Τρίτη 28 Ιανουαρίου 2020

MDPI


IJERPH, Vol. 17, Pages 800: Economic Evaluation of Hepatitis C Treatment Extension to Acute Infection and Early-Stage Fibrosis Among Patients Who Inject Drugs in Developing Countries: A Case of China
IJERPH, Vol. 17, Pages 800: Economic Evaluation of Hepatitis C Treatment Extension to Acute Infection and Early-Stage Fibrosis Among Patients Who Inject Drugs in Developing Countries: A Case of China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030800 Authors: Liu Zhang Zhang Zou Ling We aimed to assess the cost-effectiveness of (1) treating acute hepatitis C virus (HCV) vs deferring treatment until the chronic phase and (2)...
International Journal of Environmental Research and Public Health
Tue Jan 28, 2020 02:00
IJERPH, Vol. 17, Pages 798: Predictive Factors of Response to Selective Progesterone Receptor Modulator (Ulipristal Acetate) in the Pharmacological Treatment of Uterine Fibroids
IJERPH, Vol. 17, Pages 798: Predictive Factors of Response to Selective Progesterone Receptor Modulator (Ulipristal Acetate) in the Pharmacological Treatment of Uterine Fibroids International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030798 Authors: Szydłowska Marciniak Nawrocka-Rutkowska Rył Starczewski Background: Selective progesterone receptor modulator ulipristal acetate (UPA) is a drug used in management of symptomatic myomas. It...
International Journal of Environmental Research and Public Health
Tue Jan 28, 2020 02:00
IJERPH, Vol. 17, Pages 790: Cancer Prevention Using Machine Learning, Nudge Theory and Social Impact Bond
IJERPH, Vol. 17, Pages 790: Cancer Prevention Using Machine Learning, Nudge Theory and Social Impact Bond International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030790 Authors: Misawa Fukuyoshi Sengoku There have been prior attempts to utilize machine learning to address issues in the medical field, particularly in diagnoses using medical images and developing therapeutic regimens. However, few cases have demonstrated the usefulness of machine...
International Journal of Environmental Research and Public Health
Tue Jan 28, 2020 02:00
IJERPH, Vol. 17, Pages 793: Physical Activity Promotion for Apprentices in Nursing Care and Automotive Mechatronics–Competence Counts More than Volume
IJERPH, Vol. 17, Pages 793: Physical Activity Promotion for Apprentices in Nursing Care and Automotive Mechatronics–Competence Counts More than Volume International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030793 Authors: Carl Grüne Popp Pfeifer Apprentices in the area of nursing care and automotive mechatronics are exposed to increased health risks. In this context, the promotion of physical activity (PA) is considered an effective strategy...
International Journal of Environmental Research and Public Health
Tue Jan 28, 2020 02:00
IJERPH, Vol. 17, Pages 791: A Spatial-Temporal Resolved Validation of Source Apportionment by Measurements of Ambient VOCs in Central China
IJERPH, Vol. 17, Pages 791: A Spatial-Temporal Resolved Validation of Source Apportionment by Measurements of Ambient VOCs in Central China International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030791 Authors: Shen Wang Cheng Liang Xiang Hu Yin Yu Understanding the sources of volatile organic compounds (VOCs) is essential in the implementation of abatement measures of ground-level ozone and secondary organic aerosols. In this...
International Journal of Environmental Research and Public Health
Tue Jan 28, 2020 02:00
IJERPH, Vol. 17, Pages 797: Reference Values for Fitness Level and Gross Motor Skills of 4–6-Year-Old Chilean Children
IJERPH, Vol. 17, Pages 797: Reference Values for Fitness Level and Gross Motor Skills of 4–6-Year-Old Chilean Children International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030797 Authors: Godoy-Cumillaf Bruneau-Chávez Fuentes-Merino Vásquez-Gómez Sánchez-López Alvárez-Bueno Cavero-Redondo In childhood, fitness level is considered an important indicator of health, while gross motor skills are the basis of future motor competence....
International Journal of Environmental Research and Public Health
Tue Jan 28, 2020 02:00
IJERPH, Vol. 17, Pages 799: Understanding Physical Activity Intentions in Physical Education Context: A multi-level Analysis from the Self-Determination Theory
IJERPH, Vol. 17, Pages 799: Understanding Physical Activity Intentions in Physical Education Context: A multi-level Analysis from the Self-Determination Theory International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030799 Authors: Sánchez-Oliva Mouratidis Leo Chamorro Pulido-González García-Calvo Using self-determination theory as a framework, we aimed to study the relationships between perceived need support and need satisfaction...
International Journal of Environmental Research and Public Health
Tue Jan 28, 2020 02:00
IJERPH, Vol. 17, Pages 795: Influence of a Water-Based Exercise Program in the Rate of Spontaneous Birth: A Randomized Clinical Trial
IJERPH, Vol. 17, Pages 795: Influence of a Water-Based Exercise Program in the Rate of Spontaneous Birth: A Randomized Clinical Trial International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030795 Authors: Rodríguez-Blanque Aguilar-Cordero Marín-Jiménez Núñez-Negrillo Sánchez-López Sánchez-García Introduction: Many women change their lifestyles and habits when they become pregnant, to avoid potentially harmful effects to themselves...
International Journal of Environmental Research and Public Health
Tue Jan 28, 2020 02:00
IJERPH, Vol. 17, Pages 789: Adsorption of Phenol on Commercial Activated Carbons: Modelling and Interpretation
IJERPH, Vol. 17, Pages 789: Adsorption of Phenol on Commercial Activated Carbons: Modelling and Interpretation International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17030789 Authors: Xie Qin Wang Li Sun Chen Adsorption by activated carbons (AC) is an effective option for phenolic wastewater treatment. Three commercial AC, including coal-derived granular activated carbons (GAC950), coal-derived powdered activated carbons (PAC800), and...
International Journal of Environmental Research and Public Health
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 856: Deletion of the Nucleotide Exchange Factor Vav3 Enhances Axonal Complexity and Synapse Formation but Tampers Activity of Hippocampal Neuronal Networks In Vitro
IJMS, Vol. 21, Pages 856: Deletion of the Nucleotide Exchange Factor Vav3 Enhances Axonal Complexity and Synapse Formation but Tampers Activity of Hippocampal Neuronal Networks In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms21030856 Authors: Wegrzyn Wegrzyn Tedford Fischer Faissner Vav proteins activate GTPases of the RhoA subfamily that regulate the cytoskeleton and are involved in adhesion, migration, differentiation, polarity and the cell cycle....
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 855: Changes in the Surface Expression of Intercellular Adhesion Molecule 3, the Induction of Apoptosis, and the Inhibition of Cell-Cycle Progression of Human Multidrug-Resistant Jurkat/A4 Cells Exposed to a Random Positioning Machine
IJMS, Vol. 21, Pages 855: Changes in the Surface Expression of Intercellular Adhesion Molecule 3, the Induction of Apoptosis, and the Inhibition of Cell-Cycle Progression of Human Multidrug-Resistant Jurkat/A4 Cells Exposed to a Random Positioning Machine International Journal of Molecular Sciences doi: 10.3390/ijms21030855 Authors: Sokolovskaya Korneeva Zaichenko Virus Kolesov Moskovtsev Kubatiev Experiments from flight- and ground-based model systems suggest...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 852: Melatonin Alleviates Drought Stress by a Non-Enzymatic and Enzymatic Antioxidative System in Kiwifruit Seedlings
IJMS, Vol. 21, Pages 852: Melatonin Alleviates Drought Stress by a Non-Enzymatic and Enzymatic Antioxidative System in Kiwifruit Seedlings International Journal of Molecular Sciences doi: 10.3390/ijms21030852 Authors: Xia Ni Hu Lin Deng Wang Tang Sun Wang Li Liao Lv Liang Although melatonin was affirmed to alleviate drought stress in various plant species, the mechanism in kiwifruit remains to be elucidated. In this study, the transcriptomes...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 853: Lung Macrophage Functional Properties in Chronic Obstructive Pulmonary Disease
IJMS, Vol. 21, Pages 853: Lung Macrophage Functional Properties in Chronic Obstructive Pulmonary Disease International Journal of Molecular Sciences doi: 10.3390/ijms21030853 Authors: Akata van Eeden Chronic obstructive pulmonary disease (COPD) is caused by the chronic exposure of the lungs to toxic particles and gases. These exposures initiate a persistent innate and adaptive immune inflammatory response in the airways and lung tissues. Lung macrophages (LMs) are key innate immune...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 854: EVI1 as a Marker for Lymph Node Metastasis in HNSCC
IJMS, Vol. 21, Pages 854: EVI1 as a Marker for Lymph Node Metastasis in HNSCC International Journal of Molecular Sciences doi: 10.3390/ijms21030854 Authors: Idel Ribbat-Idel Kuppler Krupar Offermann Vogel Rades Kirfel Wollenberg Perner Background: HNSCC is the sixth most common cancer in humans and has still a very poor prognosis. The treatment methods so far are very often associated with mutilation and impairment in the quality of life. Except for...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 845: PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila
IJMS, Vol. 21, Pages 845: PERK-Mediated eIF2α Phosphorylation Contributes to The Protection of Dopaminergic Neurons from Chronic Heat Stress in Drosophila International Journal of Molecular Sciences doi: 10.3390/ijms21030845 Authors: Elvira Cha Noh Kim Han Environmental high-temperature heat exposure is linked to physiological stress such as disturbed protein homeostasis caused by endoplasmic reticulum (ER) stress. Abnormal proteostasis in neuronal cells is a common...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 846: Transcriptomic Analyses of Camellia oleifera ‘Huaxin’ Leaf Reveal Candidate Genes Related to Long-Term Cold Stress
IJMS, Vol. 21, Pages 846: Transcriptomic Analyses of Camellia oleifera ‘Huaxin’ Leaf Reveal Candidate Genes Related to Long-Term Cold Stress International Journal of Molecular Sciences doi: 10.3390/ijms21030846 Authors: Wu Li Li Zhang Tan ‘Huaxin’ is a new high-yielding timber cultivar of Camellia oleifera of high economic value, and has been widely cultivated in the red soil hilly region of Hunan Province of the People´s Republic of China...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 847: Integrated Computational Approaches and Tools for Allosteric Drug Discovery
IJMS, Vol. 21, Pages 847: Integrated Computational Approaches and Tools for Allosteric Drug Discovery International Journal of Molecular Sciences doi: 10.3390/ijms21030847 Authors: Sheik Amamuddy Veldman Manyumwa Khairallah Agajanian Oluyemi Verkhivker Tastan Bishop Understanding molecular mechanisms underlying the complexity of allosteric regulationin proteins has attracted considerable attention in drug discovery due to the benefits and versatilityof...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 848: Transcriptome Analysis of Rice Roots in Response to Root-Knot Nematode Infection
IJMS, Vol. 21, Pages 848: Transcriptome Analysis of Rice Roots in Response to Root-Knot Nematode Infection International Journal of Molecular Sciences doi: 10.3390/ijms21030848 Authors: Zhou Zhao Shuang Xiao Xuan Duan Chen Wang Liu Fan Zhu Meloidogyne incognita and Meloidogyne graminicola are root-knot nematodes (RKNs) infecting rice (Oryza sativa L.) roots and severely decreasing yield, whose mechanisms of action remain unclear. We investigated...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 849: Editorial of Special Issue “Adipokines 2.0”
IJMS, Vol. 21, Pages 849: Editorial of Special Issue “Adipokines 2.0” International Journal of Molecular Sciences doi: 10.3390/ijms21030849 Authors: Buechler This editorial aims to summarize the 19 scientific papers that contributed to the Special Issue “Adipokines 2” [...]
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 850: Cellular localization of carbonic anhydrase Nce103p in Candida albicans and Candida parapsilosis
IJMS, Vol. 21, Pages 850: Cellular localization of carbonic anhydrase Nce103p in Candida albicans and Candida parapsilosis International Journal of Molecular Sciences doi: 10.3390/ijms21030850 Authors: Dostál Blaha Hadravová Hubálek Heidingsfeld Pichová Pathogenic yeasts Candida albicans and Candida parapsilosis possess a ß-type carbonic anhydrase Nce103p, which is involved in CO2 hydration and signaling. C. albicans lacking Nce103p cannot survive in low...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 851: Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease
IJMS, Vol. 21, Pages 851: Neutrophil Adaptations upon Recruitment to the Lung: New Concepts and Implications for Homeostasis and Disease International Journal of Molecular Sciences doi: 10.3390/ijms21030851 Authors: Giacalone Margaroli Mall Tirouvanziam Neutrophils have a prominent role in all human immune responses against any type of pathogen or stimulus. The lungs are a major neutrophil reservoir and neutrophilic inflammation is a primary response to both infectious...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 844: Spectrum of Tendon Pathologies: Triggers, Trails and End-State
IJMS, Vol. 21, Pages 844: Spectrum of Tendon Pathologies: Triggers, Trails and End-State International Journal of Molecular Sciences doi: 10.3390/ijms21030844 Authors: Steinmann Pfeifer Brochhausen Docheva The biggest compartment of the musculoskeletal system is the tendons and ligaments. In particular, tendons are dense tissues connecting muscle to bone that are critical for the integrity, function and locomotion of this system. Due to the increasing age of our society...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 841: Brain-Derived Neurotrophic Factor and Diabetes
IJMS, Vol. 21, Pages 841: Brain-Derived Neurotrophic Factor and Diabetes International Journal of Molecular Sciences doi: 10.3390/ijms21030841 Authors: Rozanska Uruska Zozulinska-Ziolkiewicz Diabetes and its chronic complications still represent a great clinical problem, despite improvements made in the diagnosis and treatment of the disease. People with diabetes have a much higher risk of impaired brain function and psychiatric disorders. Neurotrophins are factors that protect...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 838: Mass Spectrometry-Based Multivariate Proteomic Tests for Prediction of Outcomes on Immune Checkpoint Blockade Therapy: The Modern Analytical Approach
IJMS, Vol. 21, Pages 838: Mass Spectrometry-Based Multivariate Proteomic Tests for Prediction of Outcomes on Immune Checkpoint Blockade Therapy: The Modern Analytical Approach International Journal of Molecular Sciences doi: 10.3390/ijms21030838 Authors: Grigorieva Asmellash Net Tsypin Order Roder The remarkable success of immune checkpoint inhibitors (ICIs) has given hope of cure for some patients with advanced cancer; however, the fraction of responding patients...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 834: Maternal Overweight Downregulates MME (Neprilysin) in Feto-Placental Endothelial Cells and in Cord Blood
IJMS, Vol. 21, Pages 834: Maternal Overweight Downregulates MME (Neprilysin) in Feto-Placental Endothelial Cells and in Cord Blood International Journal of Molecular Sciences doi: 10.3390/ijms21030834 Authors: Weiß Berger Brandl Strutz Hirschmugl Simovic Tam-Ammersdorfer Cvitic Hiden Maternal overweight in pregnancy alters the metabolic environment and generates chronic low-grade inflammation. This affects fetal development and programs the offspring’s...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 835: RPGR-Associated Dystrophies: Clinical, Genetic, and Histopathological Features
IJMS, Vol. 21, Pages 835: RPGR-Associated Dystrophies: Clinical, Genetic, and Histopathological Features International Journal of Molecular Sciences doi: 10.3390/ijms21030835 Authors: Nguyen Talib van Schooneveld Brinks ten Brink Florijn Wijnholds Verdijk Bergen Boon This study describes the clinical, genetic, and histopathological features in patients with RPGR-associated retinal dystrophies. Nine male patients from eight unrelated families underwent...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 836: Alpha-1 Antitrypsin—A Target for MicroRNA-Based Therapeutic Development for Cystic Fibrosis
IJMS, Vol. 21, Pages 836: Alpha-1 Antitrypsin—A Target for MicroRNA-Based Therapeutic Development for Cystic Fibrosis International Journal of Molecular Sciences doi: 10.3390/ijms21030836 Authors: Hunt Glasgow Humphreys Greene Cystic fibrosis (CF) is an autosomal recessive genetic disorder arising from mutations to the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Disruption to normal ion homeostasis in the airway results in impaired mucociliary clearance,...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 837: Modeling Anomalous Moisture Transport in Cement-Based Materials with Kinetic Permeability
IJMS, Vol. 21, Pages 837: Modeling Anomalous Moisture Transport in Cement-Based Materials with Kinetic Permeability International Journal of Molecular Sciences doi: 10.3390/ijms21030837 Authors: Zhang Angst The durability of reinforced concrete structures is closely related to moisture state in cement-based materials. Therefore, it is crucial to develop moisture models that can accurately predict moisture state in the materials. However, many studies reported anomalous moisture...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 840: MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma
IJMS, Vol. 21, Pages 840: MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21030840 Authors: Oto Navarro Larsen Solmoirago Plana Hervás Fernández-Pardo España Kristensen Thorlacius-Ussing Medina Cancer-associated venous thrombosis (VTE) increases mortality and morbidity. However, limited...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 839: Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome
IJMS, Vol. 21, Pages 839: Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome International Journal of Molecular Sciences doi: 10.3390/ijms21030839 Authors: Hancock Portbury Gunn Roberts Bush Adlard Metals are critical cellular elements that are involved in a variety of cellular processes, with recent literature demonstrating that zinc, and the synaptic zinc transporter (ZnT3), are specifically involved in learning and memory...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 843: Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model
IJMS, Vol. 21, Pages 843: Environmental Enrichment: Disentangling the Influence of Novelty, Social, and Physical Activity on Cerebral Amyloid Angiopathy in a Transgenic Mouse Model International Journal of Molecular Sciences doi: 10.3390/ijms21030843 Authors: Robison Francis Popescu Anderson Hatfield Xu Anderson Van Nostrand Robinson Cerebral amyloid angiopathy (CAA) is the deposition of amyloid protein in the cerebral vasculature, a common feature in...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 842: Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration
IJMS, Vol. 21, Pages 842: Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms21030842 Authors: Majewski Maciąg Boguszewski Kuznicki The maintenance of proper cytosolic Ca2+ level is crucial for neuronal survival, and dysregulation of Ca2+ homeostasis is found in a variety of neurological disorders, including...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 832: Black Edible Films from Protein-Containing Defatted Cake of Nigella sativa Seeds
IJMS, Vol. 21, Pages 832: Black Edible Films from Protein-Containing Defatted Cake of Nigella sativa Seeds International Journal of Molecular Sciences doi: 10.3390/ijms21030832 Authors: Sabbah Altamimi Di Pierro Schiraldi Cammarota Porta Black biodegradable/edible protein-based films were prepared from defatted cake waste obtained from Nigella sativa (black cumin) seeds as by-product of oil extraction process. The effects of pH, glycerol concentrations, and transglutaminase-catalyzed...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 830: Practical Guidance in Genome-Wide RNA:DNA Triple Helix Prediction
IJMS, Vol. 21, Pages 830: Practical Guidance in Genome-Wide RNA:DNA Triple Helix Prediction International Journal of Molecular Sciences doi: 10.3390/ijms21030830 Authors: Matveishina Antonov Medvedeva Long noncoding RNAs (lncRNAs) play a key role in many cellular processes including chromatin regulation. To modify chromatin, lncRNAs often interact with DNA in a sequence-specific manner forming RNA:DNA triple helices. Computational tools for triple helix search do not always...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 827: The Neuroprotective and Biomarker Potential of PACAP in Human Traumatic Brain Injury
IJMS, Vol. 21, Pages 827: The Neuroprotective and Biomarker Potential of PACAP in Human Traumatic Brain Injury International Journal of Molecular Sciences doi: 10.3390/ijms21030827 Authors: Denes Andrea Dora Traumatic brain injury remains a growing public health concern and represents the greatest contributor to death and disability globally among all trauma-related injuries. There are limited clinical data regarding biomarkers in the diagnosis and outcome prediction of TBI....
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 828: Region-Specific Sialylation Pattern of Prion Strains Provides Novel Insight into Prion Neurotropism
IJMS, Vol. 21, Pages 828: Region-Specific Sialylation Pattern of Prion Strains Provides Novel Insight into Prion Neurotropism International Journal of Molecular Sciences doi: 10.3390/ijms21030828 Authors: Makarava Chang Baskakov Mammalian prions are unconventional infectious agents that invade and replicate in an organism by recruiting a normal form of a prion protein (PrPC) and converting it into misfolded, disease-associated state referred to as PrPSc. PrPC is posttranslationally...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 831: Circadian Clock, Time-Restricted Feeding and Reproduction
IJMS, Vol. 21, Pages 831: Circadian Clock, Time-Restricted Feeding and Reproduction International Journal of Molecular Sciences doi: 10.3390/ijms21030831 Authors: Pan Taylor Cohen Hanna Mota The goal of this review was to seek a better understanding of the function and differential expression of circadian clock genes during the reproductive process. Through a discussion of how the circadian clock is involved in these steps, the identification of new clinical targets...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 829: Targeting the Immune system and Epigenetic Landscape of Urological Tumors
IJMS, Vol. 21, Pages 829: Targeting the Immune system and Epigenetic Landscape of Urological Tumors International Journal of Molecular Sciences doi: 10.3390/ijms21030829 Authors: Lobo Jerónimo Henrique In the last years, we have witnessed remarkable advances in targeted therapies for cancer patients. There is a growing effort to either replace or reduce the dose of unspecific, systemic (chemo)therapies, given the associated short- and long-term side effects, by introducing more...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 833: Light Weight, Easy Formable and Non-Toxic Polymer-Based Composites for Hard X-ray Shielding: A Theoretical and Experimental Study
IJMS, Vol. 21, Pages 833: Light Weight, Easy Formable and Non-Toxic Polymer-Based Composites for Hard X-ray Shielding: A Theoretical and Experimental Study International Journal of Molecular Sciences doi: 10.3390/ijms21030833 Authors: Lopresti Alberto Cantamessa Cantino Conterosito Palin Milanesio Composite lightweight materials for X-ray shielding applications were studied anddeveloped with the goal of replacing traditional screens made of lead and steel,...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00

IJMS, Vol. 21, Pages 826: The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review
IJMS, Vol. 21, Pages 826: The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review International Journal of Molecular Sciences doi: 10.3390/ijms21030826 Authors: Lauren M. Webb Kathryn E. Phillips Man Choi Ho Marin Veldic Caren J. Blacker Major depressive disorder (MDD) is the leading cause of disability worldwide and is associated with high rates of suicide and medical comorbidities. Current antidepressant medications are suboptimal, as...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 825: Tight Junction Proteins and the Biology of Hepatobiliary Disease
IJMS, Vol. 21, Pages 825: Tight Junction Proteins and the Biology of Hepatobiliary Disease International Journal of Molecular Sciences doi: 10.3390/ijms21030825 Authors: Roehlen Roca Suarez El Saghire Saviano Schuster Lupberger Baumert Tight junctions (TJ) are intercellular adhesion complexes on epithelial cells and composed of integral membrane proteins as well as cytosolic adaptor proteins. Tight junction proteins have been recognized to play a key role in...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJMS, Vol. 21, Pages 824: FGF21 Protects against Aggravated Blood-Brain Barrier Disruption after Ischemic Focal Stroke in Diabetic db/db Male Mice via Cerebrovascular PPARγ Activation
IJMS, Vol. 21, Pages 824: FGF21 Protects against Aggravated Blood-Brain Barrier Disruption after Ischemic Focal Stroke in Diabetic db/db Male Mice via Cerebrovascular PPARγ Activation International Journal of Molecular Sciences doi: 10.3390/ijms21030824 Authors: Jiang Lin Liu Wang Yuan Li Chung Guo Yu Wang : Recombinant fibroblast growth factor 21 (rFGF21) has been shown to be potently beneficial for improving long-term neurological outcomes in type...
International Journal of Molecular Sciences
Tue Jan 28, 2020 02:00
IJNS, Vol. 6, Pages 6: Measurement of 17-Hydroxyprogesterone by LCMSMS Improves Newborn Screening for CAH Due to 21-Hydroxylase Deficiency in New Zealand
IJNS, Vol. 6, Pages 6: Measurement of 17-Hydroxyprogesterone by LCMSMS Improves Newborn Screening for CAH Due to 21-Hydroxylase Deficiency in New Zealand International Journal of Neonatal Screening doi: 10.3390/ijns6010006 Authors: de Hora Heather Patel Bresnahan Webster Hofman The positive predictive value of newborn screening for congenital adrenal hyperplasia due to 21-hydroxylase deficiency was <2% in New Zealand. This is despite a bloodspot second-tier...
International Journal of Neonatal Screening
Tue Jan 28, 2020 02:00
JCM, Vol. 9, Pages 363: Evaluation of Sperm Mitochondrial Function: A Key Organelle for Sperm Motility
JCM, Vol. 9, Pages 363: Evaluation of Sperm Mitochondrial Function: A Key Organelle for Sperm Motility Journal of Clinical Medicine doi: 10.3390/jcm9020363 Authors: Barbagallo Vignera Cannarella Aversa Calogero Condorelli Introduction: The role of nutraceuticals in the treatment of male infertility, especially in the “idiopathic form”, remains the subject of significant debate. Many antioxidants improve sperm motility but the exact mechanism by...
Journal of Clinical Medicine
02:00
JCM, Vol. 9, Pages 361: Transvenous Lead Extraction SAFeTY Score for Risk Stratification and Proper Patient Selection for Removal Procedures Using Mechanical Tools
JCM, Vol. 9, Pages 361: Transvenous Lead Extraction SAFeTY Score for Risk Stratification and Proper Patient Selection for Removal Procedures Using Mechanical Tools Journal of Clinical Medicine doi: 10.3390/jcm9020361 Authors: Jacheć Polewczyk Polewczyk Tomasik Kutarski Background: To ensure the safety and efficacy of the increasing number of transvenous lead extractions (TLEs), it is necessary to adequately assess the procedure-related risk. Methods: We analyzed potential...
Journal of Clinical Medicine
Tue Jan 28, 2020 02:00
JCM, Vol. 9, Pages 362: Cognitive Improvement in Older Adults with Mild Cognitive Impairment: Evidence from a Multi-Strategic Metamemory Training
JCM, Vol. 9, Pages 362: Cognitive Improvement in Older Adults with Mild Cognitive Impairment: Evidence from a Multi-Strategic Metamemory Training Journal of Clinical Medicine doi: 10.3390/jcm9020362 Authors: Youn Park Lee Cho kim Ryu Intervention programs to relieve memory impairment and memory-related complaints in older adults with mild cognitive impairment are needed. Objective: The purpose of the current study was to assess the efficacy of a novel cognitive training...
Journal of Clinical Medicine
Tue Jan 28, 2020 02:00
JCM, Vol. 9, Pages 357: Prospective, Clinical Pilot Study with Eleven 4-Mm Extra-Short Implants Splinted to Longer Implants for Posterior Maxilla Rehabilitation
JCM, Vol. 9, Pages 357: Prospective, Clinical Pilot Study with Eleven 4-Mm Extra-Short Implants Splinted to Longer Implants for Posterior Maxilla Rehabilitation Journal of Clinical Medicine doi: 10.3390/jcm9020357 Authors: Torassa Naldini Calvo-Guirado Fernández-Bodereau In many clinical situations, rehabilitation with implants in the posterior maxillary region is complicated by limited bone availability. In this context, the use of 4 mm long implants (known as extra-short...
Journal of Clinical Medicine
Tue Jan 28, 2020 02:00
JCM, Vol. 9, Pages 358: Transcriptional Expression in Human Periodontal Ligament Cells Subjected to Orthodontic Force: An RNA-Sequencing Study
JCM, Vol. 9, Pages 358: Transcriptional Expression in Human Periodontal Ligament Cells Subjected to Orthodontic Force: An RNA-Sequencing Study Journal of Clinical Medicine doi: 10.3390/jcm9020358 Authors: Kim Kang Yook Yu Kim Cha Choi : This study was performed to investigate the changes in gene expression in periodontal ligament (PDL) cells following mechanical stimulus through RNA sequencing. In this study, premolars extracted for orthodontic treatment were...
Journal of Clinical Medicine
Tue Jan 28, 2020 02:00
JCM, Vol. 9, Pages 360: Retinoic Acids in the Treatment of Most Lethal Solid Cancers
JCM, Vol. 9, Pages 360: Retinoic Acids in the Treatment of Most Lethal Solid Cancers Journal of Clinical Medicine doi: 10.3390/jcm9020360 Authors: Costantini Molinari Farinon Merendino Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA) concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 years and used as standard therapy still to date, the same use in solid cancers is still controversial. In the present...
Journal of Clinical Medicine
Tue Jan 28, 2020 02:00
JCM, Vol. 9, Pages 359: Central Resistance to Thyroid Hormones in Morbidly Obese Subjects Is Reversed after Bariatric Surgery-Induced Weight Loss
JCM, Vol. 9, Pages 359: Central Resistance to Thyroid Hormones in Morbidly Obese Subjects Is Reversed after Bariatric Surgery-Induced Weight Loss Journal of Clinical Medicine doi: 10.3390/jcm9020359 Authors: Juiz-Valiña Cordido Outeiriño-Blanco Pértega Varela-Rodríguez García-Brao Mena Pena-Bello Sangiao-Alvarellos Cordido Endocrine abnormalities are common in obesity, including altered thyroid function. The altered thyroid function of obesity may...
Journal of Clinical Medicine
Tue Jan 28, 2020 02:00
JCM, Vol. 9, Pages 356: Amniotic Membrane Graft in the Management of Complex Vaginal Mesh Erosion
JCM, Vol. 9, Pages 356: Amniotic Membrane Graft in the Management of Complex Vaginal Mesh Erosion Journal of Clinical Medicine doi: 10.3390/jcm9020356 Authors: Lau Jou Huang Su Vaginal mesh erosion is a devastating complication after pelvic floor mesh surgery and it can be treated conservatively or with surgical revision. However, the management options following a failed primary revision or complex vaginal erosions are very limited. The aim of this study is to describe...
Journal of Clinical Medicine
Tue Jan 28, 2020 02:00
JCM, Vol. 9, Pages 355: Long-Term Influence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Retrospective Clinical and Radiological Outcomes of a Randomized Controlled Clinical Trial
JCM, Vol. 9, Pages 355: Long-Term Influence of Platelet-Rich Plasma (PRP) on Dental Implants after Maxillary Augmentation: Retrospective Clinical and Radiological Outcomes of a Randomized Controlled Clinical Trial Journal of Clinical Medicine doi: 10.3390/jcm9020355 Authors: Attia Narberhaus Schaaf Streckbein Pons-Kühnemann Schmitt Neukam Howaldt Böttger : The long-term clinical and radiological outcomes of dental implants inserted in augmented bone treated...
Journal of Clinical Medicine
Tue Jan 28, 2020 02:00
JCM, Vol. 9, Pages 279: Comparison of Ilizarov Bifocal, Acute Shortening and Relengthening with Bone Transport in the Treatment of Infected, Segmental Defects of the Tibia
JCM, Vol. 9, Pages 279: Comparison of Ilizarov Bifocal, Acute Shortening and Relengthening with Bone Transport in the Treatment of Infected, Segmental Defects of the Tibia Journal of Clinical Medicine doi: 10.3390/jcm9020279 Authors: Irene K. Sigmund Jamie Ferguson Geertje A.M. Govaert David Stubbs Martin A. McNally This prospective study compared bifocal acute shortening and relengthening (ASR) with bone transport (BT) in a consecutive series of complex tibial infected non-unions...
Journal of Clinical Medicine
Tue Jan 28, 2020 02:00
JDB, Vol. 8, Pages 2: Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate.
JDB, Vol. 8, Pages 2: Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate. Journal of Developmental Biology doi: 10.3390/jdb8010002 Authors: Liberton Verma Almpani Fung Mishra Oberoi Şenel Mah Huang Padwa Lee Non-syndromic orofacial clefts encompass a range of morphological changes affecting the oral cavity and the craniofacial skeleton, of which the genetic and...
Journal of Developmental Biology
Tue Jan 28, 2020 02:00
Medicina, Vol. 56, Pages 54: Financial Burden of Stroke Reflected in a Pilot Center for the Implementation of Thrombolysis
Medicina, Vol. 56, Pages 54: Financial Burden of Stroke Reflected in a Pilot Center for the Implementation of Thrombolysis Medicina doi: 10.3390/medicina56020054 Authors: Uivarosan Bungau Tit Moisa Fratila Rus Bratu Diaconu Pantis Stroke represents a serious illness and is extremely relevant from the public health point of view, implying important social and economic burdens. Introducing new procedures or therapies that reduce the costs both in the acute...
Medicina
Tue Jan 28, 2020 02:00
Metabolites, Vol. 10, Pages 50: Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy
Metabolites, Vol. 10, Pages 50: Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy Metabolites doi: 10.3390/metabo10020050 Authors: Beyoğlu Idle In recent years, there has been a plethora of attempts to discover biomarkers that are more reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma (HCC). Efforts have involved such fields as genomics, transcriptomics, epigenetics, microRNA, exosomes,...
Metabolites
Tue Jan 28, 2020 02:00
Metabolites, Vol. 10, Pages 49: A Data Mining Metabolomics Exploration of Glaucoma
Metabolites, Vol. 10, Pages 49: A Data Mining Metabolomics Exploration of Glaucoma Metabolites doi: 10.3390/metabo10020049 Authors: Kouassi Nzoughet Guehlouz Leruez Gohier Bocca Muller Blanchet Bonneau Simard Milea Procaccio Lenaers Chao de la Barca Reynier Glaucoma is an age related disease characterized by the progressive loss of retinal ganglion cells, which are the neurons that transduce the visual information from the retina to...
Metabolites
Tue Jan 28, 2020 02:00
MPs, Vol. 3, Pages 13: ESR and Radiocarbon Dating of Gut Strings from Early Plucked Instruments
MPs, Vol. 3, Pages 13: ESR and Radiocarbon Dating of Gut Strings from Early Plucked Instruments Methods and Protocols doi: 10.3390/mps3010013 Authors: Tsukamoto Takeuchi Tani Miyairi Yokoyama Early European plucked instruments have recently experienced a great revival, but a few aspects remain unknown (e.g., the gauge of gut strings). Here we report, for the first time, that the electron spin resonance (ESR) signal intensity of oxidized iron, Fe(III), from gut strings...
Methods and Protocols
Tue Jan 28, 2020 02:00
Microorganisms, Vol. 8, Pages 186: Model-Driven Controlled Alteration of Nanopillar Cap Architecture Reveals its Effects on Bactericidal Activity
Microorganisms, Vol. 8, Pages 186: Model-Driven Controlled Alteration of Nanopillar Cap Architecture Reveals its Effects on Bactericidal Activity Microorganisms doi: 10.3390/microorganisms8020186 Authors: Zahir Pesek Franke Pee Rathore Smeets Ramon Xu Fauvart Michiels Nanostructured surfaces can be engineered to kill bacteria in a contact-dependent manner. The study of bacterial interactions with a nanoscale topology is thus crucial to developing...
Microorganisms
Tue Jan 28, 2020 02:00

Microorganisms, Vol. 8, Pages 182: Complete Genome Sequence Reveals Evolutionary and Comparative Genomic Features of Xanthomonas albilineans Causing Sugarcane Leaf Scald
Microorganisms, Vol. 8, Pages 182: Complete Genome Sequence Reveals Evolutionary and Comparative Genomic Features of Xanthomonas albilineans Causing Sugarcane Leaf Scald Microorganisms doi: 10.3390/microorganisms8020182 Authors: Zhang Ntambo Rott Chen Chen Huang Gao Leaf scald (caused by Xanthomonas albilineans) is an important bacterial disease affecting sugarcane in most sugarcane growing countries, including China. High genetic diversity exists among strains...
Microorganisms
Tue Jan 28, 2020 02:00
Microorganisms, Vol. 8, Pages 181: Candida auris, an Agent of Hospital-Associated Outbreaks: Which Challenging Issues Do We Need to Have in Mind?
Microorganisms, Vol. 8, Pages 181: Candida auris, an Agent of Hospital-Associated Outbreaks: Which Challenging Issues Do We Need to Have in Mind? Microorganisms doi: 10.3390/microorganisms8020181 Authors: Sabino Veríssimo Pereira Antunes The emergence of Candida auris is considered as one of the most serious problems associated with nosocomial transmission and with infection control practices in hospital environment. This multidrug resistant species is rapidly spreading...
Microorganisms
Tue Jan 28, 2020 02:00
Microorganisms, Vol. 8, Pages 183: Effects of Life Stage, Site, and Species on the Dragonfly Gut Microbiome
Microorganisms, Vol. 8, Pages 183: Effects of Life Stage, Site, and Species on the Dragonfly Gut Microbiome Microorganisms doi: 10.3390/microorganisms8020183 Authors: Nobles Jackson Insects that undergo metamorphosis from juveniles to adults provide an intriguing opportunity to examine the effects of life stage, species, and the environment on their gut microbiome. In this study, we surveyed the gut microbiomes of 13 species of dragonfly collected from five different locations subject...
Microorganisms
Tue Jan 28, 2020 02:00
Microorganisms, Vol. 8, Pages 185: Changes of Quality of Minimally-Processed Pineapple (Ananas comosus, var. ‘Queen Victoria’) during Cold Storage: Fungi in the Leading Role
Microorganisms, Vol. 8, Pages 185: Changes of Quality of Minimally-Processed Pineapple (Ananas comosus, var. ‘Queen Victoria’) during Cold Storage: Fungi in the Leading Role Microorganisms doi: 10.3390/microorganisms8020185 Authors: Leneveu-Jenvrin Quentin Assemat Hoarau Meile Remize Minimally-processed pineapple stored under refrigerated conditions is highly perishable. We aimed to characterize the evolution of physicochemical, sensory and microbiological quality...
Microorganisms
Tue Jan 28, 2020 02:00
Microorganisms, Vol. 8, Pages 184: Benzalkonium Chloride Induces a VBNC State in Listeria monocytogenes
Microorganisms, Vol. 8, Pages 184: Benzalkonium Chloride Induces a VBNC State in Listeria monocytogenes Microorganisms doi: 10.3390/microorganisms8020184 Authors: Noll Trunzer Vondran Vincze Dieckmann Al Dahouk Gold The objective of our study was to investigate the effects of benzalkonium chloride (BC) adaptation of L. monocytogenes on the susceptibility to antimicrobial agents and on the viable but non culturable (VBNC) state of the bacterial cells. We adapted...
Microorganisms
Tue Jan 28, 2020 02:00
Microorganisms, Vol. 8, Pages 180: Environmental Factors That Contribute to the Maintenance of Cryptococcus neoformans Pathogenesis
Microorganisms, Vol. 8, Pages 180: Environmental Factors That Contribute to the Maintenance of Cryptococcus neoformans Pathogenesis Microorganisms doi: 10.3390/microorganisms8020180 Authors: Maphori Maliehe Mathope A. Ntoi Shayanki Lahiri Olufemi S. Folorunso Adepemi O. Ogundeji Carolina H. Pohl Olihile M. Sebolai The ability of microorganisms to colonise and display an intracellular lifestyle within a host body increases their fitness to survive and avoid extinction....
Microorganisms
Tue Jan 28, 2020 02:00

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