Cancer treatment appears to alter a patient's immune response to COVID-19 to make infection less severe, and not more severe as has been assumed, suggests a small Israeli study.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
While combination immunotherapy did not show a survival benefit after chemoradiotherapy in small cell lung cancer, longer follow-up and biomarker analysis may reveal some gains, suggests trial data.Medscape News UK (Source: Medscape Hematology-Oncology Headlines)
Pembrolizumab plus chemotherapy should be a new standard of care for first-line treatment, say researchers. Patients with squamous cell carcinomas and higher levels of PD-L1 benefited most.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
While the PARP inhibitor olaparib is the first of its kind to show an overall survival benefit in progressed metastatic prostate cancer, questions remain over its use in men without BRCA1/2 mutations.Medscape News UK (Source: Medscape Hematology-Oncology Headlines)
Breath analysis for non-invasive diagnosis of early-stage head and neck squamous cell carcinoma appears to be practical and accurate.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Expect another 30 to 40 years of increasing numbers of HPV-related oropharynx cancers, said an expert.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Patients with HR+, HER2- breast cancer at high risk of early recurrence on endothelial therapy could highly improve their invasive disease-free survival with adjuvant abemaciclib, a new trial shows.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Determining treatment options, as well as the prognosis of patients, may rely on changes in biomarker status during the course of advanced disease progression.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
The combination of lenvatinib and pembrolizumab may extend by more than 1 year the lives of patients with advanced melanoma who progress after immunotherapy, show'important'trial results.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
The drug inhibits KRAS p.G12C-mutant tumors, which are seen in about 13% of patients with non-small cell lung cancer.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
CMS unveiled a final rule allowing Medicare to next year begin a test of bundled payment for radiation therapy. The rule also approves a kidney care model that encourages use of home-based treatments.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Compared to the general population, women with ductal carcinoma in situ (DCIS) were more than three times more likely to die from breast cancer; the risk was particularly high for Black women and young women.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
An easy-to-use predictive model can estimate 10-year and lifetime risk for cancer in patients with established cardiovascular disease (CVD), new research shows.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
AbbVie reports that upfront veliparib maintains carboplatin-paclitaxel response, with manageable side effects.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Abnormal coagulation is a hallmark of COVID-19. Physicians need to prescribe prophylaxis routinely in the hospital and act immediately when signs of trouble appear.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
The incidence of hepatocellular carcinoma declined after widespread use of direct-acting antiviral therapies to treat hepatitis C, according to findings from a large population-based study.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Your patients with atezolizumab-treated bladder cancer may not benefit if they are on a PPI.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Despite the challenges of conducting cancer clinical research during a pandemic, Dr David Kerr says good things may come out of it.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Checkpoint inhibitors may offer a'unique opportunity'to improve the cure rate in lung cancer, says Dr Mark Kris.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
At the ESMO 2020 Congress, there will be no shortage of advances in cancer care on display, say experts.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
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We report for the first time that the molecular gene signatures are specific to the different types of breast cancer metastasis. Several genes, including CHPF, ARC, ANGPTL4, NR2E1, SH2D1A, CTSW, POLR2J4, SPTLC1, ILK, ALDH3B1, PDE6A, SCTR, ADM, HEY1, KCNF1, and UVRAG, were found to be predictors of the risk for site-specific metastasis of breast cancer. Expression of POLR2JA, SPTLC1, ILK, ALDH3B1, and the estrogen receptor was significantly associated with breast cancer bone metastasis. Expression...
AbstractTo evaluate feasibility, frequency and severity of peri-procedural complications and post-procedural adverse events (AEs) in patients with advanced cholangiocarcinoma or liver metastasis of uveal melanoma and prior hemihepatectomy undergoing chemosaturation percutaneous hepatic perfusion (CS-PHP) and to analyze therapy response and overall survival compared to a matched group without prior surgery. CS-PHP performed between 10/2014 and 02/2018 were retrospectively assessed. To determine peri-procedural...
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. (Source: Nutrition and Cancer)
. (Source: Nutrition and Cancer)
CONCLUSIONS: The calculation of PNI value is simple, reliable and repeatable and can improve the accuracy of a patient's prognosis. Confirmation of these results by a large-sample prospective study is desirable. PMID: 33044092 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
Authors: Majumder M, Sharma M, Maiti S, Mukhopadhyay R Abstract Medicinal plants offer enormous possibilities in the quest of novel bioactive formulation for cancer therapy. Here, we studied the anticancer efficacy of the extract of edible tuber Amorphophallus paeoniifolius (Dennst.) (APTE) against estrogen positive MCF-7 and triple negative MDA-MB-231 breast cancer cell lines. APTE showed significant cytotoxic activity in both MCF-7 and MDA-MB-231 cells in a dose and time-dependent manner....
Conclusion: Andrographolide repressed the colon cancer cell growth via inhibiting Hh signaling pathway. PMID: 33030050 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
Authors: Bhattacharya R, Chatterjee R, Mandal AKA, Mukhopadhyay A, Basu S, Giri AK, Chatterji U, Bhattacharjee P Abstract Tea is the most popularly consumed beverage in the world. Theaflavin and thearubigins are the key bioactive compounds of black tea that have anticarcinogenic properties as reported in several studies. However, the epigenetic potential of these compounds has not yet been explored. DNA methyltransferase (DNMT) enzymes induce methylation of DNA at cytosine residues and...
Conclusions: We showed for the first time that EA and SOR are effective on the HCC rat model through mitochondria and hepatocytes targeting. PMID: 33030061 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
In conclusion, the addition of ω-3 fish oil fat emulsion to parenteral nutrition after operation can effectively reduce the incidence of short-term complications in patients with gastric cancer after laparoscopic surgery. PMID: 33026250 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
In this study, we determined the effect of low dose piperlongumine on the motility/invasive capacity and epithelial-to-mesenchymal transition (EMT) of MDA-MB-231 triple-negative breast cancer (TNBC) cells and the metastasis of 4T1 mouse mammary carcinoma cells. MTT assays measured the effect of piperlongumine on TNBC cell growth. Motility/invasiveness were determined by gap closure/transwell assays. Western blotting assessed ZEB1, Slug, and matrix metalloproteinase (MMP) 9 expression. Interleukin...
In conclusion, the results of this meta-analysis indicate that tea consumption is not relevant to the incidence of endometrial cancer. Further research and cohort studies should be conducted to validate our result. PMID: 33016141 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
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Authors: Pandey P, Khan F Abstract Modern research propounded that alteration in signaling pathways have shown strong connection with the progression of cervical cancer and modulation of these pathways by natural compounds could be a better treatment approach for the management of cervical cancer. Additionally, inhibitory role of methanolic extract of Moringa oleifera leaves against Jab1 has not been elucidated yet. Therefore, we have elucidated the inhibitory potential of MMLE against...
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Authors: Migita K, Matsumoto S, Wakatsuki K, Kunishige T, Nakade H, Miyao S, Sho M Abstract This prospective study was undertaken to investigate whether preoperative oral nutritional supplementation (ONS) would increase the prognostic nutritional index (PNI) in gastric cancer patients undergoing gastrectomy. Before surgery for resectable gastric cancer, Racol® NF (Otsuka Pharmaceutical Factory, Japan) was administered orally at a recommended dose of 600 kcal/600 ml per day to patients with...
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Authors: Tonkaboni A, Lotfibakhshaiesh N, Danesh P, Tajerian R, Ziaei H Abstract One of the world's most consumed medications is caffeine which is available in the vast majority of beverages. Previously, some effects of caffeine have been evaluated including its inhibitory effect on cancer cells. But, the influence of caffeine on esophagus carcinoma squamous cells (CSC) and head and neck carcinoma cells still has not well understood. Herein, the relation between different amounts of caffeine...
CONCLUSIONS: Our findings suggest that a predominance of antioxidant over pro-oxidant dietary and lifestyle exposures-separately and especially jointly-may be inversely associated with CRC risk among older women. PMID: 32981353 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
CONCLUSION: The findings from the present study showed that MEMC can exert a potential role to ameliorate the oxidative stress and inflammation associated with colorectal cancer. PMID: 32972250 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
This study aimed to investigate the impact of ginger extract (GE) loaded into chitosan nanoparticles (CNPs) in enhancing cytotoxicity and reducing cardiotoxicity of doxorubicin (DXN) in hepatocellular carcinoma (HCC) induced mice. DXN and GE were loaded into CNPs and cytotoxicity of loaded and unloaded drugs against HepG2 cells was evaluated. HCC was induced in male albino mice by injection of diethylnitrosamine (DINA). Mice were divided into eight groups (n = 15): (1) normal control, (2) DINA, (3)...
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This study revealed that VAC EOs may be a promising candidate in the development of novel therapeutic agents for multi-drug resistant lung cancer treatment. PMID: 32972249 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
The objectives of this review were to examine the gaps and opportunities in the extent, range and nature of nutrition-related BC research in Arab countries. Studies (n = 286) were identified through searching 14 electronic databases. Among the gaps identified were limited international collaborations, preponderance of laboratory-based research at the expense of population-based research, focus on single supplement/nutrient/food research, limited use of dietary assessment tools, and studying nutrition...
CONCLUSION: Overweight patients have a better survival than normal weight patients, while underweight patients have a poorer survival in DLBCL. PMID: 32964748 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
Authors: Lee Y, Park SH, Lee JH, Ryu HW, Jang HJ, Kim WJ, Hwang E, Kim SJ, Jun HS, Ha UH Abstract Cancer is caused by uncontrolled cell division and is a leading cause of mortality worldwide. Oenothera odorata (O. odorata) extract is used in herbal medicine to inhibit inflammation, but its potential anti-tumor properties have not been fully evaluated. Here, we demonstrated that O. odorata extract inhibits the proliferation of lung adenocarcinoma and melanoma cell lines In Vitro, and also...
. (Source: Nutrition and Cancer)
In conclusion L-arginine supplementation potentially reduces the jejunal lesions and DNA damage caused by 5-FU. PMID: 32959704 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
CONCLUSION: The cancer cell-selective cytotoxicity apoptosis, and anti-angiogenic effects of LSEO-NE indicate its potential as a novel anticancer compound. However, further cell lines have to be analyzed in case of its potential anticancer impacts on human ovarian cancer cells. PMID: 32959696 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
All-Trans Retinoic Acid Rescues the Tumor Suppressive Role of RAR-β by Inhibiting LncHOXA10 Expression in Gastric Tumorigenesis. Nutr Cancer. 2020 Sep 22;:1-13 Authors: Wang C, Zhao D, Wang K, Gao L, He Y, Wu H, Ruan L, Chen W, Zhang D, Xia T, Qian S, Liu Z, Yang Y, Yang W, Hu A, Zhao Q Abstract Numerous long noncoding RNAs (LncRNAs) were having recently been shown to be involved in cancer development, including gastric cancer (GC). However, the precise mechanism and treatments...
CONCLUSION: The Ea-AcOEt extract is a potential candidate for breast cancer treatment. PMID: 32959676 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
In this study, the syngenic, orthotopic GL261 mouse glioma model was used to evaluate the effects of KD on the metabolic responses of the tumor using 7T magnetic resonance imaging/spectroscopy. GL261 cells were injected into the caudate nucleus of mice. Following implantation, animals were fed with standard chow or underwent a KD. 18 days after initiating the diet, mice fed with KD displayed significantly higher plasmatic levels of ketone bodies and survived longer than those fed with the standard...
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Authors: Jabbari M, Barati M, Fathollahi A, Javanmardi F, Hemmati F, Farahmand F, Mirmiran P, Eini-Zinab H, Mousavi Khaneghah A Abstract Among the gastrointestinal tract cancers, the risk of colon cancer is strongly dependent on dietary factors. For the first time in the current review, all the original case-control studies, associated with the correlation between total dietary diversity score and colon cancer risk, were evaluated. In this regard, three databases, including PubMed/MEDLINE,...
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CONCLUSIONS: The present meta-analysis suggests that high CRP/Alb is predictive of poor OS and DFS in gastric cancer. CRP/Alb is therefore a potential prognostic factor in the management of patients with gastric cancer. PMID: 32940549 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
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Authors: Li C, Ci Y, Liu X, Chen C, Liu C, Li X, Li Q, Song Y Abstract To investigate the effects of inositol hexaphosphate (IP6) and inositol (INS) with capecitabine treatment on colorectal cancer (CRC) growth and liver metastasis in mice, we established an orthotopic xenograft mouse model. The study designated five experimental groups: a control group, a model group, a capecitabine (60 mg/kg) treatment group, an IP6 + INS (80 mg/kg: 80 mg/kg) treatment group, and a capecitabine + IP6 + INS...
In conclusion, these findings provide first evidences about potential anticancer properties of TPEM. PMID: 32933316 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
Authors: Mehrzadi S, Hosseini P, Mehrabani M, Siahpoosh A, Goudarzi M, Khalili H, Malayeri A Abstract The present study aimed to investigate the protective effects of two potent natural antioxidants, gallic acid and quercetin as single or combination treatment against bleomycin-induced pulmonary fibrosis (PF). A total of 50 Wistar rats were randomly divided into 5 groups. Group 1 and 2 intratracheally received saline and bleomycin (7.5 UI/kg), respectively, on day 7, accompanied by oral...
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Authors: Erden Y Abstract Carotenoids found in fruits and vegetables are compounds with significant biological activities. Epidemiological studies report that these compounds have significant anticancer effects, as well reducing the risk of cancer. In the present study, we aimed to determine the effects of capsanthin, an important carotenoid of paprika, on expressions of proteins playing roles in the mitochondrial apoptosis pathway, in addition to its possible cytotoxic and genotoxic effects...
This study examined associations between the effect of treatment with nano-cassava starch that contained cordycepin (CS) extract, targeting human submandibular gland cells (HSGs), and human oral squamous carcinoma cells (HSC-4). Cassava starch nanoparticles (CSNPs) were prepared by either physical or acid treatment. These nanoparticles were then loaded with either CS or cordyceps medium and then treated with HSG or HSC-4 cells in different concentrations of CS and nanoparticles. Moreover, the protein...
Authors: Samodien S, Kock M, Joubert E, Swanevelder S, Gelderblom WCA Abstract Differential anti-proliferative and pro-apoptotic effects of aqueous extracts of green rooibos (Rg; Aspalathus linearis) and green tea (GT; Camellia sinensis) and an aspalathin-enriched extract of green rooibos (GRE), were investigated in primary rat hepatocytes (PH) and human liver (HepG2) and colon (HT-29) cancer cells. Rooibos flavonoids, aspalathin and luteolin, and the green tea flavanol, epigallocatechin...
Authors: Abdel-Rahman O Abstract To assess the patterns of use of dietary supplements among cancer survivors in the United States in a population-based setting. National Health and Nutrition Examination Survey (NHANES) datasets (1999-2016) were accessed, and adult respondents (≥ 20 years old) with a known status of cancer diagnosis and a known status of dietary supplements intake were included. Multivariable logistic regression analysis was then used to assess factors associated with dietary...
CONCLUSION: The low PNI is significantly associated with inferior prognosis of patients with BTC and aggressive clinical factors. The PNI could be applied as an independent prognostic marker for patients with BTC. PMID: 32933337 [PubMed - as supplied by publisher] (Source: Nutrition and Cancer)
This study proposes a protocol for nutritional intervention beginning preoperatively and lasting up to three months postoperatively. Twenty patients with confirmed diagnosis of colon adenocarcinoma who underwent resection surgery were included. Anthropometric and food intake data-assessed through two 24-hour recalls, one weekday and one weekend-were collected at baseline, one month postoperative (PO), and three months PO. Anthropometric evaluation showed a decrease in the first month PO in weight,...
. (Source: Nutrition and Cancer)
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Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology,Volume 16, Issue 29, Page 2371-2371, October 2020. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology,Volume 16, Issue 29, Page 2269-2271, October 2020. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
High preoperative levels of circulating SFRP5 predict better prognosis in colorectal cancer patients
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
Future Oncology, Ahead of Print. (Source: Future Oncology)
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