Τρίτη 20 Οκτωβρίου 2020

 

Primary undifferentiated carcinoma with osteoclast-like giant cells in liver and rapidly developing multiple metastases after curative hepatectomy: a case report
Abstract A 64-year-old man was diagnosed with cholangiocellular carcinoma based on preoperative computed tomography and magnetic resonance imaging and underwent laparoscopic segmentectomy (Segment 8) of the liver for radical operation. Pathological examination revealed the presence of an undifferentiated carcinoma with osteoclast-like giant cells, which were categorized as T3N0M0 and Stage III based on the third English edition of the Japanese classification of liver cancer....
Latest Results for International Cancer Conference Journal
1w
A rare case of esophageal adenocarcinoma with urinary bladder metastasis
Abstract A 75-year-old man was admitted to our hospital for treatment of esophageal cancer (EC) in March 2017. Esophagogastroduodenoscopy revealed Barrett’s esophagus and superficial, distal EC (type 0-IIc). Tumor biopsy showed esophageal adenocarcinoma. Computed tomography revealed no lymph node metastasis but did reveal a 19-mm tumor on the right side of the urinary bladder. Bladder cancer (BC) was also suspected, and the patient underwent endoscopic submucosal dissection...
Latest Results for International Cancer Conference Journal
1w
A case of multiple metastatic gastric cancer with primary lesion vanished after administrating nivolumab, and the effect remains even after discontinuance of therapy
Abstract Nivolumab is one of the immune checkpoint inhibitors available for chemotherapy-resistant gastric cancer. There have been few reports of confirmed prominent shrinkage of the primary tumor and some reports of prolonged antitumor effect after discontinuance of the drug, but it is not universal. A 67-year-old male was admitted to our hospital and diagnosed with metastatic gastric cancer that had spread to the bilateral lobe of the liver, distant lymph nodes, and peritoneum....
Latest Results for International Cancer Conference Journal
1w
Xp11.2 translocation renal cell carcinoma with TFE3 gene fusion in the elderly: case report and literature review
Abstract A 68-year-old man was followed up with chronic kidney disease. Follow-up CT incidentally detected a tumor at the left kidney and multiple small nodular shadows in the lungs bilaterally. The patient underwent needle biopsy and was diagnosed with Xp11.2 translocation renal cell carcinoma (RCC) pathologically. Hence, laparoscopic nephrectomy was performed. Fluorescence in situ hybridization analysis revealed a break-apart of the transcription factor E3 (TFE3) genes in...
Latest Results for International Cancer Conference Journal
1w
Reduced port laparoscopic radical nephrectomy using an umbilical zigzag skin incision for renal cell carcinoma
Abstract Reduced port laparoscopic radical nephrectomy (RPLRN) is an equivalent approach to conventional laparoscopic radical nephrectomy (LRN). In LRN, one wound generally needs to be extended for specimen extraction; therefore, some ingenuity is needed to achieve a good cosmetic outcome. We herein describe our initial experience of RPLRN using an umbilical zigzag skin incision for renal cell carcinoma (RCC). A 64-year-old female [body mass index (BMI): 20.0 kg/m2] was diagnosed...
Latest Results for International Cancer Conference Journal
1w
Primary adenocarcinoma of the rete testis with elevated serum CA19-9 antigen levels
Abstract Primary adenocarcinoma of the rete testis is an extremely rare tumor with a poor prognosis. Herein, we report a case of primary adenocarcinoma of the rete testis accompanied by elevated serum carbohydrate antigen 19-9 (CA19-9) antigen levels in a 44-year-old man who presented with left scrotal swelling. Para-aortic lymph node swelling was observed on the computed tomography scan. Germ cell tumor markers were within the normal range, but serum CA19-9 antigen levels were...
Latest Results for International Cancer Conference Journal
1w
A long-term survival case of unresectable gastric cancer with multidisciplinary therapy including immunotherapy and abscopal effect
Abstract The prognosis of unresectable gastric cancer remains poor. Multidisciplinary treatment of unresectable gastric cancer is, therefore, thought to be essential for improving patients’ outcomes. Here, we report a successful case of multidisciplinary therapy for unresectable gastric cancer. The patient was a 69-year-old woman who was diagnosed with type 2 gastric cancer with remote lymph node metastases and peritoneal dissemination. Although shrinkage of the primary lesion...
Latest Results for International Cancer Conference Journal
1w
Prostate-specific antigen (PSA) bounce following salvage radiotherapy to the prostate bed in a patient with prostate cancer post-prostatectomy
Abstract We present a case of prostate-specific antigen (PSA) bounce in a 76 year old man who underwent salvage radiotherapy to the prostate bed following biochemical relapse 6 years post-radical prostatectomy for a T2N0 Gleason grade 3 + 3 prostate adenocarcinoma; 10 months following completion of salvage radiotherapy for biochemical PSA recurrence of 0.2 μg/L. Following undetectable results (<0.03 μg/L), his PSA rose from 0.04 to 0.3 μg/L with no evidence of prostate cancer...
Latest Results for International Cancer Conference Journal
1w
Laparoscopic left hemicolectomy with regional lymph node navigation and intracorporeal anastomosis for splenic flexure colon cancer
Abstract Laparoscopic approaches have become a standard strategy for colon cancer patients who undergo surgical treatment. Complete mesocolic excision (CME) with central vascular ligation (CVL) is the fundamental principle of radical resection of colon cancers. Splenic flexure colon cancer (SFCC) is rare, accounting for less than 4% of all colorectal cancer cases. Moreover, a laparoscopic approach for SFCC following the CME/CVL concept can be challenging because the blood supply...
Latest Results for International Cancer Conference Journal
1w
A long-term survival case following salvage stereotactic radiotherapy for local recurrence after definitive chemoradiotherapy for stage III non-small cell lung cancer
Abstract A 56-year-old male with stage IIIA (UICC 7th) non-small cell lung cancer (adenocarcinoma) received radiotherapy with 66 Gy/33 fractions concomitant with CBDCA and PTX. A partial response was achieved after chemoradiotherapy and the tumor continued to shrink over a period of 1 year; however, regrowth of the tumor attached to the aortic arch was observed without any other residual tumor or metastases. We diagnosed recurrence with slightly increased 18F-FDG uptake...
Latest Results for International Cancer Conference Journal
1w
A review with an additional case: amelanotic malignant melanoma at mandibular gingiva
Abstract The purpose of this review with an additional case is to evaluate the clinical, ultrasonographic and histopathological features of a rare case of Amelanotic Malignant Melanoma (AMM) at mandibular gingiva and to compare our case with other published AMMs at mandibular gingiva. A 52-year-old male patient with no systemic diseases was referred to our clinic with a soft tissue lesion at mandibular gingiva. Ultrasonographic examination was performed and a lesion with malignant...
Latest Results for International Cancer Conference Journal
1w
Complete atrioventricular block and torsade de pointes due to dose-dense epirubicin and cyclophosphamide therapy
Abstract The dose-dense epirubicin and cyclophosphamide (EC) therapy for breast cancer decreases the risk of cancer recurrence and death. However, epirubicin and cyclophosphamide also cause cardiotoxicity, and cardiomyopathy is the most well-known related adverse effect. A 58-year-old woman presented to our hospital with palpitations 2 weeks after her final dose-dense EC therapy for breast cancer. Holter electrocardiogram (ECG) showed transitory complete atrioventricular block...
Latest Results for International Cancer Conference Journal
1w
A rare case of synchronous bilateral epididymal and testicular metastases of urothelial carcinoma of the bladder after intravesical bacillus Calmette–Guérin
Abstract A 68-year-old man was diagnosed with non-muscle-invasive bladder cancer and underwent transurethral resection of the bladder tumor (TURBT) in June 2014. The pathological diagnosis was urothelial carcinoma (UC), Grade 2, pT1. He was treated with intravesical bacillus Calmette–Guérin (BCG) instillation after TURBT. In February 2016, he received anti-tuberculosis treatment for systemic BCG infection, and tuberculosis treatment was continued. In September 2018, he presented...
Latest Results for International Cancer Conference Journal
1w
Identification of key genes unique to the luminal a and basal-like breast cancer subtypes via bioinformatic analysis
Breast cancer subtypes are statistically associated with prognosis. The search for markers of breast tumor heterogeneity and the development of precision medicine for patients are the current focuses of the fi... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
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Platelet-to-lymphocyte ratio is correlated with a delay in feeding resumption following a transhiatal esophagectomy with cervical anastomosis
The lymphocytic population, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are prognostic tools predictive of adverse outcomes for several solid tumors and oncologic surgeries, on... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
5d
Short- and long-term outcomes after colonic self-expandable metal stent placement for malignant large-bowel obstruction as a bridge to surgery focus on the feasibility of the laparoscopic approach: a retrospective, single center study
Malignant large-bowel obstruction (MLBO) is a highly urgent condition in colorectal cancer with high complication rates. Self-expandable metal stent (SEMS) placement in MLBO is a new decompression treatment in... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
5d
Prognosis of papillary thyroid cancer in patients with Graves ’ disease: a propensity score-matched analysis
Patients with Graves ’ disease (GD) are at a 2.5 times higher risk of developing thyroid cancer than the general population. Previous studies reported conflicting results about the prognosis of thyroid cancer c... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
5d
Prognostic impact of lymph node parameters in distal cholangiocarcinoma after pancreaticoduodenectomy
Pancreaticoduodenectomy is the only definitively curative therapy for the long-term survival of distal cholangiocarcinoma patients. Lymph node metastasis is widely accepted as an important prognostic factor fo... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
6d
Clinical benefits of adjuvant chemotherapy with carboplatin and gemcitabine in patients with non-small cell lung cancer: a single-center retrospective study
In cases of non-small cell lung cancer (NSCLC), surgery remains the best option for cure, but surgery is of benefit only when the disease is localized. Although adjuvant chemotherapy reportedly has a significa... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
6d
Imaging in disappearing colorectal liver metastases and their accuracy: a systematic review
Approximately 30% of patients with colorectal cancer develop colorectal liver metastases (CRLM). CRLM that become undetectable by imaging after chemotherapy are called disappearing liver metastases (DLM). But ... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
6d
 
LncRNA NEAT1 mediates progression of oral squamous cell carcinoma via VEGF-A and Notch signaling pathway
lncRNAs and VEGF have been shown to have close connections with oral squamous cell carcinoma (OSCC). We explored the interaction between lncRNA NEAT1 and VEGF-A in OSCC. (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Primary epithelioid angiosarcoma originating from the mandibular gingiva: a case report of an extremely rare oral lesion
Angiosarcoma occurs very rarely in the oral cavity, and the epithelioid type is even rarer. Here, we report a rare case involving an elderly man with a primary epithelioid angiosarcoma that originated from the... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Splenic marginal zone lymphoma: a case report and literature review
Splenic marginal zone lymphoma (SMZL) is a rare non-Hodgkin lymphoma, and much little is known about its clinical characteristics and management strategies. Here we present a case of SMZL and review relevant l... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Correction to: Early gastric cancer with three gastric gastrointestinal stromal tumors combined with synchronous colon cancer: a case report
An amendment to this paper has been published and can be accessed via the original article. (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Prognosis and risk factors for malignant peripheral nerve sheath tumor: a systematic review and meta-analysis
No available meta-analysis was printed to systematically introduce the MPNST clinic outcome and risk factors based on largely pooled data. This systematic review and meta-analysis aimed to investigate 5-year O... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Significance of accurate hilar and intrapulmonary lymph node examination and prognostication in stage IA –IIA non-small cell lung cancer, a retrospective cohort study
The examination of lymph nodes (LNs) plays an important role in the nodal staging of non-small cell lung cancer (NSCLC). For patients without LN metastasis, the main role of thorough LN examination is accurate... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Hsa_circ_0000231 knockdown inhibits the glycolysis and progression of colorectal cancer cells by regulating miR-502-5p/MYO6 axis
Colorectal cancer (CRC) poses a heavy threat to human health owing to its high incidence and mortality. Circular RNAs (circRNAs) were investigated to participate in the progression of CRC, whereas there was no... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Prognostic biomarkers related to breast cancer recurrence identified based on Logit model analysis
This study intended to determine important genes related to the prognosis and recurrence of breast cancer. (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Major complications of post-chemotherapy retroperitoneal lymph node dissection in a contemporary cohort of patients with testicular cancer and a review of the literature
Post-chemotherapy retroperitoneal lymph node dissection (pc-RPLND) is one cornerstone in the clinical management of patients with nonseminomatous testicular germ cell tumours (GCT). A wide range of complicatio... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Long-term outcomes and safety of radical transmediastinal esophagectomy with preoperative docetaxel, cisplatin, and 5-fluorouracil combination chemotherapy for locally advanced squamous cell carcinoma of the thoracic esophagus
It is unknown whether transmediastinal esophagectomy (TME) is an acceptable surgical procedure for locally advanced esophageal squamous cell carcinoma (ESCC). Therefore, we investigated the feasibility of long... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Laparoscopic procedure is associated with lower morbidity for simultaneous resection of colorectal cancer and liver metastases: an updated meta-analysis
It has been demonstrated that simultaneous resection of both primary colorectal lesion and metastatic hepatic lesion is a safe approach with low mortality and postoperative complication rates. However, there a... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Development of a novel prognostic score combining clinicopathologic variables, gene expression, and mutation profiles for lung adenocarcinoma
In this study, we developed a new prognostic model for event-free... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
A case of long-term survival after splenectomy for solitary splenic metastasis from gastric cancer
Very rarely does a splenic solitary metastasis arise from a gastric carcinoma because splenic metastasis is usually seen in association with widespread visceral metastasis. Splenectomy is considered to be a cu... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Total resection of a giant retroperitoneal and mediastinal ganglioneuroma —case report and systematic review of the literature
Ganglioneuromas (GNs) are extremely rare, slowly growing, benign tumors that can arise from Schwann cells, ganglion cells, and neuronal or fibrous tissues. Due to their origin from the sympathetic neural crest... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
A novel skin-stretching device for closing large skin-soft tissue defects after soft tissue sarcoma resection
The objective of this study was to evaluate the effectiveness of a novel, simple, and cheap s... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Plastic lengthening amputation with vascularized bone grafts in children with bone sarcoma: a preliminary report
At present, amputation was widely adopted for young patients when limb salvage was deemed risky with several surgical strategy such as rotationplasty. However, leg length discrepancies and unfavorable cosmetic... (Source: World Journal of Surgical Oncology)
World Journal of Surgical Oncology
1w
Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response
Oncogenesis, Published online: 18 October 2020; doi:10.1038/s41389-020-00279-7Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response
Oncogenesis - nature.com science feeds
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Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response
Oncogenesis - nature.com science feeds
2d
Aberrant super-enhancer landscape reveals core transcriptional regulatory circuitry in lung adenocarcinoma
Oncogenesis, Published online: 17 October 2020; doi:10.1038/s41389-020-00277-9Aberrant super-enhancer landscape reveals core transcriptional regulatory circuitry in lung adenocarcinoma
Oncogenesis - nature.com science feeds
3d
Aberrant super-enhancer landscape reveals core transcriptional regulatory circuitry in lung adenocarcinoma
Oncogenesis - nature.com science feeds
3d
High-risk factors for lymph node metastasis in contralateral central compartment in unilateral papillary thyroid carcinoma(cT1N0)
Publication date: Available online 18 October 2020Source: European Journal of Surgical OncologyAuthor(s): Bin Zhou, Jianwu Qin
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
2d
Post-mastectomy seromas and wound drains
Publication date: Available online 17 October 2020Source: European Journal of Surgical OncologyAuthor(s): Kieran Horgan
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
2d
Long-term outcomes for patients with peritoneal acellular mucinosis secondary to low grade appendiceal mucinous neoplasms
Publication date: Available online 16 October 2020Source: European Journal of Surgical OncologyAuthor(s): Evans T, Aziz O, Chakrabarty B, M.S. Wilson, Malcomson L, Lavelle C, S.T. O’Dwyer
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
3d
Outside front cover
Publication date: October 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 10, Part BAuthor(s):
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
3d
Case-mix adjustment to compare nationwide hospital performances after resection of colorectal liver metastases
Publication date: Available online 16 October 2020Source: European Journal of Surgical OncologyAuthor(s): Arthur K.E. Elfrink, Erik W. van Zwet, Rutger-Jan Swijnenburg, Marcel den Dulk, Peter B. van den Boezem, J. Sven D. Mieog, Wouter W. te Riele, Gijs A. Patijn, Wouter K.G. Leclercq, Daan J. Lips, Arjen M. Rijken, Cornelis Verhoef, Koert F.D. Kuhlmann, Carlijn I. Buis, Koop Bosscha, Eric J.T. Belt, Maarten Vermaas, N. Tjarda van Heek, Steven J. Oosterling, Hans Torrenga
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
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Prediction of tumor recurrence by α-fetoprotein model after curative resection for hepatocellular carcinoma
Publication date: Available online 15 October 2020Source: European Journal of Surgical OncologyAuthor(s): Hong-Fan Ding, Xu-Feng Zhang, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Yi Lv, Timothy M. Pawlik
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
4d
Surgical site complications of post-chemoradiotherapy neck dissection: Urgent need for standard registration
Publication date: Available online 15 October 2020Source: European Journal of Surgical OncologyAuthor(s): Roel Henneman, Winnie Schats, M.Baris Karakullukcu, Michiel WM. van den Brekel, Ludwig E. Smeele, Peter FJM. Lohuis, Jos A. van der Hage, Abrahim Al-Mamgani, Alfons JM. Balm
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
4d
Long-term standard sentinel node biopsy after neoadjuvant treatment in breast cancer: A single institution ten-year follow-up
Publication date: Available online 15 October 2020Source: European Journal of Surgical OncologyAuthor(s): Sabrina Kahler-Ribeiro-Fontana, Eleonora Pagan, Francesca Magnoni, Elisa Vicini, Consuelo Morigi, Giovanni Corso, Mattia Intra, Fiorella Canegallo, Silvia Ratini, Maria Cristina Leonardi, Eliana La Rocca, Vincenzo Bagnardi, Emilia Montagna, Marco Colleoni, Giuseppe Viale, Luca Bottiglieri, Chiara Maria Grana, Jorge Villanova Biasuz, Paolo Veronesi, Viviana Galimberti
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
4d
Lymphadenectomy for gastric cancer at European specialist centres
Publication date: Available online 15 October 2020Source: European Journal of Surgical OncologyAuthor(s): M. Bencivenga, L. Torroni, G. Verlato, V. Mengardo, M. Sacco, W.H. Allum, G. de Manzoni
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
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Distribution of residual disease in the peritoneum following neoadjuvant chemotherapy in advanced epithelial ovarian cancer and its potential therapeutic implications
Publication date: Available online 14 October 2020Source: European Journal of Surgical OncologyAuthor(s): Aditi Bhatt, Naoual Bakrin, Praveen Kammar, Sanket Mehta, Snita Sinukumar, Loma Parikh, Sakina Shaikh, Suniti Mishra, Mrinal Mallaya, Vahan Kepenekian, Nazim Benzerdjeb, Olivier Glehen
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
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Managing NON-DIAGNOSTIC biopsies in musculoskeletal tumours in a specialist centre: Deciding on the algorithm
Publication date: Available online 14 October 2020Source: European Journal of Surgical OncologyAuthor(s): George S. Tamvakopoulos, Barry Rose, Asif Saifuddin, John A. Skinner, Robin Pollock
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
6d
Long term survival in patients with peritoneal metastasised gastric cancer treated with cytoreductive surgery and HIPEC: A multi-institutional cohort from PSOGI
Publication date: Available online 14 October 2020Source: European Journal of Surgical OncologyAuthor(s): Andreas Brandl, Yutaka Yonemura, Olivier Glehen, Paul Sugarbaker, Beate Rau
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
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Increased ultrasonographic endometrial thickness is associated with poor survival in patients with endometrial cancer: An Israel gynecologic oncology group study
Publication date: Available online 14 October 2020Source: European Journal of Surgical OncologyAuthor(s): Ahmet Namazov, Ofer Gemer, Nasreen Hag-Yahia, Ram Eitan, Oded Raban, Zvi Vaknin, Sophia Leytes, Ofer Lavie, Alon Ben-Arie, Amnon Amit, Tally Levy, Michael Volodarsky, Inbar Ben Shachar, Ilan Atlas, Ilan Bruchim, Limor Helpman
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
6d
Prognosis impact of posttreatment pelvic MRI in patients treated for stage IB2-IIB cervical cancer with chemoradiation therapy
Publication date: Available online 13 October 2020Source: European Journal of Surgical OncologyAuthor(s): Tiphaine Moussilmani, Sophie Knight, Julien Mancini, Cyril Touboul, Florence Rodriguez, Pierre Adrien Bolze, Sofiane Bendifallah, Marcos Ballester, Pierre Collinet, Yohan Kerbage, Lobna Ouldamer, Geoffroy Atrous, Vincent Lavoué, Ludivine Dion, Yohann Dabi, Emilie Raimond, Olivier Graesslin, Cyrille Huchon, Myriam Mimouni, Alexandre Bricou
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
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Breast cancer in the oldest old (≥ 89 years): Tumor characteristics, treatment choices, clinical outcomes and literature review
Publication date: Available online 13 October 2020Source: European Journal of Surgical OncologyAuthor(s): Simona Di Lascio, Enrico Tognazzo, Sara Bigiotti, Marta Bonollo, Alberto Costa, Olivia Pagani, Francesco Meani
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
6d
Absence of residual fluorescence in the surgical bed at near-infrared fluorescence imaging predicts negative margins at final pathology in patients treated with breast-conserving surgery for breast cancer
Publication date: Available online 13 October 2020Source: European Journal of Surgical OncologyAuthor(s): Florin-Catalin Pop, Isabelle Veys, Sophie Vankerckhove, Romain Barbieux, Marie Chintinne, Michel Moreau, Vincent Donckier, Denis Larsimont, Pierre Bourgeois, Gabriel Liberale
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
1w
Robot-assisted surgery for women with endometrial cancer: Surgical and oncologic outcomes within a Belgium gynaecological oncology group cohort
Publication date: Available online 13 October 2020Source: European Journal of Surgical OncologyAuthor(s): A. Kakkos, C. Ver Eecke, S. Ongaro, K. Traen, F. Peeters, Ph Van Trappen, A. Laenen, E. Despierre, E. Van Nieuwenhuysen, I. Vergote, F. Goffin
ScienceDirect Publication: European Journal of Surgical Oncology (EJSO)
1w
TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3K α inhibition in head and neck squamous cell carcinoma
Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outco... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
2d
SETDB1 promotes glioblastoma growth via CSF-1-dependent macrophage recruitment by activating the AKT/mTOR signaling pathway
Glioblastoma is a common disease of the central nervous system (CNS), with high morbidity and mortality. In the infiltrate in the tumor microenvironment, tumor-associated macrophages (TAMs) are abundant, which... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
2d
Long noncoding RNA Linc00337 functions as an E2F1 co-activator and promotes cell proliferation in pancreatic ductal adenocarcinoma
Long noncoding RNA (lncRNA) Linc00337 has been implicated in lung, gastric, colorectal and esophageal squamous cell carcinoma progression via various mechanisms; however, its clinicopathological significance a... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
4d
Correction to: YPEL3 suppresses epithelial –mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/β-catenin signaling pathway
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
5d
Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progression
Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that oncogene amplification via ecDNA is widespread across a diverse... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
5d
Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition
Despite the introduction of several novel therapeutic approaches that improved survival, metastatic castration-resistant prostate cancer (mCRPC) remains an incurable disease. Herein we report the synergistic a... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Mir-20a-5p induced WTX deficiency promotes gastric cancer progressions through regulating PI3K/AKT signaling pathway
The X-linked gene WTX (also called AMER1) has been reported to function as a tumour suppressor gene in Wilms ’ tumour. In our previous study, WTX expression was shown to be significantly reduced in gastric canc... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+ dependent acute and chronic endoplasmic reticulum stress
Our previous study showed that calreticulin (CRT) promoted EGF-induced epithelial-mesenchymal transition (EMT) in pancreatic cancer (PC) via Integrin/EGFR-ERK/MAPK signaling. We next investigated the novel sig... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal prognosis with a median survival of le... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Nicotinamide inhibits melanoma in vitro and in vivo
Even though new therapies are available against melanoma, novel approaches are needed to overcome resistance and high-toxicity issues. In the present study the anti-melanoma activity of Nicotinamide (NAM), the... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Oral mucositis: the hidden side of cancer therapy
Inflammation response of epithelial mucosa to chemo- radiotherapy cytotoxic effects leads to mucositis, a painful side effect of antineoplastic treatments. About 40% of the patients treated with chemotherapy d... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Long noncoding RNA RP11-757G1.5 sponges miR-139-5p and upregulates YAP1 thereby promoting the proliferation and liver, spleen metastasis of colorectal cancer
Accumulating evidence indicates that long non-coding RNAs (lncRNAs) acting as crucial regulators in tumorigenesis. However, its biological functions of lncRNAs in colorectal cancer (CRC) have not been systemat... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
The role of TRPV1 ion channels in the suppression of gastric cancer development
Although the aberrant expression and function of most Ca2+-permeable channels are known to promote gastrointestinal tumors, the association between transient receptor potential vanilloid receptor 1 (TRPV1) channe... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
The role of microenvironment in tumor angiogenesis
Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment —composed of tumor ce... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Tubulin Tyrosine Ligase Like 4 (TTLL4) overexpression in breast cancer cells is associated with brain metastasis and alters exosome biogenesis
The survival rate is poor in breast cancer patients with brain metastases. Thus, new concepts for therapeutic approaches are required. During metastasis, the cytoskeleton of cancer cells is highly dynamic and ... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer
N6-Methyladenosine (m6A) modification has been implicated in multiple processes for colon cancer development. IGF2BP3 was a newly reported m6A reader, whereas its role in colon cancer remains unclear. (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2
Globally, colorectal cancer (CRC) affects more than 1 million people each year. In addition to non-modifiable and other environmental risk factors, Fusobacterium nucleatum infection has been linked to CRC recentl... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1 α/HES1 signaling axis
Although cisplatin-based chemotherapy represents the standard regimen for osteosarcoma (OS), OS patients often exhibit treatment failure and poor prognosis due to chemoresistance to cisplatin. Emerging researc... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Correction to: Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKK βkinase activity and interrupting NF-κB/COX-2-mediated signaling cascades
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients
SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in ... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib
Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment. Among this class of drugs, ponatinib (PON) has been shown to have... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop
Glioblastoma is the most common primary malignant intracranial tumor with poor clinical prognosis in adults. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) function as important regulators... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced cytotoxic death of cervical cancer cells through the AMPK/mTOR pathway
Autophagy is an intracellular process through which intracellular components are recycled in response to nutrient or growth factor deficiency to maintain homeostasis. We identified the peptide autophagy-relate... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy
Advanced colorectal adenocarcinoma (CRAC), featured by distinctive histopathological appearance, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a group of heterogeneous cancers... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Exosomal miR-141 promotes tumor angiogenesis via KLF12 in small cell lung cancer
Angiogenesis, a basic requirement for tumor cell survival, is considered to be a malignant characteristic of small cell lung cancer (SCLC) and is closely related to the poor outcomes of SCLC patients. miR-141 ... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
NUCKS promotes cell proliferation and suppresses autophagy through the mTOR-Beclin1 pathway in gastric cancer
Nuclear casein kinase and cyclin-dependent kinase substrate (NUCKS), a novel gene first reported in 2001, is a member of the high mobility group (HMG) family. Although very little is known regarding the biolog... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Linc00514 promotes breast cancer metastasis and M2 polarization of tumor-associated macrophages via Jagged1-mediated notch signaling pathway
Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be in... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
m6A modification in RNA: biogenesis, functions and roles in gliomas
The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the mo... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way
Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been testified to be overexpressed in prostate cancer and strongly related to patients ’ poor prognosis. However, the functions of ... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
CDK4/6 inhibitors: a novel strategy for tumor radiosensitization
Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle t... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Proteolysis targeting chimeras (PROTACs) in cancer therapy
Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs)... (Source: Journal of Experimental and Clinical Cancer Research)
Journal of Experimental and Clinical Cancer Research
1w
Ultrasound visibility of select breast biopsy markers for targeted axillary node localization following neoadjuvant treatment: simulation using animal tissue models
ConclusionThe Twirl ™ followed by the Tumark® Q and Vision biopsy markers demonstrates the highest visibility scores using a four-point grading system and by radiologist vote. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Influence of green tea consumption on endoxifen steady-state concentration in breast cancer patients treated with tamoxifen
ConclusionsThis study demonstrated the absence of a pharmacokinetic interaction between green tea supplements and tamoxifen. Therefore, the use of green tea by patients with tamoxifen does not have to be discouraged. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
57% decline in Rhode Island invasive breast cancer mortality between 1987 and 2017: mammography predominates in preventing mortality
DiscussionImprovements in initial presentation of IBC are consistent with most having progressive growth, from cellular origin to palpable mass, the currently accepted biological model. Breast cancers identified earlier at initial diagnosis through screening mammography are characterized by smaller size, fewer axillary LNMs, better grade differentiation, and decreased mortality. Statistical analysis from these improved diagnostic parameters indicate that the majority of mortality decline from invasive...
Breast Cancer Research and Treatment
3d
Influenza vaccination in breast cancer patients during subcutaneous trastuzumab in adjuvant setting
ConclusionBreast cancer patients treated with trastuzumab in adjuvant setting seem to benefit from influenza vaccination in terms of immunogenicity without increasing the risk for adverse events. The current data support the recommendation to offer influenza vaccination in breast cancer patients treated with this type of targeted therapy. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
The impact of selected risk factors among breast cancer molecular subtypes: a case-only study
ConclusionsThis study supported BC etiologic heterogeneity across subtypes, particularly for triple negative. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer
ConclusionsThe combination of vantictumab and weekly paclitaxel was generally well tolerated with promising efficacy; however, the incidence of fractures limits future clinical development of this particular WNT inhibitor in metastatic breast cancer.Clinical Trial Registration:ClinicalTrials.gov registration: NCT01973309 (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Frequency and spectrum of founder and non-founder BRCA1 and BRCA2 mutations in a large series of Russian breast cancer and ovarian cancer patients
ConclusionFull-lengthBRCA1 andBRCA2 sequencing is strongly advised to Slavic subjects, who have medical indications forBRCA1 andBRCA2 testing but are negative for recurrentBRCA1 andBRCA2 mutations. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Treatment effect of palbociclib plus endocrine therapy by prognostic and intrinsic subtype and biomarker analysis in patients with bone-only disease: a joint analysis of PALOMA-2 and PALOMA-3 clinical trials
ConclusionsThese findings support palbociclib plus endocrine therapy as standard of care for HR+  /HER2− ABC patients, regardless of baseline TFI/DFI or intrinsic molecular subtype, including patients with bone-only disease.Trial registrationPfizer (clinicaltrials.gov:NCT01740427, NCT01942135). (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Effect of functional variant rs11466313 on breast cancer susceptibility and TGFB1 promoter activity
ConclusionsThis study elucidates the impact of functional polymorphism rs11466313 in the regulatory region of TGFB1 on breast cancer susceptibility and gene expression, and could be helpful for future research to determine the value of this TGFB1 variant in the clinical setting. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Psychoneurological symptom cluster in breast cancer: the role of inflammation and diet
This article reviews the role of inflammation and high quality diet on the prevalence of psychoneurological symptoms clusters. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Previously diagnosed multiple primary malignancies in patients with breast carcinoma in Western Sweden between 2007 and 2018
ConclusionsThe overall survival rates for cancer patients have improved tremendously during the past 40  years, in part due to individually tailored therapies and screening programs. Our study revealed an increasing trend of OPPMs in breast cancer patients. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Exercise training affects hemodynamics not cardiac function during anthracycline-based chemotherapy
ConclusionExercise training during anthracycline chemotherapy treatment had no effect on resting cardiac function but appeared to modify hemodynamic responses. Specifically, exercise training attenuated the drop in SVR in response to chemotherapy-related reductions in hematocrit potentially  by increasing vessel lumen radius. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Outcomes following lymphaticovenous anastomosis (LVA) for 100 cases of lymphedema: results over 24-months follow-up
ConclusionsLVA resulted in significant QoL improvement in upper and lower extremity lymphedema patients. Limb circumference did not significantly improve but good results concerning compression garments, cellulitis  episodes, and MLD sessions were obtained. Additionally, a simple and patient-friendly method for outpatient ICG lymphography is presented. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Shoulder amplitude movement does not influence postoperative wound complications after breast cancer surgery: a randomized clinical trial
ConclusionFAM exercises do not increase the incidence of postoperative wound complications compared to RAM exercises.Trial registration: NCT03796845 (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Real-world survival outcomes of heavily pretreated patients with refractory HR+, HER2 −metastatic breast cancer receiving single-agent chemotherapy—a comparison with MONARCH 1
ConclusionsThis study demonstrates an approach to create a real-world chemotherapy cohort suitable to serve as a comparator for trial data. These exploratory results suggest a survival advantage and place the benefit of abemaciclib monotherapy in clinical context. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Minimally invasive breast cancer excision using the breast lesion excision system under ultrasound guidance
ConclusionsBLES allows accurate diagnosis of small invasive breast carcinomas. However, BLES cannot be considered as a therapeutic device for small invasive breast carcinomas due to not achieving adequate excision. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Impact of breast cancer subtype on clinical outcomes after Gamma Knife radiosurgery for brain metastases from breast cancer: a multi-institutional retrospective study (JLGK1702)
ConclusionsHER2 positivity is related to the longer OS after SRS; however, we should pay attention to preventing recurrence in Luminal-HER2 patients. Also, TN patients require meticulous follow-up observation to detect distant metastases and/or LMD. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Induction of PIK3CA alterations during neoadjuvant letrozole may improve outcome in postmenopausal breast cancer patients
ConclusionConsiderable heterogeneity was identified both among patients and between pre- and posttreatment samples.PIK3CA has the potential to be a predictive biomarker. To further assess the implications of a treatment related alteredPIK3CA mutation profile, more data are needed. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Impact of prior (neo)adjuvant trastuzumab (NAT) exposure on the efficacy of HER2-targeted therapy for metastatic breast cancer
ConclusionsPrior receipt of NAT was associated with inferior median PFS following first-line HER2-based therapy in the metastatic setting. However, prior NAT exposure did not significantly impact OS, supporting the efficacy of taxane, trastuzumab, pertuzumab combination for first-line HER2+ MBC regardless of prior NAT exposure. Patients with de novo MBC had the longest survival, suggesting stratification for synchronous versus metachronous disease in prospective clinical trials of MBC should be considered....
Breast Cancer Research and Treatment
3d
Axillary lymph node and non-sentinel lymph node metastasis among the ACOSOG Z0011 eligible breast cancer patients with invasive ductal, invasive lobular, or other histological special types: a multi-institutional retrospective analysis
ConclusionAmong patients with 1 –2 + SLNs, ILC or other HST had similar rates of non-SLN metastasis compared with IDC. Omission of ALND may not influence adjuvant chemotherapy usage or disease outcome regardless of histological types. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
3d
Gene expression of adipokines and adipokine receptors in the tumor microenvironment: associations of lower expression with more aggressive breast tumor features
ConclusionThese findings suggest that lower expression of ADIPOQ, ADIPOR2, LEP, and LEPR in the breast TME might be indicators of more aggressive breast cancer phenotypes. Validation of these findings are warranted to elucidate the role of the adipokines and adipokine receptors in long-term breast cancer prognosis. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
4d
A population-based comparison of treatment patterns, resource utilization, and costs by cancer stage for Ontario patients with hormone receptor-positive/HER2-negative breast cancer
ConclusionThe costs associated with metastatic HR+/HER2 − BC reflect a significant disease burden. Low endocrine treatment rates captured by the publicly funded system suggest guideline non-adherence or that a fair portion of Ontarian patients may be incurring out-of-pocket drug costs. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
4d
Association between statin use and second cancer risk in breast cancer patients: a nationwide population-based cohort study
ConclusionThis study showed that there is little association between statin use and second cancer risk in breast cancer patients. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
4d
Genetic ablation of pregnancy zone protein promotes breast cancer progression by activating TGF- β/SMAD signaling
ConclusionTaken together, our results suggest that genetic ablation ofPZP results in tumor progression and low expression ofPZP is associated with poor survival of breast cancer patients. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
5d
KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer
ConclusionsOur results establish that KDM1A inhibition mitigates CSCs functions via inhibition of STAT3 and EMT signaling, and KDM1A inhibitor NCD38 may represent a novel class of drug for treating TNBC. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
5d
Tumor localization for breast cancer patients receiving neoadjuvant chemotherapy
(Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
5d
Risk of chemotherapy-related amenorrhoea (CRA) in premenopausal women undergoing chemotherapy for early stage breast cancer
ConclusionsAge at menarche and, specially, at time of treatment are important risk factors for CRA. These variables could aid decision-making for treatment selection and fertility preservation among premenopausal women with early breast cancer. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
5d
Central nervous system metastases in breast cancer: the impact of age on patterns of development and outcome
ConclusionWhile the presentation of CNS involvement was similar between the different age groups, younger patients had significantly longer CNS-free interval and longer overall survival, and for the subgroups of triple-negative patients, younger age at breast cancer diagnosis was associated with longer survival after diagnosis of CNS disease. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments
ConclusionsWe confirmed that equol has dual action, specifically a tumor growth-promoting effect and an antitumor effect. Although the results suggested that equol might exert an antagonistic effect against tamoxifen depending on the concentration, equol did not exert an antagonistic effect on other therapeutic agents. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Incidence and survival of inflammatory breast cancer between 1973 and 2015 in the SEER database
ConclusionsIBC survival has increased over four decades. Despite the improvement in survival for all racial groups, a persistent survival disparity that has not narrowed over two decades remains between white and black patients. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Patient-reported outcomes among women with unilateral breast cancer undergoing breast conservation versus single or double mastectomy
ConclusionWhile patients who undergo mastectomy have less long-term breast satisfaction, all patients can expect to experience similar improvements in anxiety and PSWB. Efforts should be made to ensure that patients are informed and confident regardless of which surgery is chosen, for this is the greatest predictor of better outcomes. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Enhanced axillary assessment using intradermally injected microbubbles and contrast-enhanced ultrasound (CEUS) before neoadjuvant systemic therapy (NACT) identifies axillary disease missed by conventional B-mode ultrasound that may be clinically relevant
ConclusionsEnhanced assessment with CEUS before NACT identifies patients with axillary metastases missed by conventional B-mode ultrasound. Without CEUS, 22 (63%) of cases in Group B (negative B-mode ultrasound) may have been erroneously classed as progressive disease by surgical SLN excision after NACT. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Acknowledgement of  reviewers 2019
(Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
A dynamic portrait of adverse events for breast cancer patients: results from a phase II clinical trial of eribulin in advanced HER2-negative breast cancer
ConclusionsEribulin is active in HER2 − breast cancer. This study reveals that provider-assessed AEs can vary greatly from patient experiences. Future studies should incorporate CTCAE and PRO instruments to improve reporting of treatment-related AEs.ClinicalTrials.gov Registration: NCT01827787 (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
A multicentre prospective feasibility study of carbon dye tattooing of biopsied axillary node and surgical localisation in breast cancer patients
ConclusionIt is feasible to mark the axillary node with carbon dye and identify it intra-operatively.ClinicalTrials.gov: NCT03640819. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Performance of a clinical and imaging-based multivariate model as decision support tool to help save unnecessary surgeries for high-risk breast lesions
ConclusionOur multivariate model using lesion size, needle size and patient age had a high diagnostic performance in decreasing unnecessary surgeries and shows promise as a decision support tool. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Obesity and breast cancer risk for pre- and postmenopausal women among over 6 million Korean women
ConclusionsThere was a positive relationship between obesity and breast cancer in postmenopausal women, and an inverse association in premenopausal women. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Immune microenvironment in different molecular subtypes of ductal breast carcinoma
ConclusionDetermining the specific immune response in each subtype could be helpful in estimating the possible behavior of the tumor cells in TME. It is important to realize that different frequencies of immune cells in BC environment likely determine the patients ’ prognosis and their survival in each subtype. Therefore, elucidation of the distinct immune players in TME would be helpful toward developing targeted therapies in each subtype. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Prospective surveillance model in the home for breast cancer-related lymphoedema: a feasibility study
ConclusionsThese findings indicate a prospective surveillance model of care in the home with BIS is feasible and associated with increased self-management. A Phase II randomised trial is warranted as well as research exploring the costs associated with implementing this model of care for high-risk individuals. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Contrasting activities of estrogen receptor beta isoforms in triple negative breast cancer
ConclusionsER β2/ERβ5 and ERβ1 exhibit sharply contrasting activities in TNBC cells. Our findings imply that delineating the absolute amounts and relative ratios of the different ERβ isoforms might have prognostic and therapeutic relevance, and could enable better selection of optimal approaches for treatment of this often aggressive form of breast cancer. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Evaluating the impact of axillary dissection on recurrence-free survival by extent of nodal disease in invasive lobular carcinoma of the breast
ConclusionsThese findings support the safety of omitting ALND in selected patients with ILC. Further studies of axillary management in ILC and imaging tools to predict nodal involvement and therapeutic response are warranted. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Associations of plasma brain-derived neurotrophic factor (BDNF) and Val66Met polymorphism (rs6265) with long-term cancer-related cognitive impairment in survivors of breast cancer
ConclusionBDNF plasma level or rs6265 genotype information may facilitate the identification of patients at higher risk of long-term CRCI during survivorship and enable the implementation of early intervention strategies that increase BDNF levels. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Variation in the UGT2B17 genotype, exemestane metabolism and menopause-related toxicities in the CCTG MAP.3 trial
ConclusionVariation in the metabolism of exemestane through theUGT2B17-mediated pathway is associated with subsequent risk of commonly reported symptoms in MAP.3. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Atypical lobular hyperplasia on core needle biopsy: contemporary results from a large community hospital breast program
ConclusionPatients with pure ALH with radiographic concordance have a low risk of pathologic upgrading on excisional biopsy. Potential predictors of upgrade rate warrant further analysis in a larger dataset. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Identification of candidate mediators of chemoresponse in breast cancer through therapy-driven selection of somatic variants
ConclusionsGenomic analysis of paired pre- and post-therapy samples resulting from neoadjuvant therapy provides a powerful method for identification of mediators of response. Genes we identified should be assessed as predictive markers or targets in chemo-sensitization. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Lysine oxidase exposes a dependency on the thioredoxin antioxidant pathway in triple-negative breast cancer cells
ConclusionsLO exposes a redox vulnerability of TNBC cells to TXNRD inhibition by rendering tumor cells dependent on the thioredoxin antioxidant pathway for survival. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Financial toxicity and contralateral prophylactic mastectomy: an analysis using propensity score methods
ConclusionsChoice for CPM was associated with higher minor complications, but led to improved psychosocial well-being without a higher degree of patient-reported financial toxicity. Prospective studies are needed to discern the influence of CPM on the incidence and trajectory of financial toxicity. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Diagnostic workup of early-stage breast cancer: can we choose more wisely?
ConclusionsOur data indicate  a high rate of non-adherence to guidelines, physicians recommending extensive systemic evaluation for women with early breast cancer. These deviations from the guidelines are associated with subjective factors, some of them being physician-dependent. Initiatives aimed at improving adherence to g uidelines, and specifically to guidelines recommending"doing less" should therefore include not just knowledge-based education but also encourage conversation about what is appropriate...
Breast Cancer Research and Treatment
1w
The histopathological and molecular features of breast carcinoma with tumour budding —a systematic review and meta-analysis
ConclusionHigh-grade TB is enriched in hormone receptor-positive BC and is associated with known adverse prognostic variables. TB may offer new insights into the metastatic process of BC. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
Phase 1 study of TTC-352 in patients with metastatic breast cancer progressing on endocrine and CDK4/6 inhibitor therapy
ConclusionsTTC-352 demonstrates safety and early clinical evidence of antitumor activity against heavily pretreated hormone-refractory breast cancer. Based upon TTC-352 plasma concentrations and tolerability, the 180  mg twice a day is recommended for further testing.(ClinicalTrials.gov Identifier: NCT03201913) (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w
The impact of sociodemographic factors and health insurance coverage in the diagnosis and clinicopathological characteristics of breast cancer in Brazil: AMAZONA III study (GBECAM 0115)
ConclusionsPatients with public health coverage were diagnosed with symptomatic disease, later stages and more aggressive subtypes when compared to privately insured patients. (Source: Breast Cancer Research and Treatment)
Breast Cancer Research and Treatment
1w

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