Experimental Study of Nerve Transfer to Restore Diaphragm Function.

Experimental Study of Nerve Transfer to Restore Diaphragm Function.:

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Experimental Study of Nerve Transfer to Restore Diaphragm Function.

World Neurosurg. 2020 Jan 23;:

Authors: Ding W, Jiang J, Xu L

Abstract

OBJECTIVE: Diaphragmatic paralysis following phrenic nerve injury is an infrequent but serious condition. The destruction of respiratory function after unilateral phrenic nerve injury has been the subject of many investigations.

METHODS: In this study, we used a rat model of complete paralysis of the unilateral diaphragm to observe the changes of pulmonary function.

RESULTS: It is found that in the young rats of complete paralysis of the unilateral diaphragm, the vital capacity and total lung capacity show compensation after 4 weeks, and contralateral phrenic nerve transfer can enhance pulmonary function. However, in the aged rats, respiratory function parameters do not show compensation until 16 weeks after injury.

CONCLUSION: These findings suggest that contralateral phrenic nerve end-to-side anastomosis is a promising therapeutic strategy. In general, our results suggest that this surgical method may hold great potential to be a secure, feasible, and effective technique to rescue diaphragmatic function.

PMID: 31982596 [PubMed - as supplied by publisher]