Outcomes of definitive radiotherapy for early laryngeal cancer in terms of survival and patterns of failure.

Outcomes of definitive radiotherapy for early laryngeal cancer in terms of survival and patterns of failure.:

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Outcomes of definitive radiotherapy for early laryngeal cancer in terms of survival and patterns of failure.

J Laryngol Otol. 2019 Dec 03;:1-5

Authors: Adeel M, Faisal M, Rashid A, Rasheed S, Hussain R, Malik KI, Hameed MY, Jamshed A

Abstract

BACKGROUND: Early laryngeal cancer treated with definitive radiotherapy or surgery has a high cure rate. This study evaluated the patterns of treatment failure and long-term results of early laryngeal cancers treated with definitive radiotherapy.

METHOD: From January 2002 to December 2014, a total of 242 patients with early-stage laryngeal cancers were treated with radical radiotherapy.

RESULTS: All patients had squamous cell carcinoma of the larynx (92 per cent male and 8 per cent female). Median follow-up was 4.5 years. The majority of patients were smokers (57.4 per cent). Local failure was seen in 12.5 per cent of stage I patients and 22.8 per cent of stage II patients. The 5-year overall survival and disease specific survival were 84 per cent and 91 per cent, respectively.

CONCLUSION: In summary, radiotherapy is a suitable treatment modality for patients with early-stage laryngeal cancer, with an overall locoregional control rate of 84 per cent. Patients who fail radiotherapy may still undergo salvage laryngectomy.

PMID: 31791441 [PubMed - as supplied by publisher]