Cancers, Vol. 11, Pages 1073: GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival

Cancers, Vol. 11, Pages 1073: GSK3-β Stimulates Claspin Degradation via β-TrCP Ubiquitin Ligase and Alters Cancer Cell Survival Cancers doi: 10.3390/cancers11081073 Authors: Cabrera Raninga Khanna Freire : Claspin is essential for activating the DNA damage checkpoint effector kinase Chk1, a target in oncotherapy. Claspin functions are tightly correlated to Claspin protein stability, regulated by ubiquitin-dependent proteasomal degradation. Here we identify Glycogen Synthase...

Cancers

Mon Jul 29, 2019 03:00

Cancers, Vol. 11, Pages 1072: Extent of Resection, MGMT Promoter Methylation Status and Tumor Location Independently Predict Progression-Free Survival in Adult Sporadic Pilocytic Astrocytoma

Cancers, Vol. 11, Pages 1072: Extent of Resection, MGMT Promoter Methylation Status and Tumor Location Independently Predict Progression-Free Survival in Adult Sporadic Pilocytic Astrocytoma Cancers doi: 10.3390/cancers11081072 Authors: Jungk Reinhardt Warta Capper Deimling Herold-Mende Unterberg In adults, pilocytic astrocytomas (PA) account for less than 2% of gliomas, resulting in uncertainty regarding the clinical course and optimal treatment, particularly...

Cancers

Mon Jul 29, 2019 03:00

Cancers, Vol. 11, Pages 1071: Immunotherapy in Hodgkin Lymphoma: Present Status and Future Strategies

Cancers, Vol. 11, Pages 1071: Immunotherapy in Hodgkin Lymphoma: Present Status and Future Strategies Cancers doi: 10.3390/cancers11081071 Authors: Theodoros P. Vassilakopoulos Chrysovalantou Chatzidimitriou John V. Asimakopoulos Maria Arapaki Evangelos Tzoras Maria K. Angelopoulou Kostas Konstantopoulos Although classical Hodgkin lymphoma (cHL) is usually curable, 20–30% of the patients experience treatment failure and most of them are typically treated with...

Cancers

Mon Jul 29, 2019 03:00

Cancers, Vol. 11, Pages 1070: Pheochromocytomas and Paragangliomas: New Developments with Regard to Classification, Genetics, and Cell of Origin

Cancers, Vol. 11, Pages 1070: Pheochromocytomas and Paragangliomas: New Developments with Regard to Classification, Genetics, and Cell of Origin Cancers doi: 10.3390/cancers11081070 Authors: Karen Koopman Jose Gaal Ronald R. de Krijger Pheochromocytomas (PCC) and paragangliomas (PGL) are rare neuroendocrine tumors that arise in the adrenal medulla and in extra-adrenal locations, such as the head, neck, thorax, abdomen, and pelvis. Classification of these tumors into those with...

Cancers

Mon Jul 29, 2019 03:00

Cancers, Vol. 11, Pages 1069: Liquid Biopsy in Lung Cancer Screening: The Contribution of Metabolomics. Results of A Pilot Study

Cancers, Vol. 11, Pages 1069: Liquid Biopsy in Lung Cancer Screening: The Contribution of Metabolomics. Results of A Pilot Study Cancers doi: 10.3390/cancers11081069 Authors: Sandeep Singhal Christian Rolfo Andrew W. Maksymiuk Paramjit S. Tappia Daniel S. Sitar Alessandro Russo Parveen S. Akhtar Nazrina Khatun Parveen Rahnuma Ahmed Rashiduzzaman Rashid Ahmed Bux Guoyu Huang Bram Ramjiawan Background: Lung cancer is the most common cause of cancer-related...

Cancers

Mon Jul 29, 2019 03:00