Τρίτη 20 Οκτωβρίου 2020

 

Next-generation sequencing of circulating tumor DNA for metastatic non-small cell lung cancer: a discussion on its implementation in the Brazilian clinical practice
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
6d
Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
6d
Targeting FGFR2 in advanced cholangiocarcinoma: an interview with Arndt Vogel
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
High preoperative levels of circulating SFRP5 predict better prognosis in colorectal cancer patients
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Pemigatinib, a potent inhibitor of FGFRs for the treatment of cholangiocarcinoma
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Exploratory analysis of the platelet-to-lymphocyte ratio prognostic value in the adjuvant renal cell cancer setting
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Integrating the melanoma 31-gene expression profile test to surgical oncology practice within national guideline and staging recommendations
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Comparative effectiveness study of chemotherapy in follicular lymphoma patients in the rituximab era: a Japanese claims database study
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Effect of comorbidities/comedications on sunitinib outcomes for metastatic renal cell carcinoma: the STAR-TOR registry
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Pembrolizumab plus axitinib combination and the paradigm change in the treatment of advanced renal cell carcinoma
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Healthcare utilization and total costs of care among patients with advanced metastatic gastric and esophageal cancer
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Development of a prognostic model based on an immunogenomic landscape analysis of colorectal cancer
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Liquid biopsy for ALK-positive early non-small-cell lung cancer predicts disease relapse
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Brigatinib in ALK-positive non-small cell lung cancer: real-world data in the Latin American population (Bri-world extend CLICaP)
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Long noncoding RNA ANRIL as a novel biomarker in human cancer
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
A Phase III study of zanubrutinib plus rituximab versus bendamustine plus rituximab in transplant-ineligible, untreated mantle cell lymphoma
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Gilteritinib use in the treatment of relapsed or refractory acute myeloid leukemia with a FLT3 mutation
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Role of indoleamine 2,3-dioxygenase in acute myeloid leukemia
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Clinical applications of circulating tumor DNA in monitoring breast cancer drug resistance
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Demographic factors associated with missed follow-up among solid tumor patients treated at a large multi-site academic institution
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
A theoretical model of financial burden after cancer diagnosis
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Alpelisib in the treatment of metastatic HR+ breast cancer with PIK3CA mutations
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Consensus paper: current state of first- and second-line therapy in advanced clear-cell renal cell carcinoma
Future Oncology, Volume 16, Issue 29, Page 2307-2328, October 2020.
Future Medicine: Future Oncology: Table of Contents
1w
Indirect analysis of first-line therapy for advanced non-small-cell lung cancer with activating mutations in the Japanese population
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
REVIVE study: a prospective observational study in chemotherapy after nivolumab therapy for advanced gastric cancer
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Polatuzumab vedotin, an anti-CD79b antibody–drug conjugate for the treatment of relapsed/refractory diffuse large B-cell lymphoma
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Physician treatment of metastatic triple-negative breast cancer in the immuno-oncology era: a discrete choice experiment
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
PIVOT-10: Phase II study of bempegaldesleukin plus nivolumab in cisplatin-ineligible advanced urothelial cancer
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Afatinib for the first-line treatment of EGFR mutation-positive NSCLC in China: a review of clinical data
Future Oncology, Ahead of Print.
Future Medicine: Future Oncology: Table of Contents
1w
Collaborative Approaches to Engineer Biology for Cancer Applications (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-CA-20-054 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) invites applications to develop and apply innovative synthetic biology approaches to address challenges across the spectrum of cancer research. Projects will be required to apply a technology, based on an engineered biological system, to an important and well-defined cancer research question. Collaborative transdisciplinary teams are expected with PIs representing expertise...
MedWorm Cancer & Oncology Funding
1d
New Cohorts for Environmental Exposures and Cancer Risk (CEECR) Coordinating Center (U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-CA-20-050 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) and National Institute of Environmental Health Sciences (NIEHS) will support a Coordinating Center to facilitate coordination across the new Cohorts for Environmental Exposures and Cancer Risk (CEECR) (see UG3/UH3 phased awards supported under companion RFA-CA-20-049). The overarching goal of the CEECR is to support innovative scientific...
MedWorm Cancer & Oncology Funding
6d
New Cohorts for Environmental Exposures and Cancer Risk (CEECR; UG3/UH3 Clinical Trial Not Allowed)
Funding Opportunity RFA-CA-20-049 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications to support innovative scientific research in new prospective cohorts that addresses knowledge gaps in cancer etiology and carcinogenesis process with a focus on environmental exposures. Applicants are encouraged to use validated and reproducible innovative techniques to measure environmental exposures relevant...
MedWorm Cancer & Oncology Funding
6d
Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3 Clinical Trials Not Allowed)
Funding Opportunity PAR-20-314 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to accelerate the adoption and validation of molecular/cellular/imaging markers (referred to as "markers" or "biomarkers") and assays for cancer detection, diagnosis, prognosis, monitoring, and prediction of response or resistance to treatment, as well as markers for cancer prevention and control. This FOA will also support the validation of pharmacodynamic markers...
MedWorm Cancer & Oncology Funding
6d
Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH2/UH3 Clinical Trial Not Allowed)
Funding Opportunity PAR-20-313 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications to support the validation of molecular/cellular/imaging markers (referred to as "markers" or "biomarkers") and assays for cancer detection, diagnosis, prognosis, monitoring, and prediction of response or resistance to treatment, as well as markers for cancer prevention and control. This FOA will support investigator-initiated...
MedWorm Cancer & Oncology Funding
6d
The Incidence of Adjacent Synchronous Invasive Carcinoma and/or Ductal Carcinoma In Situ in Patients with Intraductal Papilloma without Atypia on Core Biopsy: Results from a Prospective Multi-Institutional Registry (TBCRC 034).
CONCLUSION: In this prospective study of 116 IPs without atypia on CB, the upgrade rate was 1.7% by local review, suggesting that routine excision is not indicated for IP without atypia on CB with concordant imaging findings. PMID: 33047246 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Ann Oncol
1d
ASO Author Reflections: What will be Required to Safely Omit Breast Surgery for Early-Stage Breast Cancer?
Authors: Ishitobi M, Hayashi N PMID: 33047247 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Ann Oncol
1d
Safety and Oncological Benefit of Hepatopancreatoduodenectomy for Advanced Extrahepatic Cholangiocarcinoma with Horizontal Tumor Spread: Shinshu University Experience.
CONCLUSIONS: HPD is a valid treatment option for extensive cholangiocarcinoma, offering long-term survival benefit at the cost of relatively high but acceptable morbidity and mortality rates. HPD is advocated in selected patients provided that it is considered possible to achieve R0 resection. PMID: 33044629 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Ann Oncol
6d
Stratification of Postoperative Prognosis by Invasive Tumor Thickness in Perihilar Cholangiocarcinoma.
CONCLUSION: ITT could be measured using simple methods and may be used to stratify postoperative prognosis in patients with PHCC. PMID: 33040247 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Ann Oncol
6d
ASO Author Reflections: How Does Social Vulnerability Impact Hospice Utilization Among Patients Undergoing Cancer Surgery?
Authors: Abbas A, Pawlik TM PMID: 33037536 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Ann Oncol
6d
Dose-Finding Study of a CEA-Targeting Agent, SGM-101, for Intraoperative Fluorescence Imaging of Colorectal Cancer.
CONCLUSIONS: The optimal imaging dose was established at 10 mg 4 days before surgery. The results accentuate the potential of SGM-101 and designated a promising base for the multinational phase III study, which enrolled the first patients in June 2019. PMID: 33034788 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Ann Oncol
1w
ASO Author Reflections: Fluorescence-Guided Surgery in Gynecology Becomes a Standard.
Authors: Gorostidi M, Zapardiel I PMID: 33034789 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Ann Oncol
1w
Bilateral Disease Common Among Slovenian CHEK2-Positive Breast Cancer Patients.
CONCLUSION: Bilateral BC was diagnosed in as many as 19.5% of the Slovenian BC patients with CHEK2 PV/LPVs. Breast cancer associated with a germline CHEK2 PV/LPV occurs in younger patients compared with sporadic BC. PMID: 33030641 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Ann Oncol
1w
Clinical Sequencing of High-Grade Undifferentiated Sarcomas: A Case Series and Report of an Aggressive Primary Cardiac Tumor With Multiple Oncogenic Drivers.
Authors: Kumar-Sinha C, Anderson B, Heider A, Vo JN, Robinson DR, Wu YM, Chinnaiyan AM, Mody R PMID: 33015523 [PubMed] (Source: Ann Oncol)
Ann Oncol
1w
Characterization of Extracapsular Lymph Node Involvement and Its Clinicopathological Characteristics in Stage II-IIIA Lung Adenocarcinoma.
CONCLUSIONS: Our data suggest that ECLNI remains a strong prognosticator of unfavorable OS and RFS for LUADs in the context of the eighth edition N classification. Adjuvant radiation should be actively considered for pN1b and pN2 LUAD patients with ECLNI presence. PMID: 33015723 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Ann Oncol
1w
Comments on "Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma".
Comments on "Electrochemotherapy with Irreversible Electroporation and FOLFIRINOX Improves Survival in Murine Models of Pancreatic Adenocarcinoma". Ann Surg Oncol. 2020 Oct 04;: Authors: Granata V, Fusco R, Palaia R, Belli A, Petrillo A, Izzo F PMID: 33011913 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Ann Oncol
1w
Ann Oncol; +34 new citations
34 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2020/10/01PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
Ann Oncol
1w
Radiation Fractionation Schedules Published During the COVID-19 Pandemic: A Systematic Review of the Quality of Evidence and Recommendations for Future Development.
CONCLUSIONS: A large number of publications recommended hypofractionated radiation therapy schedules across numerous major disease sites during the COVID-19 pandemic, which were supported by a lower quality of evidence than the highest-quality routinely used dose fractionation schedules. This work provides an evidence-based assessment of these potentially practice-changing recommendations and informs individualized decision-making and counseling of patients. These data could also be used to support...
Ann Oncol
1w
To Evaluate the Accuracy of Axillary Staging Using Ultrasound and Ultrasound-Guided Fine-Needle Aspiration Cytology (USG-FNAC) in Early Breast Cancer Patients—a Prospective Study
Abstract In breast cancer, axillary lymph node involvement directly impacts the patient survival and prognosis. Sentinel lymph node biopsy (SLNB) is a procedure of choice for axillary staging in early breast cancer. Currently, management options for axilla management are axillary lymph node dissection and sentinel node biopsy in node positive and in node negative respectively. Accuracy of current clinical methods for evaluating axilla is low. Hence, to select patients for appropriate...
Latest Results for Indian Journal of Surgical Oncology
1d
Outcomes of Cancer Surgery During the COVID-19 Pandemic: Preparedness to Practising Continuous Cancer Care
Abstract The COVID-19 pandemic has placed unprecedented pressure on healthcare services. Deprioritisation of nonemergency clinical services and growing concerns of adverse outcomes of COVID-19 in cancer patients is having a deleterious impact across oncologic practice. We report cancer surgery outcomes taking into account the acuity of the COVID-19 situation. A prospectively maintained database of the Department of Surgical Oncology was analysed from 1st May to 30th June, 2020,...
Latest Results for Indian Journal of Surgical Oncology
2d
Expression of PDL1 and Her2neu in Gastric and Gastroesophageal Junction Adenocarcinoma
Abstract The process of tumorigenesis in gastric carcinoma involves multiple genetic alterations including overexpression of PD-L1, amplification of Her2neu, and mutation of p53. In the present study, the expressions of PD-L1 and Her2neu were analyzed in relation to clinicopathological parameters including p53 in gastric and gastroesophageal junction adenocarcinoma. We examined 100 biopsy and resection samples of gastric and gastroesophageal junction carcinomas for PD-L1, Her2neu,...
Latest Results for Indian Journal of Surgical Oncology
5d
Colorectal Services in Covid-19 Times: Minimally Invasive Surgery and Enhanced Recovery, the Need of the Hour
Abstract The health services across the world have been deeply impacted by the ongoing COVID-19 pandemic which has resulted in diversion of resources to testing, isolating and treating COVID-19 patients. This meant cutting down resources and manpower away of various healthcare facilities and severely hampering the functioning of various cancer services across the world. It is however, important to understand, cancer itself is a life-threatening condition, and there is a need to...
Latest Results for Indian Journal of Surgical Oncology
1w
A Retrospective Cohort Study of Coexistence of Carcinoma and Tuberculosis of Colon: 12-Year Experience
Abstract Coexistence of carcinoma colon and tuberculosis is rare. The aim of this study is to present our 12-year experience on colonic carcinoma with coexisting colonic TB. Histopathology and imaging records of 189 patients of colonic carcinoma patients who underwent treatment in surgical unit 6 in our institute between January 2006 and December 2017 were reviewed. In 7 patients, histopathology and/or imaging studies were suggestive of coexistence of colonic carcinoma and tuberculosis....
Latest Results for Indian Journal of Surgical Oncology
1w
A Case Series on Malignant Peripheral Nerve Sheath Tumour of Cervix: an Institutional Report
Latest Results for Indian Journal of Surgical Oncology
1w
𝛽-Catenin—a Possible Prognostic Molecular Marker for Recurrence in Histopathologically Negative Surgical Margin of Oral Cancer
Abstract The locoregional recurrence in oral cancer is not predicted by the histopathological parameters solely as the normal morphological looking cells harbor the genomic instability which acts as the potential tumor cells for recurrence in future. Therefore, there is an urgent need of the biomarker for prognostic stratification of patients with high risk of disease recurrence and appropriate management. Eighty oral squamous cell carcinoma (OSCC) patients were included in the...
Latest Results for Indian Journal of Surgical Oncology
1w
Low Cost, Low Dose, Oral, Neoadjuvant Chemotherapy Protocol in Locally Advanced Borderline Oral Cancers—Feasibility Study
Abstract A vast majority of oral cancer patients in developing countries present in an advanced stage with borderline resectable/inoperable stage to busy resource-constrained tertiary cancer centers. Conventional chemotherapy protocols are associated with issues like toxicity, tolerance, cost, and compliance. The present study was conducted to assess the feasibility of low-cost home-based chemotherapy options. Single-arm feasibility study was done in borderline resectable/inoperable...
Latest Results for Indian Journal of Surgical Oncology
1w
Bilateral Symmetric Sporadic Osteofibrous Dysplasia: an Unusual Case
Latest Results for Indian Journal of Surgical Oncology
1w
Bilobed PMMC in Females: Our Challenging yet Meritorious Experience
Abstract The gold standard reconstructive options for full-thickness defect of the oral cavity after resection of malignant lesions are the free flaps. But in developing nations due to resource constraints, it cannot be offered to all. Hence, pectoralis major myocutaneous (PMMC) flap as bilobed flaps is most commonly used. Bilobed flaps are technically demanding, and in females, it is more challenging due to higher complication rates especially in large breasts. There has been...
Latest Results for Indian Journal of Surgical Oncology
1w
Osteosarcoma with Tongue Metastasis: a Rare Case Report
Latest Results for Indian Journal of Surgical Oncology
1w
Case Report Writing
Latest Results for Indian Journal of Surgical Oncology
1w
Validation of Sentinel Lymph Node Biopsy Technique Using Dual Tracer Technique in Post Lumpectomy Early Breast Cancer Patients
Abstract Sentinel lymph node biopsy (SLNB) is the gold standard for the evaluation of axilla in clinically node-negative early breast cancers. There is limited data on the role and efficacy of the same in the post lumpectomy scenario. This prospective interventional study was conducted over 1 year on 30 post lumpectomy pT1/2 cN0 patients. SLNB was performed by preoperative lymphoscintigram using technetium-labeled human serum albumin followed by intraoperative blue dye injection....
Latest Results for Indian Journal of Surgical Oncology
1w
Who Needs Level III Lymph Node Dissection in Carcinoma Breast—Study from a Tertiary Care Center
Abstract In Indian females, breast cancer is the most common cancer with a late stage of presentation leading to one-third of patients undergoing modified radical mastectomy (MRM). Our study is undertaken to find out predictors of level III axillary lymph node metastasis in breast cancer and who needs complete axillary lymph node dissection (ALND). Retrospective study of 146 patients who undergone MRM or breast-conserving surgery (BCS) with complete ALND at Kidwai Memorial Institute...
Latest Results for Indian Journal of Surgical Oncology
1w
Bilateral Primary Ovarian Clear Cell Carcinoma in an Iranian Woman: a Case Report
Latest Results for Indian Journal of Surgical Oncology
1w
Delayed Management of Chemoport Complication
Latest Results for Indian Journal of Surgical Oncology
1w
Surgical and Oncological Outcomes in Locally Advanced Thymoma
Abstract This study aimed at reporting the surgical management of locally advanced thymoma (Masaoka stages III and IVA) and evaluating the factors predicting the survival. This is a retrospective analysis of patients operated for locally advanced thymoma from March 2012 to December 2019 in a thoracic surgery center in India. An analysis of all perioperative variables including complications was carried out. The influence of various predictors on survival was assessed by log-rank...
Latest Results for Indian Journal of Surgical Oncology
1w
Pattern of Lymph Node Metastasis in Endometrial Cancer: a Single Institution Experience
Abstract Surgical staging remains the standard primary treatment of endometrial cancer. Lymph node metastasis is the most important prognostic factor which helps in deciding adjuvant treatment. Extensive lymphadenectomy is associated with increased incidence of morbidity. The role of lymphadenectomy in surgical staging is still controversial especially in early stage disease. The surgico-pathological pattern of 155 patients with apparently stage 1 cancer endometrium who had undergone...
Latest Results for Indian Journal of Surgical Oncology
1w
Treatment Outcomes of Early Carcinoma Cervix Before and After Sub-specialization
Abstract This study aimed to compare the treatment outcomes in carcinoma cervix before and after gynecologic oncology sub-specialization at a tertiary care hospital, in India. This was a retrospective cohort study comparing women with operable cervical cancer who underwent radical hysterectomy before and after gynecologic oncology sub-specialization. Electronic medical records of women operated for early carcinoma cervix between 2001 and 2010 and 2011–2015 were reviewed and compared...
Latest Results for Indian Journal of Surgical Oncology
1w
Role of Prophylactic Coronoidectomy in Oral Cancer Treatment: a Retrospective Cohort Study
Abstract To evaluate the effectiveness of coronoidectomy to prevent trismus in patients undergoing primary surgery for oral cancer. Patients who underwent primary surgery for oral gingivo-buccal cancers were analysed. Group 1 (G1) consists of patients who underwent coronoidectomy during the primary ablative procedure and group 2 (G2) who underwent standard ablative surgery without coronoidectomy. Post-treatment maximum interincisor opening was compared between the two groups....
Latest Results for Indian Journal of Surgical Oncology
1w
COVID-19 Outbreak and Oncological Surgery Practice
Abstract The emergence of COVID-19 has caused a global public health emergency. With the World Health Organization (WHO) reporting the novel coronavirus outbreak a pandemic, the focus is needed on the influence of this rapidly spreading viral infection on cancer patients. In this study, we aimed to address cancer-related operations during the COVID-19 outbreak. We retrospectively reviewed 26 patients who had undergone cancer surgeries admitted from March 13 to May 13, 2020, during...
Latest Results for Indian Journal of Surgical Oncology
1w
Neurovascular Complications After Neck Dissection: a Prospective Analysis at a Tertiary Care Centre in South India
Abstract Owing to high incidence of oral cancers in India, neck dissection is the most commonly performed procedure in any head and neck oncology setup. This surgery is particularly prone to various neurovascular complications due to intricate anatomy of neck, but the exact incidence has been studied less especially in Indian subcontinent. A prospective observational study was done on 105 patients of oral cancer who underwent neck dissection at Regional Cancer Centre, Trivandrum,...
Latest Results for Indian Journal of Surgical Oncology
1w
A Novel and Simple Technique of Reconstructing the Central Arch Mandibular Defects—a Solution During the Resource-Constrained Setting of COVID Crisis
Abstract The current COVID 19 pandemic has a major impact on healthcare delivery globally. Oral cancer involving anterior arch of mandible is difficult to reconstruct and ideally, requires free fibular osteomyocutaneous flap. During this time of resource constraint situation, these free flaps are not a great choice, as it increases exposure of both patient and surgical team to the deadly virus. We are describing a novel method of reconstruction after resection of oral cancer involving...
Latest Results for Indian Journal of Surgical Oncology
1w
Combination of levetiracetam and IFN-α increased temozolomide efficacy in MGMT-positive glioma
Abstract Purpose Glioma, especially glioblastoma (GBM), is the most aggressive malignant brain tumor and its standard therapy is often ineffective because of temozolomide (TMZ) resistance. Reversal of the TMZ resistance might improve the prognosis of glioma patients. We previously found that interferon-α (IFN-α) and anti-epileptic drug levetiracetam (LEV) could sensitize glioma to TMZ, respectively. In this study, we further investigated...
Latest Results for Cancer Chemotherapy and Pharmacology
1d
All-oral metronomic DEVEC schedule in elderly patients with peripheral T cell lymphoma
Abstract Purpose Peripheral T cell lymphomas (PTCLs) have an overall poor prognosis. Indeed, registry data in elderly patients show that the median progression-free survival (mPFS) following first- and second-line therapies are only 6.7 and 3.1 months, respectively. The aim of the study is to show the activity of metronomic chemotherapy, a regular administration of low chemotherapeutic drug doses allowing a favourable toxicity profile,...
Latest Results for Cancer Chemotherapy and Pharmacology
2d
Exosomal miR-1246 and miR-155 as predictive and prognostic biomarkers for trastuzumab-based therapy resistance in HER2-positive breast cancer
Abstract Purpose This study aimed to investigate the predictive and prognostic roles of circulating exosomal miRNAs in breast cancer treated with trastuzumab-based chemotherapy. Methods Circulating exosomal miRNAs from trastuzumab-resistant (n = 4) and -sensitive (n = 4) patients were profiled using miRNA microarray. The predictive and prognostic roles...
Latest Results for Cancer Chemotherapy and Pharmacology
3d
Carboplatin re-treatment in platinum-resistant epithelial ovarian cancer patients
Abstract Purpose Treatment of multi-resistant epithelial ovarian cancer represents a clinical challenge with limited choices. Anti-angiogenic therapy has shown great potential in combination with frontline-therapy. Studies investigating heavily pre-treated patients are few. This study investigated the effect of re-treating patients with carboplatin combined with bevacizumab and cell-free DNA (cfDNA) as a potential predictor of outcome....
Latest Results for Cancer Chemotherapy and Pharmacology
4d
Urine NGAL and KIM-1: tubular injury markers in acute lymphoblastic leukemia survivors
Abstract Introduction Nephrotoxicity is a potential adverse effect of anticancer treatment in childhood. Cytostatics, abdominal radiotherapy, total body irradiation (TBI) and some agents used in supportive care may induce acute kidney injury (AKI) or lead to chronic kidney disease (CKD). The aim of this study was to test the hypothesis whether urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL)...
Latest Results for Cancer Chemotherapy and Pharmacology
6d
Chronic exercise training attenuates prostate cancer-induced molecular remodelling in the testis
Abstract Purpose Prostate cancer is a major cause of cancer-related death in males worldwide and, in addition to impairing prostate function, also causes testicular adaptations. In this study, we aim to investigate the preventive effect of exercise training on PCa-induced testicular dysfunction. Methods As a model, we used fifty Wistar Unilever male...
Latest Results for Cellular Oncology
1d
Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A
Abstract Purpose Deubiquitination, the inverse process of ubiquitination, is catalyzed by deubiquitinases (DUBs) that remove ubiquitin from target proteins and subsequently prevent their degradation by proteasomes. Previously, deubiquitination has been found to be involved in hepatocellular carcinoma (HCC) progression. As yet, however, little is known about the exact role of deubiquitination in the development and/or progression of...
Latest Results for Cellular Oncology
2d
Role of CK2 inhibitor CX-4945 in anti-cancer combination therapy – potential clinical relevance
Abstract Background Protein kinase CK2 inhibition has long been considered as an attractive anti-cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is frequently over-expressed in human tumours and its over-expression correlates with a worse prognosis. Preclinical evidence strongly supports the feasibility of this target and, although dozens of CK2 inhibitors have been described in the literature...
Latest Results for Cellular Oncology
6d
Circular RNA circ-102,166 acts as a sponge of miR-182 and miR-184 to suppress hepatocellular carcinoma proliferation and invasion
Abstract Purpose Multiple circular RNAs (circRNAs) have been reported to be dysregulated in hepatocellular carcinoma (HCC). However, their functions and modes of action are still largely unclear. Identifying key circRNAs and revealing their potential functions and molecular mechanisms is considered important for improving the diagnosis and treatment of HCC. Methods ...
Latest Results for Cellular Oncology
1w
BRD4 modulates vulnerability of triple-negative breast cancer to targeting of integrin-dependent signaling pathways
Abstract Purpose Stemming from a myriad of genetic and epigenetic alterations, triple-negative breast cancer (TNBC) is tied to poor clinical outcomes and aspires for individualized therapies. Here we investigated the therapeutic potential of co-inhibiting integrin-dependent signaling pathway and BRD4, a transcriptional and epigenetic mediator, for TNBC. Methods ...
Latest Results for Cellular Oncology
1w
LncRNA ZNF503-AS1 acts as a tumor suppressor in bladder cancer by up-regulating Ca 2+ concentration via transcription factor GATA6
Abstract Purpose Ca2+ homeostasis plays a pivotal role in regulating proliferation and apoptosis during cancer development. This study intended to examine the potential tumor-suppressing role of ZNF503 antisense RNA 1 (ZNF503-AS1) in bladder cancer, which may be implicated in the regulation of Ca2+ homeostasis. Methods Differentially expressed long...
Latest Results for Cellular Oncology
1w
NF-κB-mediated miR-650 plays oncogenic roles and activates AKT/ERK/NF-κB pathways by targeting RERG in glioma cells
Abstract Purpose Glioma is the most common cancer in the central nervous system and has a high mortality rate. Despite advances that have been made in the treatment of glioma, its prognosis still remains poor. Dysregulation of miRNAs has been reported in many cancers, including glioma. Here, we set out to assess the role of miR-650 in glioma, including its diagnostic and therapeutic potential. ...
Latest Results for Cellular Oncology
1w
Enhanced migration of breast and lung cancer cells deficient for cN-II and CD73 via COX-2/PGE2/AKT axis regulation
Abstract Purpose Purine metabolism involves various intracellular and extracellular enzymes, including cN-II and CD73 that dephosphorylate intracellular and extracellular nucleoside monophosphates into their corresponding nucleosides. We conducted a study to better understand the biological roles of these enzymes in breast and lung cancer cells. Methods ...
Latest Results for Cellular Oncology
1w
Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling
Abstract Purpose Currently, the exact role of estrogen receptor (ER) signaling in pancreatic cancer is unknown. Recently, we showed that expression of phosphorylated ERβ correlates with a poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Here, we hypothesized that raloxifene, a FDA-approved selective ER modulator (SERM), may suppress PDAC tumor growth by interfering with ERβ signaling. To test this hypothesis,...
Latest Results for Cellular Oncology
1w
Synergistic killing effect of paclitaxel and honokiol in non-small cell lung cancer cells through paraptosis induction
Abstract Purpose Paclitaxel is an anticancer drug for the treatment of non-small cell lung cancer (NSCLC). However, drug-resistance remains a major problem. Honokiol is a natural component which has been found to exhibit anti-tumor activity. Paclitaxel and honokiol have been reported to be able to induce paraptosis. The aim of this study was to investigate whether honokiol can reverse paclitaxel resistance by inducing paraptosis in...
Latest Results for Cellular Oncology
1w
Long non-coding RNA SNHG3, induced by IL-6/STAT3 transactivation, promotes stem cell-like properties of gastric cancer cells by regulating the miR-3619-5p/ARL2 axis
Abstract Background Chemotherapy is, next to surgery and radiotherapy, the mainstay regimen for the clinical management of gastric cancer. This therapy is, however, heavily compromised by the acquisition of resistance. Here, we aimed to clarify the potential involvement of long non-coding RNA SNGH3 in the acquisition of cisplatin resistance and stemness in gastric cancer. ...
Latest Results for Cellular Oncology
1w
Bulky peritoneal carcinosarcoma with tiny high-grade serous carcinoma of the fallopian tube: a case report
Abstract Peritoneal carcinosarcoma is a highly aggressive and uncommon neoplasm that has carcinomatous and sarcomatous components; the malignancy rarely localizes to the omentum. We report a case of a bulky peritoneal carcinosarcoma with tiny high-grade serous carcinoma of the fallopian tube. A 60-year-old female with a huge pelvic mass (12 cm in diameter) underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and omentectomy for tumor debulking. Pathological...
Latest Results for International Cancer Conference Journal
1d
First-line osimertinib for leptomeningeal metastasis from lung adenocarcinoma with EGFR mutation as the initial and solitary site of postoperative recurrence
Abstract Leptomeningeal metastasis (LM) from lung cancer has poor prognosis, and effective therapy has not been established. We present the case of a 54-year-old man with LM from lung adenocarcinoma harboring EGFR L858R point mutation, who received osimertinib as first-line therapy. He had previously undergone left lower lobectomy and lymph node dissection for lung adenocarcinoma. Five years and 9 months after the operation, he developed symptoms of dizziness, lightheadedness,...
Latest Results for International Cancer Conference Journal
4d
Osimertinib-induced cardiac failure with QT prolongation and torsade de pointes in a patient with advanced pulmonary adenocarcinoma
Abstract Osimertinib-induced cardiotoxicity is a well-known but rare disorder. An 84-year-old woman was diagnosed with recurrence of lung adenocarcinoma showing an epidermal growth factor receptor mutation of exon 19 deletion, which was initially treated by curative-intent thoracic radiotherapy 4 years prior. She started taking osimertinib (80 mg/day). She had no history of heart disease and showed no signs of cardiac problems. However, 2 months later she presented with symptoms...
Latest Results for International Cancer Conference Journal
5d
Successful treatment of advanced pancreatic leiomyosarcoma treated with gemcitabine plus nab -paclitaxel: a case report and literature review
Abstract Pancreatic leiomyosarcoma (PLMS) is an extremely rare tumor that accounts for 0.1% of pancreatic malignancies, and its chemotherapy has yet to be established. Generally, soft-tissue sarcoma chemotherapy is standard treatment with doxorubicin (DXR) alone. However, the effectiveness of gemcitabine (GEM) plus docetaxel (DOC) has been shown in uterine leiomyoma. In contrast, the GEM plus nab-paclitaxel (PTX) regimen has been established as first-line chemotherapy for unresectable...
Latest Results for International Cancer Conference Journal
1w
Germline multigene panel testing revealed a BRCA2 pathogenic variant in a patient with suspected Lynch syndrome
Abstract There has been a rapid advance in germline multigene panel testing by next-generation sequencing, and it is being widely used in clinical settings. A 56-year-old woman suspected of having Lynch syndrome was identified as a BRCA2 pathogenic variant carrier by multigene panel testing. The patient was diagnosed with endometrial cancer at the age of 39 years, and total laparoscopic hysterectomy and bilateral salpingectomy were performed at the age of 49 years; however, bilateral...
Latest Results for International Cancer Conference Journal
1w
Dynamic tumor-tracking stereotactic body radiation therapy for a solitary tumor in a transplanted organ: two case reports
Abstract Solid-organ transplant recipients require long-term immunosuppressants to prevent graft rejection. However, immunosuppressant use increases the risk of malignancy. Radiotherapy can be a treatment option for patients who are medically inoperable or refuse surgery; however, whether the irradiation of transplanted organs is safe remains unclear. We present two patients with malignancies that developed in transplanted organs and were treated with dynamic tumor-tracking...
Latest Results for International Cancer Conference Journal
1w
Various therapeutic effects of immune checkpoint inhibitors
Latest Results for International Cancer Conference Journal
1w
Two cases of osteoblastic bone metastasis from muscle-invasive bladder cancer with discrepancy in response to chemotherapy: problems and limitations of bone biopsy
Abstract We report two cases of muscle-invasive bladder cancer (MIBC) with increasing multiple osteoblastic bone lesions but shrinking other lesions in response to chemotherapy. Case 1 had MIBC and received radical cystectomy followed by adjuvant gemcitabine plus cisplatin chemotherapy (GC). Three years after, follow computed tomography (CT) showed development of multiple lymph node metastasis, and then we performed GC as a first-line systemic chemotherapy. After two cycles...
Latest Results for International Cancer Conference Journal
1w
Primary undifferentiated carcinoma with osteoclast-like giant cells in liver and rapidly developing multiple metastases after curative hepatectomy: a case report
Abstract A 64-year-old man was diagnosed with cholangiocellular carcinoma based on preoperative computed tomography and magnetic resonance imaging and underwent laparoscopic segmentectomy (Segment 8) of the liver for radical operation. Pathological examination revealed the presence of an undifferentiated carcinoma with osteoclast-like giant cells, which were categorized as T3N0M0 and Stage III based on the third English edition of the Japanese classification of liver cancer....
Latest Results for International Cancer Conference Journal
1w

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