Τρίτη 20 Οκτωβρίου 2020

 


Loss of progesterone receptor is associated with distinct tyrosine kinase profiles in breast cancer
ConclusionsOur results suggest that the PR status has a profound effect on tyrosine kinases, especially for FGFR4 and LCK genes, in ER+/HER2 − breast cancer patients. The influence of these genes on the PI3K/AKT signaling pathway may potentially lead to novel drug targets for ER+/PR− breast cancer patients. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Optimism and coping: do they influence health outcomes in women with breast cancer? A systemic review and meta-analysis
ConclusionsDespite many limitations of this literature, including the heterogeneity of study designs, differing sample sizes, across different countries, cultures, ethnicities, and races, most studies support that optimism and coping are predictors of anxiety, distress, depression, or HRQOL. Awareness of these psychological constructs and their potential impact on anxiety, depression, and HRQOL are a high priority. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Parity reduces mammary repopulating activity but does not affect mammary stem cells defined as CD24  + CD29/CD49fhi in mice
ConclusionsOur data show instead that parity impacts on the stem-like activity of cells outside the MaSC population. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Evaluation of PD-L1, tumor-infiltrating lymphocytes, and CD8+  and FOXP3+ immune cells in HER2-positive breast cancer treated with neoadjuvant therapies
ConclusionsHigh Ki-67 is a strong predictor for pCR in HER2+  breast cancer. TIL and FOXP3 T cells may play a role in tumor response in HER2+ cancer. PD-L1 is expressed in a subset of HER2+ breast cancer, supporting a role of immunotherapy in treating a subset of HER2+ breast cancers. The role of PD-L1, TIL, and other markers of immunogenicity as pred ictors of response to neoadjuvant chemotherapy in HER2+ breast cancer should be further evaluated. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
A system for risk stratification and prioritization of breast cancer surgeries delayed by the COVID-19 pandemic: preparing for re-entry
ConclusionsThis tool generates a clinically consistent, risk-stratified priority list of breast surgical procedures delayed by the COVID-19 pandemic. This systematic approach may facilitate surgical scheduling as conditions normalize. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
The development and initial evaluation of the Diarrhoea Management Diary (DMD) in patients with metastatic breast cancer
ConclusionsAlthough further psychometric testing is recommended, initial evaluation of the DMD showed good content validity and practicability in international research with cancer patients. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Radial scars and complex sclerosing lesions on core needle biopsy of the breast: upgrade rates and long-term outcomes
ConclusionPatients with radial scar with atypia have a higher risk of upgrade to malignancy. Further research is needed to identify which patients may safely avoid excision of radial scar. Patients with a diagnosis of radial scar on CNB are at increased subsequent risk of breast cancer and may benefit from additional screening. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Comparisons of breast conserving therapy versus mastectomy in young and old women with early-stage breast cancer: long-term results using propensity score adjustment method
ConclusionsBCT did not significantly affect survival outcomes of young patients with breast cancer. Superior survival of BCT compared to mastectomy was observed only in old patients. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Patients with benign papilloma diagnosed on core biopsies and concordant pathology-radiology findings can be followed: experiences from multi-specialty high-risk breast lesion conferences in an academic center
ConclusionsOur data confirm that rad-path concordant benign papillomas diagnosed on core biopsy do not require surgery. It also supports the value of a formal multi-specialty review of all benign papilloma cases to create a consensus management plan. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Width of margins in phyllodes tumors of the breast: the controversy drags on? —a systematic review and meta-analysis
ConclusionIrrespective of tumor grade, we found that DM was a rarer event than LR. Malignant PT had the highest incidence rate of LR and DM. This meta-analysis found a clear association between width of margins and LR rates. Whatever the tumor grade, surgical margins  ≥ 10 mm guaranteed a lower risk of LR than margins <  10 mm. On the other hand, the width of margin did not influence the apparition of DM. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Impact of adjuvant chemotherapy or tamoxifen-alone on the ovarian reserve of young women with breast cancer
ConclusionsBoth AC-based regimens and CMF significantly compromise ovarian reserve, without a recovery beyond 12  months post-chemotherapy. In contrast, tamoxifen-only treatment does not seem to alter ovarian reserve. These data indicate that the commonly used chemotherapy regimens but not the hormonal therapy compromise future reproductive potential. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Long-term survival outcomes of repeat lumpectomy for ipsilateral breast tumor recurrence: a propensity score-matched analysis
ConclusionsNo significant differences were observed in survival outcomes between patients with IBTR who underwent repeat lumpectomy or total mastectomy. Our results can be helpful in selecting the appropriate surgical method for IBTR. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
The effect of breast MRI on disease-free and overall survival in breast cancer patients: a retrospective population-based study
ConclusionUse of breast MRI was not significantly associated with an improved OS or DFS in patients treated with primary surgery. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Strict bladder filling and rectal emptying during prostate SBRT: Does it make a dosimetric or clinical difference?
To evaluate inter-fractional variations in bladder and rectum during prostate stereotactic body radiation therapy (SBRT) and determine dosimetric and clinical consequences. (Source: Radiation Oncology)
Radiation Oncology
3d
125I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts
Lung cancer is a fatal disease and a serious health problem worldwide. Patients are usually diagnosed at an advanced stage, and the effectiveness of chemotherapy for such patients is very limited. Iodine 125 s... (Source: Radiation Oncology)
Radiation Oncology
4d
The prognostic value of the lymph node ratio for local advanced gastric cancer patients with intensity-modulated radiation therapy and concurrent chemotherapy after radical gastrectomy in China
Nearly 50% of new gastric cancer cases and gastric cancer-related deaths worldwide occur in China. No global consensus has been reached about the optimal management of locally advanced gastric cancer. Although... (Source: Radiation Oncology)
Radiation Oncology
4d
Leaf open time sinogram (LOTS): a novel approach for patient specific quality assurance of total marrow irradiation
In this study, 3D dose reconstruction using mega... (Source: Radiation Oncology)
Radiation Oncology
4d
Acute toxicity of normofractionated intensity modulated radiotherapy with simultaneous integrated boost compared to three-dimensional conformal radiotherapy with sequential boost in the adjuvant treatment of breast cancer
Intensity-modulated radiotherapy (IMRT) improves dose homogeneity and late toxicity compared to simple tangential techniques in adjuvant whole-breast radiotherapy for patients with breast cancer. Simultaneous-... (Source: Radiation Oncology)
Radiation Oncology
5d
Phase I/IIa trial of androgen deprivation therapy, external beam radiotherapy, and stereotactic body radiotherapy boost for high-risk prostate cancer (ADEBAR)
To evaluate the clinical outcomes of combination of androgen deprivation therapy (ADT), whole pelvic radiotherapy (WPRT), and stereotactic body radiotherapy (SBRT) boost in high-risk prostate cancer patients. (Source: Radiation Oncology)
Radiation Oncology
1w
Efficacy and safety-in analysis of short-course radiation followed by mFOLFOX-6 plus avelumab for locally advanced rectal adenocarcinoma
Neoadjuvant chemotherapy and short-course radiotherapy followed by resection has been gaining recognition in the treatment of rectal cancer. Avelumab is a fully human immunoglobulin that binds Programmed Death... (Source: Radiation Oncology)
Radiation Oncology
1w
Feasibility study: spot-scanning proton arc therapy (SPArc) for left-sided whole breast radiotherapy
This study investigated the feasibility and potential clinical benefit of utilizing a new proton treatment technique: Spot-scanning proton arc (SPArc) therapy for left-sided whole breast radiotherapy (WBRT) to... (Source: Radiation Oncology)
Radiation Oncology
1w
Proton pencil beam scanning reduces secondary cancer risk in breast cancer patients with internal mammary chain involvement compared to photon radiotherapy
Proton pencil beam scanning (PBS) represents an interesting option for the treatment of breast cancer (BC) patients with nodal involvement. Here we compare tangential 3D-CRT and VMAT to PBS proton therapy (PT)... (Source: Radiation Oncology)
Radiation Oncology
1w
OPTimizing Irradiation through Molecular Assessment of Lymph node (OPTIMAL): a randomized open label trial
Conservative surgery followed by breast and nodal irradiation is the standard loco-regional early breast cancer (BC) treatment for patients with four or more involved lymph nodes. However, the treatment strate... (Source: Radiation Oncology)
Radiation Oncology
1w
Effectiveness and cost-effectiveness analysis of nimotuzumab for the radiotherapy of locoregionally advanced nasopharyngeal carcinoma
This study aimed to assess the effectiveness and cost-effectiveness of nimotuzumab in patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC). (Source: Radiation Oncology)
Radiation Oncology
1w
Long-term outcomes of moderately hypofractionated radiotherapy (67.5 Gy in 25 fractions) for prostate cancer confined to the pelvis: a single center retrospective analysis
We presented our outcomes and treatment-related toxicities with moderately hypofractionated (67.5 Gy in 25 fr... (Source: Radiation Oncology)
Radiation Oncology
1w
Can 68Ga-prostate specific membrane antigen positron emission tomography/computerized tomography provide an accurate lymph node staging for patients with medium/high risk prostate cancer? A diagnostic meta-analysis
This article aims to evaluate the diagnostic value of 68Gallium-PSMA positron emission tomography/computerized tomography (68Ga-PSMA PET/CT) for lymph node (LN) staging in patients with prostate cancer (PCa) by a... (Source: Radiation Oncology)
Radiation Oncology
1w
Efficacy and safety of CyberKnife radiosurgery in elderly patients with brain metastases: a retrospective clinical evaluation
Stereotactic radiosurgery (SRS) has been increasingly applied for up to 10 brain metastases instead of whole brain radiation therapy (WBRT) to achieve local tumor control while reducing neurotoxicity. Furtherm... (Source: Radiation Oncology)
Radiation Oncology
1w
COVID-19 and radiation oncology: the experience of a two-phase plan within a single institution in central Italy
In this report, we will focus on a management model covering the two... (Source: Radiation Oncology)
Radiation Oncology
1w
A unique radioprotective effect of resolvin E1 reduces irradiation-induced damage to the inner ear by inhibiting the inflammatory response
In addition to the direct effects of irradiation, the induced inflammatory response may play an important role in the damage to the inner ear caused by radiotherapy for the treatment of head and neck cancers. ... (Source: Radiation Oncology)
Radiation Oncology
1w
p63+Krt5+ basal cells are increased in the squamous metaplastic epithelium of patients with radiation-induced chronic Rhinosinusitis
Squamous metaplasia (SM) is an irreversible form of airway epithelial remodeling. Hyperproliferation of basal cells was observed in squamous metaplastic epithelium of chronically inflamed airway. However, the ... (Source: Radiation Oncology)
Radiation Oncology
1w
Image quality of 4D in-treatment CBCT acquired during lung SBRT using FFF beam: a phantom study
Rotational beam delivery enables concurrent acquisition of cone-beam CT (CBCT), thereby facilitating further geometric verification of patient setup during radiation treatment. However, it is challenging to ac... (Source: Radiation Oncology)
Radiation Oncology
1w
Cardiac radiation dose predicts survival in esophageal squamous cell carcinoma treated by definitive concurrent chemotherapy and intensity modulated radiotherapy
The prognostic significance of cardiac radiation dose in esophageal cancer after definitive concurrent chemoradiotherapy (CCRT) remains largely unknown. We aimed to investigate the association between cardiac ... (Source: Radiation Oncology)
Radiation Oncology
1w
Efficacy of orbital radiotherapy in moderate-to-severe active graves ’ orbitopathy including long-lasting disease: a retrospective analysis
We aimed to explore the efficacy of orbital radiotherapy (RT) in patients with moderate-to-severe active Graves ’ orbitopathy (GO), including long-lasting disease, and to determine the predictive factors associ... (Source: Radiation Oncology)
Radiation Oncology
1w
Long-term analysis of multimodality treatment outcomes and prognosis of esthesioneuroblastomas: a single center results of 138 patients
The aim of this study is to evaluate the efficacy of different treatment strategies and the potential prognostic factors of esthesioneuroblastoma (ENB). (Source: Radiation Oncology)
Radiation Oncology
1w
Intensity-modulated radiation therapy versus three-dimensional conformal radiotherapy in head and neck squamous cell carcinoma: long-term and mature outcomes of a prospective randomized trial
To compare long-term disease-related outcomes and late radiation morbidity between intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) in head and neck squamous c... (Source: Radiation Oncology)
Radiation Oncology
1w
Application of dose-volume histogram prediction in biologically related models for nasopharyngeal carcinomas treatment planning
In this study, we employed a gated recurrent unit (GRU)-based recurrent neural network (RNN) using dosimetric information induced by individual beam to predict the dose-volume histogram (DVH) and investigated ... (Source: Radiation Oncology)
Radiation Oncology
1w
Stereotactic body radiotherapy versus conventional/moderate fractionated radiation therapy with androgen deprivation therapy for unfavorable risk prostate cancer
Ultrahypofractionation using stereotactic body radiotherapy (SBRT) is an increasingly utilized technique for men with prostate cancer (PC). The comparative efficacy of SBRT plus androgen deprivation therapy (A... (Source: Radiation Oncology)
Radiation Oncology
1w
Re-approximated: a Medical Student ’s Reflection on the Surgical Approach to Cancer Treatment
AbstractMedical school clerkship offers third year medical students multiple opportunities to acquire clinical experience through real patient interactions and integration into the healthcare teams of different specialities. As part of the general surgery rotation, medical students are invited to scrub in to assist with surgeries —a chance to simultaneously gain medical knowledge while developing technical skills. They learn that there is a possibility of inflicting harm to the patient at every step...
Journal of Cancer Education
3d
Knowledge of Oral Cancer Amongst Dental Patients Attending Public Clinics in South East Queensland, Australia
This study aimed to assess the knowledge of oral cancer and to ascertain socio-demographic factors that influence knowledge amongst adult dental patients attending public clinics in Brisbane, Australia. A convenience sample of 213 adult dental patients who attended the Herston and Stafford public health clinics in Brisbane, Australia, between July and August 2019 participated in the self-administered questionnaire. Multivariate analyses were performed to identify predictors for oral cancer knowledge....
Journal of Cancer Education
3d
A Survey of Therapeutic Radiographers ’ Knowledge, Practices, and Barriers in Delivering Health Behaviour Advice to Cancer Patients
AbstractTherapeutic radiographers (TRs) are well-placed to deliver advice to cancer patients; however, limited research exists on their practices in providing advice on healthy lifestyle behaviours. Through an online survey, this study aimed to explore TRs ’ current practices, barriers, and facilitators around delivering healthy behaviour advice to cancer patients. An online survey was sent to 72 radiotherapy departments in the UK and 583 TRs responded to the survey. Findings showed that levels of...
Journal of Cancer Education
3d
 
The Educational Program for Healthcare Providers Regarding Fertility Preservation for Cancer Patients: a Systematic Review
AbstractThe emerging discipline of oncofertility advocates for the timely provision of fertility preservation (FP) to all cancer patients of childbearing age by healthcare providers. A lack of practice due to limited FP-related knowledge was found among healthcare providers. A systematic review was undertaken on the educational programs on FP for healthcare providers. An initial search was performed in MEDLINE, PsycINFO, CINAHL, Web of Science, PubMed, and Scopus databases in October 2019. This review...
Journal of Cancer Education
5d
A Multicentered Academic Medical Center Experience of a Simulated Root Cause Analysis (RCA) for Hematology/Oncology Fellows
We report on a multicentered experience utilizing a simulated RCA educational module in an attempt to provide fellows with the tools needed to participate in a live RCA and to increase awareness of the need to analyze patient safety events. The 2-h module included a didactic session explaining the basics of an RCA including common terminology, effective chart review, and personal interviews. The fellows assessed a patient safety event of a missed coagulopathy and created an event flow map and fishbone...
Journal of Cancer Education
5d
The Cost of Patient Education Materials Development: Opportunities to Identify Value and Priorities
AbstractThe study aim was to evaluate the costs associated with developing and reviewing patient education materials (pamphlets) across Ontario cancer centers. While patient education often produces a positive return on investment, limited efforts have been dedicated to optimizing the personnel, time, and capital dedicated to this feat across healthcare systems. Patient education leaders at 14 cancer centers completed a survey measure, estimating the number of hours spent developing and reviewing...
Journal of Cancer Education
6d
Awareness of Self-Examination, Screening, and Risk Factors for Breast Cancer Among Women Awaiting Care at the Outpatient Clinic of a Mastology Unit
This study aimed to evaluate the awareness and practice of breast self-examination (BSE) and the awareness of screening and risk factors for breast cancer among patients from a mastology clinic and to associate such findings with sociodemographic factors of that population. A total of 202 randomly selected patients from the outpatient clinic of the Mastology Unit of S ão Paulo School of Medicine were interviewed. A structured questionnaire was used and included questions regarding sociodemographic...
Journal of Cancer Education
1w
The Last Request
AbstractThis essay is a personal reflection highlighting the importance of spirituality in the care of cancer patients and their families especially at the end-of-life. (Source: Journal of Cancer Education)
Journal of Cancer Education
1w
User-Centered Development and Patient Acceptability Testing of a Health-Coaching Intervention to Enhance Cancer Survivorship Follow-up in Primary Care
We describe an iterative three-phase approach used to develop a cancer survivorship health-coaching intervention to guide self-management and follow-up care for post-treatment breast, colorectal, and prostate cancer survivors. Informed by theory (e.g., Cognitive-Social Health Information Processing Model (C-SHIP)), relevant literature, and clinical guidelines, we engaged in a user-centered design process. In phase I, we conducted depth interviews with survivors of breast (n = 34), prostate (n = 4),...
Journal of Cancer Education
1w
Healthcare Professional and Service User Perspectives on Formal Educational Programmes for Children and Young People with Cancer in the UK
This study explored the educational gaps in caring for children and young people with cancer. To address this, a mixed methodology approach was adopted in two phases. Phase one was a questionnaire circulated to healthcare professional members (n = 850) of the Children’s Cancer and Leukaemia Group and Managed Service Network, Scotland. Response rate (n = 121) (14%) was achieved. In phase two of the study, a focus groups (n = 4) was conducted with young people in Scotland through the Managed Service...
Journal of Cancer Education
1w
Sun Protection Policies and Practices in Preschool and Elementary Schools in Andalusia (Spain)
AbstractSun exposure in childhood is a major risk factor for the development of skin cancer as an adult. School children spend much of their time outdoors exposed to ultraviolet radiation during recreational and sports activities. Skin cancer incidence tripled from 1978 to 2002 in Spain. Andalusia, the largest and sunniest region of Spain, lacks data on the sun protection measures taken in schools. To address this deficit, the aim of this study was to determine photoprotection practices and policies...
Journal of Cancer Education
1w
“Teachable Moment”: Effects of an Educational Program on Knowledge and Quality of Life of Korean Breast Cancer Survivors
This study utilized a single-arm pretest-posttest design. Participants were tested before and after an educational program to measure changes in knowledge. To measure QOL change, we conducted a QOL survey at the time of enrollment and again 6  months later. Regarding the knowledge test, mean scores increased from 9.62 to 14.74 points following education (p <  0.001). After 6 months, 97 patients completed the QOL survey and the data were analyzed, showing significant improvements in anxiety (p = 0.021),...
Journal of Cancer Education
1w
“My Husband Affects Me More Than My Cancer”: Reflections on Simultaneous Intimate Partner Violence and Breast Cancer Experience in a 48-Year-Old Woman
AbstractIn this paper, we present the case of a 48-year-old woman diagnosed with early breast cancer. As candidate for mastectomy, she refused immediate reconstruction. She was referred to a psycho-oncologist for further evaluation and support. Psychological sessions helped reveal a history of intimate partner violence and helped clarify the reason for her refusal to undergo immediate reconstruction. Experience with this case highlights the importance of a multidisciplinary practice in which collaboration...
Journal of Cancer Education
1w
Return on Investment of a Breast Cancer Screening Program in Tanzania: Opportunity for Patient and Public Education
AbstractBreast cancer is the second incident and second cause of cancer mortality among women in Tanzania due to late-stage presentation. The screening clinic at the Ocean Road Cancer Institute (ORCI) can help detect cases early and reduce cost of treatment. We calculated the return on investment (ROI) of the ORCI breast screening clinic. Screening and treatment data of all newly diagnosed breast cancer patients seen at ORCI during 2016 –2018 were abstracted from the medical records. Also, data on...
Journal of Cancer Education
1w
A Pilot Study for the Development and Evaluation of an Educational Program to Reduce Stigma Toward Cancer and Cancer Survivors: Focusing on Dating and Marriage After Cancer Diagnosis
AbstractThe marriage rate of cancer survivors is lower than that of the general population and their siblings. This appears to be attributable to negative images and stigma in society regarding cancer and cancer survivors. In order to improve images and decrease stigma regarding cancer and cancer survivors, this study aimed to develop an educational program that primarily focuses on dating and marriage after cancer diagnosis. The education program was conducted for university students, and among...
Journal of Cancer Education
1w
Impact of Cancer Survivorship Care Training on Rural Primary Care Practice Teams: a Mixed Methods Approach
AbstractWith the increasing numbers of individuals surviving a diagnosis of cancer, an aging population, and more individuals experiencing multi-morbidity, primary care providers (PCPs) are seeing more patients with a history of cancer. Effective strategies are needed to adequately prepare the primary care workforce for the phase of cancer care now widely recognized as survivorship. A survivorship education program for rural primary care practices was developed using a community engagement process...
Journal of Cancer Education
1w
Amplifying Their Voices: Advice, Guidance, and Perceived Value of Cancer Biobanking Research Among an Older, Diverse Cohort
This study was design ed using a community-based participatory research (CBPR) approach and involved eight FGDs with 67 older (65–74 years old) black and white residents from Baltimore City and Prince George’s County, MD. FGDs lasted between 90 and 120 min, and participants received a $25 Target gift card for their p articipation. Analysis involved an inductive approach in which we went through a series of open and axial coding techniques to generate themes and subthemes. Multiple themes emerged...
Journal of Cancer Education
1w
An Iterative Formative Evaluation of Medical Education for Multiple Myeloma Patients Receiving Autologous Stem Cell Transplant
AbstractMultiple myeloma (MM) is an incurable cancer characterized by abnormal plasma cells in the bone marrow, resulting in increased risk of infection. Autologous stem cell transplant (ASCT) is the most effective treatment for MM, but successful transplant requires the patient and caregiver to learn and independently implement medical tasks. The Ready for Transplant (R4T) ethnographic-based formative evaluation includes evaluation of ongoing patient education and the addition of novel supplemental...
Journal of Cancer Education
1w
Enhancing the Pre-Clerkship Residency Exploration Program (PREP): Medical Students ’ Suggestions
(Source: Journal of Cancer Education)
Journal of Cancer Education
1w
Overview of Undergraduate Oncology Interest Groups: Medical Students ’ Insights from a National Collaborative Network
(Source: Journal of Cancer Education)
Journal of Cancer Education
1w
Virtual Reality-Based Education for Patients Undergoing Radiation Therapy
AbstractWe built a virtual reality (VR) application that runs on a commercially available standalone VR headset that allows patients to view a virtual simulation of themselves receiving radiotherapy. The purpose of this study was to determine if this experience can improve patient understanding of radiotherapy and/or reduce patient anxiety. We created software that reads data from our clinical treatment planning system and renders the plan on a life-size “virtual linear accelerator.” The patient’s...
Journal of Cancer Education
1w
Strategies for Maintaining Educational Standards in Medical Oncology Residency Training in the Era of COVID-19: Experience from a Canadian Cancer Centre
(Source: Journal of Cancer Education)
Journal of Cancer Education
1w
Cancer Risk Perceptions Among People Who Check Their Skin for Skin Cancer: Results from the 2017 U.S. Health Information National Trends Survey (HINTS)
AbstractWhen detected early, melanoma is highly treatable and rarely fatal. Self-skin checks can identify changes in moles that could be an indicator of melanoma. Cancer risk perceptions may influence the uptake of important preventive health behaviors such as self-skin checks. The purpose of this study is to examine cancer risk perception factors associated with those who have checked their skin for signs of skin cancer using the 2017 HINTS data. Retrospective cross-sectional analysis of a nationally...
Journal of Cancer Education
1w
Level of Awareness Regarding Cervical Cancer Among Female Syrian Refugees in Greece
AbstractNowadays, prevention, control and treatment of cervical cancer are a worldwide public health priority. Primary objective of this study was to evaluate the level of awareness of female Syrian refugees who have recently settled in Greece regarding the warning signs and the risk factors of cervical cancer. This is a descriptive, cross-sectional study that was conducted in two facilities of the Hellenic Red Cross. The Cervical Cancer Awareness Measure questionnaire was addressed to 176 female...
Journal of Cancer Education
1w
The “Day Zero Talk”: the Initial Communication of a Pediatric Oncology Diagnosis by Primary Care Physicians and Other Primary Care Providers
AbstractWhile much is known about the initial communication of a definitive pediatric cancer diagnosis by the child ’s pediatric oncologist, little is known about the discussions leading up to this formal conversation, which are often had with nononcologists. We sought to describe these initial conversations regarding the possibility of a child’s oncologic diagnosis, from the perspective of both the patient/f amily as well as the provider. Semistructured interviews were performed with individuals...
Journal of Cancer Education
1w
The Treatment Decision-making Preferences of Patients with Prostate Cancer Should Be Recorded in Research and Clinical Routine: a Pooled Analysis of Four Survey Studies with 7169 Patients
AbstractDifferent patients want to take different roles in the treatment decision-making process; these roles can be classified as passive, collaborative, and active. The aim of this study was to investigate the correlation between decision-making preferences among patients with prostate cancer and personal, disease-related, and structural factors. In four survey studies, we asked 7169 prostate cancer patients about their decision-making preferences using the Control Preferences Scale (CPS) and collected...
Journal of Cancer Education
1w
Exploring the role of healthcare organisations in increasing women ’s participation in breast-screening in the United Arab Emirates
AbstractThe study explored the role of healthcare organisations in Ras Al Khaimah, United Arab Emirates, in improving women ’s breast cancer awareness and screening participation in a multi-cultural society. In-depth interviews were conducted with eight representatives from five healthcare organisations involved in breast cancer campaigns in RAK including hospitals, clinics, and universities. The interviews were analys ed using thematic analysis. The organisations’ campaigns focused on breast cancer...
Journal of Cancer Education
1w
Perception of Oncology Evaluated by Medical Students (P.O.E.M.S) —a Single Institutional Study
AbstractRising incidence of cancer coupled with lack of structured oncology teaching in the undergraduate (UG) medical curriculum could be detrimental by generating unmet needs in the proper care of cancer patients in the future. To determine the orientation amongst undergraduate medical students regarding Oncology as a specialization and future career option, a  cross-sectional, single institutional study was conducted amongst 950 undergraduate students by using an online survey over 2 months. The...
Journal of Cancer Education
1w
Indepth Interviews ’ on Acceptability and Concerns for Human Papilloma Virus Vaccine Uptake among Mothers of Adolescent Girls in Community Settings in Ibadan, Nigeria
This study was a qualitative study that assessed mothers’ acceptability and concerns regarding uptake of HPV vaccine by their adolescent daughters. In-dept h interviews were conducted with 20 mothers of adolescents girls aged 9–15 years. A snowballing sampling technique was adopted to select the mothers within the community. Consent was obtained for the use of audiotapes, which were transcribed verbatim with thematic analysis of data. Mothers were b etween the ages of 30–49 years and most of them...
Journal of Cancer Education
1w
Caring for the Caregivers: Mental and Spiritual Support for Healthcare Teams During the COVID-19 Pandemic and Beyond
(Source: Journal of Cancer Education)
Journal of Cancer Education
1w
The Role of N6-Methyladenosine Methylation in the Progression of Endometrial Cancer
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
3d
Upregulation of miR-519d-3p Inhibits Viability, Proliferation, and G1/S Cell Cycle Transition of Oral Squamous Cell Carcinoma Cells Through Targeting CCND1
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
3d
Efficacy and Safety of Drug-Eluting Beads Bronchial Arterial Chemoembolization in Treating Patients with Lung Cancer Who Were Complicated with Hemoptysis
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
3d
Coexpression Module Construction by Weighted Gene Coexpression Network Analysis and Identify Potential Prognostic Markers of Breast Cancer
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
3d
Retraction of: lncRNA IGF2-AS Promotes Cell Proliferation, Migration, and Invasion of Gastric Cancer by Modulating miR-937/EZH2 Axis by Li et al., Cancer Biother Radiopharm epub 25 May 2020; DOI: 10.1089/cbr.2019.3275
Cancer Biotherapy and Radiopharmaceuticals,Volume 35, Issue 8, Page 628-628, October 2020. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
3d
Circ_0004913 Inhibits Cell Growth, Metastasis, and Glycolysis by Absorbing miR-184 to Regulate HAMP in Hepatocellular Carcinoma
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
Clinical Observation of Double Percutaneous Nephrostomy Combined with Ureter Occlusion Stent for Treating Cervical Cancer Complicated with Vesicovaginal Fistula
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
CircEXOC6B Suppresses the Proliferation and Motility and Sensitizes Ovarian Cancer Cells to Paclitaxel Through miR-376c-3p/FOXO3 Axis
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
Nanoparticle-Based Radiosensitizers in Radiotherapy Applications
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
Sevoflurane Suppresses Glioma Cell Proliferation, Migration, and Invasion Both In Vitro and In Vivo Partially Via Regulating KCNQ1OT1/miR-146b-5p/STC1 Axis
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
Retraction of: A Novel CircRNA Circ_0095424 Regulates Proliferation, Metastasis, and Apoptosis of Osteosarcoma Cells Via the PI3K/AKT Signaling Pathway Through Targeting the miR-1238/HMGB1 Axis by Zhang et al., Cancer Biother Radiopharm epub 19 Aug 2020; DOI: 10.1089/cbr.2020.3563
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
Assessment of Irinotecan Loading and Releasing Profiles of a Novel Drug-Eluting Microsphere (CalliSpheres) In Vitro
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
LncRNA AFAP1-AS1 Knockdown Represses Cell Proliferation, Migration, and Induced Apoptosis in Breast Cancer by Downregulating SEPT2 Via Sponging miR-497-5p
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
Nanobodies: The Future of Antibody-Based Immune Therapeutics
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
LncRNA SNHG6 Induces Epithelial –Mesenchymal Transition of Pituitary Adenoma Via Suppressing MiR-944
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
Ethics of Pharma Clinical Trials in the Era of Precision Oncology
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Cancer Biotherapy and Radiopharmaceuticals
1w
Disparities in cancer mortality in Los Angeles County, 1999–2013: an analysis comparing trends in under-resourced and affluent regions
Abstract Purpose While cancer mortality has declined by 27% between 1991 and 2016 in the United States, there are large disparities in cancer mortality by racial/ethnic groups, socioeconomic status and access to care. The purpose of this analysis is to compare trends in cancer mortality among regions (Service Planning Areas, SPAs) in Los Angeles (LA) County that vary with respect to racial/ethnic distribution and social determinants...
Latest Results for Cancer Causes
3d
High-sensitivity C-reactive protein, hemoglobin A1c and breast cancer risk: a nested case–control study from Alberta’s Tomorrow Project cohort
Abstract Purpose Our aim is to examine the associations between high-sensitivity C-reactive protein (hsCRP) and hemoglobin A1c (HbA1c), common biomarkers of inflammation and insulin resistance, respectively, with breast cancer risk, while adjusting for measures of excess body size. Methods We conducted a nested case–control study within...
Latest Results for Cancer Causes
3d
Investigating the associations of glycemic load and glycemic index with lung cancer risk in the Southern Community Cohort Study
Abstract Purpose Diets with a high glycemic load (GL) or glycemic index (GI) may increase cancer risk. Findings from prior studies on the relationship between GL, GI, and lung cancer risk are inconsistent. We investigated this relationship in a large prospective cohort. Methods We analyzed data from the Southern Community Cohort Study,...
Latest Results for Cancer Causes
3d
Commentary: 20 years online with “Your Disease Risk”
Abstract The Your Disease Risk tool (yourdiseaserisk.wustl.edu) went live to the public in January 2000 and was one of the first personalized health risk assessment sites on the Internet. Its launch marked the culmination of years of work by a large, multi-disciplinary university team whose primary goal was to translate the science on cancer prevention into accurate, engaging, and useful messages for the public. Today, 20 years on, Your Disease Risk has expanded from its initial...
Latest Results for Cancer Causes
3d
Digoxin use is associated with pancreatic cancer risk but does not affect survival
Abstract Purpose Digoxin affects several cellular pathways involved in tumorigenesis. We sought to determine the association between digoxin use and pancreatic cancer risk and survival. Methods A nested case–control study using The Health Improvement Network (THIN), a population-representative database from the United Kingdom (UK). Cases included all...
Latest Results for Cancer Causes
5d
Is there an association between a history of military service and cancer diagnosis? Results from a US national-level study of self-reported outcomes
Abstract Purpose To examine cancer prevalence in men with and without military service history, using national-level self-reported outcomes. Methods A cross-sectional survey-based US study, including men aged 18 and above from the Health Information National Trends Survey database between 2011 and 2014. The primary endpoint was self-reported cancer...
Latest Results for Cancer Causes
5d
Adiposity over the life course and prostate cancer: unraveling the complexities
Abstract The association between obesity and prostate cancer has been extensively studied, but clear answers have evaded us. Most of the studies have been based on a single time-point measure, most commonly of body mass index (BMI) during adulthood. Emerging data suggest a complex pattern that may be better understood through a life course approach. The data suggest that early life adiposity, possibly before or during puberty, as being associated with lower risk of advanced...
Latest Results for Cancer Causes
6d
Ultra-high dose rate FLASH and conventional dose rate irradiation differentially affect human acute lymphoblastic leukemia and normal hematopoiesis
Publication date: Available online 17 October 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Sara Chabi, Thi Hong Van To, Ron Leavitt, Sandrine Poglio, Patrik Gonçalves Jorge, Maud Jaccard, Kristoffer Petersson, Benoit Petit, Paul-Henri Roméo, Françoise Pflumio, Marie-Catherine Vozenin, Benjamin Uzan
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
3d
Meetings
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s):
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
In Reply to Saini and Jalali
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Barbara J. Fisher
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
In Regard to Fisher et al
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Gagan Saini, Rakesh Jalali
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
In Reply to Sari et al
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Loren K. Mell, Ronghui Xu, Cheryl C. Saenz
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
In Regard to Mell et al
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Sezin Yuce Sari, Melis Gultekin, Ferah Yildiz
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Hobgoblins, Iron Lungs, and Surgical Perturbation Failure?
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Stuart H. Burri, Matthew C. Ward, Roshan S. Prabhu
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Broadening the Tent with Intentional Spaces
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Raymond B. Mailhot Vega
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Commentary on Cost-Effectiveness of Metastasis-Directed Therapy in Oligorecurrent Hormone-Sensitive Prostate Cancer
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Katie L. Spencer, Alison C. Tree
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Evolving Brachytherapy Boost in Prostate Cancer in the Era of Hypofractionation
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Neil B. Desai, Aurelie Garant, Raquibul Hannan, Michael R. Folkert
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Moving Beyond the Hazard Ratio to Personalized Therapy: Is it Prime Time?
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Dirk Böhmer, Stefan Höcht, Thomas Wiegel
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Absolute versus Relative Benefit of Androgen Deprivation Therapy for Prostate Cancer: Moving Beyond the Hazard Ratio to Personalize Therapy
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Daniel E. Spratt, Jonathan D. Tward
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Clinical Trialism and the Bedrock of Hope
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Eli Sapir, Benjamin W. Corn
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Insights Into Addressing Structural Barriers and Building Specialty Diversity Through a Successful Pipeline Pathway Program
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Bonnie S. Mason
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Restage and Chemoradiation
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Brandon A. Dyer, Jyoti S. Mayadev
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
A Parametrial Problem
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Christina H. Son, Yasmin Hasan
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
50 Gray is Not Enough
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Lisa Singer, Larissa J. Lee
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
A Curious Case of Cervical Cancer
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Ritu Arya, Daniel W. Golden
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Radiation for Cancers of the Uterine Corpus and Cervix: Incremental Steps, and Glimmers of the Future
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s): Junzo Chino, Shari Damast, Elizabeth Kidd, Matthew Harkenrider, Kevin Albuquerque, Mitchell Kamrava
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Issue Highlights
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s):
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Erratum to: Komaki, Ritsuko; Fujii, K; Perkins, Penny; Ro, Jae Y; Allen, Pamela; Mason, Kathryn; Mountain, Clifton F; Milas, Luka. 115 Apoptosis and Mitosis as Prognostic Factors in 173 Patients with Pathologically Staged N1 Nonsmall Cell Lung Cancer (NSCLC). Int J Radiat Oncol Biol Phys 1995;32(1 suppl):198.
Publication date: 15 November 2020Source: International Journal of Radiation Oncology*Biology*Physics, Volume 108, Issue 4Author(s):
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Safety, efficacy and patterns of failure after single fraction stereotactic body radiotherapy (SBRT) for oligometastases
Publication date: Available online 15 October 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Paolo Sogono, Mathias Bressel, Steven David, Mark Shaw, Sarat Chander, Julie Chu, Nikki Plumridge, Keelan Byrne, Nick Hardcastle, Tomas Kron, Greg Wheeler, Gerard G. Hanna, Michael MacManus, David Ball, Shankar Siva
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
4d
Generating High-Quality Lymph Node Clinical Target Volumes for Head and Neck Cancer Radiotherapy Using a Fully Automated Deep Learning-Based Approach
Publication date: Available online 14 October 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Carlos E. Cardenas, Beth M. Beadle, Adam S. Garden, Heath D. Skinner, Jinzhong Yang, Dong Joo Rhee, Rachel E. McCarroll, Tucker J. Netherton, Skylar S. Gay, Lifei Zhang, Laurence E. Court
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
5d
Quantitating Inter-fraction Target Dynamics during Concurrent Chemoradiation for Glioblastoma: A Prospective Serial Imaging Study
Publication date: Available online 14 October 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): James Stewart, Arjun Sahgal, Young Lee, Hany Soliman, Chia-Lin Tseng, Jay Detsky, Zain Husain, Ling Ho, Sunit Das, Pejman Jabehdar Maralani, Nir Lipsman, Greg Stanisz, James Perry, Hanbo Chen, Eshetu G. Atenafu, Mikki Campbell, Angus Z. Lau, Mark Ruschin, Sten Myrehaug
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
5d
Dose-Volume Effects and Risk Factors for Late Diarrhea in Cervix Cancer Patients after Radiochemotherapy with Image-Guided Adaptive Brachytherapy in the EMBRACE I Study
Publication date: Available online 14 October 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Nina Boje Kibsgaard Jensen, Richard Pötter, Sofia Spampinato, Lars Ulrik Fokdal, Cyrus Chargari, Jacob Christian Lindegaard, Maximilian Schmid, Alina Sturdza, Ina Maria Jürgenliemk-Schulz, Umesh Mahantshetty, Barbara Segedin, Kjersti Bruheim, Peter Hoskin, Bhavana Rai, Ericka Wiebe, Rachel Cooper, Elzbieta Van der Steen-Banasik, Erik Van Limbergen, Marit Sundset, Bradley...
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
5d
Refinement and Validation of the Head and Neck Lymphedema and Fibrosis Symptom Inventory
Publication date: Available online 14 October 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Jie Deng, Mary S. Dietrich, Kenneth J. Niermann, Robert J. Sinard, Anthony J. Cmelak, Sheila H. Ridner, Jill Gilbert, Barbara A. Murphy
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
5d
RO Model: The Work Continues to Get it Right
Publication date: Available online 14 October 2020Source: International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Thomas J. Eichler
ScienceDirect Publication: International Journal of Radiation Oncology*Biology*Physics
6d
Differences in PD-1 expression on CD8+ T-cells in chronic myeloid leukemia patients according to disease phase and TKI medication
Abstract Malignant cells can increase in number using immune escape mechanisms such as immune checkpoints. In this study, we evaluated the expression of an immune checkpoint programmed death 1 (PD-1) on T-cell subsets in chronic myeloid leukemia (CML). We obtained bone marrow aspirate samples from CML patients and from individuals without evidence of hematologic malignancies (controls). PD-1 expression on T-cell subsets was measured using flow cytometric analysis. PD-1 expression...
Latest Results for Cancer Immunology, Immunotherapy
3d
Differences in the sensitivity of classically and alternatively activated macrophages to TAK1 inhibitor-induced necroptosis
Abstract Controlling the balance of pro-inflammatory M1 versus anti-inflammatory M2 macrophages may have paramount therapeutic benefit in cardiovascular diseases, infections, cancer and chronic inflammation. The targeted depletion of different macrophage populations provides a therapeutic option to regulate macrophage-mediated functions. Macrophages are highly sensitive to necroptosis, a newly described regulated cell death mediated by receptor-interacting serine/threonine-protein...
Latest Results for Cancer Immunology, Immunotherapy
3d
Augmenting engineered T-cell strategies in solid cancers through epigenetic priming
Abstract T-cell receptor (TCR)- and chimeric antigen receptor (CAR)-based adoptive cell transfer (ACT) has shown promising results in hematological malignancies, but remains immature in solid cancers. The challenges associated with identification of tumor-specific targets, the heterogenic antigen expression, limited T-cell trafficking to tumor sites and the hostile tumor microenvironment (TME), are all factors contributing to the limited efficacy of ACT therapies against solid...
Latest Results for Cancer Immunology, Immunotherapy
3d
In vitro 4-1BB stimulation promotes expansion of CD8 + tumor-infiltrating lymphocytes from various sarcoma subtypes
Abstract Tumor-specific tumor-infiltrating lymphocytes (TILs) can be in vitro expanded and have the ability to induce complete and durable tumor regression in some patients with melanoma following adoptive cell therapy (ACT). In this preclinical study, we investigated the feasibility of expanding TIL from sarcomas, as well as performing functional in vitro analyses on these. TILs were expanded in vitro by the use of IL2 stimulation with or without the addition of 4-1BB and CD3...
Latest Results for Cancer Immunology, Immunotherapy
3d
Brief report: inhaled corticosteroid use and the risk of checkpoint inhibitor pneumonitis in patients with advanced cancer
Abstract Background Checkpoint inhibitor pneumonitis (CIP) is an immune-related adverse event that may complicate treatment with immune checkpoint inhibitors (ICI) and can cause significant morbidity. We sought to identify predictors for the development of CIP, and whether the use of inhaled corticosteroids (ICS) at time of ICI may be protective. Methods ...
Latest Results for Cancer Immunology, Immunotherapy
3d
Clinicopathologic correlates of first-line pembrolizumab effectiveness in patients with advanced NSCLC and a PD-L1 expression of ≥ 50%
Abstract Background Single-agent pembrolizumab represents the standard first-line option for metastatic non-small-cell lung cancer (NSCLC) patients with a PD-L1 (programmed death-ligand 1) expression of ≥ 50%. Methods We conducted a multicenter retrospective study aimed at evaluating the clinicopathologic correlates of pembrolizumab effectiveness...
Latest Results for Cancer Immunology, Immunotherapy
3d
A pan-cancer analysis of the human tumor coagulome and its link to the tumor immune microenvironment
Abstract Objective Solid tumors often establish a procoagulable state that can lead to venous thromboembolism (VTE). Although some of the key genes involved in this process are known, no previous study has compared the “coagulome”, i.e., the expression of coagulation/fibrinolysis genes, across different primary tumor types. It is also unclear whether the coagulome is associated with specific characteristics of the tumor microenvironment...
Latest Results for Cancer Immunology, Immunotherapy
5d
Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells
Abstract Following infusion of the anti-CD28 superagonist monoclonal antibody TGN1412, three of six previously healthy, young male recipients developed gastrointestinal irritability associated with increased expression of ‘gut-homing’ integrin β7 on peripheral blood αβT cells. This subset of patients with intestinal symptoms also displayed a striking and persistent expansion of putative Vδ2+ γδT cells in the circulation which declined over a 2-year period following drug infusion,...
Latest Results for Cancer Immunology, Immunotherapy
1w
Targeting HER2 heterogeneity in early-stage breast cancer
Purpose of review HER2-positive (HER2+) breast cancer is clinically and biologically a heterogenous disease and not all patients benefit to the same extent from current anti-HER2 therapies. Recent findings Among HER2+ breast cancer, molecular intrinsic subtypes, PIK3CA mutation status, levels of HER2 gene/protein, immune infiltration, or intratumor heterogeneity modulate HER2-treatment sensitivity. HER2-enriched carcinomas, with high levels of HER2 and tumor-infiltrating lymphocytes (TILs) are...
Current Opinion in Oncology
4d
Integrating immunotherapy in the (neo)adjuvant setting of early breast cancer
Purpose of review Breast cancer is a relative latecomer in the success story of immuno-oncology. In this review, we focus on the preclinical and clinical lines of evidence to justify the evaluation of immune checkpoint inhibition (ICI) for the curative-intent treatment of breast cancer, the latest and ongoing trials of (neo)adjuvant immunotherapy, and practical considerations in clinical practice associated with this new treatment paradigm. Recent findings Insights from the immunobiology of...
Current Opinion in Oncology
4d
Practical approach to the management of smoldering myeloma
Purpose of review The aim of this article is to review the diagnosis and risk stratification of smoldering myeloma (SMM), describe recently published data regarding the early treatment of SMM, and to provide practical strategies on how to manage patients with SMM in the clinic. Recent findings Recently published data from the ECOG E3A06 and GEM-CESAR studies supporting early intervention for certain subsets of high-risk SMM patients will be presented, and the relevance of these findings in relation...
Current Opinion in Oncology
4d
Adjuvant treatment of early male breast cancer
Purpose of review Male breast cancer (MaBC) is a rare disease, and some challenges exist in its management because current treatment recommendations are extrapolated from trials that mostly excluded men. This review will revise all available data that could improve the treatment of MaBC, with a special focus on adjuvant systemic treatments. Recent findings To date, men with hormone receptor-positive breast cancer, who are candidates for adjuvant endocrine therapy, should be offered tamoxifen...
Current Opinion in Oncology
4d
A precision medicine approach to management of acute myeloid leukemia in older adults
Purpose of review Therapy selection in older adults with acute myeloid leukemia (AML) can be challenging because of a higher incidence of high-risk cytogenetic and molecular features conferring chemoresistance and poor functional status leading to increased treatment-related toxicities. The purpose of this review is to highlight the recent advances in precision medicine in AML that have shown promise to improve outcomes of older adults. Recent findings The utilization of next generation sequencing...
Current Opinion in Oncology
4d
How to treat lobular cancer in the adjuvant setting?
Purpose of review The aim of this review is to understand the clinical decision- making process for the management of patients with early invasive lobular breast cancer (ILC), thereby orienting clinicians across large areas of uncertainties and extrapolations. Recent findings The analysis of the principal evidence on the management of ILC, assessing the role and benefit of systemic treatments in the curative setting, have shed the light on the opportunity to escalate and de-escalate systemic...
Current Opinion in Oncology
4d
Physical approaches to treat glioblastoma
Purpose of review Glioblastoma (GBM) patients have a poor prognosis despite the use of modern synergistic multimodal treatment strategies, with a progression-free survival estimated at 7–8 months, a median survival of 14–16 months and 5-year overall survival of 9.8%. Recent findings Physical methods hold the promise to act synergistically with classical treatments to improve the outcome of GBM patients. Fluorescent guided surgery with 5-aminolevulinic acid and tumor-treating fields therapy have...
Current Opinion in Oncology
4d
Neurological complications of chimeric antigen receptor T cells and immune-checkpoint inhibitors: ongoing challenges in daily practice
Purpose of review The aim of this review is to summarize the most recent advances in the management of neurological toxicities associated with immune-checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR)-T cells. Recent findings The advent of cancer immunotherapies has dramatically improved the prognosis of several refractory and advanced neoplasms. Owing to their mechanism of action, cancer immunotherapies have been associated with a variety of immune-related adverse events (irAE)....
Current Opinion in Oncology
4d
Mechanisms of invasion in glioblastoma
Purpose of review This review provides an overview of recent updates in understanding the mechanisms by which glioblastoma cells interact with their cellular and molecular partners within the microenvironment. Recent findings We have now a better knowledge of the cell populations involved in Glioblastoma (GBM) invasion. Recent works discovered the role of new molecular players in GBM invasion, and, most importantly, better models are emerging which better recapitulate GBM invasion. Summary...
Current Opinion in Oncology
4d
Combining poly(ADP-ribose) polymerase inhibitors and immune checkpoint inhibitors in breast cancer: rationale and preliminary clinical results
Purpose of review Recently, both immune checkpoint inhibitors and poly(ADP-ribose) polymerase inhibitors have demonstrated clinical benefit in some subsets of HER2-negative breast cancer patients. A biological rationale exists supporting a potential synergism between these compounds, which may further increase their antitumor activity in the clinic. Recent findings PARP inhibitors were shown to activate type I interferon pathway, thus eliciting local and general immune response, while inducing...
Current Opinion in Oncology
4d
Embryonal tumors of the central nervous system
Purpose of review This review aims to give an update on histopathological, molecular and clinical features of central nervous system (CNS) ‘embryonal’ tumors. Recent findings The taxonomy of previously called ‘CNS primitive neuroectodermal tumor’ (CNS PNET) has been deeply modified since the discovery of specific molecular profiles for each various sub-entity of these rare, mainly pediatric, tumors. The term ‘embryonal tumors’ now refers to medulloblastomas, atypical teratoid rhabdoid tumors...
Current Opinion in Oncology
4d
Can we cure oligometastatic disease? A practical point of view
Purpose of review To critically analyze the available evidence on oligometastatic breast cancer and to suggest therapeutic approaches for optimal management of these patients. Recent findings Unlike metastatic breast cancer, which remains incurable, patients with a limited number and extent of metastatic lesions, that is, oligometastatic disease, might achieve disease control and long-term survival when radical therapy of the primary tumor, if present, and metastatic disease is added to standard...
Current Opinion in Oncology
4d
Molecular alterations in meningioma: prognostic and therapeutic perspectives
Purpose of review To discuss recent advances in the meningioma biology and their clinical implications. Recent findings Meningioma is the most common primary intracranial tumor. Mostly benign, 20% of cases display an aggressive behavior despite best standard of care. The genetic landscape of meningiomas is divided according to NF2 mutational status. Although about 60% of meningiomas display NF2 mutations, the other share is more heterogenous. Mutations in TRAF7, SMO, v-akt murine thymoma viral...
Current Opinion in Oncology
4d
Prevention of brain metastases in human epidermal growth factor receptor 2-positive breast cancer
Purpose of review For patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer, treatments that could prevent or delay occurrence of brain metastases would improve outcome. Recent findings Few studies were specifically designed to assess brain metastasis prevention. Most evidence derives from subgroup analyses of randomized trials. In the first-line metastatic setting, lapatinib, was not superior to trastuzumab to prevent CNS metastases as first site of relapse. Pertuzumab...
Current Opinion in Oncology
4d
Editorial introductions
No abstract available (Source: Current Opinion in Oncology)
Current Opinion in Oncology
4d
Immunotherapy in multiple myeloma: when, where, and for who?
Purpose of review Immunotherapy is transforming treatment of multiple myeloma patients in all stages of their disease. This review will discuss recent developments in immunotherapy in multiple myeloma with a focus on antibodies, antibody–drug conjugates, and T-cell-redirection strategies. Recent findings CD38-targeting antibodies have single agent activity in multiple myeloma, and especially when combined with other drugs, are improving the clinical outcome of patients with newly diagnosed or...
Current Opinion in Oncology
4d

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