Hypofractionated Radiation Therapy for Progressive Heterotopic Ossification: The Relationship between Dose and Efficacy.

Hypofractionated Radiation Therapy for Progressive Heterotopic Ossification: The Relationship between Dose and Efficacy.:

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Hypofractionated Radiation Therapy for Progressive Heterotopic Ossification: The Relationship between Dose and Efficacy.

Int J Radiat Oncol Biol Phys. 2020 Jan 23;:

Authors: Lee DS, Kim Y, Cho HJ, Kim M, Whang IY

Abstract

PURPOSE: We sought to evaluate treatment outcomes after hypofractionated short-course radiation therapy (RT) for progressive heterotopic ossification (HO).

METHODS AND MATERIALS: Nine consecutive patients were treated between January 2016 and December 2018. None had received previous preventive RT. RT was performed to prevent further HO progression with 1 of the following dose-fractionation regimens: 7 Gy × 2 fractions, 9 Gy × 1 fraction, 6 Gy × 2 fractions, 6 Gy × 3 fractions, 8 Gy × 2 fractions, or 7 Gy × 3 fractions.

RESULTS: All patients were male, with a median age of 30 years (range, 16-55). Eight patients presented with grade III Brooker classification. The most commonly involved site was the hip, followed by femur and knee. With a median assessment time of 7.1 (range, 5.1-23.1) months, 8 patients achieved decreased HO, with 5 showing a dramatic (≥50%) reduction. Among the 5 excellent responders, a 21 Gy with 7 Gy per fraction schedule was used in 4 patients. HO status was maintained at the final median follow-up of 11.6 months (range, 6.2-36.1), and Brooker's grade was improved in 3 patients. No significant RT-related toxicity was noted.

CONCLUSIONS: The current RT scheme was effective for the management of progressive HO. It is speculated that higher RT doses could result in the superior efficacy of progressive HO.

PMID: 31983559 [PubMed - as supplied by publisher]