Molbank, Vol. 2020, Article M1112: (22E,24S)-24-Propylcholest-5en-3α-acetate: A New Steroid from the Stembark Aglaia angustifolia (Miq.) (Meliaceae) Molbank doi: 10.3390/M1112 Authors: Hutagaol Harneti Hidayat Nurlelasari Maharani Katja Supratman Awang Shiono A new propylcholesterol-type steroid, namely (22E,24S)-24-propylcholest-5en-3α-acetate (1), has been isolated from the stembark of Aglaia angustifolia (Miq.). The structure of 1 was determined...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 574: Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-based Scaffolds en Route to Donepezil-Like Compounds Molecules doi: 10.3390/molecules25030574 Authors: Piemontese Sergio Rinaldo Brunetti Perna Santos Capriati An unsubstituted 2-hydroxyphenylbenzimidazole has recently been included as a scaffold in a series of hybrids (including the hit compound PZ1) based on the framework of the...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 572: Interaction with Soil Bacteria Affects the Growth and Amino Acid Content of Piriformospora indica Molecules doi: 10.3390/molecules25030572 Authors: Jorge A. Leyva-Rojas Ericsson Coy-Barrera Rüdiger Hampp Exploration of the effect of soil bacteria on growth and metabolism of beneficial root endophytic fungi is relevant to promote favorable associations between microorganisms of the plant rhizosphere. Hence, the interaction between the plant-growth-promoting...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 573: Introduction of Mercaptoethyl at Sorafenib Pyridine-2-Amide Motif as a Potentially Effective Chain to Further get Sorafenib-PEG-DGL Molecules doi: 10.3390/molecules25030573 Authors: Wang Kuerbana Wan Yu Ye Chen The crystal structure of the sorafenib and B-RAF complex indicates that the binding cavity occupied by the pyridine-2-carboxamide in sorafenib has a large variable space, making it a reasonable modification site. In order to...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 570: Exploration of Mechanochemical Activation in Solid-State Fluoro-Grignard Reactions Molecules doi: 10.3390/molecules25030570 Authors: Speight Hanusa Owing to the strength of the C–F bond, the ‘direct’ preparation of Grignard reagents, i.e., the interaction of elemental magnesium with an organic halide, typically in an ethereal solvent, fails for bulk magnesium and organofluorine compounds. Previously described mechanochemical...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 571: Novel Insights into Dietary Phytosterol Utilization and Its Fate in Honey Bees (Apis mellifera L.) Molecules doi: 10.3390/molecules25030571 Authors: Chakrabarti Lucas Sagili Poor nutrition is an important factor in global bee population declines. A significant gap in knowledge persists regarding the role of various nutrients (especially micronutrients) in honey bees. Sterols are essential micronutrients in insect diets and play a physiologically...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 565: Utilization of Nutmeg (Myristica fragrans Houtt.) Seed Hydrodistillation Time to Produce Essential Oil Fractions with Varied Compositions and Pharmacological Effects Molecules doi: 10.3390/molecules25030565 Authors: Ibrahim Cantrell Jeliazkova Astatkie Zheljazkov The intent of this study was to utilize distillation timeframes (DT) of nutmeg (Myristica fragrans) essential oil (EO) to generate fractions with differential chemical compositions...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 568: Approaches to PET Imaging of Glioblastoma Molecules doi: 10.3390/molecules25030568 Authors: Drake Hillmer Cai Glioblastoma multiforme (GBM) is the deadliest type of brain tumor, affecting approximately three in 100,000 adults annually. Positron emission tomography (PET) imaging provides an important non-invasive method of measuring biochemically specific targets at GBM lesions. These powerful data can characterize tumors, predict treatment effectiveness,...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 566: Syntheses of L-Rhamnose-Linked Amino Glycerolipids and Their Cytotoxic Activities against Human Cancer Cells Molecules doi: 10.3390/molecules25030566 Authors: Ogunsina Samadder Idowu Nachtigal Schweizer Arthur A major impediment to successful cancer treatment is the inability of clinically available drugs to kill drug-resistant cancer cells. We recently identified metabolically stable L-glucosamine-based glycosylated antitumor ether...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 569: Sensory Lexicons and Formation Pathways of Off-Aromas in Dairy Ingredients: A Review Molecules doi: 10.3390/molecules25030569 Authors: Su Tortorice Ryo Li Waterman Hagen Yin Consumers are becoming increasingly aware of the health benefits of dairy ingredients. However, products fortified with dairy proteins are experiencing considerable aroma challenges. Practices to improve the flavor quality of dairy proteins require a comprehensive...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 563: Nitroso Diels-Alder Cycloadducts Derived from N-Acyl-1,2-dihydropyridines as a New Platform to Molecular Diversity Molecules doi: 10.3390/molecules25030563 Authors: Menichetti Berti Pineschi This review focuses upon the use of nitroso Diels–Alder reactions as a structural complexity generating reaction that has been so far a quite scarcely treated topic, despite its potential. In particular, the use of N-acyl-1,2-dihydropyridines as a...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 560: Cucurbitacin E Inhibits Huh7 Hepatoma Carcinoma Cell Proliferation and Metastasis via Suppressing MAPKs and JAK/STAT3 Pathways Molecules doi: 10.3390/molecules25030560 Authors: Liu Yang Guo Liu Jiang Zhao Zeng Tu Cucurbitacin E (CuE), a highly oxygenated tetracyclic triterpene from Cucurbitaceae, has shown to exhibit potent cytotoxic and anti-proliferative properties against several human cancer cells. However, the underlying...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 564: Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism Molecules doi: 10.3390/molecules25030564 Authors: Tanaka Bohár Vécsei Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive and social functions, progressing severely enough to interfere with daily life. Alzheimer’s disease (AD) accounts for most of the dementia cases. Pathological and clinical findings...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 567: Tannins of Conifer Bark as Nordic Piquancy—Sustainable Preservative and Aroma? Molecules doi: 10.3390/molecules25030567 Authors: Raitanen Järvenpää Korpinen Mäkinen Hellström Kilpeläinen Liimatainen Ora Tupasela Jyske Bark of Norway spruce and Scots pine trees contain large amounts of condensed tannins. Tannins extracted with hot water could be used in different applications as they possess antioxidative and antimicrobial...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 555: Green Synthesis of Encapsulated Copper Nanoparticles Using a Hydroalcoholic Extract of Moringa oleifera Leaves and Assessment of Their Antioxidant and Antimicrobial Activities Molecules doi: 10.3390/molecules25030555 Authors: Das Abu-Yousef Majdalawieh Narasimhan Poltronieri : The synthesis of metal nanoparticles using plant extracts is a very promising method in green synthesis. The medicinal value of Moringa oleifera leaves and the antimicrobial...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 557: Selenium Attenuates Chronic Heat Stress-Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in Mouse Granulosa Cells Molecules doi: 10.3390/molecules25030557 Authors: Xiong Yin Jin Chen He Heat stress induces apoptosis in various cells. Selenium, an essential micronutrient, has beneficial effects in maintaining the cellular physiological functions. However, its potential protective action against chronic heat stress (CHS)-induced...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 559: Antibacterial Peptide Nucleic Acids—Facts and Perspectives Molecules doi: 10.3390/molecules25030559 Authors: Wojciechowska Równicki Mieczkowski Miszkiewicz Trylska Antibiotic resistance is an escalating, worldwide problem. Due to excessive use of antibiotics, multidrug-resistant bacteria have become a serious threat and a major global healthcare problem of the 21st century. This fact creates an urgent need for new and effective antimicrobials....
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 558: PEGylated Liposomal Methyl Prednisolone Succinate does not Induce Infusion Reactions in Patients: A Correlation Between in Vitro Immunological and in Vivo Clinical Studies Molecules doi: 10.3390/molecules25030558 Authors: Bavli Chen Roffler Dobrovolskaia Elnekave Ash Barenholz Turjeman PEGylated nanomedicines are known to induce infusion reactions (IRs) that in some cases can be life-threatening. Herein, we report a case study...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 556: Bee Products in Dermatology and Skin Care Molecules doi: 10.3390/molecules25030556 Authors: Kurek-Górecka Górecki Rzepecka-Stojko Balwierz Stojko Honey, propolis, bee pollen, bee bread, royal jelly, beeswax and bee venom are natural products which have been used in medicine since ancient times. Nowadays, studies indicate that natural bee products can be used for skin treatment and care. Biological properties of these products are related...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 561: Molecular Spectroscopic Markers of DNA Damage Molecules doi: 10.3390/molecules25030561 Authors: Sofińska Wilkosz Szymoński Lipiec Every cell in a living organism is constantly exposed to physical and chemical factors which damage the molecular structure of proteins, lipids, and nucleic acids. Cellular DNA lesions are the most dangerous because the genetic information, critical for the identity and function of each eukaryotic cell, is stored...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 554: Characterization, in Vitro and in Vivo Evaluation of Naringenin-Hydroxypropyl-ß-Cyclodextrin Inclusion for Pulmonary Delivery Molecules doi: 10.3390/molecules25030554 Authors: Guan Shi Zheng Zeng Fan Wang Su Naringenin, a flavonoid compound which exists abundantly in Citrus fruits, is proven to possess excellent antitussive and expectorant effects. However, the clinical applications of naringenin are restricted by its poor solubility...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 562: Control of Erigeron bonariensis with Thymbra capitata, Mentha piperita, Eucalyptus camaldulensis, and Santolina chamaecyparissus Essential Oils Molecules doi: 10.3390/molecules25030562 Authors: Verdeguer Castañeda Torres-Pagan Llorens-Molina Carrubba In the search of sustainable and environmentally friendly methods for weed control, there is increasing interest in essential oils (EOs) as an approach to reduce synthetic herbicide use. The...
Tue Jan 28, 2020 02:00
Molecules, Vol. 25, Pages 553: The Effect of Protein-Rich Extract from Bombyx Batryticatus against Glutamate-Damaged PC12 Cells Via Regulating γ-Aminobutyric Acid Signaling Pathway Molecules doi: 10.3390/molecules25030553 Authors: Li-Ying He Mei-Bian Hu Ruo-Lan Li Rong Zhao Lin-Hong Fan Li Wang Wei Peng Yu-Jie Liu Chun-Jie Wu Bombyx Batryticatus (BB) is a known traditional Chinese medicine (TCM) utilized to treat convulsions, epilepsy, cough, asthma, headaches,...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 231: A New Approach to UV Protection by Direct Surface Functionalization of TiO2 with the Antioxidant Polyphenol Dihydroxyphenyl Benzimidazole Carboxylic Acid Nanomaterials doi: 10.3390/nano10020231 Authors: Battistin Dissette Bonetto Durini Manfredini Marcomini Casagrande Brunetta Ziosi Molesini Gavioli Nicoli Vertuani Baldisserotto Skin cancer is the most common malignant cancer with an incidence of...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 223: Cobalt Nanoparticles on Plasma-Controlled Nitrogen-Doped Carbon as High-Performance ORR Electrocatalyst for Primary Zn-Air Battery Nanomaterials doi: 10.3390/nano10020223 Authors: Kim Park Li Metal–air batteries and fuel cells have attracted much attention as powerful candidates for a renewable energy conversion system for the last few decades. However, the high cost and low durability of platinum-based catalysts used to enhance sluggish...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 227: Ecotoxicological Studies of ZnO and CdS Nanoparticles on Chlorella vulgaris Photosynthetic Microorganism in Seine River Water Nanomaterials doi: 10.3390/nano10020227 Authors: da Rocha Menguy Yéprémian Couté Brayner : Seine river water was used as natural environmental medium to study the ecotoxicological impact of ZnO and CdS nanoparticles and Zn2+ and Cd2+ free ions using Chlorella vulgaris as a biological target. It was demonstrated...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 230: Effect of Nano-Montmorillonite on Osteoblast Differentiation, Mineral Density, and Osteoclast Differentiation in Bone Formation Nanomaterials doi: 10.3390/nano10020230 Authors: Kim Kim Lee Kim Chung Choi An Calcium-type montmorillonite, a phyllosilicate mineral, has diverse health benefits when introduced into the gastrointestinal tract or applied to the skin. However, the predominant use of this layered material has thus far...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 225: KxWO is a Novel Ferroelectric Nanomaterial for Application as a Room Temperature Acetone Sensor Nanomaterials doi: 10.3390/nano10020225 Authors: Johnson Zhang Wang A newly synthesized nanomaterial known as KxW7O22 (KxWO) exhibits a stable room-temperature ferroelectric property. This unique ferroelectric property has revealed that KxWO is a promising material for application in a breath sensor, which can be used for patients to monitor their...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 226: Systemically Administered, Target-Specific, Multi-Functional Therapeutic Recombinant Proteins in Regenerative Medicine Nanomaterials doi: 10.3390/nano10020226 Authors: Järvinen Pemmari Growth factors, chemokines and cytokines guide tissue regeneration after injuries. However, their applications as recombinant proteins are almost non-existent due to the difficulty of maintaining their bioactivity in the protease-rich milieu of injured tissues in...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 228: Few Layer Graphene Does Not Affect Cellular Homeostasis of Mouse Macrophages Nanomaterials doi: 10.3390/nano10020228 Authors: Malanagahalli Murera Martín Lin Wadier Dumortier Vázquez Bianco : Graphene-related materials (GRMs) are widely used in various applications due to their unique properties. A growing number of reports describe the impact of different carbon nanomaterials, including graphene oxide (GO), reduced GO (rGO),...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 224: Chitosan-Stabilized Noble Metal Nanoparticles: Study of their Shape Evolution and Post-Functionalization Properties Nanomaterials doi: 10.3390/nano10020224 Authors: Ottonelli Zappia Demartini Alloisio Noble metal anisotropic nanostructures have achieved a growing interest in both academic and industrial domains mostly because of their shape-dependent plasmonic properties in the near-infrared region. In this paper, gold and gold-silver anisotropic...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 229: Graphene-Coated Nanowire Waveguides and Their Applications Nanomaterials doi: 10.3390/nano10020229 Authors: Teng Wang Li In recent years, graphene-coated nanowires (GCNWs) have attracted considerable research interest due to the unprecedented optical properties of graphene in terahertz (THz) and mid-infrared bands. Graphene plasmons in GCNWs have become an attractive platform for nanoscale applications in subwavelength waveguides, polarizers,...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 222: Porous Si-SiO2 UV Microcavities to Modulate the Responsivity of a Broadband Photodetector Nanomaterials doi: 10.3390/nano10020222 Authors: María R. Jimenéz-Vivanco Godofredo García Jesús Carrillo Francisco Morales-Morales Antonio Coyopol Miguel Gracia Rafael Doti Jocelyn Faubert J. Eduardo Lugo Porous Si-SiO2 UV microcavities are used to modulate a broad responsivity photodetector (GVGR-T10GD) with a detection range from 300...
Tue Jan 28, 2020 02:00
Nanomaterials, Vol. 10, Pages 221: Atomistic Study of Interactions between Intrinsic Kink Defects and Dislocations in Twin Boundaries of Nanotwinned Copper during Nanoindentation Nanomaterials doi: 10.3390/nano10020221 Authors: Xiaowen Hu Yushan Ni Zhongli Zhang In order to study the effects of kink-like defects in twin boundaries on deformation mechanisms and interaction between dislocations and defects in twin boundaries under localized load, nanotwinned Cu with two defective...
Tue Jan 28, 2020 02:00
Nutrients, Vol. 12, Pages 347: Galangin Protects against Symptoms of Dextran Sodium Sulfate-induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota Nutrients doi: 10.3390/nu12020347 Authors: Xuan Ou Hao Shi Jin Galangin is a natural flavonoid that has been reported to provide substantial health benefits. Nevertheless, little is known about the potential effects of galangin against inflammatory bowel diseases. Here, an in vivo study was performed...
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Nutrients, Vol. 12, Pages 346: The Many Faces of Kefir Fermented Dairy Products: Quality Characteristics, Flavour Chemistry, Nutritional Value, Health Benefits, and Safety Nutrients doi: 10.3390/nu12020346 Authors: Farag Jomaa El-Wahed El-Seedi Kefir is a dairy product that can be prepared from different milk types, such as goat, buffalo, sheep, camel, or cow via microbial fermentation (inoculating milk with kefir grains). As such, kefir contains various bacteria and yeasts...
Tue Jan 28, 2020 02:00
Nutrients, Vol. 12, Pages 340: Saliva Samples as A Tool to Study the Effect of Meal Timing on Metabolic And Inflammatory Biomarkers Nutrients doi: 10.3390/nu12020340 Authors: Kessler Hornemann Rudovich Weber Grune Kramer Pfeiffer Pivovarova-Ramich : Meal timing affects metabolic regulation in humans. Most studies use blood samples for their investigations. Saliva, although easily available and non-invasive, seems to be rarely used for chrononutritional studies....
Tue Jan 28, 2020 02:00
Nutrients, Vol. 12, Pages 339: The Relationship between Circulating Acetate and Human Insulin Resistance before and after Weight Loss in the DiOGenes Study Nutrients doi: 10.3390/nu12020339 Authors: González Hernández Canfora Pasmans Astrup Saris Blaak Microbially-produced acetate has been reported to beneficially affect metabolic health through effects on satiety, energy expenditure, insulin sensitivity, and substrate utilization. Here, we investigate the association...
Tue Jan 28, 2020 02:00
Nutrients, Vol. 12, Pages 341: Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet. An Open-Label Pilot Study Nutrients doi: 10.3390/nu12020341 Authors: Borghini Porpora Casale Marino Palmieri Greco Donato Picarelli Alimentary nickel (Ni) may result in allergic contact mucositis (ACM), whose prevalence is >30% and may present with IBS-like and extra-intestinal symptoms. These symptoms...
Tue Jan 28, 2020 02:00
Nutrients, Vol. 12, Pages 345: Inflaming Public Interest: A Qualitative Study of Adult Learners’ Perceptions on Nutrition and Inflammation Nutrients doi: 10.3390/nu12020345 Authors: Cowan Sood Truby Dordevic Adamski Gibson Research suggests national dietary guidelines are losing public resonance, with consumers actively seeking alternate nutrition advice from unregulated online platforms that often propagate misinformation. Improved diet quality can beneficially...
Tue Jan 28, 2020 02:00
Nutrients, Vol. 12, Pages 342: Vitamin D Supplementation Improves Adipose Tissue Inflammation and Reduces Hepatic Steatosis in Obese C57BL/6J Mice Nutrients doi: 10.3390/nu12020342 Authors: Marziou Philouze Couturier Astier Obert Landrier Riva The beneficial effect of vitamin D (VD) supplementation on body weight gain limitation and inflammation has been highlighted in primary prevention mice models, but the long-term effect of VD supplementation in tertiary...
Tue Jan 28, 2020 02:00
Nutrients, Vol. 12, Pages 344: Promoting Evidence Based Nutrition Education Across the World in a Competitive Space: Delivering a Massive Open Online Course Nutrients doi: 10.3390/nu12020344 Authors: Gibson Adamski Blumfield Dart Murgia Volders Truby The internet is the fastest growing source of nutrition information for consumers. Massive Open Online Courses (MOOCs) provide and avenue for nutrition professionals’ urgent need to respond to consumer...
Tue Jan 28, 2020 02:00
Nutrients, Vol. 12, Pages 343: Endocrine Disruptor Bisphenol A (BPA) Triggers Systemic Para-Inflammation and is Sufficient to Induce Airway Allergic Sensitization in Mice Nutrients doi: 10.3390/nu12020343 Authors: Loffredo Berdnikovs Allergic airway diseases are accompanied by increased permeability and an inflammatory state of epithelial barriers, which are thought to be susceptible to allergen sensitization. Although exogenous drivers (proteases, allergens) of epithelial barrier...
Tue Jan 28, 2020 02:00
Nutrients, Vol. 12, Pages 338: Human Cytomegalovirus Reactivation During Lactation: Impact of Antibody Kinetics and Neutralization in Blood and Breast Milk Nutrients doi: 10.3390/nu12020338 Authors: Lazar Rabe Goelz Hamprecht Human cytomegalovirus (HCMV) is shed into breast milk in nearly every seropositive woman during lactation. This reactivation shows mostly a self-limited, unimodal course. The dynamics and functional role of HCMV-specific-IgG in breast milk and in plasma...
Tue Jan 28, 2020 02:00
Pathogens, Vol. 9, Pages 84: Antifungal and Antivirulence Activities of Hydroalcoholic Extract and Fractions of Platonia insignis Leaves against Vaginal Isolates of Candida Species Pathogens doi: 10.3390/pathogens9020084 Authors: Silva Rocha Silva Júnior Mendes de Araruna Motta Silva Campos Farias Oliveira Silva Nascimento Guerra Monteiro Vulvovaginal candidiasis is a common fungal infection in women. In this study, Platonia insignis...
Tue Jan 28, 2020 02:00
Pathogens, Vol. 9, Pages 85: Human Metapneumovirus: Etiological Agent of Severe Acute Respiratory Infections in Hospitalized and Deceased Patients with a Negative Diagnosis of Influenza Pathogens doi: 10.3390/pathogens9020085 Authors: Barrera-Badillo Olivares-Flores Ruiz-López Fierro-Valdez Gutiérrez-Vargas López-Martínez Human metapneumovirus (HMPV) is one of the four major viral pathogens associated with acute respiratory tract infections (ARI) and creates a substantial...
Tue Jan 28, 2020 02:00
Pharmaceutics, Vol. 12, Pages 106: Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins Pharmaceutics doi: 10.3390/pharmaceutics12020106 Authors: Janisova Gruzinov Zaborova Velychkivska Vaněk Chytil Etrych Janoušková Zhang Blanchet Papadakis Svergun Filippov The binding of plasma proteins to a drug carrier alters the circulation of nanoparticles...
Tue Jan 28, 2020 02:00
Pharmaceutics, Vol. 12, Pages 102: Opportunities and Challenges in the Delivery of mRNA-based Vaccines Pharmaceutics doi: 10.3390/pharmaceutics12020102 Authors: Wadhwa Aljabbari Lokras Foged Thakur In the past few years, there has been increasing focus on the use of messenger RNA (mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based drugs are directed toward infectious disease vaccines, cancer immunotherapies, therapeutic protein replacement...
Tue Jan 28, 2020 02:00
Pharmaceutics, Vol. 12, Pages 104: Tablets of “Hydrochlorothiazide in Cyclodextrin in Nanoclay”: A New Nanohybrid System with Enhanced Dissolution Properties Pharmaceutics doi: 10.3390/pharmaceutics12020104 Authors: Maestrelli Cirri García-Villén Borrego-Sánchez Iborra Mura Hydrochlorothiazide (HCT), a Biopharmaceutical Classification System (BCS) class IV drug, is characterized by low solubility and permeability, that negatively affect its oral bioavailability,...
Tue Jan 28, 2020 02:00
Pharmaceutics, Vol. 12, Pages 105: Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing Pharmaceutics doi: 10.3390/pharmaceutics12020105 Authors: Stewart Domínguez-Robles McIlorum Mancuso Lamprou Donnelly Larrañeta Implantable drug delivery devices offer many advantages over other routes of drug delivery. Most significantly, the delivery of lower doses of drug, thus, potentially reducing side-effects and improving...
Tue Jan 28, 2020 02:00
Pharmaceutics, Vol. 12, Pages 103: Controlled-Release from High-Loaded Reservoir-Type Systems—A Case Study of Ethylene-Vinyl Acetate and Progesterone Pharmaceutics doi: 10.3390/pharmaceutics12020103 Authors: Koutsamanis Paudel Nickisch Eggenreich Roblegg Eder Reservoir systems (drug-loaded core surrounded by drug-free membrane) provide long-term controlled drug release. This is especially beneficial for drug delivery to specific body regions including the vagina....
Tue Jan 28, 2020 02:00
Plants, Vol. 9, Pages 159: Exogenous Isoprene Confers Physiological Benefits in a Negligible Isoprene Emitter (Acer monspessulanum L.) Under Water Deficit Plants doi: 10.3390/plants9020159 Authors: Ormeño Viros Mévy Tonetto Saunier Bousquet-Mélou Fernandez Isoprene, the main volatile released by plants, is known to protect the photosynthetic apparatus in isoprene emitters submitted to oxidative pressures caused by environmental constraints. Whether ambient isoprene...
Tue Jan 28, 2020 02:00
Plants, Vol. 9, Pages 160: Assessment of Genetic Relationships between Streptocarpus x hybridus V. Parents and F1 Progenies Using SRAP Markers and FT-IR Spectroscopy Plants doi: 10.3390/plants9020160 Authors: Hârţa Borsai Muntean Dina Fǎlǎmaş Olar Szabo Pamfil Ştefan The genetic relationship among three Streptocarpus parents and twelve F1 hybrids was assessed using sequence-related amplified polymorphism (SRAP) molecular markers and Fourier-transform...
Tue Jan 28, 2020 02:00
Religions, Vol. 11, Pages 61: A Survey of the Japanese Influence on Buddhist Education in Taiwan during the Japanese Colonial Period (1895–1945) Religions doi: 10.3390/rel11020061 Authors: Lin This paper analyses the Japanese influence upon Taiwanese Buddhist communities during the Colonial Period. I will discuss the interplay between monasticism, education, and politics by examining the process of institutionalisation of monastics and Buddhist educational programs in Taiwan between...
Tue Jan 28, 2020 02:00
Religions, Vol. 11, Pages 62: Women in Britain’s First Muslim Mosques: Hidden from History, but Not Without Influence Religions doi: 10.3390/rel11020062 Authors: Cheruvallil-Contractor Two of the earliest Muslim communities in Britain evolved around the first mosques in Liverpool and Woking (both—1889). The history of these early British Muslims is being recovered but little is known about the women (usually converts) in these communities. This article will draw upon original...
Tue Jan 28, 2020 02:00
Religions, Vol. 11, Pages 59: Sanctifying Domestic Space and Domesticating Sacred Space: Reading Ziyāra and Taṣliya in Light of the Domestic in the Early Modern Ottoman World Religions doi: 10.3390/rel11020059 Authors: Allen Shrine-visitation (ziyāra) and devotion to Muḥammad (such as expressed in taṣliya, the uttering of invocations upon the Prophet), both expressed through a range of ritualized practices and material objects, were at the heart of everyday Islam for the vast majority...
Tue Jan 28, 2020 02:00
Religions, Vol. 11, Pages 60: Time in the Upaniṣads Religions doi: 10.3390/rel11020060 Authors: Cohen The Upaniṣads (ca. 800 BCE) were composed during a transitional time period in Hinduism when Vedic ritual and cosmogonic ideas began to give way to new worldviews. The intriguing Upaniṣadic notions of time have received little attention in the scholarly literature compared to the elaborate models of cyclical time that develop in later texts. I propose, however, that the Upaniṣads represent...
Tue Jan 28, 2020 02:00
Social Sciences, Vol. 9, Pages 9: The End-Purpose of Teaching History and the Curricular Inclusion of Social Problems from the Perspective of Primary Education Trainee Teachers Social Sciences doi: 10.3390/socsci9020009 Authors: Ortega-Sánchez Pagès Blanch The principal objective of the present study is to analyze the representations of Primary Education trainee teachers (n = 232) involving the end-purposes of teaching History and, in particular, their views on the didactic treatment...
Tue Jan 28, 2020 02:00
Sports, Vol. 8, Pages 14: Absolute and Relative Strength, Power and Physiological Characteristics of Indian Junior National-Level Judokas Sports doi: 10.3390/sports8020014 Authors: Harris Kendall Haff Latella The physical qualities that underpin successful junior judokas requires continuing investigation. We investigated the physical and physiological characteristics of junior national level judokas. We tested 25 (15 male, 10 female) Indian judokas for absolute and relative...
Tue Jan 28, 2020 02:00
Toxins, Vol. 12, Pages 88: Identification of Echinacea Purpurea (L.) Moench Root LysM Lectin with Nephrotoxic Properties Toxins doi: 10.3390/toxins12020088 Authors: Balciunaite Haimi Mikniene Savickas Ragazinskiene Juodziukyniene Baniulis Pangonyte Echinacea purpurea (L.) Moench (EP) is a well-studied plant used for health benefits. Even though there are a lot of data on EP secondary metabolites, its active proteins are not studied well enough. The aim of...
Tue Jan 28, 2020 02:00
Toxins, Vol. 12, Pages 86: The Toxicological Intersection between Allergen and Toxin: A Structural Comparison of the Cat Dander Allergenic Protein Fel d1 and the Slow Loris Brachial Gland Secretion Protein Toxins doi: 10.3390/toxins12020086 Authors: Scheib Nekaris Rode-Margono Ragnarsson Baumann Dobson Wirdateti Nouwens Nijman Martelli Ma Lewis Kwok Fry Slow lorises are enigmatic animal that represent the only venomous primate lineage....
Tue Jan 28, 2020 02:00
Toxins, Vol. 12, Pages 87: Acute Oral Toxicity of Pinnatoxin G in Mice Toxins doi: 10.3390/toxins12020087 Authors: Sosa Pelin Cavion Hervé Hess Tubaro Pinnatoxin G (PnTx-G) is a marine cyclic imine toxin produced by the dinoflagellate Vulcanodinium rugosum, frequently detected in edible shellfish from Ingril Lagoon (France). As other pinnatoxins, to date, no human poisonings ascribed to consumption of PnTx-G contaminated seafood have been reported, despite its potent...
Tue Jan 28, 2020 02:00
Urban Science, Vol. 4, Pages 8: Acknowledgement to Reviewers of Urban Science in 2019 Urban Science doi: 10.3390/urbansci4010008 Authors: Urban Science Editorial Office The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not.[...]
Tue Jan 28, 2020 02:00
Vaccines, Vol. 8, Pages 51: Immunization Status against Measles, Mumps, Rubella and Varicella in a Large Population of Internationally Adopted Children Referred to Meyer Children’s University Hospital from 2009 to 2018 Vaccines doi: 10.3390/vaccines8010051 Authors: Bechini Boccalini Alimenti Bonanni Galli Chiappini Control of vaccine preventable diseases (VPDs) is a challenge for healthcare systems. Different studies highlighted the suboptimal immunization of internationally...
Tue Jan 28, 2020 02:00
Vaccines, Vol. 8, Pages 52: Exploring Influenza Vaccine Uptake and Its Determinants among University Students: A Cross-Sectional Study Vaccines doi: 10.3390/vaccines8010052 Authors: Kawahara Nishiura While vaccination is the only established option to prevent a susceptible host from influenza, we have yet to clarify the decision-making mechanisms of vaccine uptake among Japanese university and college students. We aimed to explore vaccination coverage and the related demographic,...
Tue Jan 28, 2020 02:00
Vaccines, Vol. 8, Pages 50: Infections, Vaccines and Autoimmunity: A Multiple Sclerosis Perspective Vaccines doi: 10.3390/vaccines8010050 Authors: Jakimovski Weinstock-Guttman Ramanathan Dwyer Zivadinov Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease that is associated with multiple environmental factors. Among suspected susceptibility events, studies have questioned the potential role of overt viral and bacterial infections,...
Tue Jan 28, 2020 02:00
Viruses, Vol. 12, Pages 150: Genomic Characterization, Formulation and Efficacy in Planta of a Siphoviridae and Podoviridae Protection Cocktail against the Bacterial Plant Pathogens Pectobacterium spp. Viruses doi: 10.3390/v12020150 Authors: Zaczek-Moczydłowska Young Trudgett Fleming Campbell O’Hanlon In the face of global human population increases, there is a need for efficacious integrated pest management strategies to improve agricultural production and increase...
Tue Jan 28, 2020 02:00
Viruses, Vol. 12, Pages 149: Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence Viruses doi: 10.3390/v12020149 Authors: Lambrechts Cole Rutsaert Trypsteen Vandekerckhove While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound. The persistence of this stable HIV-1 latent reservoir forms the major barrier in HIV-1 cure research. The need for a better...
Tue Jan 28, 2020 02:00
Water, Vol. 12, Pages 362: Optimizing Substrate Available Water and Coir Amendment Rate in Pine Bark Substarates Water doi: 10.3390/w12020362 Authors: Jahromi Fulcher Walker Altland Water resources can be used more efficiently by including sustainable substrate components like coir that increase water-holding capacity. The first objective of this study was to evaluate the impact of coir amendment rate on plant available water and plant gas exchange, with the goal of optimizing...
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Water, Vol. 12, Pages 361: Cost of Water Use for Negotiating Rates in Energy Exchanges: Evidence from the Hydroelectric Industry Water doi: 10.3390/w12020361 Authors: Osorio-Agudelo Naranjo-Gil Ripoll-Feliu This paper analyzes the importance of the cost of dam water use in hydroelectric generators according to the International Financial Reporting Standard (IFRS) and Management Accounting. Not valuing the use of water from dams would imply undervaluing energy generation service,...
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Water, Vol. 12, Pages 360: Coastal Vulnerability Assessment Due to Sea Level Rise: The Case Study of the Atlantic Coast of Mainland Portugal Water doi: 10.3390/w12020360 Authors: Rocha Antunes Catita Sea level rise, a consequence of climate change, is one of the biggest challenges that countries and regions with coastal lowlands will face in the medium term. This study proposes a methodology for assessing the vulnerability to sea-level rise on the Atlantic coast of mainland...
Tue Jan 28, 2020 02:00
Water, Vol. 12, Pages 358: Performance of Soil Moisture Sensors in Florida Sandy Soils Water doi: 10.3390/w12020358 Authors: Ferrarezi Nogueira Zepeda Soil moisture sensors can improve water management efficiency by measuring soil volumetric water content (θv) in real time. Soil-specific calibration equations used to calculate θv can increase sensor accuracy. A laboratory study was conducted to evaluate the performance of several commercial sensors and to...
Tue Jan 28, 2020 02:00
Water, Vol. 12, Pages 359: Optimization of the Design of Water Distribution Systems for Variable Pumping Flow Rates Water doi: 10.3390/w12020359 Authors: Martin-Candilejo Santillán Iglesias Garrote Water supply systems need to be designed in an efficient way, accounting for both construction costs and operational energy expenditures when pumping is required. Since water demand varies depending on the moment´s necessities, especially when it comes to agricultural...
Tue Jan 28, 2020 02:00
Water, Vol. 12, Pages 357: A Generalized Automated Framework for Urban Runoff Modeling and Its Application at a Citywide Landscape Water doi: 10.3390/w12020357 Authors: Hosseiny Crimmins Smith Kremer This research presents a fully automated framework for runoff estimation, applied to Philadelphia, Pennsylvania, a major urban area. Trends in global urbanization are exacerbating stormwater runoff, making it an increasingly critical challenge in urban areas. Understanding the...
Tue Jan 28, 2020 02:00
Water, Vol. 12, Pages 356: Chorological and Ecological Differentiation of the Commonest Leech Species from the Suborder Erpobdelliformes (Arhynchobdellida, Hirudinea) on the Balkan Peninsula Water doi: 10.3390/w12020356 Authors: Nikola Marinković Branko Karadžić Valentina Slavevska Stamenković Vladimir Pešić Vera Nikolić Momir Paunović Maja Raković This study is the result of extensive investigations of leeches on the Balkan Peninsula. Our aim was to detect actual and...
Tue Jan 28, 2020 02:00
Water, Vol. 12, Pages 355: Technical Note: A Device to Directly Measure Transpiration from Vegetation Grown in Containers Water doi: 10.3390/w12020355 Authors: Pflug Voortman Witte Information about evaporation and transpiration fluxes is vital for water budgets, modeling of water flows and climate, as well as for assessing the hydrological impact of land management practices. Under natural conditions, these fluxes are difficult to measure accurately, which results in large...
Tue Jan 28, 2020 02:00
Water, Vol. 12, Pages 354: Effects of Persulfate Activation with Pyrite and Zero-Valent Iron for Phthalate Acid Ester Degradation Water doi: 10.3390/w12020354 Authors: Imran Tong Hu Liu Chen Phthalic acid esters (PAEs) are often detected in remediated groundwater using appropriate oxidant materials by in situ groundwater treatment. The study compares zero-valent iron–persulfate with a pyrite–persulfate system to degrade three PAEs—di(2-ethylhexyl)...
Tue Jan 28, 2020 02:00
Water, Vol. 12, Pages 352: Implementation of Modified Acacia Tannin by Mannich Reaction for Removal of Heavy Metals (Cu, Cr and Hg) Water doi: 10.3390/w12020352 Authors: Lugo Martín Diaz Pérez-Flórez Celis The modified tannin by Mannich reaction was investigated for wastewater treatment. The removal of heavy metals, such as copper, chromium and mercury, in industrial wastewater was evaluated through the coagulation–flocculation technique, using modified Acacia...
Tue Jan 28, 2020 02:00
Water, Vol. 12, Pages 353: Oblique Wave Attack on Rubble Mound Breakwater Crest Walls of Finite Length Water doi: 10.3390/w12020353 Authors: Mares-Nasarre van Gent Rubble mound breakwaters usually present a crest wall to increase the crest freeboards without a large increase of the consumption of material. Methods in the literature to design crest walls are based on estimates of the wave loads. These methods are focused on the maximum loading that attacks a single position of the...
Tue Jan 28, 2020 02:00
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