A case of S‐100‐negative CD1a‐positive indeterminate cell histiocytosis
Sima Amin  Jordan Jamerson  Ronald G. Tee  Palak Parekh
First published: 06 July 2019 https://doi.org/10.1111/cup.13542
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Abstract
Histiocytoses are a group of rare disorders characterized by a proliferation of monocytes/macrophages and dendritic cells. We present a case of a 3‐year‐old girl with a diffuse papular eruption without systemic symptoms demonstrating a proliferation of strongly CD1a+ histiocytes, but negative for S‐100 and langerin on histopathology. Systemic work‐up including bone marrow biopsy was unremarkable, and the patient received a diagnosis of CD1a+ S− 100‐indeterminate cell histiocytosis.