J Hosp Infect. 2020 Jan 23. pii: S0195-6701(20)30038-4. doi: 10.1016/j.jhin.2020.01.014. [Epub ahead of print]
Removal of sinks and bathing changes to control multi-drug resistant Gram negative bacteria in a neonatal intensive care unit: a retrospective investigation.
Tracy M1, Ryan L2, Samarasekara H3, Leroi M4, Polkinghorne A5, Branley J6.
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PMID: 31982431 DOI: 10.1016/j.jhin.2020.01.014
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Select item 319824302.
J Hosp Infect. 2020 Jan 23. pii: S0195-6701(20)30036-0. doi: 10.1016/j.jhin.2020.01.012. [Epub ahead of print]
Precision Infection Prevention: The Next Frontier in Patient Safety.
Pryor R1, Godbout EJ2, Bearman G3.
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PMID: 31982430 DOI: 10.1016/j.jhin.2020.01.012
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Conflict of interest statement
Select item 319784173.
J Hosp Infect. 2020 Jan 21. pii: S0195-6701(20)30011-6. doi: 10.1016/j.jhin.2020.01.008. [Epub ahead of print]
Where is the strength of evidence? A review of infection prevention and control guidelines.
Mitchell BG1, Fasugba O2, Russo PL3.
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Abstract
BACKGROUND:
An important aspect of safety and quality in healthcare is the implementation of infection prevention and control guidelines. However, little is known regarding the strength of evidence on which recommendations for such guidelines are based.
AIM:
This study aimed to describe the strength of recommendations of infection prevention and control guidelines published in the last ten years.
METHODS:
For this review, we purposely searched the websites of government and professional organisations for national and international infection prevention and control clinical guidelines. The search was limited to publications between January 2009 and April 2019, and those with a formal grading system used to determine the strength of the evidence underpinning the recommendations. Recommendations from guidelines were categorised into 21 infection control categories. A descriptive synthesis of the data was undertaken.
RESULTS:
A total of 31 guidelines comprising 1855 recommendations were included. Guidelines were mainly developed in the United States (n=11, 35.5%) and Canada (n=9, 29.0%). Most guidelines used the GRADE approach (n=6, 19.4%. The majority of the guidelines contained recommendations categorised under the themes of devices (n=316, 16.9%) and transmission-based precautions (n=315, 16.8%). Most recommendations (n=769, 41.5%) were graded as using evidence from descriptive studies, expert opinion and low quality evidence.
CONCLUSION:
There is a vast number of infection prevention and control guidelines developed by national and international government or professional organisations, many without a strong evidence base. This presents multiple research opportunities that should prioritise common prevention activities that currently have a low evidence base.
Copyright © 2020 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Evidence-Based Medicine; Evidence-Based Practice; infection control; standards
PMID: 31978417 DOI: 10.1016/j.jhin.2020.01.008
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Conflict of interest statement
Select item 319784164.
J Hosp Infect. 2020 Jan 21. pii: S0195-6701(20)30008-6. doi: 10.1016/j.jhin.2020.01.006. [Epub ahead of print]
A close shave? Performance of P2/N95 respirators in health care workers with facial hair: results of the BEARDS (Adequate Respiratory DefenceS) study.
Sandaradura I1, Goeman E1, Pontivivo G1, Fine E1, Gray H1, Kerr S1, Marriott D1, Harkness J1, Andresen D2.
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Abstract
P2/N95 filtering face piece respirators (FFRs) protect Health Care Workers (HCW) from airborne infections. We assessed the impact of facial hair on quantitative respirator fit in 105 male HCW, of whom 38 were clean-shaven, and assessed male facial hair prevalence at our facility. Only 34 (32%) of male HCWs overall achieved an adequate FFR fit, including 47% of clean-shaven men. No full bearded HCW achieved a fit. Adequate respirator fit fell significantly with increasing facial hair (p<0.01 for trend). Facial hair was present on 49% of male employees. Our study supports quantitative fit testing prior to P2/N95 respirator use.
Copyright © 2020. Published by Elsevier Ltd.
PMID: 31978416 DOI: 10.1016/j.jhin.2020.01.006
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Select item 319621395.
J Hosp Infect. 2020 Jan 18. pii: S0195-6701(20)30034-7. doi: 10.1016/j.jhin.2020.01.010. [Epub ahead of print]
Preparedness and proactive infection control measures against the emerging Wuhan coronavirus pneumonia in China.
Cheng VCC1, Wong SC2, To KKW3, Ho PL3, Yuen KY4.
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PMID: 31962139 DOI: 10.1016/j.jhin.2020.01.010
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Select item 319547636.
J Hosp Infect. 2020 Jan 16. pii: S0195-6701(20)30012-8. doi: 10.1016/j.jhin.2020.01.009. [Epub ahead of print]
Sources of viral respiratory infections in Canadian acute care hospital healthcare personnel.
Buckrell S1, Coleman BL2, McNeil SA3, Katz K4, Muller MP5, Simor A6, Loeb M7, Powis J8, Kuster SP9, Di Bella JM10, Coleman KK11, Drews SJ12, Kohler P13, McGeer A14; Canadian Healthcare Worker Study Group.
Collaborators (10)
Author information
Abstract
BACKGROUND:
Viral respiratory illnesses are common causes of outbreaks and can be fatal to some patients.
AIM:
To investigate the association between laboratory-confirmed viral respiratory infections and potential sources of exposure during the previous 7 days.
METHODS:
In this nested case-control analysis, healthcare personnel from 9 Canadian hospitals who developed acute respiratory illnesses during the winters of 2010/11-2013/14 submitted swabs that were tested for viral pathogens. Associated illness diaries and non-ill participants' weekly diaries provided information on contact with people displaying symptoms of acute respiratory illness in the previous week. Conditional logistic regression assessed the association between cases, who were matched by study week and site with controls with no respiratory symptoms.
FINDINGS:
There were 814 laboratory-confirmed viral respiratory illnesses. The adjusted odds ratio (aOR) of a viral illness was higher for healthcare personnel reporting exposures to ill household members (7.0, 95% CI 5.4, 9.1), co-workers (3.4, 95% CI 2.4, 4.7) or other social contacts (5.1, 95% CI 3.6, 7.1). Exposures to patients with respiratory illness were not associated with infection (aOR 0.9, 95% CI 0.7, 1.2), however healthcare personnel with direct patient contact did have higher odds (aOR 1.3, 95% CI 1.1, 1.6). The aORs for exposure and for direct patient contact were similar for illnesses caused by influenza.
CONCLUSION:
Community and co-worker contacts are important sources of viral respiratory illness in healthcare personnel while exposure to patients with recognized respiratory infections is not associated. The comparatively low risk associated with direct patient contact may reflect transmission related to asymptomatic patients or unrecognized infections.
Copyright © 2020 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
adult; exposure; healthcare worker; hospital; respiratory; transmission; viral
PMID: 31954763 DOI: 10.1016/j.jhin.2020.01.009
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Select item 319532357.
J Hosp Infect. 2020 Jan 14. pii: S0195-6701(20)30009-8. doi: 10.1016/j.jhin.2020.01.007. [Epub ahead of print]
Imaging in the investigation and management of Staphylococcus aureus bacteraemia: A role for advanced imaging techniques.
Goodman AL, Cook GJ, Goh V.
Abstract
Staphylococcus aureus bacteraemia (SAB) continues to affect ∼25 000 patients in the UK per year with a high crude mortality of 30% at 90 days. Prompt source control improves outcomes in sepsis and SAB and is included in sepsis guidelines. A recent clinical trial of adjunctive antibiotic treatment in SAB found that the majority of recurrences of SAB were associated with a failure of source management. In this condition, the ability to control the source of infection may be limited by the ability to detect a focus of infection. Echocardiogram is now a routinely used tool to detect such unknown foci in the form of unexpected infectious vegetations. We review the literature to explore the utility of advanced imaging techniques, such as 18F-FDG PET/CT and MRI (including whole-body MRI, WB-MRI), to detect foci which may otherwise be missed. As unknown foci are associated with increased mortality, we propose that increasing the detection of foci could enable improved source control and result in improved outcomes in SAB.
Copyright © 2020. Published by Elsevier Ltd.
PMID: 31953235 DOI: 10.1016/j.jhin.2020.01.007
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Select item 319310468.
J Hosp Infect. 2020 Jan 10. pii: S0195-6701(20)30007-4. doi: 10.1016/j.jhin.2020.01.005. [Epub ahead of print]
Risk factors for Klebsiella pneumoniae carbapenemase (KPC) gene acquisition and clinical outcomes across multiple bacterial species.
Mathers AJ1, Vegesana K2, Mesner IG2, Ainsworth J2, Pannone A3, Crook DW4, Sifri CD5, Sheppard A6, Stoesser N4, Peto T6, Walker AS4, Eyre DW7.
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Abstract
INTRODUCTION:
Risk factors for carbapenemase-producing Enterobacteriales (CPE) acquisition/infection and associated clinical outcomes have been evaluated in the context of clonal, species-specific outbreaks; equivalent analyses for complex, multi-species outbreaks, which are increasingly common, are lacking.
METHODS:
We performed, Dec 2010-Jan 2017, a case-control study of Klebsiella pneumoniae carbapenemase (KPC)-producing organism (KPCO) acquisition using electronic health records from inpatients in a US academic medical centre and long-term acute care hospital (LTACH) with ongoing multi-species KPCO transmission despite a robust CPE screening programme. Cases had a first KPCO-positive culture >48 hours after admission, and included colonizations and infections (defined by clinical records). Controls had ≥2 negative peri-rectal screens and no positive cultures. Risk-factors for KPCO acquisition, first infection following acquisition, and 14-day mortality following each infection episode were identified using multivariable logistic regression.
RESULTS:
In 303 cases (89 with ≥1 infection) and 5929 controls, risk-factors for KPCO acquisition included: longer inpatient stay, transfusion, complex thoracic pathology, mechanical ventilation, dialysis, and exposure to carbapenems and β-lactam/β-lactamase inhibitors. Exposure to other KPCO-colonized patients was only a risk factor for acquisition in a single unit, suggesting that direct patient-to-patient transmission did not play a major role. There were 15 species of KPCO; 61 (20%) cases were colonized/infected with >1 species. 14-day mortality following non-urinary KPCO infection was 20% (20/97 episodes) and was associated with failure to achieve source control.
CONCLUSIONS:
Healthcare exposures, antimicrobials and invasive procedures increased risk of KPCO colonization/infection suggesting potential targets for infection control interventions in multi-species outbreaks. Evidence for patient-to-patient transmission was limited.
Copyright © 2020. Published by Elsevier Ltd.
KEYWORDS:
Carbapenemase producing Enterobacteriales (CPE); Carbapenemase producing organisms (CPO); Klebsiella pneumoniae carbapenemase (KPC); carbapenem resistant Enterobacteriales (CRE); multispecies clinical risk
PMID: 31931046 DOI: 10.1016/j.jhin.2020.01.005
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Select item 319310459.
J Hosp Infect. 2020 Jan 10. pii: S0195-6701(20)30006-2. doi: 10.1016/j.jhin.2020.01.004. [Epub ahead of print]
Surveillance of Surgical Site Infection in a teaching hospital in Ghana: A prospective cohort study.
Bediako-Bowan A1, Owusu E2, Debrah S3, Kjerulf A4, Newman MJ5, Lindholm Kurtzhals JA6, Mølbak K7.
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Abstract
BACKGROUND:
Surveillance systems for surgical site infections (SSI), as a measure of patient safety, helps health institutions devise strategies to reduce or prevent them. No surveillance systems exist to monitor SSI in Ghana.
AIM:
This study aimed to establish a system for monitoring trends and detecting outbreaks in order to create awareness of and control SSI.
METHODS:
An active 30-day surveillance was undertaken at the general surgical unit of the Korle-Bu Teaching Hospital, from 1st July 2017 to 31st December 2018 to identify SSI. It involved a daily in-patient surveillance of patients who had a surgical procedure, followed by a post discharge surveillance by means of a healthcare personnel-based survey and a patient-based telephone survey. We provided quarterly feedback of results to surgeons.
FINDINGS:
Among the 3267 patients included, 331 were identified with an SSI, a 10% incidence risk. Patients who acquired an SSI experienced increased morbidity including nine extra days in hospital and an adjusted relative mortality risk of 1.2 (95% CI 0.8-1.9) (p=0.3) compared to patients without SSI. Forty-nine percent (161/331) of SSI were diagnosed post-discharge using the healthcare personnel-based survey. The patient-based telephone survey contributed 12 additional cases. SSI incidence risk reduced from 12.8% to 7.5% over the study period.
CONCLUSION:
Post-discharge surveillance is feasible using existing healthcare personnel, and the results highlight the high risk and burden of SSI in Ghana. A surveillance system with feedback for monitoring SSI may contribute to reducing SSI, however firm conclusions as regards the impact need longer observation time.
Copyright © 2020 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Ghana; Monitoring; Surgical site infections; Surveillance; Surveillance system
PMID: 31931045 DOI: 10.1016/j.jhin.2020.01.004
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Select item 3193104410.
J Hosp Infect. 2020 Jan 10. pii: S0195-6701(20)30002-5. doi: 10.1016/j.jhin.2019.12.025. [Epub ahead of print]
Accuracy of the ELITe MGB® assays for the detection of carbapenemases, CTX-M, Staphylococcus aureus and mecA/C genes directly from respiratory samples.
Boattini M1, Bianco G2, Iannaccone M2, Charrier L3, Almeida A4, De Intinis G2, Cavallo R2, Costa C2.
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Abstract
INTRODUCTION:
Bacterial lower respiratory tract infections (BLRTI) may represent serious clinical conditions which can lead to respiratory failure, ICU admission and high hospital costs. The detection of carbapenemase- and extended-spectrum β-lactamase (ESBL)-producing Enterobacterales, as well as methicillin-resistant Staphylococcus aureus (MRSA), has become a major issue especially in health care associated infections. This study aimed to determine whether molecular assays could detect genes encoding carbapenemases, ESBL and MRSA, directly from respiratory samples, so as to expedite appropriate therapy and infection control for patients with BLRTI.
METHODS:
The CRE, ESBL and MRSA/SA ELITe MGB® assays were performed directly on 354 respiratory specimens sampled from 318 patients admitted with BLRTI. Molecular results were compared to routine culture-based diagnostics results.
RESULTS:
Positive (PPV) and negative (NPV) predictive values of the CRE ELITe MGB® kit were 75.9% [IC 95%: 60.3-86.7] and 100%, respectively. PPV and NPV of the ESBL ELITe MGB® kit were 80.8% [IC 95%: 63.6-91] and 99.1% [IC 95%: 96.6-99.8], respectively. PPV and NPV predictive values of the MRSA/SA ELITe MGB® kit were 91.7% [IC 95%: 73.7-97.7]/100% and 98.3% [IC 95%: 89.8-99.3]/96.8% [IC 95%: 81.6-99.5], respectively.
DISCUSSION:
Validity assessment of molecular assays detecting the main antibiotic resistance genes directly from respiratory samples showed a high accuracy when compared to culture-based results. Molecular assays detecting the main carbapenemase, ESBL, S. aureus and methicillin resistance encoding genes provide an interesting tool with potential to expedite optimization of antibiotic therapy and infection control practices in patients with BLRTI.
Copyright © 2020 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Antibiotic resistance genes; Antimicrobial stewardship; Bronchoalveolar lavage fluid; Molecular assay; pneumonia; respiratory samples
PMID: 31931044 DOI: 10.1016/j.jhin.2019.12.025
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Select item 3193104311.
J Hosp Infect. 2020 Jan 10. pii: S0195-6701(20)30005-0. doi: 10.1016/j.jhin.2020.01.003. [Epub ahead of print]
Direct Medical Burden of Antimicrobial Resistant Healthcare-Associated Infections - Empirical Evidence from China.
Liui X1, Cu D2, Li H2, Wang Q2, Mao Z2, Fang L3, Ren N4, Sune J5.
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Abstract
BACKGROUND:
Antimicrobial resistance (AMR) and healthcare-associated infection (HAI) are among the biggest global public health challenges, and overlap widely. These infections cause significant morbidity and mortality, put pressure on health systems, and incur rising direct and indirect costs.
OBJECTIVE:
This study analyzed the direct medical burden attributable to antimicrobial-resistant healthcare-associated infections in Chinese public tertiary hospitals, and aimed to inform both the medical regulators and hospital managers for better control of HAI and containment of AMR.
METHODS:
The propensity score matching method (γ=0.25σ, nearest neighbor 1:1 matching) was applied to conduct a retrospective cohort study in five public tertiary hospitals in the Hubei province of China during 2013-2015. Descriptive analysis, Pearson Chi-Square test, Mann-Whitney U test, Wilcoxon signed-rank test and paired/independent Z/T test were conducted. The statistically significant level was set at P < 0.05.
RESULTS:
From 2013 to 2015 in overall, the additional total medical expenditure per HAI-AMR inpatient was US$ 15 557.25 compared with that of the non-HAIs, and the additional length of per hospital stay of the HAI-AMR inpatient was 41 days compared with that of the non-HAIs (P<0.001).
CONCLUSIONS:
In combination with AMR, HAI caused significant additional medical expenses and affected the turnover rate of hospital beds. Most of the increased medical costs fell to patients and their families. These findings call for more effective control of HAI and containment of AMR. A national study is needed to estimate the medical, social and economic burden of HAI in combination with AMR.
Copyright © 2020 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Antimicrobial Resistance; Direct Medical Burden; Healthcare-Associated Infection; Propensity Score Matching
PMID: 31931043 DOI: 10.1016/j.jhin.2020.01.003
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Select item 3192703812.
J Hosp Infect. 2020 Jan 9. pii: S0195-6701(20)30003-7. doi: 10.1016/j.jhin.2020.01.001. [Epub ahead of print]
Microbiological contamination of clipboards utilised for patient records in intensive care units.
Silva LN1, de Melo Costa D1, Vickery K2, de Sousa Melo D1, Netto de Oliveira Leão Vasconcelos LS3, Hu H2, Ribeiro EL3, Veiga Tipple AF4.
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KEYWORDS:
Biofilms; Decontamination; Equipment contamination; Medical records
PMID: 31927038 DOI: 10.1016/j.jhin.2020.01.001
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Select item 3192703713.
J Hosp Infect. 2020 Jan 9. pii: S0195-6701(20)30001-3. doi: 10.1016/j.jhin.2019.12.024. [Epub ahead of print]
Antimicrobial Stewardship in Care Homes: Outcomes of Importance to Stakeholders.
Nguyen HQ1, Bradley DT2, Tunney MM1, Hughes CM3.
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Abstract
BACKGROUND:
Heterogeneity of outcomes measured in trials to improve antimicrobial stewardship (AMS) in care homes has compromised quality of evidence. A core outcome set (COS) is needed to facilitate interpretation and synthesis of evidence in this area.
AIM:
To determine outcomes deemed important by relevant stakeholders for interventions aimed at improving AMS in care homes, and to produce a refined list of outcomes that could be considered for use in future research.
METHODS:
Semi-structured face-to-face or telephone interviews were conducted with key stakeholders. Outcomes reported in previous randomised controlled trials (RCTs) of AMS in care homes were included in a topic guide for interviews. Content analysis was undertaken to identify potential outcomes suggested by participants, followed by further review.
FINDINGS:
Twenty-seven outcomes reported in RCTs were refined into a list of 12 overarching outcomes. Interviews with participants (six researchers, 31 healthcare professionals, and four family members of care home residents) identified 40 additional outcomes that were important to them. From these 52 outcomes, the total number of antimicrobials, the appropriateness of antimicrobial prescribing and adherence to guidelines were highlighted by most participants. After reviewing all 52 outcomes, a refined list of 14 outcomes potentially feasible for use in AMS trials in care homes was generated.
CONCLUSION:
A number of potential outcomes for AMS in care homes, some of which had not been reported in previous studies, were identified. The refined list of 14 outcomes will be used in a future study to agree a COS for care home AMS trials.
Copyright © 2020. Published by Elsevier Ltd.
KEYWORDS:
antimicrobial stewardship; care home; older people; outcome
PMID: 31927037 DOI: 10.1016/j.jhin.2019.12.024
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Select item 3192618814.
J Hosp Infect. 2020 Jan 8. pii: S0195-6701(20)30004-9. doi: 10.1016/j.jhin.2020.01.002. [Epub ahead of print]
A clear conscience is the sure sign of a bad memory: Vancomycin-resistant enterococci and rectal thermometers.
Oturai DB1, Bergen LK2, Frimodt-Møller N2.
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PMID: 31926188 DOI: 10.1016/j.jhin.2020.01.002
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Select item 3188733415.
J Hosp Infect. 2019 Dec 27. pii: S0195-6701(19)30546-8. doi: 10.1016/j.jhin.2019.12.023. [Epub ahead of print]
Management of peripheral venous catheters and implementation of guidelines in Germany: a national survey.
Aghdassi SJS1, Geffers C2, Behnke M2, Gropmann A2, Gastmeier P2, Kramer TS2.
Author information
Abstract
BACKGROUND:
Due to their frequent use, peripheral venous catheters (PVCs) are relevant regarding catheter-related infections and their prevention. In 2017, revised national guidelines for the prevention of PVC-related infections were published in Germany.
AIM:
Our objective was to describe the practices of PVC handling and assess the implementation of national guidelines for prevention of PVC-related infections in German acute care hospitals, 10 months after their release.
METHODS:
An online survey on the management of PVCs in hospital wards was conducted. For this, 1191 acute care hospitals participating in the national surveillance system for healthcare-associated infections in Germany were invited to participate. Each hospital was asked to complete the survey for an intensive care unit (ICU), as well as a medical and surgical ward. Participation in the survey was voluntary.
FINDINGS:
Altogether, 701 hospitals (59% response rate) participated and provided data on 1449 wards (599 ICUs, 446 medical wards, 404 surgical wards). Around 43% of wards reported having implemented the new national guidelines where necessary. Structured surveillance for PVC-associated infections was established in only 21% of wards. While 94% of wards reported including aspects of PVC handling in their general infection prevention education, questions on the methods of training yielded diverse results. Around 59% of wards reported not routinely using a combination of alcohol and a remanant disinfectant for skin disinfection before PVC insertion.
CONCLUSION:
Generally, PVC management in Germany is well organized. However, potentials for improvement were identified especially considering surveillance and implementation of selected national guidelines.
Copyright © 2019 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Implementation; Infection prevention; Peripheral venous catheter; Surveillance; Survey
PMID: 31887334 DOI: 10.1016/j.jhin.2019.12.023
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Select item 3188393816.
J Hosp Infect. 2019 Dec 26. pii: S0195-6701(19)30543-2. doi: 10.1016/j.jhin.2019.12.022. [Epub ahead of print]
Faecal Microbiota Transplantation for Recurrent Clostridioides difficile Infection: Experience with Lyophilized Oral Capsules.
Reigadas E1, Bouza E2, Olmedo M3, Vázquez-Cuesta S3, Villar-Gómara L4, Alcalá L5, Marín M6, Rodríguez-Fernández S3, Valerio M6, Muñoz P6.
Author information
Abstract
BACKGROUND:
Faecal microbiota transplantation (FMT) is a highly effective approach for refractory and recurrent Clostridioides difficile infection (CDI). Despite its excellent efficacy, FMT is not yet a routine procedure in most centres. There is very little experience with FMT based on lyophilized capsules, and data from European institutions are lacking. Here, we describe our experience with FMT to treat recurrent CDI using lyophilized oral capsules.
METHODS:
We analyzed a prospectively recorded single-center case series of patients with recurrent CDI who underwent FMT between January 2018 and May 2019. The primary outcome was defined as resolution of CDI without recurrences over a 2-month period. Overall resolution was defined as resolution of diarrhea without recurrence of CDI within 2 months after a further cycle of FMT. The FMT process involved oral ingestion of 4-5 lyophilized capsules in a single dose. All stool donors were rigorously screened.
RESULTS:
FMT was performed in 32 patients. There were no procedure-related adverse events, and no complications were observed. Primary cure was achieved in 81.3% of patients, and the overall cure rate was 87.5%. FMT via lyophilized capsules was well tolerated. No FMT procedure-related adverse events and no further complications were observed for lyophilized capsule FMT.
CONCLUSIONS:
Our initial clinical experience suggests that FMT based on oral lyophilized preparations is a safe, well-tolerated, and highly effective treatment for recurrent CDI. Administration of oral lyophilized capsules seems feasible in hospital routine and will enable FMT to be more widely used.
Copyright © 2019 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
C. difficile; bacteriotherapy; capsules; fecal microbiota transplantation; freeze-dried; gut microbiota; lyophilized
PMID: 31883938 DOI: 10.1016/j.jhin.2019.12.022
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Select item 3188125317.
J Hosp Infect. 2019 Dec 24. pii: S0195-6701(19)30541-9. doi: 10.1016/j.jhin.2019.12.020. [Epub ahead of print]
A patient sink tap facilitating carbapenemase-producing enterobacteriales transmission.
Turner C1, Mosby D2, Partridge D1, Mason C1, Parsons H1.
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PMID: 31881253 DOI: 10.1016/j.jhin.2019.12.020
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Select item 3188125218.
J Hosp Infect. 2019 Dec 24. pii: S0195-6701(19)30539-0. doi: 10.1016/j.jhin.2019.12.018. [Epub ahead of print]
Reply to E. Houltz.
Whyte W1.
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PMID: 31881252 DOI: 10.1016/j.jhin.2019.12.018
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Select item 3188125119.
J Hosp Infect. 2019 Dec 24. pii: S0195-6701(19)30540-7. doi: 10.1016/j.jhin.2019.12.019. [Epub ahead of print]
Cross-sectional survey of viral testing on nasopharyngeal aspirates by laboratories in the UK in infants - is targeted testing the way forward?
Balakumar V1, Turner PC2, Paul SP3.
Author information
KEYWORDS:
Antimicrobial stewardship; High-risk patients; NICE guidelines; Nasopharyngeal airway viral testing; Palivizumab; Targeted testing
PMID: 31881251 DOI: 10.1016/j.jhin.2019.12.019
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Select item 3188125020.
J Hosp Infect. 2019 Dec 24. pii: S0195-6701(19)30542-0. doi: 10.1016/j.jhin.2019.12.021. [Epub ahead of print]
Re: Ultraclean air systems and the claim that laminar airflow systems fail to prevent deep infections after total joint arthroplasty.
Houltz E1.
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PMID: 31881250 DOI: 10.1016/j.jhin.2019.12.021
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