Abstract A 64-year-old man was diagnosed with cholangiocellular carcinoma based on preoperative computed tomography and magnetic resonance imaging and underwent laparoscopic segmentectomy (Segment 8) of the liver for radical operation. Pathological examination revealed the presence of an undifferentiated carcinoma with osteoclast-like giant cells, which were categorized as T3N0M0 and Stage III based on the third English edition of the Japanese classification of liver cancer....
Abstract A 75-year-old man was admitted to our hospital for treatment of esophageal cancer (EC) in March 2017. Esophagogastroduodenoscopy revealed Barrett’s esophagus and superficial, distal EC (type 0-IIc). Tumor biopsy showed esophageal adenocarcinoma. Computed tomography revealed no lymph node metastasis but did reveal a 19-mm tumor on the right side of the urinary bladder. Bladder cancer (BC) was also suspected, and the patient underwent endoscopic submucosal dissection...
Abstract Nivolumab is one of the immune checkpoint inhibitors available for chemotherapy-resistant gastric cancer. There have been few reports of confirmed prominent shrinkage of the primary tumor and some reports of prolonged antitumor effect after discontinuance of the drug, but it is not universal. A 67-year-old male was admitted to our hospital and diagnosed with metastatic gastric cancer that had spread to the bilateral lobe of the liver, distant lymph nodes, and peritoneum....
Abstract A 68-year-old man was followed up with chronic kidney disease. Follow-up CT incidentally detected a tumor at the left kidney and multiple small nodular shadows in the lungs bilaterally. The patient underwent needle biopsy and was diagnosed with Xp11.2 translocation renal cell carcinoma (RCC) pathologically. Hence, laparoscopic nephrectomy was performed. Fluorescence in situ hybridization analysis revealed a break-apart of the transcription factor E3 (TFE3) genes in...
Abstract Reduced port laparoscopic radical nephrectomy (RPLRN) is an equivalent approach to conventional laparoscopic radical nephrectomy (LRN). In LRN, one wound generally needs to be extended for specimen extraction; therefore, some ingenuity is needed to achieve a good cosmetic outcome. We herein describe our initial experience of RPLRN using an umbilical zigzag skin incision for renal cell carcinoma (RCC). A 64-year-old female [body mass index (BMI): 20.0 kg/m2] was diagnosed...
Abstract Primary adenocarcinoma of the rete testis is an extremely rare tumor with a poor prognosis. Herein, we report a case of primary adenocarcinoma of the rete testis accompanied by elevated serum carbohydrate antigen 19-9 (CA19-9) antigen levels in a 44-year-old man who presented with left scrotal swelling. Para-aortic lymph node swelling was observed on the computed tomography scan. Germ cell tumor markers were within the normal range, but serum CA19-9 antigen levels were...
Abstract The prognosis of unresectable gastric cancer remains poor. Multidisciplinary treatment of unresectable gastric cancer is, therefore, thought to be essential for improving patients’ outcomes. Here, we report a successful case of multidisciplinary therapy for unresectable gastric cancer. The patient was a 69-year-old woman who was diagnosed with type 2 gastric cancer with remote lymph node metastases and peritoneal dissemination. Although shrinkage of the primary lesion...
Abstract We present a case of prostate-specific antigen (PSA) bounce in a 76 year old man who underwent salvage radiotherapy to the prostate bed following biochemical relapse 6 years post-radical prostatectomy for a T2N0 Gleason grade 3 + 3 prostate adenocarcinoma; 10 months following completion of salvage radiotherapy for biochemical PSA recurrence of 0.2 μg/L. Following undetectable results (<0.03 μg/L), his PSA rose from 0.04 to 0.3 μg/L with no evidence of prostate cancer...
Abstract Laparoscopic approaches have become a standard strategy for colon cancer patients who undergo surgical treatment. Complete mesocolic excision (CME) with central vascular ligation (CVL) is the fundamental principle of radical resection of colon cancers. Splenic flexure colon cancer (SFCC) is rare, accounting for less than 4% of all colorectal cancer cases. Moreover, a laparoscopic approach for SFCC following the CME/CVL concept can be challenging because the blood supply...
Abstract A 56-year-old male with stage IIIA (UICC 7th) non-small cell lung cancer (adenocarcinoma) received radiotherapy with 66 Gy/33 fractions concomitant with CBDCA and PTX. A partial response was achieved after chemoradiotherapy and the tumor continued to shrink over a period of 1 year; however, regrowth of the tumor attached to the aortic arch was observed without any other residual tumor or metastases. We diagnosed recurrence with slightly increased 18F-FDG uptake...
Abstract The purpose of this review with an additional case is to evaluate the clinical, ultrasonographic and histopathological features of a rare case of Amelanotic Malignant Melanoma (AMM) at mandibular gingiva and to compare our case with other published AMMs at mandibular gingiva. A 52-year-old male patient with no systemic diseases was referred to our clinic with a soft tissue lesion at mandibular gingiva. Ultrasonographic examination was performed and a lesion with malignant...
Abstract The dose-dense epirubicin and cyclophosphamide (EC) therapy for breast cancer decreases the risk of cancer recurrence and death. However, epirubicin and cyclophosphamide also cause cardiotoxicity, and cardiomyopathy is the most well-known related adverse effect. A 58-year-old woman presented to our hospital with palpitations 2 weeks after her final dose-dense EC therapy for breast cancer. Holter electrocardiogram (ECG) showed transitory complete atrioventricular block...
Abstract A 68-year-old man was diagnosed with non-muscle-invasive bladder cancer and underwent transurethral resection of the bladder tumor (TURBT) in June 2014. The pathological diagnosis was urothelial carcinoma (UC), Grade 2, pT1. He was treated with intravesical bacillus Calmette–Guérin (BCG) instillation after TURBT. In February 2016, he received anti-tuberculosis treatment for systemic BCG infection, and tuberculosis treatment was continued. In September 2018, he presented...
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Breast cancer subtypes are statistically associated with prognosis. The search for markers of breast tumor heterogeneity and the development of precision medicine for patients are the current focuses of the fi... (Source: World Journal of Surgical Oncology)
The lymphocytic population, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are prognostic tools predictive of adverse outcomes for several solid tumors and oncologic surgeries, on... (Source: World Journal of Surgical Oncology)
Malignant large-bowel obstruction (MLBO) is a highly urgent condition in colorectal cancer with high complication rates. Self-expandable metal stent (SEMS) placement in MLBO is a new decompression treatment in... (Source: World Journal of Surgical Oncology)
Patients with Graves ’ disease (GD) are at a 2.5 times higher risk of developing thyroid cancer than the general population. Previous studies reported conflicting results about the prognosis of thyroid cancer c... (Source: World Journal of Surgical Oncology)
Pancreaticoduodenectomy is the only definitively curative therapy for the long-term survival of distal cholangiocarcinoma patients. Lymph node metastasis is widely accepted as an important prognostic factor fo... (Source: World Journal of Surgical Oncology)
In cases of non-small cell lung cancer (NSCLC), surgery remains the best option for cure, but surgery is of benefit only when the disease is localized. Although adjuvant chemotherapy reportedly has a significa... (Source: World Journal of Surgical Oncology)
Approximately 30% of patients with colorectal cancer develop colorectal liver metastases (CRLM). CRLM that become undetectable by imaging after chemotherapy are called disappearing liver metastases (DLM). But ... (Source: World Journal of Surgical Oncology)
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lncRNAs and VEGF have been shown to have close connections with oral squamous cell carcinoma (OSCC). We explored the interaction between lncRNA NEAT1 and VEGF-A in OSCC. (Source: World Journal of Surgical Oncology)
Angiosarcoma occurs very rarely in the oral cavity, and the epithelioid type is even rarer. Here, we report a rare case involving an elderly man with a primary epithelioid angiosarcoma that originated from the... (Source: World Journal of Surgical Oncology)
Splenic marginal zone lymphoma (SMZL) is a rare non-Hodgkin lymphoma, and much little is known about its clinical characteristics and management strategies. Here we present a case of SMZL and review relevant l... (Source: World Journal of Surgical Oncology)
An amendment to this paper has been published and can be accessed via the original article. (Source: World Journal of Surgical Oncology)
No available meta-analysis was printed to systematically introduce the MPNST clinic outcome and risk factors based on largely pooled data. This systematic review and meta-analysis aimed to investigate 5-year O... (Source: World Journal of Surgical Oncology)
The examination of lymph nodes (LNs) plays an important role in the nodal staging of non-small cell lung cancer (NSCLC). For patients without LN metastasis, the main role of thorough LN examination is accurate... (Source: World Journal of Surgical Oncology)
Colorectal cancer (CRC) poses a heavy threat to human health owing to its high incidence and mortality. Circular RNAs (circRNAs) were investigated to participate in the progression of CRC, whereas there was no... (Source: World Journal of Surgical Oncology)
This study intended to determine important genes related to the prognosis and recurrence of breast cancer. (Source: World Journal of Surgical Oncology)
Post-chemotherapy retroperitoneal lymph node dissection (pc-RPLND) is one cornerstone in the clinical management of patients with nonseminomatous testicular germ cell tumours (GCT). A wide range of complicatio... (Source: World Journal of Surgical Oncology)
It is unknown whether transmediastinal esophagectomy (TME) is an acceptable surgical procedure for locally advanced esophageal squamous cell carcinoma (ESCC). Therefore, we investigated the feasibility of long... (Source: World Journal of Surgical Oncology)
It has been demonstrated that simultaneous resection of both primary colorectal lesion and metastatic hepatic lesion is a safe approach with low mortality and postoperative complication rates. However, there a... (Source: World Journal of Surgical Oncology)
In this study, we developed a new prognostic model for event-free... (Source: World Journal of Surgical Oncology)
Very rarely does a splenic solitary metastasis arise from a gastric carcinoma because splenic metastasis is usually seen in association with widespread visceral metastasis. Splenectomy is considered to be a cu... (Source: World Journal of Surgical Oncology)
Ganglioneuromas (GNs) are extremely rare, slowly growing, benign tumors that can arise from Schwann cells, ganglion cells, and neuronal or fibrous tissues. Due to their origin from the sympathetic neural crest... (Source: World Journal of Surgical Oncology)
The objective of this study was to evaluate the effectiveness of a novel, simple, and cheap s... (Source: World Journal of Surgical Oncology)
At present, amputation was widely adopted for young patients when limb salvage was deemed risky with several surgical strategy such as rotationplasty. However, leg length discrepancies and unfavorable cosmetic... (Source: World Journal of Surgical Oncology)
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Oncogenesis, Published online: 18 October 2020; doi:10.1038/s41389-020-00279-7Notch3 contributes to T-cell leukemia growth via regulation of the unfolded protein response
Oncogenesis, Published online: 17 October 2020; doi:10.1038/s41389-020-00277-9Aberrant super-enhancer landscape reveals core transcriptional regulatory circuitry in lung adenocarcinoma
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Publication date: Available online 18 October 2020Source: European Journal of Surgical OncologyAuthor(s): Bin Zhou, Jianwu Qin
Publication date: Available online 17 October 2020Source: European Journal of Surgical OncologyAuthor(s): Kieran Horgan
Publication date: Available online 16 October 2020Source: European Journal of Surgical OncologyAuthor(s): Evans T, Aziz O, Chakrabarty B, M.S. Wilson, Malcomson L, Lavelle C, S.T. O’Dwyer
Publication date: October 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 10, Part BAuthor(s):
Publication date: Available online 16 October 2020Source: European Journal of Surgical OncologyAuthor(s): Arthur K.E. Elfrink, Erik W. van Zwet, Rutger-Jan Swijnenburg, Marcel den Dulk, Peter B. van den Boezem, J. Sven D. Mieog, Wouter W. te Riele, Gijs A. Patijn, Wouter K.G. Leclercq, Daan J. Lips, Arjen M. Rijken, Cornelis Verhoef, Koert F.D. Kuhlmann, Carlijn I. Buis, Koop Bosscha, Eric J.T. Belt, Maarten Vermaas, N. Tjarda van Heek, Steven J. Oosterling, Hans Torrenga
Publication date: Available online 15 October 2020Source: European Journal of Surgical OncologyAuthor(s): Hong-Fan Ding, Xu-Feng Zhang, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Yi Lv, Timothy M. Pawlik
Publication date: Available online 15 October 2020Source: European Journal of Surgical OncologyAuthor(s): Roel Henneman, Winnie Schats, M.Baris Karakullukcu, Michiel WM. van den Brekel, Ludwig E. Smeele, Peter FJM. Lohuis, Jos A. van der Hage, Abrahim Al-Mamgani, Alfons JM. Balm
Publication date: Available online 15 October 2020Source: European Journal of Surgical OncologyAuthor(s): Sabrina Kahler-Ribeiro-Fontana, Eleonora Pagan, Francesca Magnoni, Elisa Vicini, Consuelo Morigi, Giovanni Corso, Mattia Intra, Fiorella Canegallo, Silvia Ratini, Maria Cristina Leonardi, Eliana La Rocca, Vincenzo Bagnardi, Emilia Montagna, Marco Colleoni, Giuseppe Viale, Luca Bottiglieri, Chiara Maria Grana, Jorge Villanova Biasuz, Paolo Veronesi, Viviana Galimberti
Publication date: Available online 15 October 2020Source: European Journal of Surgical OncologyAuthor(s): M. Bencivenga, L. Torroni, G. Verlato, V. Mengardo, M. Sacco, W.H. Allum, G. de Manzoni
Publication date: Available online 14 October 2020Source: European Journal of Surgical OncologyAuthor(s): Aditi Bhatt, Naoual Bakrin, Praveen Kammar, Sanket Mehta, Snita Sinukumar, Loma Parikh, Sakina Shaikh, Suniti Mishra, Mrinal Mallaya, Vahan Kepenekian, Nazim Benzerdjeb, Olivier Glehen
Publication date: Available online 14 October 2020Source: European Journal of Surgical OncologyAuthor(s): George S. Tamvakopoulos, Barry Rose, Asif Saifuddin, John A. Skinner, Robin Pollock
Publication date: Available online 14 October 2020Source: European Journal of Surgical OncologyAuthor(s): Andreas Brandl, Yutaka Yonemura, Olivier Glehen, Paul Sugarbaker, Beate Rau
Publication date: Available online 14 October 2020Source: European Journal of Surgical OncologyAuthor(s): Ahmet Namazov, Ofer Gemer, Nasreen Hag-Yahia, Ram Eitan, Oded Raban, Zvi Vaknin, Sophia Leytes, Ofer Lavie, Alon Ben-Arie, Amnon Amit, Tally Levy, Michael Volodarsky, Inbar Ben Shachar, Ilan Atlas, Ilan Bruchim, Limor Helpman
Publication date: Available online 13 October 2020Source: European Journal of Surgical OncologyAuthor(s): Tiphaine Moussilmani, Sophie Knight, Julien Mancini, Cyril Touboul, Florence Rodriguez, Pierre Adrien Bolze, Sofiane Bendifallah, Marcos Ballester, Pierre Collinet, Yohan Kerbage, Lobna Ouldamer, Geoffroy Atrous, Vincent Lavoué, Ludivine Dion, Yohann Dabi, Emilie Raimond, Olivier Graesslin, Cyrille Huchon, Myriam Mimouni, Alexandre Bricou
Publication date: Available online 13 October 2020Source: European Journal of Surgical OncologyAuthor(s): Simona Di Lascio, Enrico Tognazzo, Sara Bigiotti, Marta Bonollo, Alberto Costa, Olivia Pagani, Francesco Meani
Publication date: Available online 13 October 2020Source: European Journal of Surgical OncologyAuthor(s): Florin-Catalin Pop, Isabelle Veys, Sophie Vankerckhove, Romain Barbieux, Marie Chintinne, Michel Moreau, Vincent Donckier, Denis Larsimont, Pierre Bourgeois, Gabriel Liberale
Publication date: Available online 13 October 2020Source: European Journal of Surgical OncologyAuthor(s): A. Kakkos, C. Ver Eecke, S. Ongaro, K. Traen, F. Peeters, Ph Van Trappen, A. Laenen, E. Despierre, E. Van Nieuwenhuysen, I. Vergote, F. Goffin
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Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outco... (Source: Journal of Experimental and Clinical Cancer Research)
Glioblastoma is a common disease of the central nervous system (CNS), with high morbidity and mortality. In the infiltrate in the tumor microenvironment, tumor-associated macrophages (TAMs) are abundant, which... (Source: Journal of Experimental and Clinical Cancer Research)
Long noncoding RNA (lncRNA) Linc00337 has been implicated in lung, gastric, colorectal and esophageal squamous cell carcinoma progression via various mechanisms; however, its clinicopathological significance a... (Source: Journal of Experimental and Clinical Cancer Research)
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Experimental and Clinical Cancer Research)
Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that oncogene amplification via ecDNA is widespread across a diverse... (Source: Journal of Experimental and Clinical Cancer Research)
Despite the introduction of several novel therapeutic approaches that improved survival, metastatic castration-resistant prostate cancer (mCRPC) remains an incurable disease. Herein we report the synergistic a... (Source: Journal of Experimental and Clinical Cancer Research)
The X-linked gene WTX (also called AMER1) has been reported to function as a tumour suppressor gene in Wilms ’ tumour. In our previous study, WTX expression was shown to be significantly reduced in gastric canc... (Source: Journal of Experimental and Clinical Cancer Research)
Our previous study showed that calreticulin (CRT) promoted EGF-induced epithelial-mesenchymal transition (EMT) in pancreatic cancer (PC) via Integrin/EGFR-ERK/MAPK signaling. We next investigated the novel sig... (Source: Journal of Experimental and Clinical Cancer Research)
High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal prognosis with a median survival of le... (Source: Journal of Experimental and Clinical Cancer Research)
Even though new therapies are available against melanoma, novel approaches are needed to overcome resistance and high-toxicity issues. In the present study the anti-melanoma activity of Nicotinamide (NAM), the... (Source: Journal of Experimental and Clinical Cancer Research)
Inflammation response of epithelial mucosa to chemo- radiotherapy cytotoxic effects leads to mucositis, a painful side effect of antineoplastic treatments. About 40% of the patients treated with chemotherapy d... (Source: Journal of Experimental and Clinical Cancer Research)
Accumulating evidence indicates that long non-coding RNAs (lncRNAs) acting as crucial regulators in tumorigenesis. However, its biological functions of lncRNAs in colorectal cancer (CRC) have not been systemat... (Source: Journal of Experimental and Clinical Cancer Research)
Although the aberrant expression and function of most Ca2+-permeable channels are known to promote gastrointestinal tumors, the association between transient receptor potential vanilloid receptor 1 (TRPV1) channe... (Source: Journal of Experimental and Clinical Cancer Research)
Tumor angiogenesis is necessary for the continued survival and development of tumor cells, and plays an important role in their growth, invasion, and metastasis. The tumor microenvironment —composed of tumor ce... (Source: Journal of Experimental and Clinical Cancer Research)
The survival rate is poor in breast cancer patients with brain metastases. Thus, new concepts for therapeutic approaches are required. During metastasis, the cytoskeleton of cancer cells is highly dynamic and ... (Source: Journal of Experimental and Clinical Cancer Research)
N6-Methyladenosine (m6A) modification has been implicated in multiple processes for colon cancer development. IGF2BP3 was a newly reported m6A reader, whereas its role in colon cancer remains unclear. (Source: Journal of Experimental and Clinical Cancer Research)
Globally, colorectal cancer (CRC) affects more than 1 million people each year. In addition to non-modifiable and other environmental risk factors, Fusobacterium nucleatum infection has been linked to CRC recentl... (Source: Journal of Experimental and Clinical Cancer Research)
Although cisplatin-based chemotherapy represents the standard regimen for osteosarcoma (OS), OS patients often exhibit treatment failure and poor prognosis due to chemoresistance to cisplatin. Emerging researc... (Source: Journal of Experimental and Clinical Cancer Research)
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Experimental and Clinical Cancer Research)
SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in ... (Source: Journal of Experimental and Clinical Cancer Research)
Autophagic flux inhibition enhances cytotoxicity of the receptor tyrosine kinase inhibitor ponatinib
Despite reported advances, acquired resistance to tyrosine kinase inhibitors still represents a serious problem in successful cancer treatment. Among this class of drugs, ponatinib (PON) has been shown to have... (Source: Journal of Experimental and Clinical Cancer Research)
Glioblastoma is the most common primary malignant intracranial tumor with poor clinical prognosis in adults. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) function as important regulators... (Source: Journal of Experimental and Clinical Cancer Research)
Autophagy is an intracellular process through which intracellular components are recycled in response to nutrient or growth factor deficiency to maintain homeostasis. We identified the peptide autophagy-relate... (Source: Journal of Experimental and Clinical Cancer Research)
Advanced colorectal adenocarcinoma (CRAC), featured by distinctive histopathological appearance, distant organ metastasis, acquired chemoresistance, and tumorigenic stemness is a group of heterogeneous cancers... (Source: Journal of Experimental and Clinical Cancer Research)
Angiogenesis, a basic requirement for tumor cell survival, is considered to be a malignant characteristic of small cell lung cancer (SCLC) and is closely related to the poor outcomes of SCLC patients. miR-141 ... (Source: Journal of Experimental and Clinical Cancer Research)
Nuclear casein kinase and cyclin-dependent kinase substrate (NUCKS), a novel gene first reported in 2001, is a member of the high mobility group (HMG) family. Although very little is known regarding the biolog... (Source: Journal of Experimental and Clinical Cancer Research)
Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be in... (Source: Journal of Experimental and Clinical Cancer Research)
The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the mo... (Source: Journal of Experimental and Clinical Cancer Research)
Insulin-like growth factor 2 (IGF2) messenger RNA binding protein 3 (IMP3) has been testified to be overexpressed in prostate cancer and strongly related to patients ’ poor prognosis. However, the functions of ... (Source: Journal of Experimental and Clinical Cancer Research)
Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle t... (Source: Journal of Experimental and Clinical Cancer Research)
Exploitation of the protein degradation machinery as a therapeutic strategy to degrade oncogenic proteins is experiencing revolutionary advances with the development of proteolysis targeting chimeras (PROTACs)... (Source: Journal of Experimental and Clinical Cancer Research)
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ConclusionThe Twirl ™ followed by the Tumark® Q and Vision biopsy markers demonstrates the highest visibility scores using a four-point grading system and by radiologist vote. (Source: Breast Cancer Research and Treatment)
ConclusionsThis study demonstrated the absence of a pharmacokinetic interaction between green tea supplements and tamoxifen. Therefore, the use of green tea by patients with tamoxifen does not have to be discouraged. (Source: Breast Cancer Research and Treatment)
DiscussionImprovements in initial presentation of IBC are consistent with most having progressive growth, from cellular origin to palpable mass, the currently accepted biological model. Breast cancers identified earlier at initial diagnosis through screening mammography are characterized by smaller size, fewer axillary LNMs, better grade differentiation, and decreased mortality. Statistical analysis from these improved diagnostic parameters indicate that the majority of mortality decline from invasive...
ConclusionBreast cancer patients treated with trastuzumab in adjuvant setting seem to benefit from influenza vaccination in terms of immunogenicity without increasing the risk for adverse events. The current data support the recommendation to offer influenza vaccination in breast cancer patients treated with this type of targeted therapy. (Source: Breast Cancer Research and Treatment)
ConclusionsThis study supported BC etiologic heterogeneity across subtypes, particularly for triple negative. (Source: Breast Cancer Research and Treatment)
ConclusionsThe combination of vantictumab and weekly paclitaxel was generally well tolerated with promising efficacy; however, the incidence of fractures limits future clinical development of this particular WNT inhibitor in metastatic breast cancer.Clinical Trial Registration:ClinicalTrials.gov registration: NCT01973309 (Source: Breast Cancer Research and Treatment)
ConclusionFull-lengthBRCA1 andBRCA2 sequencing is strongly advised to Slavic subjects, who have medical indications forBRCA1 andBRCA2 testing but are negative for recurrentBRCA1 andBRCA2 mutations. (Source: Breast Cancer Research and Treatment)
ConclusionsThese findings support palbociclib plus endocrine therapy as standard of care for HR+ /HER2− ABC patients, regardless of baseline TFI/DFI or intrinsic molecular subtype, including patients with bone-only disease.Trial registrationPfizer (clinicaltrials.gov:NCT01740427, NCT01942135). (Source: Breast Cancer Research and Treatment)
ConclusionsThis study elucidates the impact of functional polymorphism rs11466313 in the regulatory region of TGFB1 on breast cancer susceptibility and gene expression, and could be helpful for future research to determine the value of this TGFB1 variant in the clinical setting. (Source: Breast Cancer Research and Treatment)
This article reviews the role of inflammation and high quality diet on the prevalence of psychoneurological symptoms clusters. (Source: Breast Cancer Research and Treatment)
ConclusionsThe overall survival rates for cancer patients have improved tremendously during the past 40 years, in part due to individually tailored therapies and screening programs. Our study revealed an increasing trend of OPPMs in breast cancer patients. (Source: Breast Cancer Research and Treatment)
ConclusionExercise training during anthracycline chemotherapy treatment had no effect on resting cardiac function but appeared to modify hemodynamic responses. Specifically, exercise training attenuated the drop in SVR in response to chemotherapy-related reductions in hematocrit potentially by increasing vessel lumen radius. (Source: Breast Cancer Research and Treatment)
ConclusionsLVA resulted in significant QoL improvement in upper and lower extremity lymphedema patients. Limb circumference did not significantly improve but good results concerning compression garments, cellulitis episodes, and MLD sessions were obtained. Additionally, a simple and patient-friendly method for outpatient ICG lymphography is presented. (Source: Breast Cancer Research and Treatment)
ConclusionFAM exercises do not increase the incidence of postoperative wound complications compared to RAM exercises.Trial registration: NCT03796845 (Source: Breast Cancer Research and Treatment)
ConclusionsThis study demonstrates an approach to create a real-world chemotherapy cohort suitable to serve as a comparator for trial data. These exploratory results suggest a survival advantage and place the benefit of abemaciclib monotherapy in clinical context. (Source: Breast Cancer Research and Treatment)
ConclusionsBLES allows accurate diagnosis of small invasive breast carcinomas. However, BLES cannot be considered as a therapeutic device for small invasive breast carcinomas due to not achieving adequate excision. (Source: Breast Cancer Research and Treatment)
ConclusionsHER2 positivity is related to the longer OS after SRS; however, we should pay attention to preventing recurrence in Luminal-HER2 patients. Also, TN patients require meticulous follow-up observation to detect distant metastases and/or LMD. (Source: Breast Cancer Research and Treatment)
ConclusionConsiderable heterogeneity was identified both among patients and between pre- and posttreatment samples.PIK3CA has the potential to be a predictive biomarker. To further assess the implications of a treatment related alteredPIK3CA mutation profile, more data are needed. (Source: Breast Cancer Research and Treatment)
ConclusionsPrior receipt of NAT was associated with inferior median PFS following first-line HER2-based therapy in the metastatic setting. However, prior NAT exposure did not significantly impact OS, supporting the efficacy of taxane, trastuzumab, pertuzumab combination for first-line HER2+ MBC regardless of prior NAT exposure. Patients with de novo MBC had the longest survival, suggesting stratification for synchronous versus metachronous disease in prospective clinical trials of MBC should be considered....
ConclusionAmong patients with 1 –2 + SLNs, ILC or other HST had similar rates of non-SLN metastasis compared with IDC. Omission of ALND may not influence adjuvant chemotherapy usage or disease outcome regardless of histological types. (Source: Breast Cancer Research and Treatment)
ConclusionThese findings suggest that lower expression of ADIPOQ, ADIPOR2, LEP, and LEPR in the breast TME might be indicators of more aggressive breast cancer phenotypes. Validation of these findings are warranted to elucidate the role of the adipokines and adipokine receptors in long-term breast cancer prognosis. (Source: Breast Cancer Research and Treatment)
ConclusionThe costs associated with metastatic HR+/HER2 − BC reflect a significant disease burden. Low endocrine treatment rates captured by the publicly funded system suggest guideline non-adherence or that a fair portion of Ontarian patients may be incurring out-of-pocket drug costs. (Source: Breast Cancer Research and Treatment)
ConclusionThis study showed that there is little association between statin use and second cancer risk in breast cancer patients. (Source: Breast Cancer Research and Treatment)
ConclusionTaken together, our results suggest that genetic ablation ofPZP results in tumor progression and low expression ofPZP is associated with poor survival of breast cancer patients. (Source: Breast Cancer Research and Treatment)
ConclusionsOur results establish that KDM1A inhibition mitigates CSCs functions via inhibition of STAT3 and EMT signaling, and KDM1A inhibitor NCD38 may represent a novel class of drug for treating TNBC. (Source: Breast Cancer Research and Treatment)
(Source: Breast Cancer Research and Treatment)
ConclusionsAge at menarche and, specially, at time of treatment are important risk factors for CRA. These variables could aid decision-making for treatment selection and fertility preservation among premenopausal women with early breast cancer. (Source: Breast Cancer Research and Treatment)
ConclusionWhile the presentation of CNS involvement was similar between the different age groups, younger patients had significantly longer CNS-free interval and longer overall survival, and for the subgroups of triple-negative patients, younger age at breast cancer diagnosis was associated with longer survival after diagnosis of CNS disease. (Source: Breast Cancer Research and Treatment)
Effect of isoflavones on breast cancer cell development and their impact on breast cancer treatments
ConclusionsWe confirmed that equol has dual action, specifically a tumor growth-promoting effect and an antitumor effect. Although the results suggested that equol might exert an antagonistic effect against tamoxifen depending on the concentration, equol did not exert an antagonistic effect on other therapeutic agents. (Source: Breast Cancer Research and Treatment)
ConclusionsIBC survival has increased over four decades. Despite the improvement in survival for all racial groups, a persistent survival disparity that has not narrowed over two decades remains between white and black patients. (Source: Breast Cancer Research and Treatment)
ConclusionWhile patients who undergo mastectomy have less long-term breast satisfaction, all patients can expect to experience similar improvements in anxiety and PSWB. Efforts should be made to ensure that patients are informed and confident regardless of which surgery is chosen, for this is the greatest predictor of better outcomes. (Source: Breast Cancer Research and Treatment)
ConclusionsEnhanced assessment with CEUS before NACT identifies patients with axillary metastases missed by conventional B-mode ultrasound. Without CEUS, 22 (63%) of cases in Group B (negative B-mode ultrasound) may have been erroneously classed as progressive disease by surgical SLN excision after NACT. (Source: Breast Cancer Research and Treatment)
(Source: Breast Cancer Research and Treatment)
ConclusionsEribulin is active in HER2 − breast cancer. This study reveals that provider-assessed AEs can vary greatly from patient experiences. Future studies should incorporate CTCAE and PRO instruments to improve reporting of treatment-related AEs.ClinicalTrials.gov Registration: NCT01827787 (Source: Breast Cancer Research and Treatment)
ConclusionIt is feasible to mark the axillary node with carbon dye and identify it intra-operatively.ClinicalTrials.gov: NCT03640819. (Source: Breast Cancer Research and Treatment)
ConclusionOur multivariate model using lesion size, needle size and patient age had a high diagnostic performance in decreasing unnecessary surgeries and shows promise as a decision support tool. (Source: Breast Cancer Research and Treatment)
ConclusionsThere was a positive relationship between obesity and breast cancer in postmenopausal women, and an inverse association in premenopausal women. (Source: Breast Cancer Research and Treatment)
ConclusionDetermining the specific immune response in each subtype could be helpful in estimating the possible behavior of the tumor cells in TME. It is important to realize that different frequencies of immune cells in BC environment likely determine the patients ’ prognosis and their survival in each subtype. Therefore, elucidation of the distinct immune players in TME would be helpful toward developing targeted therapies in each subtype. (Source: Breast Cancer Research and Treatment)
ConclusionsThese findings indicate a prospective surveillance model of care in the home with BIS is feasible and associated with increased self-management. A Phase II randomised trial is warranted as well as research exploring the costs associated with implementing this model of care for high-risk individuals. (Source: Breast Cancer Research and Treatment)
ConclusionsER β2/ERβ5 and ERβ1 exhibit sharply contrasting activities in TNBC cells. Our findings imply that delineating the absolute amounts and relative ratios of the different ERβ isoforms might have prognostic and therapeutic relevance, and could enable better selection of optimal approaches for treatment of this often aggressive form of breast cancer. (Source: Breast Cancer Research and Treatment)
ConclusionsThese findings support the safety of omitting ALND in selected patients with ILC. Further studies of axillary management in ILC and imaging tools to predict nodal involvement and therapeutic response are warranted. (Source: Breast Cancer Research and Treatment)
ConclusionBDNF plasma level or rs6265 genotype information may facilitate the identification of patients at higher risk of long-term CRCI during survivorship and enable the implementation of early intervention strategies that increase BDNF levels. (Source: Breast Cancer Research and Treatment)
ConclusionVariation in the metabolism of exemestane through theUGT2B17-mediated pathway is associated with subsequent risk of commonly reported symptoms in MAP.3. (Source: Breast Cancer Research and Treatment)
ConclusionPatients with pure ALH with radiographic concordance have a low risk of pathologic upgrading on excisional biopsy. Potential predictors of upgrade rate warrant further analysis in a larger dataset. (Source: Breast Cancer Research and Treatment)
ConclusionsGenomic analysis of paired pre- and post-therapy samples resulting from neoadjuvant therapy provides a powerful method for identification of mediators of response. Genes we identified should be assessed as predictive markers or targets in chemo-sensitization. (Source: Breast Cancer Research and Treatment)
ConclusionsLO exposes a redox vulnerability of TNBC cells to TXNRD inhibition by rendering tumor cells dependent on the thioredoxin antioxidant pathway for survival. (Source: Breast Cancer Research and Treatment)
ConclusionsChoice for CPM was associated with higher minor complications, but led to improved psychosocial well-being without a higher degree of patient-reported financial toxicity. Prospective studies are needed to discern the influence of CPM on the incidence and trajectory of financial toxicity. (Source: Breast Cancer Research and Treatment)
ConclusionsOur data indicate a high rate of non-adherence to guidelines, physicians recommending extensive systemic evaluation for women with early breast cancer. These deviations from the guidelines are associated with subjective factors, some of them being physician-dependent. Initiatives aimed at improving adherence to g uidelines, and specifically to guidelines recommending"doing less" should therefore include not just knowledge-based education but also encourage conversation about what is appropriate...
ConclusionHigh-grade TB is enriched in hormone receptor-positive BC and is associated with known adverse prognostic variables. TB may offer new insights into the metastatic process of BC. (Source: Breast Cancer Research and Treatment)
ConclusionsTTC-352 demonstrates safety and early clinical evidence of antitumor activity against heavily pretreated hormone-refractory breast cancer. Based upon TTC-352 plasma concentrations and tolerability, the 180 mg twice a day is recommended for further testing.(ClinicalTrials.gov Identifier: NCT03201913) (Source: Breast Cancer Research and Treatment)
ConclusionsPatients with public health coverage were diagnosed with symptomatic disease, later stages and more aggressive subtypes when compared to privately insured patients. (Source: Breast Cancer Research and Treatment)
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