Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice

Antihyperuricemic and nephroprotective effects of extracts from Orthosiphon stamineus in hyperuricemic mice:

Abstract

Objectives

To investigate the antihyperuricemia and nephroprotective effects of Orthosiphon stamineus extracts on hyperuricemia (HUA) mice and explore the potential mechanisms.

Methods

Orthosiphon stamineus extracts were extracted using 50% ethanol and enriched using ethyl acetate, and characterised utilising UPLC/ESI‐MS. A potassium oxonate (PO) induced hyperuricemic mouse model was used to evaluate antihyperuricemia and nephroprotective effects of O. stamineus ethyl acetate extracts (OSE).

Key findings

Eight constituents from OSE were identified and OSE treatment ameliorated HUA by regulating key indicators of kidney dysfunction and xanthine oxidase, adenosine deaminase activity and urate transporters in hyperuricemic mice. Moreover, in renal histopathology analysis, OSE significantly alleviated kidney injury.

Conclusions

These findings demonstrate that OSE has antihyperuricemic and nephroprotective effects on PO‐induced HUA mice and those results indicate that OSE could be a safe and effective agent or functional ingredient for treating HUA.

More images

Orthosiphon aristatus

Plants

Description

Orthosiphon aristatus is a plant species in the family of Lamiaceae / Labiatae. The plant is a medicinal herb found mainly throughout southern China, the Indian Subcontinent, South East Asia and tropical Queensland. Wikipedia

Scientific name: Orthosiphon aristatus

Kingdom: Plantae

Family: Lamiaceae

Rank: Species

Higher classification: Orthosiphon

Order: Lamiales