IJMS, Vol. 20, Pages 6065: An Ancient Mutation in the TPH1 Gene is Consistent with the Changes in Mammalian Reproductive Rhythm International Journal of Molecular Sciences doi: 10.3390/ijms20236065 Authors: Chenhui Liu Xunping Jiang Guiqiong Liu Teketay Wassie Shishay Girmay The reproductive rhythm undergoes several changes during the evolution of mammals to adapt to local environmental changes. Although the critical roles of melatonin (MLT) in the formation of reproductive...
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IJMS, Vol. 20, Pages 6064: Genetic Parameters and QTLs for Total Phenolic Content and Yield of Wheat Mapping Population of CSDH Lines under Drought Stress International Journal of Molecular Sciences doi: 10.3390/ijms20236064 Authors: Czyczyło-Mysza Cyganek Dziurka Quarrie Skrzypek Marcińska Myśków Dziurka Warchoł Kapłoniak Bocianowski A doubled haploid population of 94 lines from the Chinese Spring × SQ1 wheat cross (CSDH) was used to...
Sun Dec 01, 2019 02:00
IJMS, Vol. 20, Pages 6063: Pairing and Exchanging between Daypyrum villosum Chromosomes 6V#2 and 6V#4 in the Hybrids of Two Different Wheat Alien Substitution Lines International Journal of Molecular Sciences doi: 10.3390/ijms20236063 Authors: Ma Xu Wang Chen Ye Lin Normal pairing and exchanging is an important basis to evaluate the genetic relationship between homologous chromosomes in a wheat background. The pairing behavior between 6V#2 and 6V#4, two chromosomes...
Sun Dec 01, 2019 02:00
IJMS, Vol. 20, Pages 6061: Expression of Salivary and Serum Malondialdehyde and Lipid Profile of Patients with Periodontitis and Coronary Heart Disease International Journal of Molecular Sciences doi: 10.3390/ijms20236061 Authors: Gaetano Isola Alessandro Polizzi Simona Santonocito Angela Alibrandi Sebastiano Ferlito Malondialdehyde (MAA) within a lipid pathway has been demonstrated to possess an important role in endothelial function that undergoes periodontitis and coronary...
Sun Dec 01, 2019 02:00
IJMS, Vol. 20, Pages 6060: Differential Regulation of Anthocyanin Synthesis in Apple Peel under Different Sunlight Intensities International Journal of Molecular Sciences doi: 10.3390/ijms20236060 Authors: Weifeng Chen Mengxia Zhang Guojing Zhang Pengmin Li Fengwang Ma Sunlight radiation is a main environmental factor which affects anthocyanin synthesis. To clarify the regulatory mechanism of sunlight on the synthesis of anthocyanin in apple peel, bagged apples were exposed...
Sun Dec 01, 2019 02:00
IJMS, Vol. 20, Pages 6062: Analysis of the Molecular Signaling Signatures of Muscle Protein Wasting Between the Intercostal Muscles and the Gastrocnemius Muscles in db/db Mice International Journal of Molecular Sciences doi: 10.3390/ijms20236062 Authors: Kun Woo Kim Mi-Ock Baek Ji-Young Choi Kuk Hui Son Mee-Sup Yoon Type 2 diabetes (T2D) patients suffer from dyspnea, which contributes to disease-related morbidity. Although T2D has been reported to induce a catabolic state...
Sun Dec 01, 2019 02:00
IJMS, Vol. 20, Pages 6059: Assessment of Bones Deficient in Fibrillin-1 Microfibrils Reveals Pronounced Sex Differences International Journal of Molecular Sciences doi: 10.3390/ijms20236059 Authors: Lukas Altinbas Nicole Bormann Daniel Lehmann Sarah Jeuthe Dag Wulsten Uwe Kornak Peter N. Robinson Britt Wildemann Georgios Kararigas Defects in the extracellular matrix protein fibrillin-1 that perturb transforming growth factor beta (TGFβ) bioavailability...
Sun Dec 01, 2019 02:00
IJMS, Vol. 20, Pages 6058: 3’-O-Methylorobol Inhibits the Voltage-Gated Sodium Channel Nav1.7 with Anti-Itch Efficacy in A Histamine-Dependent Itch Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms20236058 Authors: Fan Zhang Ying Wu Shuwen Xue Shuangyan Wang Chunlei Zhang Zhengyu Cao An itch is a clinical complication that affects millions of patients. However, few treatment options are available. The voltage-gated sodium channel Nav1.7 is predominantly...
Sun Dec 01, 2019 02:00
IJMS, Vol. 20, Pages 6056: Overcoming Hurdles in Nanoparticle Clinical Translation: The Influence of Experimental Design and Surface Modification International Journal of Molecular Sciences doi: 10.3390/ijms20236056 Authors: Shreffler Pullan Dailey Mallik Brooks Nanoparticles are becoming an increasingly popular tool for biomedical imaging and drug delivery. While the prevalence of nanoparticle drug-delivery systems reported in the literature increases yearly, relatively...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6054: Modeling the Effect of Hypoxia and DNA Repair Inhibition on Cell Survival After Photon Irradiation International Journal of Molecular Sciences doi: 10.3390/ijms20236054 Authors: Liew Klein Zenke Abdollahi Debus Dokic Mairani Mechanistic approaches to modeling the effects of ionizing radiation on cells are on the rise, promising a better understanding of predictions and higher flexibility concerning conditions to be accounted for. In...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6055: Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20236055 Authors: Konovalova Gerasymchuk Parkkinen Chmielarz Domanskyi MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis increases neuronal vulnerability to cellular stress and...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6057: From Local to Global Modeling for Characterizing Calcium Dynamics and Their Effects on Electrical Activity and Exocytosis in Excitable Cells International Journal of Molecular Sciences doi: 10.3390/ijms20236057 Authors: Francesco Montefusco Morten G. Pedersen Electrical activity in neurons and other excitable cells is a result of complex interactions between the system of ion channels, involving both global coupling (e.g., via voltage or bulk cytosolic Ca2+concentration)...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6053: Teaching an Old Molecule New Tricks: Drug Repositioning for Duchenne Muscular Dystrophy International Journal of Molecular Sciences doi: 10.3390/ijms20236053 Authors: Vitiello Tibaudo Pegoraro Bello Canton : Duchenne muscular dystrophy (DMD) is one of the most severe forms of inherited muscular dystrophies. The disease is caused by the lack of dystrophin, a structurally essential protein; hence, a definitive cure would necessarily have to pass...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6051: Colon Cancer and Perturbations of the Sphingolipid Metabolism International Journal of Molecular Sciences doi: 10.3390/ijms20236051 Authors: Miroslav Machala Jiřina Procházková Jiřina Hofmanová Lucie Králiková Josef Slavík Zuzana Tylichová Petra Ovesná Alois Kozubík Jan Vondráček The development and progression of colon cancer (CRC), a major cause of cancer-related death in the western world, is accompanied with alterations of sphingolipid...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6050: Endogenous Retroviruses Activity as a Molecular Signature of Neurodevelopmental Disorders International Journal of Molecular Sciences doi: 10.3390/ijms20236050 Authors: Balestrieri Matteucci Cipriani Grelli Ricceri Calamandrei Vallebona Human endogenous retroviruses (HERVs) are genetic elements resulting from relics of ancestral infection of germline cells, now recognized as cofactors in the etiology of several complex diseases. Here...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6049: Re-Evaluating Biologic Pharmacotherapies that Target the Host Response during Sepsis International Journal of Molecular Sciences doi: 10.3390/ijms20236049 Authors: Tuttle McDonald Anderson Multiple organ dysfunction syndrome (MODS) caused by the systemic inflammatory response during sepsis is responsible for millions of deaths worldwide each year, and despite broad consensus concerning its pathophysiology, no specific or effective therapies exist....
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6052: The TFF Peptides xP1 and xP4 Appear in Distinctive Forms in the Xenopus laevis Gastric Mucosa: Indications for Different Protective Functions International Journal of Molecular Sciences doi: 10.3390/ijms20236052 Authors: Stürmer Reising Hoffmann The gastric secretory trefoil factor family (TFF) peptides xP1 and xP4 are the Xenopus laevis orthologs of mammalian TFF1 and TFF2, respectively. The aim of this study was to analyze the molecular forms of...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6048: Decreased Activity of Blood Acid Sphingomyelinase in the Course of Multiple Myeloma International Journal of Molecular Sciences doi: 10.3390/ijms20236048 Authors: Marzena Wątek Ewelina Piktel Joanna Barankiewicz Ewa Sierlecka Sylwia Kościołek-Zgódka Anna Chabowska Łukasz Suprewicz Przemysław Wolak Bonita Durnaś Robert Bucki Ewa Lech-Marańda Acid sphingomyelinase (aSMase) is involved in the generation of metabolites that function...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6046: DeepMiR2GO: Inferring Functions of Human MicroRNAs Using a Deep Multi-Label Classification Model International Journal of Molecular Sciences doi: 10.3390/ijms20236046 Authors: Jiacheng Wang Jingpu Zhang Yideng Cai Lei Deng MicroRNAs (miRNAs) are a highly abundant collection of functional non-coding RNAs involved in cellular regulation and various complex human diseases. Although a large number of miRNAs have been identified, most of their physiological...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6047: Bone Pain in Cancer Patients: Mechanisms and Current Treatment International Journal of Molecular Sciences doi: 10.3390/ijms20236047 Authors: Renata Zajączkowska Magdalena Kocot-Kępska Wojciech Leppert Jerzy Wordliczek The skeletal system is the third most common site for cancer metastases, surpassed only by the lungs and liver. Many tumors, especially those of the breast, prostate, lungs, and kidneys, have a strong predilection to metastasize to bone,...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6045: Gonadotropin Releasing Hormone Agonists Have an Anti-apoptotic Effect on Cumulus Cells International Journal of Molecular Sciences doi: 10.3390/ijms20236045 Authors: Scaruffi Stigliani Cardinali Massarotti Lambertini Sozzi Dellepiane Merlo Anserini Mastro Background: Ovaries are sensitive to chemotherapy, which may lead to early depletion of primordial follicle reserve. One strategy for gonadal function preservation is temporary...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6044: Estimation of Forces on Actin Filaments in Living Muscle from X-ray Diffraction Patterns and Mechanical Data International Journal of Molecular Sciences doi: 10.3390/ijms20236044 Authors: Srboljub M. Mijailovich Momcilo Prodanovic Thomas C. Irving Many biological processes are triggered or driven by mechanical forces in the cytoskeletal network, but these transducing forces have rarely been assessed. Striated muscle, with its well-organized structure...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6042: Integration of Epigallocatechin Gallate in Gelatin Sponges Attenuates Matrix Metalloproteinase-Dependent Degradation and Increases Bone Formation International Journal of Molecular Sciences doi: 10.3390/ijms20236042 Authors: Anqi Huang Yoshitomo Honda Peiqi Li Tomonari Tanaka Shunsuke Baba Matrix metalloproteinase (MMP)-2 and MMP-9 are well-known gelatinases that disrupt the extracellular matrix, including gelatin. However, the advantages of modulating...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6043: Effect of Long-Term Brushing on Deflection, Maximum Load, and Wear of Stainless Steel Wires and Conventional and Spot Bonded Fiber-Reinforced Composites International Journal of Molecular Sciences doi: 10.3390/ijms20236043 Authors: Andrea Scribante Pekka Vallittu Lippo V. J. Lassila Annalisa Viola Paola Tessera Paola Gandini Maria Francesca Sfondrini Fiber-reinforced composite (FRC) retainers are an aesthetic alternative to conventional Stainless...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6041: Dead Cas Systems: Types, Principles, and Applications International Journal of Molecular Sciences doi: 10.3390/ijms20236041 Authors: Sergey Brezgin Anastasiya Kostyusheva Dmitry Kostyushev Vladimir Chulanov The gene editing tool CRISPR-Cas has become the foundation for developing numerous molecular systems used in research and, increasingly, in medical practice. In particular, Cas proteins devoid of nucleolytic activity (dead Cas proteins; dCas) can...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6040: Whole Genome Expression Analyses of miRNAs and mRNAs Suggest the Involvement of miR-320a and miR-155-3p and their Targeted Genes in Lithium Response in Bipolar Disorder International Journal of Molecular Sciences doi: 10.3390/ijms20236040 Authors: Pisanu Merkouri Papadima Melis Congiu Loizedda Orrù Calza Orrù Carcassi Severino Ardau Chillotti Del Zompo Squassina Lithium is the mainstay in the maintenance...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6037: Phenotypic Screen with the Human Secretome Identifies FGF16 as Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells International Journal of Molecular Sciences doi: 10.3390/ijms20236037 Authors: Karin Jennbacken Fredrik Wågberg Ulla Karlsson Jerry Eriksson Lisa Magnusson Marjorie Chimienti Piero Ricchiuto Jenny Bernström Mei Ding Douglas Ross-Thriepland Yafeng Xue Diluka Peiris Teodor Aastrup Hanna Tegel Sophia...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6038: PatJAZ6 Acts as a Repressor Regulating JA-Induced Biosynthesis of Patchouli Alcohol in Pogostemon Cablin International Journal of Molecular Sciences doi: 10.3390/ijms20236038 Authors: Xiaobing Wang Xiuzhen Chen Liting Zhong Xuanxuan Zhou Yun Tang Yanting Liu Junren Li Hai Zheng Ruoting Zhan Likai Chen The JASMONATE ZIM DOMAIN (JAZ) proteins act as negative regulators in the jasmonic acid (JA) signaling pathways of plants, and these...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6039: Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways International Journal of Molecular Sciences doi: 10.3390/ijms20236039 Authors: Luigi Chiricosta Serena Silvestro Jacopo Pizzicannella Francesca Diomede Placido Bramanti Oriana Trubiani Emanuela Mazzon Inflammation is a common feature of many neurodegenerative diseases. The treatment of stem cells as a therapeutic approach...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6036: Heterogeneous Pattern of Dependence on Anti-Apoptotic BCL-2 Family Proteins upon CHOP Treatment in Diffuse Large B-Cell Lymphoma International Journal of Molecular Sciences doi: 10.3390/ijms20236036 Authors: Mathilde Rikje Willemijn de Jong Myra Langendonk Bart Reitsma Marcel Nijland Anke van den Berg Emanuele Ammatuna Lydia Visser Tom van Meerten Expression of the anti-apoptotic B-cell lymphoma 2 (BCL-2) protein in patients with diffuse...
Sat Nov 30, 2019 02:00
IJMS, Vol. 20, Pages 6035: A Paradigm in Immunochemistry, Revealed by Monoclonal Antibodies to Spatially Distinct Epitopes on Syntenin-1 International Journal of Molecular Sciences doi: 10.3390/ijms20236035 Authors: Johnson Sorvina Logan Moore Heatlie Parkinson-Lawrence Selemidis O’Leary Butler Brooks Syntenin-1 is an essential multi-functional adaptor protein, which has multiple roles in membrane trafficking and exosome biogenesis, as well as scaffolding...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6034: Analysis of Centranthera grandiflora Benth Transcriptome Explores Genes of Catalpol, Acteoside and Azafrin Biosynthesis International Journal of Molecular Sciences doi: 10.3390/ijms20236034 Authors: Zhang Li Wang Fei Qin Cardiovascular diseases (CVDs) are a major cause of health loss in the world. Prevention and treatment of this disease by traditional Chinese medicine is a promising method. Centranthera grandiflora Benth is a high-value medicinal...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6033: TCGA-TCIA Impact on Radiogenomics Cancer Research: A Systematic Review International Journal of Molecular Sciences doi: 10.3390/ijms20236033 Authors: Zanfardino Pane Mirabelli Salvatore Franzese In the last decade, the development of radiogenomics research has produced a significant amount of papers describing relations between imaging features and several molecular ‘omic signatures arising from next-generation sequencing technology...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6031: The Phylogeny and Biological Function of Gastric Juice—Microbiological Consequences of Removing Gastric Acid International Journal of Molecular Sciences doi: 10.3390/ijms20236031 Authors: Martinsen Fossmark Waldum Gastric juice is a unique combination of hydrochloric acid (HCl), lipase, and pepsin. Acidic gastric juice is found in all vertebrates, and its main function is to inactivate microorganisms. The phylogenetic preservation of this energy-consuming...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6030: PP2Ac Modulates AMPK-Mediated Induction of Autophagy in Mycobacterium bovis—Infected Macrophages International Journal of Molecular Sciences doi: 10.3390/ijms20236030 Authors: Hussain Zhao Shah Sabir Wang Liao Song Hussain Mangi Yao Dong Yang Zhou Mycobacterium bovis (M. bovis) is the causative agent of bovine tuberculosis in cattle population across the world. Human beings are at equal risk of developing tuberculosis...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6032: A Phase II, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of Alpha-1 Antitrypsin (AAT) (Glassia®) in the Treatment of Recent-Onset Type 1 Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms20236032 Authors: Lebenthal Brener Hershkovitz Shehadeh Shalitin Lewis Elias Haim Barash Loewenthal Zuckerman-Levin Stein Tov Rachmiel Our aim was...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6028: Oxidative Stress-Induced Pentraxin 3 Expression Human Retinal Pigment Epithelial Cells is Involved in the Pathogenesis of Age-Related Macular Degeneration International Journal of Molecular Sciences doi: 10.3390/ijms20236028 Authors: Hwang Kwon Woo Chung : (1) Background: Age-related macular degeneration (AMD) is closely related with retinal pigment epithelial (RPE) cell dysfunction. Although the exact pathogenesis of AMD remains largely unknown,...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6029: Recent Advances in Mono- and Combined Stem Cell Therapies of Stroke in Animal Models and Humans International Journal of Molecular Sciences doi: 10.3390/ijms20236029 Authors: Surugiu Olaru Hermann Glavan Catalin Popa-Wagner Following the failure of acute neuroprotection therapies, major efforts are currently made worldwide to promote neurological recovery and brain plasticity in the subacute and post-acute phases of stroke. Currently, there...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6027: Evidence for the Capability of Roxadustat (FG-4592), an Oral HIF Prolyl-Hydroxylase Inhibitor, to Perturb Membrane Ionic Currents: An Unidentified yet Important Action International Journal of Molecular Sciences doi: 10.3390/ijms20236027 Authors: Wei-Ting Chang Yi-Ching Lo Zi-Han Gao Sheng-Nan Wu Roxadustat (FG-4592), an analog of 2-oxoglutarate, is an orally-administered, heterocyclic small molecule known to be an inhibitor of hypoxia inducible factor...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6025: The Regional Specific Alterations in BBB Permeability are Relevant to the Differential Responses of 67-kDa LR Expression in Endothelial Cells and Astrocytes Following Status Epilepticus International Journal of Molecular Sciences doi: 10.3390/ijms20236025 Authors: Hana Park Tae-Cheon Kang Status epilepticus (a prolonged seizure activity, SE) differently affects vasogenic edema formation and dystrophin-aquaporin 4 (AQP4) expressions between the rat hippocampus...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6026: A Small Compound KJ-28d Enhances the Sensitivity of Non-Small Cell Lung Cancer to Radio- and Chemotherapy International Journal of Molecular Sciences doi: 10.3390/ijms20236026 Authors: Hwani Ryu Hyo Jeong Kim Jie-Young Song Sang-Gu Hwang Jae-Sung Kim Joon Kim Thi Hong Nhung Bui Hyun-Kyung Choi Jiyeon Ahn We previously reported on a poly (ADP-ribose) polymerase (PARP) 1/2 inhibitor N-(3-(hydroxycarbamoyl)phenyl)carboxamide (designated...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6024: Renal Tubular Glucagon-Like Peptide-1 Receptor Expression Is Increased in Early Sepsis but Reduced in Chronic Kidney Disease and Sepsis-Induced Kidney Injury International Journal of Molecular Sciences doi: 10.3390/ijms20236024 Authors: Jae Hyun Choi Seung Jung Kim Soon Kil Kwon Hye-Young Kim Hyunjung Jeon Acute kidney injury (AKI) is common in patients with sepsis and causes renal ischemia. Glucagon-like peptide-1 (GLP-1) protects the vascular...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6022: Charge Transfer, Complexes Formation and Furan Fragmentation Induced by Collisions with Low-Energy Helium Cations International Journal of Molecular Sciences doi: 10.3390/ijms20236022 Authors: Tomasz J. Wasowicz Marta Łabuda Boguslaw Pranszke The present work focuses on unraveling the collisional processes leading to the fragmentation of the gas-phase furan molecules under the He+ and He2+ cations impact in the energy range 5–2000 eV. The presence...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6023: p53 Isoforms in Cellular Senescence- and Ageing-Associated Biological and Physiological Functions International Journal of Molecular Sciences doi: 10.3390/ijms20236023 Authors: Kaori Fujita Cellular senescence, a term originally used to define the characteristics of normal human fibroblasts that reached their replicative limit, is an important factor for ageing, age-related diseases including cancer, and cell reprogramming. These outcomes are mediated by senescence-associated...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6021: Multiple Functions of B Cells in the Pathogenesis of Systemic Lupus Erythematosus International Journal of Molecular Sciences doi: 10.3390/ijms20236021 Authors: Kongyang Ma Wenhan Du Xiaohui Wang Shiwen Yuan Xiaoyan Cai Dongzhou Liu Jingyi Li Liwei Lu Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by excessive autoantibody production and multi-organ involvement. Although the etiology of SLE still remains unclear,...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6019: Molecular Cavity Topological Representation for Pattern Analysis: A NLP Analogy-Based Word2Vec Method International Journal of Molecular Sciences doi: 10.3390/ijms20236019 Authors: Dongliang Guo Qiaoqiao Wang Meng Liang Wei Liu Junlan Nie Cavity analysis in molecular dynamics is important for understanding molecular function. However, analyzing the dynamic pattern of molecular cavities remains a difficult task. In this paper, we propose a novel...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6020: Structural Features of Tight-Junction Proteins International Journal of Molecular Sciences doi: 10.3390/ijms20236020 Authors: Udo Heinemann Anja Schuetz Tight junctions are complex supramolecular entities composed of integral membrane proteins, membrane-associated and soluble cytoplasmic proteins engaging in an intricate and dynamic system of protein–protein interactions. Three-dimensional structures of several tight-junction proteins or their...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6012: Reciprocal Association between the Apical Junctional Complex and AMPK: A Promising Therapeutic Target for Epithelial/Endothelial Barrier Function? International Journal of Molecular Sciences doi: 10.3390/ijms20236012 Authors: Kazuto Tsukita Tomoki Yano Atsushi Tamura Sachiko Tsukita Epithelial/endothelial cells adhere to each other via cell–cell junctions including tight junctions (TJs) and adherens junctions (AJs). TJs and AJs are spatiotemporally...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6015: On the Road to Accurate Biomarkers for Cardiometabolic Diseases by Integrating Precision and Gender Medicine Approaches International Journal of Molecular Sciences doi: 10.3390/ijms20236015 Authors: Letizia Scola Rosa Maria Giarratana Salvatore Torre Vincenzo Argano Domenico Lio Carmela Rita Balistreri The need to facilitate the complex management of cardiometabolic diseases (CMD) has led to the detection of many biomarkers, however, there are...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6016: A Snapshot of The Tumor Microenvironment in Colorectal Cancer: The Liquid Biopsy International Journal of Molecular Sciences doi: 10.3390/ijms20236016 Authors: Mercedes Herrera Cristina Galindo-Pumariño Vanesa García-Barberán Cristina Peña The molecular profile of liquid biopsies is emerging as an alternative to tissue biopsies in the clinical management of malignant diseases. In colorectal cancer, significant liquid biopsy-based biomarkers have demonstrated...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6018: Human Recombinant Arginase I [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Inhibits Colorectal Cancer Cell Migration and Invasion International Journal of Molecular Sciences doi: 10.3390/ijms20236018 Authors: Houssam Al-Koussa Maria Al-Haddad Ralph Abi-Habib Mirvat El-Sibai Purpose: Colorectal cancer (CRC) is the third most common type of cancer worldwide, and it represents over half of all gastrointestinal cancer deaths. Knowing that cancer cells...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6014: Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models International Journal of Molecular Sciences doi: 10.3390/ijms20236014 Authors: Kiwako Mori Toshihide Kurihara Xiaoyan Jiang Shin-ichi Ikeda Ayako Ishida Hidemasa Torii Kazuo Tsubota Whether hyperoxia affects the refraction in neonatal and adult mice is unknown. The mice exposed to 85% oxygen at postnatal 8 days (P8d) for 3 days and the mice exposed to normal air were...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6013: Usp10 Modulates the Hippo Pathway by Deubiquitinating and Stabilizing the Transcriptional Coactivator Yorkie International Journal of Molecular Sciences doi: 10.3390/ijms20236013 Authors: Yang Gao Xiaoting Zhang Lijuan Xiao Chaojun Zhai Tao Yi Guiping Wang Enlin Wang Xiaohui Ji Liangchang Hu Guangshuang Shen Shian Wu The Hippo signaling pathway is an evolutionarily conserved regulator that plays important roles in organ size control,...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6011: Interplay between miRNAs and Genes Associated with Cell Proliferation in Endometrial Cancer International Journal of Molecular Sciences doi: 10.3390/ijms20236011 Authors: Ewelina Hermyt Nikola Zmarzły Beniamin Grabarek Celina Kruszniewska-Rajs Joanna Gola Agnieszka Jęda-Golonka Katarzyna Szczepanek Urszula Mazurek Andrzej Witek Endometrial cancer develops as a result of abnormal cell growth associated with uncontrolled cell proliferation,...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6017: Pre-Clinical Drug Testing in 2D and 3D Human In Vitro Models of Glioblastoma Incorporating Non-Neoplastic Astrocytes: Tunneling Nano Tubules and Mitochondrial Transfer Modulates Cell Behavior and Therapeutic Respons International Journal of Molecular Sciences doi: 10.3390/ijms20236017 Authors: Prospero Civita Diana M. Leite Geoffrey J. Pilkington The role of astrocytes in the glioblastoma (GBM) microenvironment is poorly understood; particularly with...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6010: Effects of Cadmium on ZO-1 Tight Junction Integrity of the Blood Brain Barrier International Journal of Molecular Sciences doi: 10.3390/ijms20236010 Authors: Jacopo Junio Valerio Branca Mario Maresca Gabriele Morucci Tommaso Mello Matteo Becatti Luigia Pazzagli Ilaria Colzi Cristina Gonnelli Donatello Carrino Ferdinando Paternostro Claudio Nicoletti Carla Ghelardini Massimo Gulisano Lorenzo Di Cesare Mannelli Alessandra Pacini...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6009: Growth Plate Chondrocytes: Skeletal Development, Growth and Beyond International Journal of Molecular Sciences doi: 10.3390/ijms20236009 Authors: Shawn A. Hallett Wanida Ono Noriaki Ono Growth plate chondrocytes play central roles in the proper development and growth of endochondral bones. Particularly, a population of chondrocytes in the resting zone expressing parathyroid hormone-related protein (PTHrP) is now recognized as skeletal stem cells, defined...
Fri Nov 29, 2019 02:00
IJMS, Vol. 20, Pages 6008: Cytokines in Inflammatory Disease International Journal of Molecular Sciences doi: 10.3390/ijms20236008 Authors: Shinwan Kany Jan Tilmann Vollrath Borna Relja This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines. Numerous studies have implicated that inflammatory cytokines exert important effects with regard to various inflammatory diseases, yet the reports on their specific roles are not always consistent. They...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 6007: Integrated Metabolomics and Transcriptomics Unravel the Metabolic Pathway Variations for Different Sized Beech Mushrooms International Journal of Molecular Sciences doi: 10.3390/ijms20236007 Authors: Son Park Jung Singh Lee Kim Lee Beech mushrooms (Hypsizygus marmoreus) are largely relished for their characteristic earthy flavor, chewy-texture, and gustatory and nutritional properties in East Asian societies. Intriguingly, the aforementioned...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 6005: Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis International Journal of Molecular Sciences doi: 10.3390/ijms20236005 Authors: Christian Vogeley Charlotte Esser Thomas Tüting Jean Krutmann Thomas Haarmann-Stemmann The skin is constantly exposed to a variety of environmental threats, including solar electromagnetic radiation, microbes, airborne particulate matter, and chemicals. Acute exposure to...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 6006: Contribution of a Novel B3GLCT Variant to Peters Plus Syndrome Discovered by a Combination of Next-Generation Sequencing and Automated Text Mining International Journal of Molecular Sciences doi: 10.3390/ijms20236006 Authors: Justyna Totoń-Żurańska Przemysław Kapusta Magda Rybak-Krzyszkowska Katarzyna Lorenc Julita Machlowska Anna Skalniak Erita Filipek Dorota Pawlik Paweł P. Wołkow Anterior segment dysgenesis (ASD) encompasses a spectrum...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 6004: The Interplay between Ca2+ Signaling Pathways and Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms20236004 Authors: Ureshino Erustes Bassani Wachilewski Guarache Nascimento Costa Smaili Pereira Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in many physiological processes. For example, the spatial and temporal organization of Ca2+ signaling in the central...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 6003: The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia International Journal of Molecular Sciences doi: 10.3390/ijms20236003 Authors: Sillar Germon DeIuliis Dun Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with a poor overall survival. Reactive oxygen species (ROS) have been shown to be elevated in a wide range of cancers including AML. Whilst previously thought to be mere by-products of cellular metabolism,...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 6000: Identification of Novel PI3Kδ Selective Inhibitors by SVM-Based Multistage Virtual Screening and Molecular Dynamics Simulations International Journal of Molecular Sciences doi: 10.3390/ijms20236000 Authors: Jing-wei Liang Shan Wang Ming-yang Wang Shi-long Li Wan-qiu Li Fan-hao Meng Phosphoinositide 3 kinase delta (PI3Kδ) is a lipid kinase that has been implicated in a variety of immune mediated disorders. The research on isoform selectivity...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 6001: GaAs-Based InPBi Quantum Dots for High Efficiency Super-Luminescence Diodes International Journal of Molecular Sciences doi: 10.3390/ijms20236001 Authors: Liyao Zhang Yuxin Song Qian Gong InPBi exhibits broad and strong photoluminescence at room temperature, and is a potential candidate for fabricating super-luminescence diodes applied in optical coherence tomography. In this paper, the strained InPBi quantum dot (QD) embedded in the AlGaAs barrier on...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 6002: Biomimetic Synthesis of Nanocrystalline Hydroxyapatite Composites: Therapeutic Potential and Effects on Bone Regeneration International Journal of Molecular Sciences doi: 10.3390/ijms20236002 Authors: Chih-Hsiang Fang Yi-Wen Lin Feng-Huei Lin Jui-Sheng Sun Yuan-Hung Chao Hung-Ying Lin Zwei-Chieng Chang The development of a novel alloplastic graft with both osteoinductive and osteoconductive properties is still necessary. In this study, we...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5998: miRNAs and Novel Food Compounds Related to the Browning Process International Journal of Molecular Sciences doi: 10.3390/ijms20235998 Authors: Silvia Lorente-Cebrián Katya Herrera Fermín I. Milagro Juana Sánchez Ana Laura de la Garza Heriberto Castro Obesity prevalence is rapidly increasing worldwide. With the discovery of brown adipose tissue (BAT) in adult humans, BAT activation has emerged as a potential strategy for increasing energy expenditure....
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5999: Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors International Journal of Molecular Sciences doi: 10.3390/ijms20235999 Authors: Hui Li Jinglin Zhang Joanna Hung Man Tong Anthony Wing Hung Chan Jun Yu Wei Kang Ka Fai To Colorectal cancer (CRC) is a kind of solid tumor and the third most common cancer type in the world. It is a heterogeneous disease characterized by genetic and epigenetic aberrations. The TP53...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5996: The Dual Interactions of p53 with MDM2 and p300: Implications for the Design of MDM2 Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms20235996 Authors: Srinivasaraghavan Kannan Anthony W. Partridge David P. Lane Chandra S. Verma Proteins that limit the activity of the tumour suppressor protein p53 are increasingly being targeted for inhibition in a variety of cancers. In addition to the development of small molecules, there has...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5995: From Tumor Metastasis towards Cerebral Ischemia—Extracellular Vesicles as a General Concept of Intercellular Communication Processes International Journal of Molecular Sciences doi: 10.3390/ijms20235995 Authors: Xuan Zheng Mathias Bähr Thorsten R. Doeppner Extracellular vesicles (EVs) have been tremendous carriers in both experimental and translational science. These vesicles—formerly regarded as artifacts of in vitro research—have...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5997: Deubiquitinating Enzymes: A Critical Regulator of Mitosis International Journal of Molecular Sciences doi: 10.3390/ijms20235997 Authors: Jinyoung Park Jinhong Cho Eunice EunKyeong Kim Eun Joo Song Mitosis is a complex and dynamic process that is tightly regulated by a large number of mitotic proteins. Dysregulation of these proteins can generate daughter cells that exhibit genomic instability and aneuploidy, and such cells can transform into tumorigenic...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5993: A Benzothiazole-Based Fluorescent Probe for Ratiometric Detection of Al3+ and Its Application in Water Samples and Cell Imaging International Journal of Molecular Sciences doi: 10.3390/ijms20235993 Authors: Zhen-Nan Tian Ding-Qi Wu Xue-Jiao Sun Ting-Ting Liu Zhi-Yong Xing An easily prepared benzothiazole-based probe (BHM) was prepared and characterized by general spectra, including 1H NMR, 13C NMR, HRMS, and single-crystal X-ray diffraction. Based...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5992: Comprehensive Identification of PTI Suppressors in Type III Effector Repertoire Reveals that Ralstonia solanacearum Activates Jasmonate Signaling at Two Different Steps International Journal of Molecular Sciences doi: 10.3390/ijms20235992 Authors: Masahito Nakano Takafumi Mukaihara Ralstonia solanacearum is the causative agent of bacterial wilt in many plants. To identify R. solanacearum effectors that suppress pattern-triggered immunity (PTI) in plants,...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5994: NLRP7 Is Involved in the Differentiation of the Decidual Macrophages International Journal of Molecular Sciences doi: 10.3390/ijms20235994 Authors: Pei-Yin Tsai Kuan-Ru Chen Yueh-Chun Li Pao-Lin Kuo Macrophage polarization, regulated appropriately, may play important roles in successful pregnancy. In the face of the vital roles of decidua macrophages in pregnancy, it is insufficient to recognize the trigger of macrophage differentiation and polarization....
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5990: Genetic and Functional Diversity of Nitrilases in Agaricomycotina International Journal of Molecular Sciences doi: 10.3390/ijms20235990 Authors: Lenka Rucká Martin Chmátal Natalia Kulik Lucie Petrásková Helena Pelantová Petr Novotný Romana Příhodová Miroslav Pátek Ludmila Martínková Nitrilases participate in the nitrile metabolism in microbes and plants. They are widely used to produce carboxylic acids from nitriles. Nitrilases were...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5991: UV Treatment Improves the Biocompatibility and Antibacterial Properties of Crystallized Nanostructured Titanium Surface International Journal of Molecular Sciences doi: 10.3390/ijms20235991 Authors: Mai Hatoko Satoshi Komasa Honghao Zhang Tohru Sekino Joji Okazaki This study describes the production of a new material composed of pure titanium (Ti) metal with a crystallized nanostructure and investigated whether heat treatment and ultraviolet (UV)...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5988: Parallel Bud Mutation Sequencing Reveals that Fruit Sugar and Acid Metabolism Potentially Influence Stress in Malus International Journal of Molecular Sciences doi: 10.3390/ijms20235988 Authors: Jirong Zhao Fei Shen Yuan Gao Dajiang Wang Kun Wang Apple sugar and acid are the most important traits of apple fruit. Bud sport cultivars can provide abundant research materials for functional gene studies in apple. In this study, using bud sport materials...
Thu Nov 28, 2019 02:00
IJMS, Vol. 20, Pages 5989: Epicardial Adipose Tissue: Clinical Biomarker of Cardio-Metabolic Risk International Journal of Molecular Sciences doi: 10.3390/ijms20235989 Authors: Alexandra C. Villasante Fricke Gianluca Iacobellis Epicardial adipose tissue (EAT) is part of the visceral adipose tissue (VAT) that surrounds the heart and it is a quantifiable, modifiable, and multifaceted tissue that has both local and systemic effects. When EAT is enlarged, EAT contributes to atherosclerotic...
Thu Nov 28, 2019 02:00
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