Prognostic values of preoperative platelet‐to‐lymphocyte ratio (PLR) and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma

Prognostic values of preoperative platelet‐to‐lymphocyte ratio (PLR) and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma:

Abstract

Objectives

To investigate the prognostic values of preoperative platelet‐to‐lymphocyte ratio (PLR) and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma (HPSCC).

Methods

The data of 247 eligible advanced HPSCC patients were reviewed retrospectively. Pretreatment hematological parameters were categorized into 2 groups based on the result of X‐tile and several variates were assessed using chi‐square test, Kaplan‐Meier method, Cox univariate and multivariate analysis.

Results

The optimal cut‐off points of 171.4 for PLR, 260×10^9/L for platelet, 10.4 fL for mean platelet volume (MPV), 16.5% for platelet distribution width (PDW) were defined. The hematological parameters PLR and MPV, postoperative metastasis and internal jugular vein invasion (IJVI) were statistically significant in OS and DFS analyses (P<0.05). The high PLR (>171.4) or high MPV (>10.4 fL) was significantly associated with worse OS and DFS (P<0.05).

Conclusions

The preoperative levels of PLR and MPV could be considered as independent prognostic predictors in patients with advanced HPSCC.