IJMS, Vol. 20, Pages 3718: Transactivation Function-1-Mediated Partial Agonist Activity of Selective Estrogen Receptor Modulator Requires Homo-Dimerization of the Estrogen Receptor α Ligand Binding Domain International Journal of Molecular Sciences doi: 10.3390/ijms20153718 Authors: Yukitomo Arao Kenneth S. Korach The isolation of estrogen receptor alpha (ERα) cDNA was successful around 30 years ago. The characteristics of ERα protein have been examined from various...
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IJMS, Vol. 20, Pages 3719: Strategies to Increase On-Target and Reduce Off-Target Effects of the CRISPR/Cas9 System in Plants International Journal of Molecular Sciences doi: 10.3390/ijms20153719 Authors: Zahra Hajiahmadi Ali Movahedi Hui Wei Dawei Li Yasin Orooji Honghua Ruan Qiang Zhuge The CRISPR/Cas9 system (clustered regularly interspaced short palindromic repeat-associated protein 9) is a powerful genome-editing tool in animals, plants, and humans. This system...
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IJMS, Vol. 20, Pages 3716: Furosine Posed Toxic Effects on Primary Sertoli Cells through Regulating Cep55/NF-κB/PI3K/Akt/FOX01/TNF-α Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20153716 Authors: Huiying Li Bingyuan Wang Huaigu Yang Yizhen Wang Lei Xing Wei Chen Jiaqi Wang Nan Zheng As one of the Maillard reaction products, furosine has been widely reported in a variety of heat-processed foods, while the toxicity of furosine on the reproductive...
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IJMS, Vol. 20, Pages 3717: A Systems Biology Approach for Personalized Medicine in Refractory Epilepsy International Journal of Molecular Sciences doi: 10.3390/ijms20153717 Authors: Giuseppina Daniela Naimo Maria Guarnaccia Teresa Sprovieri Carmine Ungaro Francesca Luisa Conforti Sebastiano Andò Sebastiano Cavallaro Epilepsy refers to a common chronic neurological disorder that affects all age groups. Unfortunately, antiepileptic drugs are ineffective in about one-third...
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IJMS, Vol. 20, Pages 3715: DNAM-1 Activating Receptor and Its Ligands: How Do Viruses Affect the NK Cell-Mediated Immune Surveillance during the Various Phases of Infection? International Journal of Molecular Sciences doi: 10.3390/ijms20153715 Authors: Loredana Cifaldi Margherita Doria Nicola Cotugno Sonia Zicari Caterina Cancrini Paolo Palma Paolo Rossi Natural Killer (NK) cells play a critical role in host defense against viral infections. The mechanisms of recognition...
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IJMS, Vol. 20, Pages 3714: Potential Prognostic Markers of Acute Kidney Injury in the Early Phase of Acute Pancreatitis International Journal of Molecular Sciences doi: 10.3390/ijms20153714 Authors: Justyna Wajda Paulina Dumnicka Małgorzata Maraj Piotr Ceranowicz Marek Kuźniewski Beata Kuśnierz-Cabala Acute kidney injury (AKI) is a serious complication of acute pancreatitis (AP), which occurs in up to 70% of patients with severe AP and significantly increases the risk...
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IJMS, Vol. 20, Pages 3712: Mucin Thin Layers: A Model for Mucus-Covered Tissues International Journal of Molecular Sciences doi: 10.3390/ijms20153712 Authors: Rondelli Cola Koutsioubas Alongi Ferruti Ranucci Brocca The fate of macromolecules of biological or pharmacological interest that enter the mucus barrier is a current field of investigation. Studies of the interaction between the main constituent of mucus, mucins, and molecules involved in topical transmucoidal...
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3711: Oxidative Stress in the Pathogenesis and Evolution of Chronic Kidney Disease: Untangling Ariadne’s Thread International Journal of Molecular Sciences doi: 10.3390/ijms20153711 Authors: Anila Duni Vassilios Liakopoulos Stefanos Roumeliotis Dimitrios Peschos Evangelia Dounousi Amplification of oxidative stress is present since the early stages of chronic kidney disease (CKD), holding a key position in the pathogenesis of renal failure. Induction of...
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3709: Estrogen Deficiency Potentiates Thioacetamide-Induced Hepatic Fibrosis in Sprague-Dawley Rats International Journal of Molecular Sciences doi: 10.3390/ijms20153709 Authors: Yong Hee Lee Ji Yeon Son Kyeong Seok Kim Yoo Jung Park Hae Ri Kim Jae Hyeon Park Kyu-Bong Kim Kwang Youl Lee Keon Wook Kang In Su Kim Sam Kacew Byung Mu Lee Hyung Sik Kim Hepatic fibrosis is characterized by persistent deposition of extracellular matrix...
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3708: Editorial of Special Issue “The Interplay of Microbiome and Immune Response in Health and Diseases” International Journal of Molecular Sciences doi: 10.3390/ijms20153708 Authors: Amedeo Amedei Gwendolyn Barceló-Coblijn Increasing data suggests and supports the idea that the gut microbiota (GM) modulates different host pathways, playing a crucial role in human physiology and consequently impacting in the development of some pathologic conditions [...]
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3702: The Protective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK Activities International Journal of Molecular Sciences doi: 10.3390/ijms20153702 Authors: Irina O. Zakharova Tatiana V. Sokolova Liubov V. Bayunova Inna I. Zorina Maria P. Rychkova Alexander O. Shpakov Natalia F. Avrova Insulin is a promising drug for the treatment of diseases associated with...
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3710: Gene-Wide Analysis of Aquaporin Gene Family in Malus domestica and Heterologous Expression of the Gene MpPIP2;1 Confers Drought and Salinity Tolerance in Arabidposis thaliana International Journal of Molecular Sciences doi: 10.3390/ijms20153710 Authors: Haili Liu Leilei Yang Miaomiao Xin Fengwang Ma Jingying Liu The aquaporins (AQPs) are a family of integral membrane proteins involved in the transcellular membrane transport of water and other small...
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3707: Physiological and Transcriptomic Changes during the Early Phases of Adventitious Root Formation in Mulberry Stem Hardwood Cuttings International Journal of Molecular Sciences doi: 10.3390/ijms20153707 Authors: Chunqiong Shang Honglei Yang Sang Ma Qiudi Shen Li Liu Chengxiang Hou Xu Cao Jialing Cheng The initiation and induction of root primordia are of great importance for adventitious root (AR) formation in cutting propagation of horticultural...
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3705: ESRP1 Induces Cervical Cancer Cell G1-Phase Arrest Via Regulating Cyclin A2 mRNA Stability International Journal of Molecular Sciences doi: 10.3390/ijms20153705 Authors: Zhi-Hong Chen Ya-Jie Jing Jian-Bo Yu Zai-Shu Jin Zhu Li Ting-Ting He Xiu-Zhen Su Accumulating evidence indicates that epithelial splicing regulatory protein 1 (ESRP1) can inhibit the epithelial-to-mesenchymal transition (EMT), thus playing a central role in regulating the...
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3704: Variations in Surgical Procedures for Inducing Hind Limb Ischemia in Mice and the Impact of These Variations on Neovascularization Assessment International Journal of Molecular Sciences doi: 10.3390/ijms20153704 Authors: Zeen Aref Margreet R. de Vries Paul H.A. Quax Mouse hind limb ischemia is the most common used preclinical model for peripheral arterial disease and critical limb ischemia. This model is used to investigate the mechanisms of neovascularization...
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3706: Expression of HERV Genes as Possible Biomarker and Target in Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms20153706 Authors: Antonina Dolei Gabriele Ibba Claudia Piu Caterina Serra Human endogenous retroviruses (HERVs) are genetic parasites, in-between genetics and environment. Few HERVs retain some coding capability. Sometimes, the host has the advantage of some HERV genes; conversely, HERVs may contribute...
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3703: Comparative Analysis of the Characteristics of Triterpenoid Transcriptome from Different Strains of Wolfiporia cocos International Journal of Molecular Sciences doi: 10.3390/ijms20153703 Authors: Guiping Zeng Zhong Li Zhi Zhao The dried sclerotia of Wolfiporia cocos (Schwein.) Ryvarden & Gilb., a traditional Chinese medicine, has triterpenoid as its main active component. Breeding high-yield triterpenoid in W. cocos is an important research topic...
Mon Jul 29, 2019 03:00
IJMS, Vol. 20, Pages 3701: Mast Cells May Regulate The Anti-Inflammatory Activity of IL-37 International Journal of Molecular Sciences doi: 10.3390/ijms20153701 Authors: Theoharis C. Theoharides Irene Tsilioni Pio Conti Mast cells are unique immune cells involved in allergic reactions, but also in immunity and inflammation. Interleukin 37 (IL-37) has emerged as an important regulatory cytokine with ability to inhibit immune and inflammatory processes. IL-37 is made primarily by...
Mon Jul 29, 2019 03:00
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