Cancers, Vol. 11, Pages 1909: A Novel Anti-PD-L1 Vaccine for Cancer Immunotherapy and Immunoprevention Cancers doi: 10.3390/cancers11121909 Authors: Jie Chen Hui Liu Tiffany Jehng Yanqing Li Zhoushi Chen Kuan-Der Lee Hsieh-Tsung Shen Lindsey Jones Xue F. Huang Si-Yi Chen Dendritic cells (DCs) are potent antigen-presenting cells that play a critical role in activating cellular and humoral immune responses. DC-based tumor vaccines targeting tumor-associated antigens...
Sun Dec 01, 2019 02:00
Cancers, Vol. 11, Pages 1913: Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells Cancers doi: 10.3390/cancers11121913 Authors: Takeuchi Tanikawa Nagasaka Oda Kawata Oki Agapiti Sone Miyagawa Hiraike Wada-Hiraike Kuramoto Ayabe Osuga Fujii : While the incidence of endometrial cancer continues to rise, the therapeutic options remain limited for advanced or recurrent cases, and...
Sun Dec 01, 2019 02:00
Cancers, Vol. 11, Pages 1908: Monitoring Patients with Metastatic Hormone-Sensitive and Metastatic Castration-Resistant Prostate Cancer: A Multidisciplinary Consensus Document Cancers doi: 10.3390/cancers11121908 Authors: Lapini Caffo Pappagallo Iacovelli D'Angelillo Vavassori Ceccarelli Bracarda Jereczek-Fossa Da Pozzo Conti Background: The availability of a number of agents that are efficacious in patients with metastatic prostate cancer (mPC)...
Sun Dec 01, 2019 02:00
Cancers, Vol. 11, Pages 1907: Proteogenomics of Colorectal Cancer Liver Metastases: Complementing Precision Oncology with Phenotypic Data Cancers doi: 10.3390/cancers11121907 Authors: Blank-Landeshammer Richard Mitsa Marques LeBlanc Kollipara Feldmann Couetoux du Tertre Gambaro McNamara Spatz Zahedi Sickmann Batist Borchers : Hotspot testing for activating KRAS mutations is used in precision oncology to select colorectal cancer...
Sun Dec 01, 2019 02:00
Cancers, Vol. 11, Pages 1903: WISP-1 Promotes Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Cells Via the miR-153-3p/Snail Axis Cancers doi: 10.3390/cancers11121903 Authors: Chang Lien Tsai Hua Tang Around half of all patients with oral squamous cell carcinoma (OSCC) present with lymphatic metastasis, a strong predictor of poor survival. Improving survival rates depends on preventing the first step in the “invasion-metastasis cascade,”...
Fri Nov 29, 2019 02:00
Cancers, Vol. 11, Pages 1904: Potent Antitumor Activity of Liposomal Irinotecan in an Organoid- and CRISPR-Cas9-Based Murine Model of Gallbladder Cancer Cancers doi: 10.3390/cancers11121904 Authors: Erlangga Wolff Poth Peltzer Nahnsen Spielberg Timrott Woller Kühnel Manns Saborowski Vogel Saborowski Gallbladder cancer is associated with a dismal prognosis, and accurate in vivo models will be elemental to improve our understanding of this...
Fri Nov 29, 2019 02:00
Cancers, Vol. 11, Pages 1905: Analysis of the Whole-Exome Sequencing of Tumor and Circulating Tumor DNA in Metastatic Melanoma Cancers doi: 10.3390/cancers11121905 Authors: Diefenbach Lee Strbenac Yang Menzies Carlino Long Spillane Stretch Saw Thompson Ch’ng Scolyer Kefford Rizos The use of circulating tumor DNA (ctDNA) to monitor cancer progression and response to therapy has significant potential but there is only limited data...
Fri Nov 29, 2019 02:00
Cancers, Vol. 11, Pages 1902: PAK4-NAMPT Dual Inhibition as a Novel Strategy for Therapy Resistant Pancreatic Neuroendocrine Tumors Cancers doi: 10.3390/cancers11121902 Authors: Gabriel Mpilla Amro Aboukameel Irfana Muqbil Steve Kim Rafic Beydoun Philip A. Philip Ramzi M. Mohammad Mandana Kamgar Vinod Shidham William Senapedis Erkan Baloglu Jing Li Gregory Dyson Yue Xue Bassel El-Rayes Asfar S. Azmi Pancreatic neuroendocrine tumors (PNET)...
Fri Nov 29, 2019 02:00
Cancers, Vol. 11, Pages 1901: Parallel Structure Deep Neural Network Using CNN and RNN with an Attention Mechanism for Breast Cancer Histology Image Classification Cancers doi: 10.3390/cancers11121901 Authors: Hongdou Yao Xuejie Zhang Xiaobing Zhou Shengyan Liu In this paper, we present a new deep learning model to classify hematoxylin–eosin-stained breast biopsy images into four classes (normal tissues, benign lesions, in situ carcinomas, and invasive carcinomas)....
Fri Nov 29, 2019 02:00
Cancers, Vol. 11, Pages 1900: Association of Polyps with Early-Onset Colorectal Cancer and Throughout Surveillance: Novel Clinical and Molecular Implications Cancers doi: 10.3390/cancers11121900 Authors: José Perea García Julia Arribas Ángel Cañete Juan Luis García Edurne Álvaro Sandra Tapial Cristina Narváez Alfredo Vivas Lorena Brandáriz Sergio Hernández-Villafranca Daniel Rueda Yolanda Rodríguez Jessica Pérez-García Susana Olmedillas-López Damián...
Fri Nov 29, 2019 02:00
Cancers, Vol. 11, Pages 1899: Omics-based Investigation of Diet-induced Obesity Synergized with HBx, Src, and p53 Mutation Accelerating Hepatocarcinogenesis in Zebrafish Model Cancers doi: 10.3390/cancers11121899 Authors: Yang Rao Luo Lin Huang Yang Yuh The primary type of liver cancer, hepatocellular carcinoma (HCC), has been associated with nonalcoholic steatohepatitis, diabetes, and obesity. Previous studies have identified some genetic risk factors, such...
Thu Nov 28, 2019 02:00
Cancers, Vol. 11, Pages 1898: Addendum: de Leve, S.; et al. The CD73/Ado System—A New Player in RT Induced Adverse Late Effects. Cancers 2019, 11, 1578 Cancers doi: 10.3390/cancers11121898 Authors: Leve Wirsdörfer Jendrossek The authors would like to make an addendum to their published paper [...]
Thu Nov 28, 2019 02:00
Cancers, Vol. 11, Pages 1895: Identification of Circulating Genomic and Metabolic Biomarkers in Intrahepatic Cholangiocarcinoma Cancers doi: 10.3390/cancers11121895 Authors: Helen Winter Pamela J. Kaisaki Joe Harvey Edoardo Giacopuzzi Matteo P. Ferla Melissa M. Pentony Samantha J.L. Knight Ricky A. Sharma Jenny C. Taylor James S.O. McCullagh Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer arising from the bile ducts with a need for earlier diagnosis...
Thu Nov 28, 2019 02:00
Cancers, Vol. 11, Pages 1896: Long-Term Fatigue and Cognitive Disorders in Breast Cancer Survivors Cancers doi: 10.3390/cancers11121896 Authors: Joly Lange Dos Santos Vaz-Luis Di Meglio Survivors of early-stage breast cancer may report treatment-related side effects that persist for several years after the end of primary treatment. Among these, fatigue and cognitive disorders are frequent complaints and can negatively impact quality of life. Cancer-related fatigue is...
Thu Nov 28, 2019 02:00
Cancers, Vol. 11, Pages 1894: The Emerging Role of ESR1 Mutations in Luminal Breast Cancer as a Prognostic and Predictive Biomarker of Response to Endocrine Therapy Cancers doi: 10.3390/cancers11121894 Authors: Irene De Santo Amelia McCartney Ilenia Migliaccio Angelo Di Leo Luca Malorni Mutations in the hotspot ligand-binding domain of the estrogen receptor (ER) gene ESR1 have recently been recognized as mechanisms of endocrine resistance in endocrine receptor-positive metastatic...
Thu Nov 28, 2019 02:00
Cancers, Vol. 11, Pages 1897: FOXD1 and Gal-3 Form a Positive Regulatory Loop to Regulate Lung Cancer Aggressiveness Cancers doi: 10.3390/cancers11121897 Authors: Li Chang Hsiao Liang Dysregulation of forkhead box D1 (FOXD1) is known to promote tumor progression; however, its molecular mechanism of action is unclear. Based on microarray analysis, we identified galectin-3/LGALS3 (Gal-3) as a potential downstream target of FOXD1, as FOXD1 transactivated Gal-3 by interacting...
Thu Nov 28, 2019 02:00
Cancers, Vol. 11, Pages 1893: Radiosensitization of Non-Small Cell Lung Cancer Cells by the Plk1 Inhibitor Volasertib Is Dependent on the p53 Status Cancers doi: 10.3390/cancers11121893 Authors: Jolien Van den Bossche Andreas Domen Marc Peeters Christophe Deben Ines De Pauw Julie Jacobs Sven De Bruycker Pol Specenier Patrick Pauwels Jan Baptist Vermorken Filip Lardon An Wouters Polo-like kinase 1 (Plk1), a master regulator of mitotic cell division, is...
Thu Nov 28, 2019 02:00
Cells, Vol. 8, Pages 1554: Transcriptional Characterization of Stage I Epithelial Ovarian Cancer: A Multicentric Study Cells doi: 10.3390/cells8121554 Authors: Enrica Calura Matteo Ciciani Andrea Sambugaro Lara Paracchini Giuseppe Benvenuto Salvatore Milite Paolo Martini Luca Beltrame Flaminia Zane Robert Fruscio Martina Delle Marchette Fulvio Borella Germana Tognon Antonella Ravaggi Dionyssios Katsaros Eliana Bignotti Franco Odicino Maurizio...
Sun Dec 01, 2019 02:00
Cells, Vol. 8, Pages 1552: Towards a Better Understanding of Beige Adipocyte Plasticity Cells doi: 10.3390/cells8121552 Authors: Paulo Wang Beige adipocytes are defined as Ucp1+, multilocular adipocytes within white adipose tissue (WAT) that are capable of thermogenesis, the process of heat generation. In both mouse models and humans, the increase of beige adipocyte population, also called WAT browning, is associated with certain metabolic benefits, such as reduced obesity and increased...
Sun Dec 01, 2019 02:00
Cells, Vol. 8, Pages 1553: Cellular Model of Endotoxin Tolerance in Astrocytes: Role of Interleukin 10 and Oxylipins Cells doi: 10.3390/cells8121553 Authors: Chistyakov Astakhova Azbukina Goriainov Chistyakov Sergeeva A phenomenon of endotoxin tolerance where prior exposure of cells to minute amounts of lipopolysaccharide (LPS) causes them to become refractory to a subsequent high-amount endotoxin challenge is well described for innate immune cells such as monocytes/macrophages,...
Sun Dec 01, 2019 02:00
Cells, Vol. 8, Pages 1551: Interaction between Angiotensin Type 1, Type 2, and Mas Receptors to Regulate Adult Neurogenesis in the Brain Ventricular–Subventricular Zone Cells doi: 10.3390/cells8121551 Authors: Maria Garcia-Garrote Ana Perez-Villalba Pablo Garrido-Gil German Belenguer Juan A. Parga Francisco Perez-Sanchez Jose Luis Labandeira-Garcia Isabel Fariñas Jannette Rodriguez-Pallares The renin–angiotensin system (RAS), and particularly its angiotensin...
Sat Nov 30, 2019 02:00
Cells, Vol. 8, Pages 1549: mTORC1 Mediates Lysine-Induced Satellite Cell Activation to Promote Skeletal Muscle Growth Cells doi: 10.3390/cells8121549 Authors: Cheng-long Jin Jin-ling Ye Jinzeng Yang Chun-qi Gao Hui-chao Yan Hai-chang Li Xiu-qi Wang As the first limiting amino acid, lysine (Lys) has been thought to promote muscle fiber hypertrophy by increasing protein synthesis. However, the functions of Lys seem far more complex than that. Despite the fact that satellite...
Sat Nov 30, 2019 02:00
Cells, Vol. 8, Pages 1550: Conditional Deletion of LRP1 Leads to Progressive Loss of Recombined NG2-Expressing Oligodendrocyte Precursor Cells in a Novel Mouse Model Cells doi: 10.3390/cells8121550 Authors: Ina Schäfer Johannes Kaisler Anja Scheller Frank Kirchhoff Aiden Haghikia Andreas Faissner The low-density lipoprotein receptor-related protein 1 (LRP1) is a transmembrane receptor, mediating endocytosis and activating intracellular signaling cascades. LRP1 is highly...
Sat Nov 30, 2019 02:00
Cells, Vol. 8, Pages 1548: miR-1185-1 and miR-548q Are Biomarkers of Response to Weight Loss and Regulate the Expression of GSK3B Cells doi: 10.3390/cells8121548 Authors: Marcos Garcia-Lacarte Maria L. Mansego M. Angeles Zulet J. Alfredo Martinez Fermin I. Milagro The aim of the present investigation was to identify putative miRNAs involved in the response to weight loss. Reverse-transcribed RNA isolated from white blood cells (WBCs) of a subpopulation from the Reduction...
Sat Nov 30, 2019 02:00
Cells, Vol. 8, Pages 1547: Dibutyltin(IV) and Tributyltin(IV) Derivatives of meso-Tetra(4-sulfonatophenyl)porphine Inhibit the Growth and the Migration of Human Melanoma Cells Cells doi: 10.3390/cells8121547 Authors: Francesca Costantini Fabiana Di Leo Caterina Di Sano Tiziana Fiore Claudia Pellerito Giovanna Barbieri Melanoma is the most aggressive and deadly form of skin cancer, which is largely due to its propensity to metastasize. Therefore, with the aim to inhibit...
Sat Nov 30, 2019 02:00
Cells, Vol. 8, Pages 1545: Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins Cells doi: 10.3390/cells8121545 Authors: Inoue Nakatsu Yamamotoya Hasei Kanamoto Naitou Matsunaga Sakoda Fujishiro Ono Kushiyama Asano Pin1 is one of the three known prolyl-isomerase types and its hepatic expression level is markedly enhanced in the obese state. Pin1 plays critical roles in favoring the exacerbation of both lipid...
Fri Nov 29, 2019 02:00
Cells, Vol. 8, Pages 1546: Amitosenescence and Pseudomitosenescence: Putative New Players in the Aging Process Cells doi: 10.3390/cells8121546 Authors: Wengerodt Schmeer Witte Kretz Replicative senescence has initially been defined as a stress reaction of replication-competent cultured cells in vitro, resulting in an ultimate cell cycle arrest at preserved growth and viability. Classically, it has been linked to critical telomere curtailment following repetitive cell divisions,...
Fri Nov 29, 2019 02:00
Cells, Vol. 8, Pages 1543: The Epac1 Protein: Pharmacological Modulators, Cardiac Signalosome and Pathophysiology Cells doi: 10.3390/cells8121543 Authors: Bouvet Blondeau Lezoualc’h The second messenger 3′,5′-cyclic adenosine monophosphate (cAMP) is one of the most important signalling molecules in the heart as it regulates many physiological and pathophysiological processes. In addition to the classical protein kinase A (PKA) signalling route, the exchange...
Fri Nov 29, 2019 02:00
Cells, Vol. 8, Pages 1544: Platyconic Acid A, Platycodi Radix-Derived Saponin, Suppresses TGF-1-induced Activation of Hepatic Stellate Cells via Blocking SMAD and Activating the PPAR Signaling Pathway Cells doi: 10.3390/cells8121544 Authors: Choi Kim Lee Jin Lee Chung Jeong Platycodi radix is a widely sold health food worldwide, which contains numerous phytochemicals that are beneficial to health. Previously, we reported that saponin from the roots of Platycodi...
Fri Nov 29, 2019 02:00
Cells, Vol. 8, Pages 1542: Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential Cells doi: 10.3390/cells8121542 Authors: Digregorio Marina Lombard Arnaud Lumapat Paul Noel Scholtes Félix Rogister Bernard Coppieters Natacha Cancer cells are continually exposed to environmental stressors forcing them to adapt their protein production to survive. The translational machinery can be recruited by malignant cells to synthesize proteins required...
Fri Nov 29, 2019 02:00
Cells, Vol. 8, Pages 1541: A Software Tool for High-Throughput Real-Time Measurement of Intensity-Based Ratio-Metric FRET Cells doi: 10.3390/cells8121541 Authors: Masoud Ramuz Alveera Hasan Lena Gruscheski Ivan Diakonov Nikoleta Pavlaki Viacheslav O. Nikolaev Sian Harding Chris Dunsby Julia Gorelik Förster resonance energy transfer (FRET) is increasingly used for non-invasive measurement of fluorescently tagged molecules in live cells. In this study,...
Fri Nov 29, 2019 02:00
Cells, Vol. 8, Pages 1540: From Endogenous to Synthetic microRNA-Mediated Regulatory Circuits: An Overview Cells doi: 10.3390/cells8121540 Authors: Elsi Ferro Chiara Enrico Bena Silvia Grigolon Carla Bosia MicroRNAs are short non-coding RNAs that are evolutionarily conserved and are pivotal post-transcriptional mediators of gene regulation. Together with transcription factors and epigenetic regulators, they form a highly interconnected network whose building blocks can be classified...
Fri Nov 29, 2019 02:00
Cells, Vol. 8, Pages 1538: Afatinib Overcomes Pemetrexed-Acquired Resistance in Non-Small Cell Lung Cancer Cells Harboring an EML4-ALK Rearrangement Cells doi: 10.3390/cells8121538 Authors: Kwon Kim Sung Suh Lee Kim Kim Lee Kim Kim Lee Kim Bang Kim Yoon Lee Background: The aim of this study is to elucidate the mechanisms of acquired resistance to pemetrexed in echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic...
Thu Nov 28, 2019 02:00
Cells, Vol. 8, Pages 1539: Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer’s Disease Cells doi: 10.3390/cells8121539 Authors: Bussiere Oulès Mary Vaillant-Beuchot Martin Manaa Vallée Duplan Paterlini-Bréchot Costa Checler Chami Dysregulation of the Endoplasmic Reticulum (ER) Ca2+ homeostasis and subsequent ER stress activation occur in Alzheimer Disease (AD). We studied...
Thu Nov 28, 2019 02:00
Cells, Vol. 8, Pages 1536: Cardiac Progenitor Cells from Stem Cells: Learning from Genetics and Biomaterials Cells doi: 10.3390/cells8121536 Authors: Barreto Hamel Schiatti Yang George Cardiac Progenitor Cells (CPCs) show great potential as a cell resource for restoring cardiac function in patients affected by heart disease or heart failure. CPCs are proliferative and committed to cardiac fate, capable of generating cells of all the cardiac lineages. These cells offer...
Thu Nov 28, 2019 02:00
Cells, Vol. 8, Pages 1537: Mathematical Model Explaining the Role of CDC6 in the Diauxic Growth of CDK1 Activity during the M-Phase of the Cell Cycle Cells doi: 10.3390/cells8121537 Authors: Mateusz Dębowski Zuzanna Szymańska Jacek Z. Kubiak Mirosław Lachowicz In this paper we propose a role for the CDC 6 protein in the entry of cells into mitosis. This has not been considered in the literature so far. Recent experiments suggest that CDC 6 , upon entry into mitosis,...
Thu Nov 28, 2019 02:00
Cells, Vol. 8, Pages 1535: Regulation of Oncogenic Targets by miR-99a-3p (Passenger Strand of miR-99a-Duplex) in Head and Neck Squamous Cell Carcinoma Cells doi: 10.3390/cells8121535 Authors: Okada Koshizuka Yamada Moriya Kikkawa Kinoshita Hanazawa Seki To identify novel oncogenic targets in head and neck squamous cell carcinoma (HNSCC), we have analyzed antitumor microRNAs (miRNAs) and their controlled molecular networks in HNSCC cells. Based on our miRNA...
Thu Nov 28, 2019 02:00
Cells, Vol. 8, Pages 1533: MicroRNA Signatures as Future Biomarkers for Diagnosis of Diabetes States
Cells, Vol. 8, Pages 1533: MicroRNA Signatures as Future Biomarkers for Diagnosis of Diabetes States Cells doi: 10.3390/cells8121533 Authors: Vasu Kumano Darden Rahman Lawrence Naziruddin Diabetes results from the inability of pancreatic islets to maintain blood glucose concentrations within a normal physiological range. Clinical features are usually not observed until islets begin to fail and irreversible damage has occurred. Diabetes is generally diagnosed based...
Thu Nov 28, 2019 02:00
Cells, Vol. 8, Pages 1532: Reconstitution of the Jasmonate Signaling Pathway in Plant Protoplasts Cells doi: 10.3390/cells8121532 Authors: Ning Li Joachim F. Uhrig Corinna Thurow Li-Jun Huang Christiane Gatz The phytohormone jasmonic acid (JA) plays an important role in various plant developmental processes and environmental adaptations. The JA signaling pathway has been well-elucidated in the reference plant Arabidopsis thaliana. It starts with the perception of the active...
Thu Nov 28, 2019 02:00
Cells, Vol. 8, Pages 1534: Good News for Nuclear Transgene Expression in Chlamydomonas Cells doi: 10.3390/cells8121534 Authors: Schroda Chlamydomonas reinhardtii is a well-established model system for basic research questions ranging from photosynthesis and organelle biogenesis, to the biology of cilia and basal bodies, to channelrhodopsins and photoreceptors. More recently, Chlamydomonas has also been recognized as a suitable host for the production of high-value chemicals and high-value...
Thu Nov 28, 2019 02:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου