: The Phenotype and Secretory Activity of Adipose-Derived Mesenchymal Stem Cells (ASCs) of Patients with Rheumatic Diseases Cells doi: 10.3390/cells8121659 Authors: Kuca-Warnawin Skalska Janicka Musiałowicz Bonek Głuszko Szczęsny Olesińska Kontny Mesenchymal stem/stromal cells (MSCs) have immunosuppressive and regenerative properties. Adipose tissue is an alternative source of MSCs, named adipose-derived mesenchymal stem cells...
Tue Dec 17, 2019 02:00
Cells, Vol. 8, Pages 1657: Salinity Stress Responses and Adaptation Mechanisms in Eukaryotic Green Microalgae Cells doi: 10.3390/cells8121657 Authors: Shetty Gitau Maróti High salinity is a challenging environmental stress for organisms to overcome. Unicellular photosynthetic microalgae are especially vulnerable as they have to grapple not only with ionic imbalance and osmotic stress but also with the generated reactive oxygen species (ROS) interfering with photosynthesis. This...
Tue Dec 17, 2019 02:00
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