Massive activity of cytotoxic cells during refractory Neuromyelitis Optica spectrum disorder.

Massive activity of cytotoxic cells during refractory Neuromyelitis Optica spectrum disorder.:

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Massive activity of cytotoxic cells during refractory Neuromyelitis Optica spectrum disorder.

J Neuroimmunol. 2020 Jan 09;340:577148

Authors: Boldrini VO, Brandão CO, Pimentel MLV, Vidal A, Mansur LF, Quintiliano RPS, Santos LMB, Farias AS

Abstract

Our group is interested in the cytotoxic mechanism during autoimmune neuroinflammation. Unexpectedly, we come across a case that presents a massive enhancement of cytotoxic behavior in lymphocytes, either in peripheral blood and cerebrospinal fluid. Interestingly, this specific patient was refractory to Methylprednisolone treatment. Hypothetically, the cytotoxic activity could represent a novel and complementary effector mechanism to NMOSD pathogenesis. Nevertheless, further investigation is needed to evaluate the extension and the clinical relevance of our finds.

PMID: 31986375 [PubMed - as supplied by publisher]