Abstract Taxanes and anthracyclines have been among the best-studied chemotherapy classes in castration-resistant prostate cancer (CRPC). Docetaxel (D) 75 mg/m2 every 3 weeks has been the standard first line chemotherapy for CRPC. Encapsulation of doxorubicin in polyethylene glycol-coated liposomes (PLD) was developed to enhance the safety and efficacy of conventional doxorubicin. We hypothesize that the combination of weekly low dose-D and PLD would result in a high response...
Sat Sep 26, 2020 03:00
Abstract Asthma is a generalized term that describes a scope of distinct pathologic phenotypes of variable severity, which share a common complication of reversible airflow obstruction. Asthma is estimated to affect almost 400 million people worldwide, and nearly ten percent of asthmatics have what is considered “severe” disease. The majority of moderate to severe asthmatics present with a “type 2‐high” (T2‐hi) phenotypic signature, which pathologically is driven by the type 2 cytokines Interleukin‐(IL)‐4,...
Fri Sep 25, 2020 11:20
Publication date: Available online 25 September 2020Source: Medical Mycology Case ReportsAuthor(s): Rodrigo Vettorato, Daiane Heidrich, Letícia Maria Eidt, Danielle Machado Pagani, Amanda Carvalho Ribeiro, Priscila Dallé da Rosa, Gerson Vettorato, Taís Guarienti Amaro, Maria Lúcia Scroferneker
Sat Sep 26, 2020 12:46
Publication date: Available online 25 September 2020Source: Medical Mycology Case ReportsAuthor(s): Kensuke Uraguchi, Kenichi Kozakura, Satoshi Oka, Takaya Higaki, Seiichiro Makihara, Toshi Imai, Akira Doi, Tsuyoshi Ohta, Shin Kariya, Kazunori Nishizaki
Sat Sep 26, 2020 12:46
Abstract Background A high proportion of COVID‐19 patients have cardiac involvement, even those without known cardiac disease. Downregulation of angiotensin converting enzyme 2 (ACE2), a receptor for SARS‐CoV‐2 and the renin‐angiotensin system, as well as inflammatory mechanisms have been suggested to play a role. ACE2 is abundant in the gut and associated with gut microbiota composition. We hypothesized that gut leakage of microbial products, and subsequent inflammasome activation could contribute...
Fri Sep 25, 2020 19:59
Abstract Healthy tissues harbor a surprisingly high number of cells that carry well‐known cancer‐causing mutations without impacting their physiological function. In recent years, strong evidence accumulated that the immediate environment of mutant cells profoundly impact their prospect of malignant progression. In this review, focusing on the skin, we investigate potential key mechanisms that ensure tissue homeostasis despite the presence of mutant cells, as well as critical factors that may nudge...
Fri Sep 25, 2020 20:16
Related Articles Long non-coding RNA AWPPH interacts with ROCK2 and regulates the proliferation and apoptosis of cancer cells in pediatric T-cell acute lymphoblastic leukemia. Oncol Lett. 2020 Nov;20(5):239 Authors: Li X, Song F, Sun H Abstract The long non-coding (lnc)RNA associated with poor prognosis of hepatocellular carcinoma (AWPPH) serves as an oncogene in several cancers, such as liver and bladder cancers, however, to the best of our...
Sat Sep 26, 2020 13:01
Related Articles ANGPTL1 is a potential biomarker for differentiated thyroid cancer diagnosis and recurrence. Oncol Lett. 2020 Nov;20(5):240 Authors: Sun R, Yang L, Hu Y, Wang Y, Zhang Q, Zhang Y, Ji Z, Zhao D Abstract Differentiated thyroid cancer (DTC) is a common type of cancer among women with an increasing worldwide incidence rate. However, there are no specific and sensitive molecular biomarkers for DTC diagnosis or prognosis. Angiopoietin-like...
Sat Sep 26, 2020 13:01
Related Articles KIF9-AS1 promotes nasopharyngeal carcinoma progression by suppressing miR-16. Oncol Lett. 2020 Nov;20(5):241 Authors: You H, Wang S, Yu S Abstract Long non-coding RNAs (lncRNAs) have been reported to serve a crucial role in the progression of nasopharyngeal carcinoma (NPC); however, the underlying molecular mechanisms of lncRNA KIF9-AS1 in the tumorigenesis of NPC remains poorly understood. Reverse transcription-quantitative...
Sat Sep 26, 2020 13:01
Related Articles Patterns of recurrence in patients with curative resected rectal cancer according to different chemoradiotherapy strategies: Does preoperative chemoradiotherapy lower the risk of peritoneal recurrence? Oncol Lett. 2020 Nov;20(5):242 Authors: Cho H, Kim JE, Kim SY, Kim KP, Kim TW, Park JH, Kim JH, Lim SB, Yu CS, Kim JC, Hong YS Abstract The present study aimed to compare the pattern of distant recurrence between patients with...
Sat Sep 26, 2020 13:01
Related Articles RAB31 is targeted by miR-26b and serves a role in the promotion of osteosarcoma. Oncol Lett. 2020 Nov;20(5):244 Authors: Wu Q, Feng Q, Xiong Y, Liu X Abstract Ras-related protein Rab-31 (RAB31), a small guanosine 5'-triphosphate-binding protein, is a member of the Rab family and has been demonstrated to serve an oncogenic role in several common types of human cancer. However, the function of RAB31 in osteosarcoma (OS) has not...
Sat Sep 26, 2020 13:01
Related Articles Long non-coding RNA HOXA-AS2 promotes the expression levels of hypoxia-inducible factor-1α and programmed death-ligand 1, and regulates nasopharyngeal carcinoma progression via miR-519. Oncol Lett. 2020 Nov;20(5):245 Authors: Wang S, You H, Yu S Abstract Nasopharyngeal carcinoma (NPC) is a rare malignancy arising from the nasopharyngeal epithelium and belongs to the group of head and neck cancer types, which are usually associated...
Sat Sep 26, 2020 13:01
Related Articles USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin. Oncol Lett. 2020 Nov;20(5):246 Authors: Lin Y, Zhong H, Sun B, Peng Y, Lu F, Chen M, Zhu M, Huang J Abstract Renal cell carcinoma (RCC) is one of the commonest urological tumors. The incidence of RCC ranks third among urological tumors, after prostate cancer and bladder tumors. However, the etiology of RCC remains unclear. Ubiquitin-specific protease...
Sat Sep 26, 2020 13:01
Related Articles Gemcitabine resistance in triple-negative breast cancer cells can be reverted by Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol. Oncol Lett. 2020 Nov;20(5):247 Authors: Zhao Y, Jiang H, Gu M, Zu C, Zheng X Abstract The development of drug resistance to chemotherapeutic agents has consistently presented a challenge in terms of the treatment of patients with triple-negative breast cancer (TNBC). In...
Sat Sep 26, 2020 13:01
Objectives: Androgen deprivation therapy (ADT) is the standard of care for men with nonmetastatic hormone-sensitive prostate cancer (nmHSPC) after treatment failure. Although intermittent ADT (iADT) is noninferior to continuous ADT for prostate cancer outcomes, with superior quality of life and cost-to-benefit ratio, little is known regarding its real-world utilization. The authors aimed to determine the utilization of iADT in a Canadian Provincial Cancer Program for relapsed nmHSPC and identified...
Wed Sep 23, 2020 03:00
Background: When, whether, and in whom primary tumor resection (PTR) for patients with metastatic colorectal cancer (CRC) is indicated remains unknown. With advances in multiagent systemic chemotherapy, PTR may be undertaken less frequently. The aim of this study was to obtain estimates of changes in the utilization of PTR and chemotherapy for metastatic CRC. Methods: Patients diagnosed with metastatic CRC between 2000 and 2016 were identified from Surveillance Epidemiology, and End...
Wed Sep 23, 2020 03:00
Objectives: Multiple clinical trials have established a role for adjuvant chemotherapy for patients with pancreatic ductal adenocarcinoma. Adjuvant FOLFIRINOX increases survival as compared with gemcitabine but with increased toxicity. FOLFOX+nab-paclitaxel (FOLFOX-A) was developed by the Brown University Oncology Research Group (BrUOG) as an alternative to FOLFIRINOX. This phase II trial explored the feasibility and toxicity of adjuvant FOLFOX-A in patients who have completed resection for...
Wed Sep 23, 2020 03:00
Objective: The objective of the study is to test the effect of age on cancer-specific mortality (CSM) in patients with urothelial carcinoma of the urinary bladder (UCUB), across all disease stages. Materials and Methods: Within the Surveillance, Epidemiology, and End Results (SEER) registry (2004-2016), we identified 207,714 patients. Age was categorized as: below 60 versus 60 to 69 versus 70 to 79 versus 80 years and above. Multivariable competing-risks regression (CRR) models were...
Wed Sep 23, 2020 03:00
Related Articles Gilteritinib use in the treatment of relapsed or refractory acute myeloid leukemia with a FLT3 mutation. Future Oncol. 2020 Sep 25;: Authors: Ballesta-López O, Solana-Altabella A, Megías-Vericat JE, Martínez-Cuadrón D, Montesinos P Abstract The prognosis of patients with relapsed or refractory acute myeloid leukemia (R/R AML) is dismal with salvage standard approaches, and mutations of FMS-like tyrosine kinase 3 (FLT3) gene,...
Sat Sep 26, 2020 13:03
Related Articles Clinical applications of circulating tumor DNA in monitoring breast cancer drug resistance. Future Oncol. 2020 Sep 25;: Authors: Liu Y, Du Q, Sun D, Han R, Teng M, Chen S, You H, Dong Y Abstract Breast cancer is one of the leading causes of cancer-related deaths in women worldwide. Unfortunately, treatments often fail because of the development of drug resistance, the underlying mechanisms of which remain unclear. Circulating...
Sat Sep 26, 2020 13:03
Related Articles Role of indoleamine 2,3-dioxygenase in acute myeloid leukemia. Future Oncol. 2020 Sep 25;: Authors: Sobash PT, Kolhe R, Karim NA, Guddati AK, Jillella A, Kota V Abstract Indoleamine 2,3 dioxygenase (IDO), first discovered in the 1960s, is an enzyme that has become a highly investigated metabolic target in cancer research. IDO is the rate-limiting step in tryptophan metabolism catabolism into its byproducts - kynurenines. Both...
Sat Sep 26, 2020 13:03
Related Articles A theoretical model of financial burden after cancer diagnosis. Future Oncol. 2020 Sep 25;: Authors: Jones SM, Henrikson NB, Panattoni L, Syrjala KL, Shankaran V Abstract Current models of financial burden after cancer do not adequately define types of financial burden, moderators or causes. We propose a new theoretical model to address these gaps. This model delineates the components of financial burden as material and psychological...
Sat Sep 26, 2020 13:03
Related Articles Demographic factors associated with missed follow-up among solid tumor patients treated at a large multi-site academic institution. Future Oncol. 2020 Sep 25;: Authors: Freije SL, Holmes JA, Rachidi S, Ellsworth SG, Zellars RC, Lautenschlaeger T Abstract Aim: To identify demographic predictors of patients who miss oncology follow-up, considering that missed follow-up has not been well studies in cancer patients. Methods: Patients...
Sat Sep 26, 2020 13:03
Related Articles PON1 hypermethylation is associated with progression of renal cell carcinoma. J Cell Mol Med. 2019 10;23(10):6646-6657 Authors: Li X, Yu Q Abstract In this study, our aim was to exploring the influences of DNA methylation of PON1 on cell proliferation, migration and apoptosis of renal cancer cells. The genome-wide methylation array of renal cell carcinoma samples and adjacent tissues were obtained from the cancer genome atlas...
Sat Sep 26, 2020 13:12
Related Articles Ginsenoside Rd reverses cisplatin resistance in non-small-cell lung cancer A549 cells by downregulating the nuclear factor erythroid 2-related factor 2 pathway. Anticancer Drugs. 2019 09;30(8):838-845 Authors: Chian S, Zhao Y, Xu M, Yu X, Ke X, Gao R, Yin L Abstract Clinical drug resistance to platinum-based chemotherapy is considered a major impediment in the successful treatment of non-small-cell lung cancer (NSCLC). The...
Sat Sep 26, 2020 13:12
Related Articles Chlamydomonas cell cycle mutant crcdc5 over-accumulates starch and oil. Biochimie. 2020 Feb;169:54-61 Authors: Torres-Romero I, Kong F, Légeret B, Beisson F, Peltier G, Li-Beisson Y Abstract The use of algal biomass for biofuel production requires improvements in both biomass productivity and its energy density. Green microalgae store starch and oil as two major forms of carbon reserves. Current strategies to increase the amount...
Sat Sep 26, 2020 13:12
Related Articles Liposomes Co-Encapsulating Cisplatin/Mifepristone Improve the Effect on Cervical Cancer: In Vitro and In Vivo Assessment. Pharmaceutics. 2020 Sep 22;12(9): Authors: Ledezma-Gallegos F, Jurado R, Mir R, Medina LA, Mondragon-Fuentes L, Garcia-Lopez P Abstract Cervical cancer is usually diagnosed in the later stages despite many campaigns for early detection and continues to be a major public health problem. The standard treatment...
Sat Sep 26, 2020 13:12
Related Articles The Role of Chaperone-Mediated Autophagy in Cell Cycle Control and Its Implications in Cancer. Cells. 2020 Sep 22;9(9): Authors: Andrade-Tomaz M, de Souza I, Rocha CRR, Gomes LR Abstract The cell cycle involves a network of proteins that modulate the sequence and timing of proliferation events. Unregulated proliferation is the most fundamental hallmark of cancer; thus, changes in cell cycle control are at the heart of malignant...
Sat Sep 26, 2020 13:12
Related Articles 4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model. Int J Mol Sci. 2020 Sep 22;21(18): Authors: Wu CH, Ou CH, Yen IC, Lee SY Abstract Astronauts suffer from 1-2% bone loss per month during space missions. Targeting osteoclast differentiation has been regarded as a promising strategy to prevent osteoporosis in microgravity (μXg). 4-acetylantroquinonol...
Sat Sep 26, 2020 13:12
Related Articles PIK3R3 inhibits cell senescence through p53/p21 signaling. Cell Death Dis. 2020 Sep 24;11(9):798 Authors: Chen Q, Sun X, Luo X, Wang J, Hu J, Feng Y Abstract Cellular senescence is a stress response of human cells that removes potentially harmful cells by initiating cell cycle arrest. Inducing senescence of tumor cells may be an effective tumor-inhibiting strategy. In this study we found that PIK3R3 could inhibit the cell...
Sat Sep 26, 2020 13:12
Related Articles Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling. Acta Pharmacol Sin. 2020 Sep 24;: Authors: Park HS, Han JH, Park JW, Lee DH, Jang KW, Lee M, Heo KS, Myung CS Abstract Propionate is a short-chain fatty acid (SCFA) mainly produced from carbohydrates by gut microbiota. Sodium propionate (SP) has shown to suppress the invasion in G protein-coupled...
Sat Sep 26, 2020 13:12
Related Articles XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity. Cell Div. 2020;15:11 Authors: Mitchell E, Mellor CEL, Purba TS Abstract Background: XMU-MP-1 is an inhibitor of the Hippo pathway kinases MST1/2 and has been shown to promote the downstream activation of the pro-proliferative, pro-regenerative and anti-apoptotic transcriptional regulator YAP1. We tested...
Sat Sep 26, 2020 13:12
Related Articles ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest. Oncotarget. 2020 Sep 15;11(37):3432-3442 Authors: Scotto L, Serrano XJ, Zullo K, Kinahan C, Deng C, Sawas A, Bates S, O'Connor OA Abstract The antiproliferative effect induced by histone deactylase inhibitors (HDACi) is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21....
Sat Sep 26, 2020 13:12
Related Articles Metabolic plasticity imparts erlotinib-resistance in pancreatic cancer by upregulating glucose-6-phosphate dehydrogenase. Cancer Metab. 2020;8:19 Authors: Sharma N, Bhushan A, He J, Kaushal G, Bhardwaj V Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant forms of cancer. Lack of effective treatment options and drug resistance contributes to the low survival among PDAC patients. In this study,...
Sat Sep 26, 2020 13:12
Related Articles Upregulated hsa_circ_0005785 Facilitates Cell Growth and Metastasis of Hepatocellular Carcinoma Through the miR-578/APRIL Axis. Front Oncol. 2020;10:1388 Authors: Wu A, Li Y, Kong M, Zhu B, Liu R, Bao F, Ju S, Chen L, Wang F Abstract Although accumulating documents have expounded the pivotal position of circular RNAs (circRNAs) in hepatocarcinogenesis and progression, the overwhelming majority of their functions and molecular...
Sat Sep 26, 2020 13:12
Related Articles Key Players in the Mutant p53 Team: Small Molecules, Gene Editing, Immunotherapy. Front Oncol. 2020;10:1460 Authors: Chasov V, Mirgayazova R, Zmievskaya E, Khadiullina R, Valiullina A, Stephenson Clarke J, Rizvanov A, Baud MGJ, Bulatov E Abstract The transcription factor p53 is a key tumor suppressor that is inactivated in almost all cancers due to either point mutations in the TP53 gene or overexpression of its negative...
Sat Sep 26, 2020 13:12
Related Articles Introduction of hsa-miR-512-3p as a new regulator of HER2 signaling pathway in breast cancer. Breast Cancer Res Treat. 2020 Sep 24;: Authors: Mohamadzade Z, Mahjoubi F, Soltani BM Abstract PURPOSE: Dysregulation of HER2 signaling pathway in breast cancer is well documented. Our bioinformatics analysis predicted hsa-miR-512-3p (miR-512-3p) as a bona fide regulator of HER2 as well as HER3, PIK3R2, and AKT1 genes. Then, we...
Sat Sep 26, 2020 13:12
Related Articles Cotinus coggygria Scop. induces cell cycle arrest, apoptosis, genotoxic effects, thermodynamic and epigenetic events in MCF7 breast cancer cells. Z Naturforsch C J Biosci. 2020 Sep 25;: Authors: Gospodinova ZI, Zupkó I, Bózsity N, Manova VI, Georgieva MS, Todinova SJ, Taneva SG, Ocsovszki I, Krasteva ME Abstract Current plant-derived anticancer therapeutics aim to reach higher effectiveness, to potentiate chemosensitivity...
Sat Sep 26, 2020 13:12
Related Articles Functional imaging of RAS pathway targeting in malignant peripheral nerve sheath tumor cells and xenografts. Pediatr Blood Cancer. 2020 Sep 25;:e28639 Authors: Butler E, Schwettmann B, Geboers S, Hao G, Kim J, Nham K, Sun X, Laetsch TW, Xu L, Williams NS, Skapek SX Abstract BACKGROUND: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive form of soft-tissue sarcoma (STS) in children. Despite intensive therapy,...
Sat Sep 26, 2020 13:12
Related Articles Synthesis, biological evaluation, in silico modeling and crystallization of novel small monocationic molecules with potent antiproliferative activity by dual mechanism. Eur J Med Chem. 2020 Sep 06;207:112797 Authors: Serrán-Aguilera L, Mariotto E, Rubbini G, Castro Navas FF, Marco C, Carrasco-Jiménez MP, Ballarotto M, Macchiarulo A, Hurtado-Guerrero R, Viola G, Lopez-Cara LC Abstract Seeking for new anticancer drugs with strong...
Sat Sep 26, 2020 13:12
Related Articles Brain connectivity in patients with dystonia during motor tasks. J Neural Eng. 2020 Sep 25;: Authors: Baltazar CA, Machado BS, de Faria DDS, Paulo AJM, Silva SMCA, Ferraz HB, Aguiar PMC Abstract The pathophysiology of dystonia has been related to abnormalities of sensorimotor integration and disorders in basal nuclei, but the role of other brain regions is still unclear. This study aims to investigate alterations of brain connectivity...
Sat Sep 26, 2020 13:13
Publication date: Available online 26 September 2020Source: CortexAuthor(s): Lucy L. Russell, Caroline V. Greaves, Martina Bocchetta, Jennifer Nicholas, Rhian S. Convery, Katrina Moore, David M. Cash, John van Swieten, Lize Jiskoot, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Emanuela Rotondo, Daniela Galimberti, James B. Rowe, Elizabeth Finger
Sat Sep 26, 2020 13:14
Publication date: October 2020Source: Cortex, Volume 131Author(s):
Sat Sep 26, 2020 13:14
Publication date: October 2020Source: Cortex, Volume 131Author(s):
Sat Sep 26, 2020 13:14
Publication date: Available online 25 September 2020Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): A. Cobo-Rodríguez, M. Moreno-Caballero, A. Martínez-Esteve, M. Relaño-Mesa, P. Jiménez-Granero, J.R. Infante-de la Torre
Sat Sep 26, 2020 13:16
No abstract available
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Counterfeit medical devices and injectables have recently garnered interest in the field of aesthetics. Unlike their original counterparts, these counterfeit products have neither been tested nor verified using certified quality control measures. OBJECTIVE Our study investigated the pervasiveness of counterfeit products in the field as well as the experiences and attitudes of practitioners. MATERIALS AND METHODS An online survey was distributed to current members of the American...
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Blind individuals have demonstrated the ability to detect danger and facial expressions without conscious awareness of visual stimuli. These embodied sensations are believed to be the result of primitive neural networks refined by evolutionary adaptations. We postulate that similar embodied sensations may have evolved to allow blind individuals to perceive beauty. OBJECTIVE To determine whether the visually blind can detect physical beauty. PATIENTS AND METHODS This observational...
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Fractional microneedle radiofrequency (FMRF) systems are popular options for treating acne scars. However, treatment efficacy when used in combination with traditional ablative fractional laser (AFL) and the safety profile with concomitant use of isotretinoin remain unknown. OBJECTIVE The aim of this study was to assess the safety and efficacy of an early intervention combination treatment protocol for inflammatory acne and acne scars. MATERIALS AND METHODS The electronic...
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Foam sclerotherapy is an effective treatment strategy for vascular malformations, and its sclerosing power depends on foam stability. Twenty quick passages have been widely used as an indicator of the most stable state of sclerosants, but the universality of their effectiveness has not been proven yet. OBJECTIVE We aimed to identify simple and objective indicators of the most stable state of commonly used sclerosants and provide practitioners with suggestions to judge when foam...
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Noncultured Epidermal Cell Suspension (NCECS) is a surgical modality used in treating stable vitiligo. Trypsinization of the epidermis may be done either at 4°C overnight (cold) or at 37°C for 30 to 50 minutes (warm). Recently, trypsinization was done at room temperature (25°C) in an in vitro trial. OBJECTIVE To compare different trypsinization techniques in NCECS regarding cell viability and clinical outcome. METHODS This comparative multicenter study was conducted on 20...
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Direct incision (DI) for forehead lipoma removal has a considerable risk of damaging the vertical vessels and leaving a visible scar. OBJECTIVE To evaluate the usefulness of the hairline incision (HI) in minimizing scars and neurovascular damage. PATIENTS AND METHODS Retrospective analysis was done for 30 patients with forehead lipomas who underwent excision between 2011 and 2019 at the Severance Hospital of the Yonsei University Health System, Seoul, Korea. Fourteen patients...
Sat Sep 26, 2020 13:17
Autologous Fat Grafting for Correction of Intramuscular Corticosteroid Injection–Induced Fat Atrophy
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Electroabrasion, which uses an in-office electrosurgical device, is a method of surgical planning that ablates the skin to the papillary dermis. Several reports demonstrate that intraoperative ablative interventions with lasers or dermabrasion can modulate scar formation more effectively. This investigation uses electroabrasion intraoperatively to mitigate scar formation. OBJECTIVE To evaluate the effectiveness of intraoperative electroabrasion for scar revision. MATERIALS AND...
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Dermatologic surgery is associated with low postoperative infection rates, averaging from approximately 1% to 4.25%. Often, postoperative infections are treated empirically based on clinical diagnosis of infection, given it can take 48 to 72 hours for a wound culture to identify a pathogen. OBJECTIVE We aimed to evaluate the efficacy of empiric antibiotics in dermatologic surgery postoperative infections and if wound cultures change postoperative antibiotic therapy. METHODS ...
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Inadequate pain reduction during anesthetic injection is a significant medical and surgical problem. Vibratory distraction reduces this pain; however, there are minimal data identifying those who respond best. OBJECTIVE To quantify analgesia from vibration before anesthetic injection. MATERIALS AND METHODS In this partially blinded, single-institution trial, adult participants were randomized to intervention (vibratory anesthetic device, VAD ON) or placebo (VAD OFF). Pain...
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Bilobed transposition flaps are versatile random pattern flaps used in nasal and extranasal reconstruction as they preserve free margins, access distal tissue reservoirs, and reliably repair dynamic defects. OBJECTIVE We highlight the utility of extranasal bilobed flaps to encourage surgeons to consider these flaps for Mohs micrographic surgery defects. METHODS A two-institution retrospective chart review of patients reconstructed using an extranasal bilobed flap after Mohs...
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND Topical photodynamic therapy (PDT) and imiquimod 5% (IMQ) cream are established treatments for superficial basal cell carcinoma (sBCC). Both have high initial response rates and recurrence rates of up to 37%. Recent studies demonstrate that PDT and imiquimod may act on sBCCs via synergistic immunomodulatory pathways. OBJECTIVE To describe the sequential use of MAL-PDT and imiquimod 5% cream in the treatment of sBCCs and report treatment tolerability, cosmetic outcomes, and efficacy. ...
Sat Sep 26, 2020 13:17
No abstract available
Sat Sep 26, 2020 13:17
BACKGROUND The increased use of Mohs micrographic surgery (MMS) to treat melanoma has been accompanied by wide variations in practice patterns and a lack of best practice guidelines. OBJECTIVE The present study was a nationwide cross-sectional survey of Mohs surgeons to elucidate commonalities and variations in their use of MMS to treat melanoma. MATERIALS AND METHODS A cross-sectional analysis was performed using survey responses of Mohs surgeons with membership in the American College...
Sat Sep 26, 2020 13:17
Related Articles Predictors of occult lymph node metastases in lip cancer. Am J Otolaryngol. 2020 May - Jun;41(3):102419 Authors: Walton E, Cramer JD Abstract OBJECTIVE: The incidence of lymph node metastases (LNM) in squamous cell carcinoma of the lip is modest (8%), making it challenging to identify patients that may benefit from elective pathologic staging evaluation of the neck. We evaluated predictors of LNM in patients with lip cancer...
Sat Sep 26, 2020 13:19
Related Articles Patient safety and the annulment of medical clearance exams for hearing aids: Are we "closing the book" too soon? Am J Otolaryngol. 2020 May - Jun;41(3):102443 Authors: Green T, Sinan M, Hong RS Abstract PURPOSE: To determine the utility of medical clearance exams by otolaryngologists prior to the distribution of hearing aids to patients with hearing loss. MATERIAL AND METHODS: Medical records of 313 consecutive hearing-impaired...
Sat Sep 26, 2020 13:19
Related Articles NSAID-ERD Syndrome: the New Hope from Prevention, Early Diagnosis, and New Therapeutic Targets. Curr Allergy Asthma Rep. 2020 03 14;20(4):10 Authors: Laidlaw TM, Levy JM Abstract PURPOSE OF REVIEW: This review summarizes the latest information on the appropriate identification, evaluation, and treatment of patients with nonsteroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NSAID-ERD), also known as aspirin-exacerbated...
Sat Sep 26, 2020 13:19
Related Articles Response to "Impact of Online Sources and Social Media on Plastic Surgery in China". Aesthet Surg J. 2020 08 14;40(9):NP584 Authors: Ward B, Ayyala HS, Zhang K, Manuskhani PA, Paskhover B, Lee ES PMID: 32597968 [PubMed - indexed for MEDLINE]
Sat Sep 26, 2020 13:19
Related Articles Nonsurgical management of resectable oral cavity cancer in the wake of COVID-19: A rapid review and meta-analysis. Oral Oncol. 2020 10;109:104849 Authors: Forner D, Noel CW, Wu V, Parmar A, Chan KKW, de Almeida JR, Husain Z, Eskander A Abstract OBJECTIVE: Surgery is the preferred treatment modality for oral squamous cell carcinoma (OSCC). However, due to limited resources, re-assessment of treatment paradigms in the wake of...
Sat Sep 26, 2020 13:19
Related Articles [; THE RESULTS OF APPLICATION OF THE ADVANCED SUPRAGIOID AND SUPRAOMOGIOID NECK DISSECTION IN THE TREATMENT OF REGIONAL METASTASES OF MAXILLOFACIAL AREA CANCER]. Georgian Med News. 2020 Jul-Aug;(304-305):32-37 Authors: Tsentilo V, Udod A Abstract The goal of research is to optimize the results of surgical treatment of the regional metastases of the maxillofacial area cancer by improving the technique of supragioid and supraomogioid...
Sat Sep 26, 2020 13:19
Related Articles Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones. Cells. 2020 Sep 22;9(9): Authors: Schapher M, Koch M, Weidner D, Scholz M, Wirtz S, Mahajan A, Herrmann I, Singh J, Knopf J, Leppkes M, Schauer C, Grüneboom A, Alexiou C, Schett G, Iro H, Muñoz LE, Herrmann M Abstract Salivary gland stones, or sialoliths, are the most common cause of the obstruction of salivary glands. The mechanism...
Sat Sep 26, 2020 13:19
Related Articles Radiation-Induced Hypothyroidism in Patients with Oropharyngeal Cancer Treated with IMRT: Independent and External Validation of Five Normal Tissue Complication Probability Models. Cancers (Basel). 2020 Sep 22;12(9): Authors: Nowicka Z, Tomasik B, Papis-Ubych A, Bibik R, Graczyk Ł, Latusek T, Rutkowski T, Wyka K, Fijuth J, Schoenfeld JD, Chałubińska-Fendler J, Fendler W Abstract We aimed to externally validate five normal...
Sat Sep 26, 2020 13:19
Related Articles Epstein-Barr Virus Infection of Pseudostratified Nasopharyngeal Epithelium Disrupts Epithelial Integrity. Cancers (Basel). 2020 Sep 22;12(9): Authors: Yu F, Lu Y, Li Y, Uchio Y, Pangnguriseng UA, Kartika AV, Iizasa H, Yoshiyama H, Loh KS Abstract Epstein-Barr virus (EBV) is a human oncogenic virus that causes several types of tumor, such as Burkitt's lymphoma and nasopharyngeal carcinoma (NPC). NPC tumor cells are clonal...
Sat Sep 26, 2020 13:19
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