This protocol aims to transplant a 3D bioprinted patch onto the epicardium of infarcted mice modeling heart failure. It includes details regarding anesthesia, the surgical chest opening, permanent ligation of the left anterior descending (LAD) coronary artery and application of a bioprinted patch onto the infarcted area of the heart.
Sat Sep 26, 2020 21:48
Abstract Rationale Opioid receptor antagonists reliably alter the expression or extinction of ethanol’s conditioned motivational effects as indexed by the place conditioning procedure, suggesting endogenous opioids are normally involved. These studies examined how exogenous stimulation of opioid receptors alters ethanol’s conditioned rewarding and aversive effects. Objectives...
Sat Sep 26, 2020 03:00
Publication date: Available online 25 September 2020Source: Radiotherapy and OncologyAuthor(s): Jie Li, Yixue Wen, Zhongzheng Xiang, Huan Du, Lidan Geng, Xiyue Yang, Yu Zhang, Jie Bai, Tangzhi Dai, Gang Feng, Lei Liu, Xiaobo Du
Sat Sep 26, 2020 22:40
Publication date: Available online 25 September 2020Source: Radiotherapy and OncologyAuthor(s): Victor Hernandez, Christian Rønn Hansen, Lamberto Widesott, Anna Bäck, Richard Canters, Marco Fusella, Julia Götstedt, Diego Jurado-Bruggeman, Nobutaka Mukumoto, Laura Patricia Kaplan, Irena Koniarová, Tomasz Piotrowski, Lorenzo Placidi, Ana Vaniqui, Nuria Jornet
Sat Sep 26, 2020 22:40
Publication date: Available online 26 September 2020Source: Radiotherapy and OncologyAuthor(s): Vania Batista, Juergen Meyer, Malin Kügele, Hania Al-Hallaq
Sat Sep 26, 2020 22:40
Objective In spinocerebellar ataxia type 3/Machado‐Joseph disease (SCA3/MJD), the expanded CAG repeat in ATXN3 is the causal mutation, and its length is the main factor in determining the age at onset (AO) of clinical symptoms. However, the contribution of the expanded CAG repeat length to the rate of disease progression after onset has remained a matter of debate, even though an understanding of this factor is crucial for experimental data on disease modifiers and their translation to clinical...
Fri Sep 25, 2020 21:04
Application of Coblation Tonsillectomy with Inferior Pole Capsule Preservation in Pediatric Patients
Objectives/Hypothesis To evaluate the application and advantages of coblation tonsillectomy with inferior pole capsule preservation in pediatric patients with tonsillar hypertrophy and recurrent tonsillitis. Study Design Retrospective chart review. Methods A total of 726 children who were diagnosed with either tonsillar hypertrophy or recurrent tonsillitis were included. Children were divided into two groups according to the surgical technique: conventional coblation tonsillectomy and...
Fri Sep 25, 2020 18:03
Objectives/Hypothesis To elucidate and review current literature on the surgical technique for laryngochondroplasty in male‐to‐female transgender patients. To determine the degree of benefit afforded to male‐to‐female transgender patients by laryngochondroplasty using the Glasgow Benefit Inventory (GBI). Study Design Retrospective case series. Methods After institutional review board approval was obtained, the GBI survey was given to patients who underwent laryngochondroplasty by the author....
Sat Sep 26, 2020 11:07
YKL-40, also known as chitinase-3-like protein 1, is an inflammatory glycoprotein that is secreted by various cell types under acute, chronic, and subclinical inflammation conditions. Elevated serum YKL-40 levels are reportedly independently related to diabetes mellitus, coronary artery disease, acute myocardial infarction, and cardiovascular mortality in adults. Therefore, we aimed to investigate the relationship between serum YKL-40 levels, lipid abnormalities, and the atherogenic index of plasma...
Sat Sep 26, 2020 14:35
We read with great interest the work of Gómez-Barrachina et al.1. Their systematic review covers the prevalence, causes, and risk factors of titanium plate removal in orthognathic surgery. We have some concerns, however, regarding the completeness of the review due to the search strategy used and the interpretation of funnel plots.
Sat Sep 26, 2020 03:00
In response to the Letter to the Editor, “Trust, but verify”, we thank the readers for their interest and contributions.
Sat Sep 26, 2020 03:00
Current knowledge of blunt cerebrovascular injuries (BCVIs) in craniomaxillofacial fracture (CMF) patients is limited. The purpose of this study was to determine the occurrence of BCVIs in patients with all types of CMF. This retrospective study included CMF patients in a level 1 trauma centre during a 3-year period. Patients who were not imaged with computed tomography angiography and patients with mechanisms other than blunt injury were excluded. The primary outcome variable was BCVI. A total of...
Sat Sep 26, 2020 03:00
The management of temporomandibular joint (TMJ) ankylosis requires complete removal of the ankylosed block and the prevention of recurrence. For this purpose, the ramus–condyle unit can be reconstructed with a second metatarsal free flap. This article reports the use of this flap in a young patient treated for left TMJ ankylosis, post costochondral graft for the treatment of hemifacial microsomia. Data from the 10-year follow-up are reported. The glenoid fossa was reconstructed with a graft of the...
Sat Sep 26, 2020 03:00
Based on the analysis of cpxP genes among Escherichia coli strains, cpxP gene-targeting short guide RNA (sgRNA) was designed and inserted into the pGL3-MGP-RNA. The donor sequences (MG-HR) for homologous repair w...
Sat Sep 26, 2020 03:00
Abstract Introduction Choroid plexus tumors are uncommon intraventricular tumors that develop from the choroid plexus of the central nervous system. Choroid plexus papillomas arising from the cerebellopontine angle have been reported to almost exclusively occur in adults and are rarely found in children. Methods We report a systematic review conducted...
Sat Sep 26, 2020 03:00
Abstract Background/objective Childhood epilepsy is one of the disease groups with the highest disease burden in society. This study aimed to guide researchers for new studies by determining the most compelling studies and current issues through a bibliometric analysis of scientific outputs about childhood epilepsy between 1980 and 2018. Methods The...
Sat Sep 26, 2020 03:00
Abstract Photodynamic therapy (PDT), traditionally used in patients with nonmelanoma skin cancer, has been found to be effective for various inflammatory skin conditions. Daylight‐activated PDT (DL‐PDT), in which the sun serves as the light source, is substantially less painful than conventional PDT. To determine the safety and efficacy of DL‐PDT in a series of patients with chronic hand eczema (CHE). A proof‐of‐concept prospective design was used. Eight patients diagnosed with CHE at a tertiary...
Fri Sep 25, 2020 13:59
Abstract The clinical symptoms of glomus tumors are pain, tenderness, nail discoloration, and cold intolerance. The only treatment for subungual glomus tumors is surgical removal. In this clinical study, we present an eponychium preserving method as a new innovative surgical approach for subungual glomus tumor. We retrospectively reviewed the the data of 27 patients with subungual glomus tumors who underwent tumor resection using the eponychial flap elevation method between March 2010 and 2019....
Fri Sep 25, 2020 14:04
Abstract Chilblain‐like acral lesions have been identified in some COVID‐19 patients. It has been suggested that these pseudo‐chilblains could be a specific marker of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. Most patients with these lesions have had negative PCRs, but some authors believe serology tests are likely to give positive results. We designed a prospective study including all patients with pseudo‐chilblains treated in out department in April and May 2020 then...
Fri Sep 25, 2020 14:19
Fri Sep 25, 2020 14:42
Abstract Introduction NMSC is the most common cancer in countries with a largely fair skin phenotype population and moderate sun exposure. Objectives Assessing risk factors in the military personnel. Comparing the risk factors in this occupational group to the general population. Materials and Methods 200 active‐duty military members and 1000 individuals (the control group) were randomly selected from the general population. We used transversal data collection through a questionnaire,...
Fri Sep 25, 2020 15:00
Abstract Onychomycosis(OM) is a chronic fungal infection of the nail caused by dermatophytes, yeasts, and non‐dermatophytes. Tioconazole is one of the topical antifungal belonging to imidazole derivatives. Tazarotene is a synthetic retinoid, with immunomodulating properties and anti‐inflammatory activity. To evaluate the efficacy of Tazarotene 0.1% gel alone in comparison with its combination with tioconazole nail paint in the treatment of onychomycosis. Forty patients presented with onychomycosis,...
Fri Sep 25, 2020 18:50
Abstract Erythroderma, orexfoliativedermatitis, is an inflammatorydisordercharacterizedbyerythemaandscalingaffectingmost of the skin surface. Itmay be a result of manydifferentcausessuch as previousdermatoses (psoriasis, eczema, atopicdermatitis, pityriasisrubrapilaris, pemphigusfoliaceous), drugreactions, malignancies (mycosisfungoides, Sézarysyndrome, adult T‐cellleukemia/lymphoma), infectionsandidiopathicdisorders. Regardless of theetiology, theclinicalappearance of erythroderma is similar in...
Sat Sep 26, 2020 15:23
Abstract “Sometimes you have to travel a long way to find what is near.” This quote by Paulo Coelho stands true for Platelet Rich Plasma (PRP) as we know of it today. Large strides have been made to understand this “youth” in blood, but there still seems a long way to go in our understanding of it. Despite advances, clarity in its preparation, biology and the properties of the final product still remain elusive. The concepts of an ideal number or concentration of platelets in the final enriched...
Sat Sep 26, 2020 19:11
Exercise-induced laryngeal obstruction (EILO) occurs with paradoxical vocal fold motion or supraglottic collapse during moderate to vigorous exercise. Previously, Gallena et al (2015) reported lower-than-normal inspiratory (Ri) and expiratory (Re) resistances during resting tidal breathing (RTB) in female teenage athletes with EILO. This study aimed to replicate that unexpected result.
Sat Sep 26, 2020 03:00
Abstract The surgeon needs to assess clinically significant thyroid nodules as they may represent aggressive forms of thyroid cancer or ectopic parathyroid glands. We discuss one such unusual nodule in the thyroid.
Sat Sep 26, 2020 03:00
We present results on the first principle study of the elastic constants and the phonon dispersion of EuFe2As2 at zero pressure. The ground-state energy calculations were performed within Density Functional Theory (DFT) and the generalized gradient approximation using the pseudopotential method with plane-wave basis sets. The projector augmented-wave (PAW) pseudopotentials were used in our calculation. The open source code QUANTUM ESPRESSSO was used with its pseudopotential database. The study on...
Sat Sep 26, 2020 19:20
Abstract Objectives The aim of this short term double‐blind, parallel, randomized clinical trial was to compare bone augmentation grafting with 100% autogenous bone (AB) or 50% deproteinized bovine bone matrix (DBBM) / 50% autogenous bone (BOAB) using a guided bone regeneration procedure, the fence technique, in a two‐stage implant placement. Material and methods Partially edentulous patients with extensive three‐dimensional osseous defects were included in this study. The main outcome...
Sat Sep 26, 2020 12:11
Abstract Objectives The study purpose was to examine peri‐implant bone alternations around osseointegrated implants caused solely by abutment screw preload stress using different tightening torque values. Materials and Methods Twenty 20–22‐week‐old Japanese white rabbits received two implants each in right and left femurs. Implants were randomly assigned to one of three tightening torque groups or the control (Cont) group. After 8 weeks, 35Ncm torque was delivered to abutment screws in...
Sat Sep 26, 2020 12:55
Abstract It has been recognized for nearly a century that human beings are inhabited by a remarkably dense and diverse microbial ecosystem, yet we are only just beginning to understand and appreciate the many roles that these microbes play in human health and development. Establishment of the microbiome begins at birth but many previous studies on infant skin health have focused on Candida species. Little is known on the full microbial composition across different areas and even less is known on...
Fri Sep 25, 2020 11:30
Markers for Ca++‐induced terminal differentiation of keratinocytes in vitro under defined conditions
Abstract Differentiation of normal human keratinocytes (NHK) grown in vitro as a monolayer to confluency can be triggered with an acute increase in concentration of extracellular Ca++. Over several days, induced by Ca++, the cells form pseudostratified sheets that somewhat resemble the basic organization of the intact skin. This experimental system is widely used in studies of keratinocyte biology and skin pathology. However, expression pattern of the genes considered as markers for cells in specific...
Fri Sep 25, 2020 17:59
Some of the genetic differences that have arisen between domesticated chickens and their wild ancestors, the red junglefowl, are linked to epigenetic changes, according to a new study. Scientists have discovered a small number of 'hotspots' in the DNA that control epigenetic changes at hundreds of other locations throughout the genome.
Mon Sep 21, 2020 18:16
COVID-19 infection caused by SARS-CoV2 virus is an acute respiratory illness which was declared as a pandemic by the World Health Organization. Usually, SARS-CoV2 infects independently and can cause spectrum of disease ranging from mild illness to severe progressive pneumonia, multiorgan dysfunction, and death; however, co-infections with other respiratory pathogens have been noted. Here, we present 2 fatal cases with co-infection, one with parainfluenza-4 virus and other co-infection/secondary infection...
Sat Sep 26, 2020 20:35
Abstract Introduction Allergic rhinitis (AR) is a common inflammatory condition of the nasal mucosa affecting approximately 20% of the population worldwide. Current therapies include intranasal antihistamines, corticosteroids, subcutaneous and sublingual immunotherapy (SLIT). This review and meta‐analysis assesses the efficacy of SLIT in the management of grass pollen‐induced AR in adults. Methods Ovid EMBASE, Ovid EBM Reviews, Cochrane Central Register of Controlled Trials, Ovid MedLine...
Sat Sep 26, 2020 13:44
Abstract Introduction This study aimed to compare the cost utility of concurrent chemoradiation (CCRT) to CCRT followed by adjuvant chemotherapy (CCRT/ACT) in locally advanced cervical cancer (LACC) using provider and societal viewpoints. Methods Data from our trial which was a multi‐centre study evaluating the efficacy of ACT compared to CCRT/ACT were entered into a decision tree model. The data included clinical probability, direct medical and non‐medical costs, and utility obtained from...
Sat Sep 26, 2020 11:19
Summary Duodenal volvulus is an extremely rare condition, with few cases reported in the literature. We present the case of an 83‐year‐old man with spontaneous duodenal volvulus diagnosed on CT imaging. Findings included volvulus of the third part of the duodenum, the characteristic whirl pattern of the superior mesenteric vessels and medialisation of the gallbladder. He was treated with nasogastric tube decompression and follow‐up CT demonstrated complete resolution of the volvulus.
Sat Sep 26, 2020 11:20
Abstract Introduction Ionizing radiation is a known etiologic factor in tumorigenesis and its role in inducing malignancy in the treatment of vestibular schwannoma has been debated. The purpose of this study was to identify a copy number aberration (CNA) profile or specific CNAs associated with radiation exposure which could either implicate an increased risk of malignancy or elucidate a mechanism of treatment resistance. ...
Sun Sep 27, 2020 03:00
Abstract ObjectiveAssess the feasibility of conducting a cluster randomized trial (RCT) comparing technology‐delivered mindfulness‐based intervention (MBI) programs against a waitlist control arm targeting advanced cancer patients and their informal caregivers.MethodsTwo‐arm cluster RCT within Kaiser Permanente Northern California (KPNC). We recruited patients with metastatic solid malignancies or hematological cancers and their informal caregivers. Intervention‐group participants chose to use either...
Sat Sep 26, 2020 22:18
Abstract The mechanism underlying the role of tumor necrosis factor alpha (TNF‐α) in the development of inflammatory hyperalgesia has been extensively studied, mainly the role of TNF‐α in the release of pro‐inflammatory cytokines. The current concept relies in the fact that TNF‐α stimulates the cascade release of other pro‐inflammatory cytokines, such as IL‐1β, IL‐6 and IL‐8 (CINC‐1 in rats), triggering the release of the final inflammatory mediator prostaglandin E2 (PGE2) and sympathetic amines...
Sat Sep 26, 2020 12:29
Abstract Stroke is an event causing a disturbance in cerebral function leading to death and disability worldwide. Both acute kidney injury and chronic kidney disease (CKD) are associated with an increased risk of stroke and cerebrovascular events. The underlying mechanistic approach between impaired renal function and stroke is limitedly explored and has attracted researchers to learn more for developing therapeutic intervention. Common risk factors such as hypertension, hyperphosphatemia, atrial...
Sat Sep 26, 2020 12:51
Abstract Neural oscillations are at the core of important computations in the mammalian brain. Interactions between oscillatory activities in different frequency bands, such as delta (1‐4 Hz), theta (4‐8 Hz), or gamma (>30 Hz), are a powerful mechanism for binding fundamentally distinct spatiotemporal scales of neural processing. Phase‐amplitude coupling (PAC) is one such plausible and well‐described interaction, but much is yet to be uncovered regarding how PAC dynamics contribute to sensory...
Sat Sep 26, 2020 13:12
Abstract A ubiquitous problem in science – from a physicist estimating the position of an electron (Heisenberg, 1927) to a social scientist conducting opinion polling (Bishop, 2004) – is that the measurement process can change the measured quantity itself. In addition, variation in measurement methodology may inadvertently favor one component of the measured quantity over another, leading to different results even though the measured quantity has not changed – for example, both gross domestic product...
Sat Sep 26, 2020 16:46
ABSTRACT People with cognitive impairments show deficits during physical performances such as gait, in particular during cognitively‐challenging conditions (i.e. dual‐task gait [DTG]). However it is unclear if people at risk of dementia, such as those with subjective memory complaints (SMC), also display gait and central deficits associated with DTG. In this study, we investigated the effects of single‐ and dual‐task gait (STG and DTG), on left prefrontal cortex (PFC) activation in elderly people...
Sat Sep 26, 2020 22:00
Abstract Background There are still only a few therapeutic strategies to improve taste sensation, which is part of oral health and quality of life. Objective Therefore, here we aimed to investigate gustatory functions of healthy subjects performing mechanical tongue cleaning (MTC), an easy‐to‐perform oral hygiene procedure, to demonstrate taste changes and to describe possible negative side effects. Methods Prior to and 14 days following MTC with an Orabrush®, the following tests...
Sat Sep 26, 2020 11:55
Abstract Background The diagnosis of temporomandibular disorders (TMD) is based on patient history and physical exam, and may require medical imaging. Masticatory muscle palpation is essential to make a diagnosis of TMD. However, the response of masticatory muscles to mechanical pressure stimuli depends on many physical and psychological factors. Objective This study aimed at determining the impact of somatosensory amplification (SSA)—an estimate of somatic awareness and bodily hypervigilance—on...
Sat Sep 26, 2020 12:44
Abstract Objectives Burning mouth syndrome (BMS) is a medical entity characterized by a spontaneous sensation of burning, numbness, or pain of the oral mucosa in the absence of clinical symptoms. The goal of this systematic review was to assess the efficacy of various current treatments for BMS. Methods The literature search used the following inclusion criteria: randomized controlled trials (RCTs) which compared one or more treatment strategies for patients with primary/idiopathic BMS...
Sat Sep 26, 2020 13:05
Abstract Background The clinical care of chronic pain requires personalized understanding of the mechanisms involved. Temporomandibular disorders (TMD) are the most common chronic orofacial pain conditions, and oxidative stress has been proposed to be implicated in their pathophysiology, especially in arthrogenous TMD. However, few studies have explored oxidative stress in myogenous TMD (TMDM). Objective The aims of this study were to compare the salivary oxidative stress profiles between...
Sat Sep 26, 2020 13:19
Background Immune checkpoint inhibitor therapy has revolutionized lung adenocarcinoma therapy. Treatment with antibodies against the immune checkpoint molecules programmed death‐1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) can induce a durable response in a subset of patients. Immunohistochemistry characterization of tumor PD‐L1 expression using either a histopathology specimen or a cytopathology specimen has been shown to correlate with treatment response. However, the current practice relies...
Fri Sep 25, 2020 21:51
Abstract Purpose Intraventricular neuroendoscopic techniques, particularly third ventriculostomy, are employed increasingly in the management of infantile hydrocephalus. However, surgical access to the ventricular cavities is associated with a risk of post-operative cerebrospinal fluid (CSF) leak. Here, we describe a structured, multi-layered approach to wound opening and closure which aims to maximise the natural tissue barriers against...
Sun Sep 27, 2020 03:00
Gases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti-inflammatory and antiapoptotic activities. The gas H2S is emerging as a novel regulator of important physiologic functions such as arterial diameter, blood...
Sun Sep 27, 2020 14:05
The current work proposes a multimodal evaluation protocol focused on metacognitive, self-regulation of learning, and emotional processes, which make up the basis of the difficulties in adults with LDs.
Sun Sep 27, 2020 19:48
The goal of the protocol is to provide a method for producing non-invasive neuronal lesions in the brain. The method utilizes Magnetic Resonance-guided Focused Ultrasound (MRgFUS) to open the Blood Brain Barrier in a transient and focal manner, in order to deliver a circulating neurotoxin to the brain parenchyma.
Sun Sep 27, 2020 20:48
Langerhans cell tumors are rare clonal disorders characterized by neoplastic proliferation of dendritic cells that can be further classified into the subtypes Langerhans cell histiocytosis and Langerhans cell ...
Sun Sep 27, 2020 03:00
Background. Small nucleolar RNAs (snoRNAs) have been proved to play important roles in various cellular physiological process. Recently, dysregulation of snoRNA SNORA71A has been found involved in tumorigenesis of various malignant cancers. However, the emerging effects of SNORA71A in hepatocellular carcinoma (HCC) remain largely unclear. In this study, we aimed to explore the SNORA71A expression and its underlying significance in HCC. Methods. Expression of SNORA71A in cell lines and clinical specimens...
Sun Sep 27, 2020 08:20
This paper describes the isolation and culturing of embryonic rat sympathetic neurons from the superior cervical ganglia. It also provides detailed protocols for immunocytochemical staining and for preparing neuronal extracts for mass spectrometric analysis.
Sun Sep 27, 2020 21:48
This technical report describes a variation of the modified Bergström technique for the biopsy of the musculus tibialis anterior that limits fiber damage.
Sun Sep 27, 2020 21:48
The Hong Kong cetacean stranding response program has incorporated postmortem computed tomography, which provides valuable information on the biological health and profile of the deceased animals. This study describes 8 image rendering techniques that are essential for the identification and visualization of postmortem findings in stranded cetaceans, which will help clinicians, veterinarians and stranding response personnel worldwide to fully utilize the radiological modality.
Sun Sep 27, 2020 22:48
Much has already been written about the harmful effects of COVID-19 on maxillofacial surgery, however we have found that there have also been enormous opportunities to be experienced in sick patient management during this period, and this has been to the benefit of our maxillofacial patients on return to normal duties.
Sun Sep 27, 2020 03:00
Whilst there have been great improvements in the management of injuries in elite and professional athletes with the formalisation of the clinical specialty of sports and exercise medicine, the management of facial injuries has perhaps lagged in this group. Professional athletic careers can be put in jeopardy by unnecessarily long absences from training and competition after facial injuries. Professional and elite sports athletes can benefit from different approaches to the management of their facial...
Sun Sep 27, 2020 03:00
Birds are unique among living vertebrates in having air‐filled sinuses in their postcranial skeletons, a phenomenon called postcranial skeletal pneumaticity (PSP). The factors that account for serial and interspecific variation in PSP are poorly understood. Using micro‐CT scans of stork vertebrae and geometric morphometric methods, I show that vertebral shape is strongly correlated with PSP, supporting the hypothesis that locus‐ and shape‐specific biomechanics influence skeletal pneumatization....
Sat Sep 26, 2020 18:03
Introduction. Giant cell arteritis (GCA) is a large vessel (LV) vasculitis, mainly affecting elder patients. Monitoring GCA activity during tocilizumab (TCZ) treatment is an unmet need, since low serum levels of C-reactive protein (CRP) during treatment may underestimate disease activity. To date, few data are available on the role of different imaging techniques in monitoring GCA activity and response to treatment. We report herein a cohort of GCA patients treated with TCZ and followed up with multimodal...
Sun Sep 27, 2020 14:05
Abstract BackgroundThe distribution, utilisation and accessibility of surgical robotics in England is unknown.MethodsA nationwide Freedom of Information (FOI) request was sent to all acute National Health Service (NHS) trusts. Accessibility was assessed for 32,843 Lower Super Output Areas in England.ResultsAll 149 acute NHS trusts responded to the FOI request. 61 robots are distributed between 48 trusts. The number of robots and robotic procedures has increased annually. Urological procedures comprise...
Sat Sep 26, 2020 21:43
2. Abstract BackgroundThoracoabdominal esophagectomy with lymphadenectomy is the cornerstone of curative therapy for esophageal carcinoma. To reduce postoperative morbidity, minimally invasive technology has become increasingly established. Conventional thoraco‐laparoscopic procedures, however, are limited by their technical feasibility. These limitations can be overcome using robot‐assisted technology.MethodsRobotic Ivor‐Lewis esophageal resection has gradually been implemented in our clinic from...
Sat Sep 26, 2020 22:10
Abstract SASH1 has been reported as a causal gene of lentiginous phenotypes with and without heredity, including an autosomal dominant type characterized by lentigines predominantly on sun‐exposed areas such as the face and limbs. Recently, cases of dyschromatosis with SASH1 mutations have been reported worldwide; however, only one case has been reported from Japan. Here, we analyzed six Japanese patients who characteristically showed many lentigines on sun‐exposed areas, using next‐generation sequencing....
Sun Sep 27, 2020 20:25
One important limitation of topical photodynamic therapy (PDT) is the limited tissue penetration of precursors. Microneedles (MNs) are minimally invasive devices used to promote intradermal drug delivery. Dissolving MNs contain drug‐associated to polymer blends, dissolving after insertion into skin, allowing drug release. This study comprises development and characterization of a pyramidal model of dissolving MNs (500 μm) prepared with 5% w/w aminolevulinic acid and 20% w/w Gantrez AN‐139 in aqueous...
Sun Sep 27, 2020 18:54
The present paper describes the development of a technique, applied to paraffin‐embedded tissues, which uses three different wavelengths of monochromatic light (λ1=445nm, λ2=540nm, and λ3=660nm) for the measures of the Degree of Polarization (DoP), Degree of Linear Polarization (DoLP), Degree of Circular Polarization (DoCP) and birefringence, all obtained from measurements of Stokes parameters by using polarized light. The goal of this study was to detect changes in developing embryonic mouse eye...
Sun Sep 27, 2020 18:58
Abstract The rapid identification of antibiotic resistant bacteria is an important area for public health. In the environment, bacteria are continuously exposed to sub‐inhibitory antibiotic concentrations which has major implications in the generation of multi‐drug resistant strains. To understand the impact of sub‐inhibitory antibiotic concentrations on bacteria, Raman spectroscopy was employed coupled with partial least squares‐discriminant analysis to profile Escherichia coli strains treated...
Sun Sep 27, 2020 19:00
Abstract Terahertz absorption spectroscopy based on attenuated total reflection (ATR) from a microfluidic sample cell was designed and implemented to detect gene mutations leading to Huntington's disease. The self‐developed compact ATR‐microfluidic system was employed to detect two groups of base‐repeated DNA molecules combined with a terahertz time‐domain spectrometer in a marker‐free manner. The first group featured different repetition patterns of oligonucleotide fragments, and the second group...
Sun Sep 27, 2020 19:34
Objective We conducted a Mendelian randomization study to disentangle the comparative effects of lipids and apolipoprotein on ischemic stroke. Methods Single‐nucleotide polymorphisms (SNPs) associated with low‐ and high‐density lipoprotein (LDL and HDL) cholesterol, triglycerides and apolipoprotein A‐I and B (apoA‐I and apoB) at the level of genome‐wide significance (p<5×10‐8) in the UK Biobank were used as instrumental variables. Summary‐level data for ischemic stroke and its subtypes...
Sun Sep 27, 2020 12:04
Background Anterior cephaloceles are rare congenital malformations that have historically been corrected via open approaches. Although the advent of endoscopic endonasal surgery has provided a minimally invasive and theoretically less morbid approach to the anterior skull base, whether endoscopic approaches provide superior treatment outcomes to open techniques has yet to be elucidated. The objective of this study was to systematically review the available literature regarding presentation and outcomes...
Sun Sep 27, 2020 16:29
Background Many adjunctive techniques exist for dacryocystorhinostomy (DCR), with varying levels of supportive evidence. Methods Literature from PubMed, EMBASE, and Cochrane Databases was reviewed between January 1990 and January 2020 to examine evidence regarding the utility of adjunctive techniques to DCR, including mucosal flap preservation, concurrent septoplasty, stenting, topical mitomycin C (MMC), and 5‐fluorouracil (5‐FU), as well as perioperative antibiotics and steroids. Recommendations...
Sun Sep 27, 2020 16:33
Generalized peritonitis caused by spontaneous gall bladder perforation is rare and difficult to diagnose preoperatively. The increased absorption of the spilling conjugated bile from the gall bladder by the inflamed peritoneum causes jaundice and direct hyperbilirubinemia. A 56-year-old male patient with septic generalized peritonitis and obstructive-type hyperbilirubinemia came to our hospital. The blood examination showed that total, direct, and indirect bilirubin were 6.20, 5.38, and 0.82 mg/dl....
Sun Sep 27, 2020 16:50
Abstract Hyperhidrosis is a condition of excessive sweating beyond physiological parameters that can seriously impair quality of life. This study aims to evaluate the oral oxybutynin effectiveness in hyperhidrosis, besides its tolerance and safety. In a real‐life long‐term study, thirty patients with primary hyperhidrosis and Hyperhidrosis Disease Severity Scale (HDSS) with score of at least two were submitted to a questionnaire to assess demographic data, HDSS and side effects of oxybutynin....
Sun Sep 27, 2020 19:14
Abstract Erythrodermic psoriasis (EP) is a rare form of the disease clinically characterized by a generalized erythema covering ≥90% of the body surface area (BSA). The management of EP is challenging: no standardized guidelines exist with literature suggesting cyclosporine or infliximab as first‐line therapy. However, a recent systematic review showed a positive response in EP patients treated with biologic agents. The most common biologic used for EP up until now has been ustekinumab, whereas...
Sun Sep 27, 2020 19:58
Abstract Purpose of Review Traumatic brain injury (TBI) is highly prevalent among service members and Veterans (SMVs) and associated with changes in blood-based biomarkers. This manuscript reviews candidate biomarkers months/years following military-associated TBI. Recent Findings Several blood-based biomarkers have been investigated...
03:00
Oral squamous cell carcinoma (OSCC) remains the most common cancer among males in Sri Lanka. Metastasis to neck is a crucial prognostic factor. A modified radical/ radical neck dissection including levels I –V, is performed in patients with OSCC who has a clinically positive neck (cN+). Currently, evidence suggest sparing level V in a cN + may be justified due to less chance of metastasis in early stages of the disease. The incidence of metastasis to level V in patients with cN + s have not been...
Sun Sep 27, 2020 03:00
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