Histological characteristics of early-stage oral tongue cancer in young versus older patients: A multicenter matched-pair analysis.

Histological characteristics of early-stage oral tongue cancer in young versus older patients: A multicenter matched-pair analysis.:

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Histological characteristics of early-stage oral tongue cancer in young versus older patients: A multicenter matched-pair analysis.

Oral Dis. 2020 Jan 29;:

Authors: Bello IO, Almangush A, Heikkinen I, Haglund C, Coletta RD, Kowalski LP, Mäkitie AA, Nieminen P, Leivo I, Salo T

Abstract

The mean age of diagnosis of new oral squamous cell carcinoma (OSCC) cases is around 60 years with less than 5% of all patients aged 45 years or younger (Taybos, 2003). Oral tongue squamous cell carcinoma (OTSCC) is the most common, and presents with the worst prognosis (Ng et al., 2017). Several risk factors have been associated with OTSCC, many of which appear to be more related to older age (Farquhar et al., 2018). Young OTSCC patients lack these risk factors or when present, they have much shorter exposure time to the risk factors, suggesting different genomic and molecular changes than seen in older OTSCC patients (Llewellyn et al., 2004).

PMID: 31994277 [PubMed - as supplied by publisher]